Induction of metallothionein by stress and its molecular mechanisms

Gene Expression

Volumn 7, Issue 4-6, 1999, Pages 301-310

  Jacob, Samson T ^a,c   Ghoshal, Kalpana ^a   Sheridan, John F ^b  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c 333 Hamilton Hall ^*  (United States)

Author keywords

Metallothionein; Molecular mechanisms; Restraint stress; Social reorganization stress

Indexed keywords

CADMIUM; CORTICOSTERONE; DNA BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; ISOPROTEIN; MESSENGER RNA; METALLOTHIONEIN; MIFEPRISTONE; NADOLOL; ZINC SULFATE;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GENE INDUCTION; HABITUATION; IMMOBILIZATION STRESS; LIVER LEVEL; MENTAL STRESS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN INDUCTION; RNA ANALYSIS; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0032804191     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (56)

1. Aniskovitch, L. P.; Jacob, S. T. Purification and characterization of a rat liver protein that recognizes CCAAT-homologous sequences of the metallothionein promoter and trans-activates this promoter. Arch. Biochem. Biophys. 341:337-346; 1997.
2. Aniskovitch, L. P.; Jacob, S. T. Distinct proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and trans-activates this promoter. Oncogene 16:1475-1486; 1998.
3. Barnard, C. J.; Behnke, J. M.; Sewell, J. Social behaviour, stress and susceptibility to infection in house mice (Mus musculus): Effects of duration of grouping and aggressive behaviour prior to infection on susceptibility to Babesia microti. Parasitology 107:183-192; 1993.
4. Belloso, E.; Hernandez, J.; Giralt, M.; Kille, P.; Hidalgo, J. Effect of stress on mouse and rat brain metallothionein I and III mRNA levels. Neuroendocrinology 64:430-439; 1996.
5. Bremner, I. Metallothionein and copper metabolism in liver. Methods Enzymol. 205:584-591; 1994.
6. Carr, D. J.; Rogers, T. J.; Weber, R. J. The relevance of opioids and opioid receptors on immunocompetence and immune homeostasis. Proc. Soc. Exp. Biol. Med. 213:248-257; 1996.
7. Carthew, R. W.; Chodosh, L. A.; Sharp, P. A. The major late transcription factor binds to and activates the mouse metallothionein I promoter. Genes Dev. 1:973; 1987.
8. Ciminero, A. R. Behavioral assessment: An overview. In: Ciminero, A. R.; Calhoun, K. S.; Adams, H. E., eds. Handbook of behavioral assessment. New York: Wiley; 1986:3-12.
9. Cohen, S.; Tyrrel, D. A. J.; Smith, A. P. Psychological stress and susceptibility to the common cold. N. Engl. J. Med. 325:606-612; 1991.
10. Cousins, R. J. Absorption, transport, and hepatic metabolism of copper and zinc: Special reference to metallothionein and ceruloplasmin. Physiol. Rev. 65:238-309; 1985.
11. Dalton, T. P.; Li, Q. W.; Bittel, D.; Liang, L. C.; Andrews, G. K. Oxidative stress activates metal-responsive transcription factor-1 binding activity-occupancy in vivo of metal response elements in the metallothionein-I gene promoter. J. Biol. Chem. 271:26233-26241; 1996.
12. Datta, P. K.; Jacob, S. T. Identification of a sequence within the mouse metallothionein-I gene promoter mediating its basal transcription and of a protein interacting with this element. Cell. Mol. Biol. Res. 39:439-449; 1993.
13. Dobbs, C. M.; Vasquez, M.; Glaser, R.; Sheridan, J. F. Mechanisms of stress-induced modulation of viral pathogenesis and immunity. J. Neuroimmunol. 48: 151-160; 1993.
14. Dobbs, C. M.; Feng, N.; Beck, F. M.; Sheridan, J. F. Neuroendocrine regulation of cytokine production during experimental influenza viral infection. J. Immunol. 157:1870-1877; 1996.
15. Garg, L. C.; Dixit, A.; Webb, M. L.; Jacob, S. T. Interaction of a positive regulatory factor(s) with a 106-base pair upstream region controls transcription of metallothionein-I gene in the liver. J. Biol. Chem. 264: 2134-2138; 1989.
