Interferon-Gamma and TRAIL in Human Breast Tumor Cells

Vitamins and Hormones

Volumn 67, Issue , 2004, Pages 291-318

  Almodóvar, Carmen Ruiz de ^a   López Rivas, Abelardo ^a   Ruiz Ruiz, Carmen ^b  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; CASP8 PROTEIN, HUMAN; CASPASE; CASPASE 8; GAMMA INTERFERON; MEMBRANE PROTEIN; TNFSF10 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL; APOPTOSIS; BREAST TUMOR; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CASPASE 8; CASPASES; GENE EXPRESSION REGULATION; HUMANS; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 3042784477     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(04)67016-6     Document Type: Article

References (158)

1. S Aaltomaa P Lipponen M Eskelinen V.M Kosma S Marin E Alhava K Syrjanen Lymphocyte infiltrates as a prognostic variable in female breast cancer Eur. J. Cancer 28A 1992 859 864
2. Y Adachi S Taketani H Oyaizu K Ikebukuro R Tokunaga S Ikehara Apoptosis of colorectal adenocarcinoma induced by 5-FU and⧸or IFN-gamma through caspase 3 and caspase 8 Int. J. Oncol. 15 1999 1191 1196
3. E.Y Ahn G Pan S.M Vickers J.M McDonald IFN-gamma upregulates apoptosis-related molecules and enhances Fas-mediated apoptosis in human cholangiocarcinoma Int. J. Cancer 100 2002 445 451
4. A.L Angiolillo C Sgadari D.D Taub F Liao J.M Farber S Maheshwari H.K Kleinman G.H Reaman G Tosato Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo J. Exp. Med. 182 1995 155 162
5. A Ashkenazi V.M Dixit Death receptors: Signaling and modulation Science 281 1998 1305 1308
6. A Ashkenazi R.C Pai S Fong S Leung D.A Lawrence S.A Marsters C Blackie L Chang A.E McMurtrey A Hebert L DeForge I.L Koumenis D Lewis L Harris J Bussiere H Koeppen Z Shahrokh R.H Schwall Safety and antitumor activity of recombinant soluble Apo2 ligand J. Clin. Invest. 104 1999 155 162
7. V Barak I Kalickman B Nisman H Farbstein Z.G Fridlender L Baider A Kaplan S Stephanos T Peretz Changes in cytokine production of breast cancer patients treated with interferons Cytokine 10 1998 977 983
8. J Bartek R Iggo J Gannon D.P Lane Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines Oncogene 5 1990 893 899
9. T Berger M Kretzler TRAIL-induced apoptosis is independent of the mitochondrial apoptosis mediator DAP3 Biochem. Biophys. Res. Commun. 297 2002 880 884
10. D Bernard B Quatannens B Vandenbunder C Abbadie Rel⧸NF-kappaB transcription factors protect against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by up-regulating the TRAIL decoy receptor DcR1 J. Biol. Chem. 276 2001 27322 27328
11. U Boehm T Klamp M Groot J.C Howard Cellular responses to interferon-gamma Annu. Rev. Immunol. 15 1997 749 795
12. E.C Borden J.F Holland T.L Dao J.U Gutterman L Wiener Y.C Chang J Patel Leukocyte-derived interferon (alpha) in human breast carcinoma. The American Cancer Society phase II trial Ann. Intern. Med. 97 1982 1 6
13. C Carnaud D Lee O Donnars S.H Park A Beavis Y Koezuka A Bendelac Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells J. Immunol. 163 1999 4647 4650
14. J Chai C Du J.W Wu S Kyin X Wang Y Shi Structural and biochemical basis of apoptotic activation by Smac⧸DIABLO Nature 406 2000 855 862
15. M Chawla-Sarkar D.W Leaman E.C Borden Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: Correlation with TRAIL⧸Apo2L induction in melanoma cell lines Clin. Cancer Res. 7 2001 1821 1831
16. Y.E Chin M Kitagawa K Kuida R.A Flavell X.Y Fu Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis M. Cell Biol. 17 1997 5328 5337
