IFN-γ inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-γ-enhanced TRAIL-induced apoptosis

Biochemical and Biophysical Research Communications

Volumn 291, Issue 2, 2002, Pages 233-236

  Park, Sang Youel ^a   Billiar, Timothy R ^a   Seol, Dai Wu ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; IAP 2; IFN ; TRAIL

Indexed keywords

FAS ASSOCIATED DEATH DOMAIN PROTEIN; GAMMA INTERFERON; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN IAP 1; PROTEIN IAP 2; RECEPTOR; RECOMBINANT PROTEIN; TRAIL PROTEIN RECEPTOR 1; TRAIL PROTEIN RECEPTOR 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CONTROLLED STUDY; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SENSITIZATION; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; DRUG SYNERGISM; HELA CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; PROTEINS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0036291234     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6452     Document Type: Article

References (25)

1. Apoptosis by death factor
2. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
3. Identification and characterization of a new member of the TNF family that induces apoptosis
4. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
5. Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis
6. Natural killer T cell activation inhibits hepatitis B virus replication in vivo
7. Effects of IL-12 on the response and susceptibility to experimental viral infections
8. Interferon-γ inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation
9. IFNalpha sensitizes ME-180 human cervical cancer cells to TNF alpha-induced apoptosis by inhibiting cytoprotective NF-kappaB activation
10. IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: A key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell death
11. Synergistic induction of apoptosis in murine hepatoma Hepa1-6 cells by IFN-γ and TNF-α
12. Synergistic effects of interferon gamma and tumour necrosis factor alpha on T84 cell function
13. Cysteine 230 modulates tumor necrosis factor-related apoptosis-inducing ligand activity
14. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
15. Effect of interferon-gamma on the susceptibility to Fas (CD95/APO-1)-mediated cell death in human hepatoma cells
16. Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis
17. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule
18. TRAIL receptor-2 signals apoptosis through FADD and caspase-8
19. FADD is required for DR4- and DR5-mediated apoptosis: Lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts
20. Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): Caspase-8 is required for TRAIL-induced apoptosis
21. Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis
22. Endogenous inhibitors of caspases
23. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
24. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
25. X-linked IAP is a direct inhibitor of cell-death proteases