16. Ghoshal, K.; Wang, Y.; Sheridan, J. F.; Jacob, S. T. Metallothionein induction in response to restraint stress: Transcriptional control, adaptation to stress and the role of glucocorticoid. J. Biol. Chem. 272:27904-27910; 1998.
17. Ghoshal, K.; Li, Z.; Jacob, S. T. Overexpression of the large subunit of the protein Ku suppresses metallothionein-I induction by heavy metals. Proc. Natl. Acad. Sci. USA 95:10390-10395; 1998.
18. Gunes, C.; Heuschel, R.; Georgiev, O.; Muller, K. H.; Lichtlen, P.; Bluthmann, H.; Marino, S.; Aguzzi, A.; Schaffner, W. Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 17:2846-2854; 1998.
19. Hager, L. J.; Palmiter, R. D. Transcriptional regulation of mouse liver metallothionein-I gene by glucocorticoids. Nature 291:340-342; 1981.
20. Hamer, D. H. Metallothionein. Annu. Rev. Biochem. 55:913-951; 1986.
21. Hermann, G.; Tovar, C. A.; Beck, F. M.; Allen, C.; Sheridan, J. F. Restraint stress differentially affects the pathogenesis of an experimental influenza viral infection in three inbred stains of mice. J. Neuroimmunol. 47:83-94; 1993.
22. Hermann, G.; Tovar, C. A.; Beck, F. M.; Sheridan, J. F. Kinetics of glucocorticoid response to restraint stress and/or experimental influenza viral infection in two inbred strains of mice. J. Neuroimmunol. 49:25-33; 1994.
23. Hermann, G.; Beck, F. M.; Tovar, C. A.; Malarkey, W. B.; Allen, C.; Sheridan, J. F. Kinetics of glucocorticoid response to restraint stress and/or experimental influenza viral infection in two inbred strains of mice. J. Neuroimmunol. 53:173-180; 1994.
24. Hermann, G.; Beck, F. M.; Sheridan, J. F. Stress-induced glucocorticoid response modulates mononuclear cell trafficking during an experimental influenza viral infection. J. Neuroimmunol. 56:179-186; 1995.
25. Heuchel, R.; Radtke, F.; Georgiev, O.; Stark, G.; Aguet, M.; Schaffner, W. The transcription factor MTF-1 is essential for basal heavy metal-induced metallothionein gene expression. EMBO J. 13:2870-2875; 1994.
26. Hidalgo, J.; Giralt, M.; Garvey, J. S.; Armario, A. Physiological role of glucocorticoids on rat serum and liver metallothionein and stress conditions. Am. J. Physiol. 254:E71-E78; 1988.
27. Hidalgo, J.; Borrás, M.; Garvey, J. S.; Armario, A. Liver, brain, and heart metallothionein induction by stress. J. Neurochem. 55:651-654; 1990.
28. Hidalgo, J.; Giralt, M.; Garvey, J. S.; Armario, A. Effect of morphine on rat liver metallothionein and zinc metabolism. J. Pharmacol. Exp. Ther. 259:274-278; 1991.
29. Hidalgo, J.; Rhee, S.; Huang, P. C.; Garvey, J. S. Differential effect of adrenalectomy on rat liver metallothionein mRNA levels in basal and stress conditions. Horm. Metab. Res. 24:233-236; 1992.
30. Jacob, C.; Maret, W.; Vallee, B. L. Control of zinc transfer between thionein, metallothionein, and zinc proteins. Proc. Natl. Acad. Sci. USA 95:3489-3494; 1998.
31. Kagi; J. H. R. Overview of metallothionein. Methods Enzymol. 205:613-626; 1991.
32. Kang, Y. J.; Chen, Y.; Yu, A.; Vos-McCowan, M.; Epstein, P. N. Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J. Clin. Invest. 100:1501-1506; 1997.
33. Kelly, S. L.; Basu, A.; Teicher, B. A.; Hacker, M. P.; Hamer, D. H.; Lazo, J. S. Overexpression of metallothionein confers resistance to anticancer drugs. Science 241:1813-1815; 1990.
34. Kelly, E. J.; Palmiter, R. D. A murine model of Menekes disease reveals a physiological function of metallothionein. Nat. Genet. 13:219-222; 1996.
35. Kelly, E. J.; Sandgren, E. P.; Brinster, R. L.; Palmiter, R. D. A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes. Proc. Natl. Acad. Sci. USA 94:10045-10050; 1997.