17. A.M Chinnaiyan U Prasad S Shankar D.A Hamstra M Shanaiah T.L Chenevert B.D Ross A Rehemtulla Combined effect ot tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy Proc. Natl. Acad. Sci. USA 97 2000 1754 1759
18. C.M Coughlin K.E Salhany M.S Gee D.C LaTemple S Kotenko X Ma G Gri M Wysocka J.E Kim L Liu F Liao J.M Farber S Pestka G Trinchieri W.M Lee Tumor cell responses to IFNgamma affect tumorigenicity and response to IL-12 therapy and antiangiogenesis Immunity 9 1998 25 34
19. J.E Darnell Jr. I.M Kerr G.R Stark Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins Science 264 1994 1415 1421
20. C.R de Almodóvar C Ruiz-Ruiz C Munoz-Pinedo G Robledo A Lopez-Rivas The differential sensitivity of Bcl-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bcl-2 protein levels Oncogene 20 2001 7128 7133
21. M.A Degli-Esposti W.C Dougall P.J Smolak J.Y Waugh C.A Smith R.G Goodwin The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain Immunity 7 1997 813 820
22. Y Deng Y Lin X Wu TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac⧸DIABLO Genes Dev. 16 2002 33 45
23. M.L Disis E Calenoff G McLaughlin A.E Murphy W Chen B Groner M Jeschke N Lydon E McGlynn R.B Livingston Existent T-cell and antibody immunity to HER-2⧸neu protein in patients with breast cancer Cancer Res. 54 1994 16 20
24. P Domanski O.R Colamonici The type-I interferon receptor. The long and short of it Cytokine Growth Factor Rev. 7 1996 143 151
25. S.E Ealick W.J Cook S Vijay-Kumar M Carson T.L Nagabhushan P.P Trotta C.E Bugg Three-dimensional structure of recombinant human interferon-gamma Science 252 1991 698 702
26. F Fallarino T.F Gajewski Cutting edge: Differentiation of antitumor CTL in vivo requires host expression of Stat1 J. Immunol. 163 1999 4109 4113
27. N.A Fanger C.R Maliszewski K Schooley T.S Griffith Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) J. Exp. Med. 190 1999 1155 1164
28. M.A Farrar R.D Schreiber The molecular cell biology of interferon-gamma and its receptor Annu. Rev. Immunol. 11 1993 571 611
29. C.G Ferreira S.W Span G.J Peters F.A.E Kruyt G Giaccone Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460 Cancer Res. 60 2000 7133 7141
30. D.E Fisher Apoptosis in cancer therapy: Crossing the threshold Cell 78 1994 539 542
31. K Forrester S.E Lupold V.L Ott C.H Chay V Band X.W Wang C.C Harris Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent Oncogene 10 1995 2103 2111
32. D.M Frucht T Fukao C Bogdan H Schindler J.J O'Shea S Koyasu IFN-gamma production by antigen-presenting cells: Mechanisms emerge Trends Immunol. 22 2001 556 560
33. S Fulda K.M Debatin IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway Oncogene 21 2002 2295 2308
34. S Fulda E Meyer K.M Debatin Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression Oncogene 21 2002 2283 2294
35. S Gessani F Belardelli IFN-gamma expression in macrophages and its possible biological significance Cytokine Growth Factor Rev. 9 1998 117 123
36. J Gil M Esteban The interferon-induced protein kinase (PKR), triggers apoptosis through FADD-mediated activation of caspase 8 in a manner independent of Fas and TNF-alpha receptors Oncogene 19 2000 3665 3674
37. J Gil M.A Garcia M Esteban Caspase 9 activation by the dsRNA-dependent protein kinase, PKR: Molecular mechanism and relevance FEBS Lett. 529 2002 249 255
38. P Golstein Cell death: TRAIL and its receptors Curr. Biol. 7 1997 R750 R753
39. B Gong A Almasan Genomic organization and transcriptional regulation of human Apo2⧸TRAIL gene Biochem. Biophys. Res. Commun. 278 2000 747 752
40. D.R Green J.C Reed Mitochondria and apoptosis Science 281 1998 1309 1312
41. T.S Griffith W.A Chin G.C Jackson D.H Lynch M.Z Kubin Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells J. Immunol. 161 1998 2833 2840
42. T.S Griffith S.R Wiley M.Z Kubin L.M Sedger C.R Maliszewski N.A Fanger Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL J. Exp. Med. 189 1999 1343 1354
43. A Gross J.M McDonnell S.J Korsmeyer BCL-2 family members and the mitochondria in apoptosis Genes Dev. 13 1999 1899 1911
44. B.C Guo Y.H Xu Bcl-2 over-expression and activation of protein kinase C suppress the trail-induced apoptosis in Jurkat T cells Cell Res. 11 2001 101 106
45. J.U Gutterman G.R Blumenschein R Alexanian H.Y Yap A.U Buzdar F Cabanillas G.N Hortobagyi E.M Hersh S.L Rasmussen M Harmon M Kramer S Pestka Leukocyte interferon-induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma Ann. Intern. Med. 93 1980 399 406
46. K Harada S Toyooka N Shivapurkar A Maitra J.L Reddy H Matta K Miyajima C.F Timmons G.E Tomlinson D Mastrangelo R.J Hay P.M Chaudhary A.F Gazdar Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines Cancer Res. 62 2002 5897 5901
47. N Harper S.N Farrow A Kaptein G.M Cohen M MacFarlane Modulation of tumor necrosis factor apoptosis-inducing ligand-induced NF-kappa B activation by inhibition of apical caspases J. Biol. Chem. 276 2001 34743 34752
48. S Hopkins-Donaldson J.-L Bodmer K.B Bourloud C.B Brognara J Tschopp N Gross Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis Cancer Res. 60 2000 4315 4319
49. S Hopkins-Donaldson A Ziegler S Kurtz C Bigosch D Kandioler C Ludwig U Zangemeister-Wittke R Stahel Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation Cell Death Differ. 10 2003 356 364
50. R.U Jänicke M.L Sprengart M.R Wati A.G Porter Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis J. Biol. Chem. 273 1998 9357 9360
51. M Jo T.-H Kim D.-W Seol J.E Esplen K Dorko T.R Billiar S.C Strom Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand Nat. Med. 6 2000 564 567
52. N Kayagaki N Yamaguchi M Nakayama H Eto K Okumura H Yagita Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs J. Exp. Med. 189 1999 1451 1460
53. M.C Keane S.A Ettenberg M.M Nau E.K Russell S Lipkowitz Chemotherapy augments TRAIL-induced apoptosis in breast cell lines Cancer Res. 59 1999 734 741
54. M.M Keane S.A Ettenberg G.A Lowrey E.K Russell S Lipkowitz Fas expression and function in normal and malignant breast cell lines Cancer Res. 56 1996 4791 4798
55. M.M Keane Y Rubinstein M Cuello S.A Ettenberg P Banerjee M.M Nau S Lipkowitz Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines Breast Cancer Res. Treat. 64 2000 211 219
56. T Kimura Y Kadokawa H Harada M Matsumoto M Sato Y Kashiwazaki M Tarutani R.S Tan T Takasugi T Matsuyama T.W Mak S Noguchi T Taniguchi Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies Genes Cells 1 1996 115 124
57. J.L Kissil O Cohen T Raveh A Kimchi Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death EMBO J. 18 1999 353 362
58. J.L Kissil L.P Deiss M Bayewitch T Raveh G Khaspekov A Kimchi Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death J. Biol. Chem. 270 1995 27932 27936
59. H.U Kontny K Hammerle R Klein P Shayan C.L Mackall C.M Niemeyer Sensitivity of Ewing's sarcoma to TRAIL-induced apoptosis Cell Death Differ. 8 2001 506 514