36. Lazo, J. S.; Bruce, B. R. Metallothioneins and cell death by anticancer drugs. Annu. Rev. Pharmacol. Toxicol. 35:635-653; 1995.
37. Lazo, J. S.; Kondo, Y.; Dellapiazza, D.; Michalska, A. E.; Choo, K. H. A.; Pitt, B. R. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes. J. Biol. Chem. 270:5506-5510; 1995.
38. Lee, D. K.; Carrasco, J.; Hidalgo, J.; Andrews, G. K. Identification of a signal transducer and activator of transcription (STAT) in the mouse metallothionein promoter involved in interleukin-6-induced gene expression. Biochem. J. 331:59-65; 1999.
39. Li, Q.; Hu, N.; Daggett, M. A. F.; Chu, W. A.; Bittel, D.; Johnson, J. A.; Andrews, G. K. Participation of upstream stimulator factor (USF) in cadmium induction of the mouse metallothionein-I gene. Nucleic Acids Res. 26:5182-5189; 1998.
40. Maret, W.; Vallee, B. L. Thiolate ligands in metallothionein confer redox activity on zinc clusters. Nucleic Acids Res. 26:3478-3482; 1998.
41. Masters, B. A.; Kelly, E. J.; Quaife, C. J.; Brinster, R. L.; Palmiter, R. D. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA 91:584-588; 1994.
42. Mayo, K. E.; Palmiter, R. D. Glucocorticoid regulation of metallothionein-I mRNA synthesis in cultured mouse cells. J. Biol. Chem. 256:2621-2624; 1981.
43. Padgett, D. A.; Sheridan, J. F.; Dorne, J.; Berntson, G. G.; Cendelora, J.; Glaser, R. Social stress and the : reactivation of latent herpes simplex virus type 1. Proc. Natl. Acad. Sci. USA 95:7231-7235; 1998.
44. Palmiter, R. D. Molecular biology of metallothionein gene expression. EXS 52:63-79; 1987.
45. Palmiter, R. D.; Findley, S. D.; Whitmore, T. E.; Durnam, D. M. MT-III, a brain-specific member of the metallothionein family. Proc. Natl. Acad. Sci. USA 89: 6333-6337; 1992.
46. Pitt, B. R.; Schwarz, M.; Woo, E. S.; Yee, E.; Wasserloos, K.; Tran, S.; Weng, W.; Mannix, R. J.; Watkins, S. A.; Tyurina, Y. Y.; Tyurin, V. A.; Kagan, V. E.; Lazo, J. S. Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. Am. J. Physiol. 273:L856-L865; 1997.
47. Quaife, C. J.; Erickson, J. C.; Froelick, G. J.; Kelly, E. J.; Zambrowicz, B. P.; Palmiter, R. D. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia. Biochemistry 33:7250-7259; 1994.
48. Radtke, F.; Heuchel, R.; Georgiev, O.; Hergersberg, M.; Gariglio, M.; Dembic, Z.; Schaffner, W. Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J. 12:1355-1362; 1993.
49. Ramsey, J. M. Basic pathophysiology: Modern stress and the disease process. Menlo Park, CA: Addison-Wesley Publishing Company; 1982:30-73.
50. Schwarz, M. A.; Lazo, J. S.; Yalowich, J. C.; Reynolds, I.; Kagan, V. E.; Tyurin, V.; Kim, Y.-M.; Watkins, S. C.; Pitt, B. R. Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity. J. Biol. Chem. 269:15238-15243; 1994.
51. Schwarz, M. A.; Lazo, J. S.; Yalowich, J.; Allen, W. P.; Whitmore, M.; Bergonia, H. A.; Tzeng, H. A.; Billiard, T. R.; Robbins, P. D.; Lancaster, J. R., Jr.; Pitt, B. R. Metallothionein protects against the cytotoxic and DNA damaging effect of nitric oxide. Proc. Natl. Acad. Sci. USA 92, 4452-4456; 1995.
52. Sheridan, J. F.; Feng, N. G.; Bonneau, R. H.; Allen, C. M.; Huneycutt, B. S.; Glaser, R. Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice. J. Neuroimmunol. 31:245-255; 1991.
53. Vallee, B. L. The function of metallothionein. Neurochem. Int. 27:23-33; 1995.
54. 2 toxicity. Am. J. Physiol. 276:H167-H175; 1999.
55. Watkins, S. A.; Tyurina, Y. Y.; Tyurin, V. A.; Kagan, V. E.; Lazo, J. S. Overexpression of metallothionein decreases sensitivity of pulmonary endothelial cells to oxidant injury. Am. J. Physiol. 273:L856-L865; 1997.
56. Yagle, M. K.; Palmiter, R. D. Coordinate regulation of mouse metallothionein I and II genes by heavy metals and glucocorticoids. Mol. Cell. Biol. 5:291-294; 1985.