60. M Koshiji Y Adachi S Sogo S Taketani N Oyaizu S Than M Inaba S Phawa K Hioki S Ikehara Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-alpha (TNF-alpha) and⧸or interferon-gamma (IFN-gamma), resulting from down-modulation of Bcl-2 expression Clin. Exp. Immunol. 111 1998 211 218
61. M Koshiji Y Adachi S Taketani K Takeuchi K Hioki S Ikehara Mechanisms underlying apoptosis induced by combination of 5-fluorouracil and interferon-gamma Biochem. Biophys. Res. Commun. 240 1997 376 381
62. C Kumar-Sinha S Varambally A Sreekumar A.M Chinnaiyan Molecular cross-talk between the TRAIL and interferon signaling pathways J. Biol. Chem. 277 2002 575 585
63. S.E Lamhamedi-Cherradi S.J Zheng K.A Maguschak J Peschon Y.H Chen Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-⧸-mice Nat. Immunol. 4 2003 255 260
64. V Langaas S Shahzidi J.I Johnsen B Smedsrod B Sveinbjornsson Interferon-gamma modulates TRAIL-mediated apoptosis in human colon carcinoma cells Anticancer Res. 21 2001 3733 3738
65. D Lawrence Z Shahrokh S Marsters K Achilles D Shih B Mounho K Hillan K Totpal L DeForge P Schow J Hooley S Sherwood R Pai S Leung L Khan B Gliniak J Bussiere C.A Smith S.S Strom S Kelley J.A Fox D Thomas A Ashkenazi Differential hepatocyte toxicity of recombinant Apo2L⧸TRAIL versions Nat. Med. 7 2001 383 385
66. S.B Lee M Esteban The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis Virology 199 1994 491 496
67. S.B Lee D Rodriguez J.R Rodriguez M Esteban The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases Virology 231 1997 81 88
68. M Leverkus M.R Sprick T Wachter T Mengling B Baumann E Serfling E.B Brocker M Goebeler M Neumann H Walczak Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation Mol. Cell. Biol. 23 2003 777 790
69. N Levy-Strumpf A Kimchi Death associated proteins (DAPs): From gene identification to the analysis of their apoptotic and tumor suppressive functions Oncogene 17 1998 3331 3340
70. H Li H Zhu C.J Xu J Yuan Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis Cell 94 1998 491 501
71. T Lin X Huang J Gu L Zhang J.A Roth M Xiong S.A Curley Y Yu K.K Hunt B Fang Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells Oncogene 21 2002 8020 8028
72. G Lu B.M Janjic J Janjic T.L Whiteside W.J Storkus N.L Vujanovic Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand J. Immunol. 168 2002 1831 1839
73. X Luo I Budihardjo H Zou C Slaughter X Wang Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Cell 94 1998 481 490
74. M MacFarlane M Ahmad S.M Srinivasula T Fernandes-Alnemri G.M Cohen E.S Alnemri Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL J. Biol. Chem. 272 1997 25417 25420
75. M MacFarlane N Harper R.T Snowden M.J Dyer G.A Barnett J.H Pringle G.M Cohen Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia Oncogene 21 2002 6809 6818
76. M MacFarlane W Merrison S.B Bratton G.M Cohen Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro J. Biol. Chem. 277 2002 36611 36616
77. M Mandal D Bandyopadhyay T.M Goepfert R Kumar Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK) Oncogene 16 1998 217 225
78. M.J Martinez-Lorenzo M.A Alava S Gamen K.J Kim A Chuntharapai A Pineiro J Naval A Anel Involvement of APO2 ligand⧸TRAIL in activation-induced death of Jurkat and human peripheral blood T cells Eur. J. Immunol. 28 1998 2714 2725
79. D.E McCloskey D.K Armstrong C Jackisch N.E Davidson Programmed cell death in human breast cancer cells Recent Prog. Horm. Res. 51 1996 493 508
80. R.D Meng W.S El-Deiry p53-independent upregulation of KILLER⧸DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma Exp. Cell Res. 262 2001 154 169
81. E.F Meurs J Galabru G.N Barber M.G Katze A.G Hovanessian Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase Proc. Natl. Acad. Sci. USA 90 1993 232 236
82. T Miyazaki J.C Reed A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins Nat. Immunol. 2 2001 493 500
83. C Munoz-Pinedo C Ruiz de Almodovar C Ruiz-Ruiz Death on the beach: A rosy forecast for the 21st century Cell Death Differ. 9 2002 1026 1029
84. P Nanni G Nicoletti C De Giovanni L Landuzzi E Di Carlo F Cavallo S.M Pupa I Rossi M.P Colombo C Ricci A Astolfi P Musiani G Forni P.L Lollini Combined allogeneic tumor cell vaccination and systemic interleukin 12 preventsmammary carcinogenesis in HER-2⧸neu transgenic mice J. Exp. Med. 194 2001 1195 1205
85. C.L Nastala H.D Edington T.G McKinney H Tahara M.A Nalesnik M.J Brunda M.K Gately S.F Wolf R.D Schreiber W.J Storkus Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production J. Immunol. 153 1994 1697 1706
86. A Nesterov X Lu M Johnson G.J Miller Y Ivashchenko A.S Kraft Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis J. Biol. Chem. 276 2001 10767 10774
87. C.P Ng B Bonavida X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand⧸tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: Sensitization by overexpression of second mitochondria-derived activator of caspase⧸direct IAP-binding protein with low pl (Smac⧸DIABLO) Mol. Cancer Ther. 1 2002 1051 1058
88. J Ogasawara F.R Watanabe M Adachi A Matsuzawa T Kasugai Y Kitamura N Itoh T Suda S Nagata Lethal effect of the anti-Fas antibody in mice Nature 364 1993 806 809
89. K Oshikawa F Shi A.L Rakhmilevich P.M Sondel D.M Mahvi N.S Yang Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA Proc. Natl. Acad. Sci. USA 96 1999 13351 13356
90. N.K Ossina A Cannas V.C Powers P.A Fitzpatrick J.D Knight J.R Gilbert E.M Shekhtman L.D Tomei S.R Umansky M.C Kiefer Interferon-gamma modulates a p53-independent apoptotic pathway and apoptosis-related gene expression J. Biol. Chem. 272 1997 16351 16357
91. M Oya M Ohtsubo A Takayanagi M Tachibana N Shimizu M Murai Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells Oncogene 20 2001 3888 3896
92. G Pan J Ni Y.-F Wei G.-L Yu R Gentz V.M Dixit An antagonist decoy receptor and a death domain-containing receptor for TRAIL Science 277 1997 815 818
93. G Pan K O'Rourke A.M Chinnaiyan R Gentz R Ebner J Ni V.M Dixit The receptor for the cytotoxic ligand TRAIL Science 276 1997 111 113
94. D.J Park H Nakamura A.M Chumakov J.W Said C.W Miller D.L Chen H.P Koeffler Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines Oncogene 9 1994 1899 1906
95. S.Y Park T.R Billiar D.W Seol IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis Biochem. Biophys. Res. Commun. 291 2002 233 236
96. S Pestka S.V Kotenko G Muthukumaran L.S Izotova J.R Cook G Garotta The interferon gamma (IFN-gamma) receptor: A paradigm for the multichain cytokine receptor Cytokine Growth Factor Rev. 8 1997 189 206
97. T.A Phillips J Ni G Pan S.M Ruben Y.F Wei J.L Pace J.S Hunt TRAIL (Apo-2L) and TRAIL receptors in human placentas: Implications for immune privilege J. Immunol. 162 1999 6053 6059
98. B.A Pulaski M.J Smyth S Ostrand-Rosenberg Interferon-gamma-dependent phagocytic cells are a critical component of innate immunity against metastatic mammary carcinoma Cancer Res. 62 2002 4406 4412
99. A.L Rakhmilevich K Janssen Z Hao P.M Sondel N.S Yang Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism Cancer Gene Ther. 7 2000 826 838
100. R Ravi G.C Bedi L.W Engstrom Q Zeng B Mookerjee C Gelinas E.J Fuchs A Bedi Regulation of death receptor expression and TRAIL⧸Apo2L-induced apoptosis by NF-kappaB Nat. Cell Biol. 3 2001 409 416
101. J.C Reed Mechanisms of apoptosis avoidance in cancer Curr. Opin. Oncol. 11 1999 68 75
102. P Rochaix S Krajewski J.C Reed F Bonnet J.J Voigt P Brousset In vivo patterns of Bcl-2 family protein expression in breast carcinomas in relation to apoptosis J. Pathol. 187 1999 410 415
103. C Ruiz-Ruiz A López-Rivas Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferon-gamma in human breast tumour cells Biochem. J. 365 2002 825 832
104. C Ruiz-Ruiz C Muñoz-Pinedo A López-Rivas Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast tumor cells to a death receptor-induced mitochondria-operated apoptotic program Cancer Res. 60 2000 5673 5680
105. M.C Ruiz-Ruiz A López-Rivas p53-mediated up-regulation of CD95 is not involved in genotoxic drug-induced apoptosis of human breast tumor cells Cell Death Differ. 6 1999 271 280
106. A Saleh S.M Srinivasula S Acharya R Fishel E.S Alnemri Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation J. Biol. Chem. 274 1999 17941 17945
107. J Sanceau D.D Boyd M Seiki B Bauvois Interferons inhibit tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 activation via interferon regulatory factor-1 binding competition with NF-kappa B J. Biol. Chem. 277 2002 35766 35775
108. M Sarker C Ruiz-Ruiz A López-Rivas Activation of protein kinase C inhibits TRAIL-induced caspase activation, mitochondrial events and apoptosis in a human leukemic T cell line Cell Death Differ. 8 2001 172 181
109. O Savinova B Joshi R Jagus Abnormal levels and minimal activity of the dsRNA-activated protein kinase, PKR, in breast carcinoma cells Int. J. Biochem. Cell Biol. 31 1999 175 189
110. C Scaffidi S Fulda A Srinivasan C Friesen F Li K.J Tomaselli K.-M Debatin P.H Krammer M.E Peter Two CD95 (APO-1⧸Fas) signalling pathways EMBO J. 17 1998 1675 1687
111. B Schlichtholz Y Legros D Gillet C Gaillard M Marty D Lane F Calvo T Soussi The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot Cancer Res. 52 1992 6380 6384
112. J Schlom J Kantor S Abrams K.Y Tsang D Panicali J.M Hamilton Strategies for the development of recombinant vaccines for the immunotherapy of breast cancer Breast Cancer Res. Treat. 38 1996 27 39
113. P Schneider J.L Bodmer M Thome K Hofmann N Holler J Tschopp Characterization of two receptors for TRAIL FEBS Lett. 416 1997 329 334
114. R.D Schreiber A Celada N Buchmeier The role of interferon-gamma in the induction of activated macrophages Ann. Inst. Pasteur Immunol. 137C 1986 203 206
115. L.M Sedger D.M Shows R.A Blanton J.J Peschon R.G Goodwin D Cosman S.R Wiley IFN-gamma mediates a novel antiviral activity through dynamic modulation of TRAIL and TRAIL receptor expression J. Immunol. 163 1999 920 926
116. S Seitz P Wassmuth J Fischer A Nothnagel B Jandrig P.M Schlag S Scherneck Mutation analysis and mRNA expression of trail-receptors in human breast cancer Int. J. Cancer 102 2002 117 128
117. C Sgadari A.L Angiolillo B.W Cherney S.E Pike J.M Farber L.G Koniaris P Vanguri P.R Burd N Sheikh G Gupta J Teruya-Feldstein G Tosato Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo Proc. Natl. Acad. Sci. USA 93 1996 13791 13796
118. C Sgadari J.M Farber A.L Angiolillo F Liao J Teruya-Feldstein P.R Burd L Yao G Gupta C Kanegane G Tosato Mig, the monokine induced by interferon-gamma, promotes tumor necrosis in vivo Blood 89 1997 2635 2643
119. V Shankaran H Ikeda A.T Bruce J.M White P.E Swanson L.J Old R.D Schreiber IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity Nature 410 2001 1107 1111
120. S Shimizu M Narita Y Tsujimoto Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC Nature 399 1999 483 487
121. E.C Shin J.M Ahn C.H Kim Y Choi Y.S Ahn H Kim S.J Kim J.H Park IFN-gamma induces cell death in human hepatoma cells through a TRAIL⧸death receptor-mediated apoptotic pathway Int. J. Cancer 93 2001 262 268
122. M.S Shin H.S Kim S.H Lee W.S Park S.Y Kim J.Y Park J.H Lee S.K Lee S.N Lee S.S Jung J.Y Han H Kim J.Y Lee N.J Yoo Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers Cancer Res. 61 2001 4942 4946
123. R.Y Shyu H.L Su J.C Yu S.Y Jiang Direct growth suppressive activity of interferon-alpha and -gamma on human gastric cancer cells J. Surg. Oncol. 75 2000 122 130
124. D Siegmund P Hadwiger K Pfizenmaier H.P Vornlocher H Wajant Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis Mol. Med. 8 2002 725 732
125. H Spets P Georgii-Hemming J Siljason K Nilsson H Jernberg-Wiklund Fas⧸APO-1 (CD95)-mediated apoptosis is activated by interferon-gamma and interferon-alpha interleukin-6 (IL-6)-dependent and IL-6-independent multiple myeloma cell lines Blood 92 1998 2914 2923
126. M.R Sprick M.A Weigand E Rieser C.T Rauch P Juo J Blenis P.H Krammer H Walczak FADD⧸MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 Immunity 12 2000 599 609
127. G.R Stark I.M Kerr B.R.G Williams R.H Silverman R.D Schreiber How cells respond to interferons Annu. Rev. Biochem. 67 1998 227 264
128. H Steller Mechanisms and genes of cellular suicide Science 267 1995 1445 1449
129. H Strander Interferon treatment of human neoplasia Adv. Cancer Res. 46 1986 1 265
130. K Suk I Chang Y.H Kim S Kim J.Y Kim H Kim M.S Lee Interferon gamma (IFNgamma) and tumor necrosis factor alpha synergism in ME-180 cervical cancer cell apoptosis and necrosis. IFNgamma inhibits cytoprotective NF-kappa B through STAT1⧸IRF-1 pathways J. Biol. Chem. 276 2001 13153 13159
131. A Suliman A Lam R Datta R.K Srivastava Intracellular mechanisms of TRAIL: Apoptosis through mitochondrial-dependent and -independent pathways Oncogene 20 2001 2122 2133
132. H Sun P Gutierrez M.J Jackson N Kundu A.M Fulton Essential role of nitric oxide and interferon-gamma for tumor immunotherapy with interleukin-10 J. Immunother. 23 2000 208 214
133. K Takeda Y Hayakawa M.J Smyth N Kayagaki N Yamaguchi S Kakuta Y Iwakura H Yagita K Okumura Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells Nat. Med. 7 2001 94 100
134. K Takeda M.J Smyth E Cretney Y Hayakawa N Yamaguchi H Yagita K Okumura Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth Cell. Immunol. 214 2001 194 200
135. K Takeda M.J Smyth E Cretney Y Hayakawa N Kayagaki H Yagita K Okumura Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development J. Exp. Med. 195 2002 161 169
136. W.D Thomas P Hersey TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells J. Immunol. 161 1998 2195 2200
137. M Thome P Schneider K Hofmann H Fickenscher E Meinl F Neipel C Mattmann K Burns J.L Bodmer M Schroter C Scaffidi P.H Krammer M.E Peter J Tschopp Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors Nature 386 1997 517 521
138. C.B Thompson Apoptosis in the pathogenesis and treatment of disease Science 267 1995 1456 1462
139. Y Tomita V Bilim N Hara T Kasahara K Takahashi Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN renal cell carcinoma cells Int. J. Cancer 104 2003 400 408
140. S.E Tran T.H Holmstrom M Ahonen V.M Kahari J.E Eriksson MAPK⧸ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors J. Biol. Chem. 276 2001 16484 16490
141. G Trinchieri Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity Annu. Rev. Immunol. 13 1995 251 276
142. N Varela C Muñoz-Pinedo C Ruiz-Ruiz G Robledo M Pedroso A López-Rivas Interferon-gamma sensitises human myeloid leukemia cells to death receptor-mediated apoptosis by a pleiotropic mechanism J. Biol. Chem. 276 2001 17779 17787
143. A.M Verhagen P.G Ekert M Pakusch J Silke L.M Connolly G.E Reid R.L Moritz R.J Simpson D.L Vaux Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins Cell 102 2000 43 53
144. S von Mensdorff-Pouilly M.M Gourevitch P Kenemans A.A Verstraeten S.V Litvinov G.J van Kamp S Meijer J Vermorken J Hilgers Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours Eur. J. Cancer 32A 1996 1325 1331
145. S Wadler E.L Schwartz Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: A review Cancer Res. 50 1990 3473 3486
146. H Walczak M.A Degli-Esposti R.S Johnson P.J Smolak J.Y Waugh N Boiani M.S Timour M.J Gerhart K.A Schooley C.A Smith R.G Goodwin C.T Rauch TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL EMBO J. 16 1997 5386 5397
147. H Walczak R.E Miller K Ariail B Gliniak T.S Griffith M Kubin W Chin J Jones A Woodward T Le C Smith P Smolak R.G Goodwin C.T Rauch J.C.L Schuh D.H Lynch Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo Nat. Med. 5 1999 157 163
148. C.Y Wang M.W Mayo R.G Korneluk D.V Goeddel A.S Baldwin Jr. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation Science 281 1998 1680 1683
149. Q Wang Y Ji X Wang B.M Evers Isolation and molecular characterization of the 5′-upstream region of the human TRAIL gene Biochem. Biophys. Res. Commun. 276 2000 466 471
150. S Wesselborg I.H Engels E Rossmann M Los K Schulze-Osthoff Anticancer drugs induce caspase-8⧸FLICE activation and apoptosis in the absence of CD95 receptor⧸ligand interaction Blood 93 1999 3053 3063
151. S.R Wiley K Schooley P.J Smolak W.S Din C.P Huang J.K Nicholl G.R Sutherland T.D Smith C Rauch C.A Smith R.G Goodwin Identification and characterization of a new member of the TNF family that induces apoptosis Immunity 3 1995 673 682
152. R.S Wu J.J Kobie D.G Besselsen T.C Fong V.D Mack J.A McEarchern E.T Akporiaye Comparative analysis of IFN-gamma B7.1 and antisense TGF-beta gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma Cancer Immunol. Immunother. 50 2001 229 240
153. X Yang M.S Merchant M.E Romero M Tsokos L.H Wexler U Kontny C.L Mackall C.J Thiele Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1⧸TR2 also contributes to TRAIL resistance in NB Cancer Res. 63 2003 1122 1129
154. X.J Yuan Y.E Whang PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway Oncogene 21 2002 319 327
155. X.D Zhang A.V Franco T Nguyen C.P Gray P Hersey Differential localization and regulation of death and decoy receptor for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells J. Immunol. 164 2000 3961 3970
156. C.C Zielinski C Muller E Kubista A Staffen M.M Eibl Effects of adjuvant chemotherapy on specific and non-specific immune mechanisms Acta Med. Austriaca 17 1990 11 14
157. H Zou Y Li X Liu X Wang An APAF-1-cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9 J. Biol. Chem. 274 1999 11549 11556
158. T.J Zuzak D.F Steinhoff L.N Sutton P.C Phillips A Eggert M.A Grotzer Loss of caspase-8 mRNA expression is common in childhood primitive neuroectodermal brain tumour⧸medulloblastoma Eur. J. Cancer 38 2002 83 91