Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines tumors by DNA methylation

Cell Death and Differentiation

Volumn 10, Issue 3, 2003, Pages 356-364

  Hopkins Donaldson, Sally ^a   Ziegler, A ^a   Kurtz, S ^a   Bigosch, C ^a   Kandioler, D ^b   Ludwig, C ^b   Zangemeister Wittke, U ^a   Stahel, R ^b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Caspase 8; DNA methylation; Fas; SCLC; TRAIL

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ADAPTOR PROTEIN; CASPASE 10; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CELL RECEPTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DNA; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; GAMMA INTERFERON; MESSENGER RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; LUNG SMALL CELL CANCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; SEQUENCE ANALYSIS; WESTERN BLOTTING;

ANTIGENS, CD95; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, SMALL CELL; CASPASE 8; CASPASE 9; CASPASES; CELL LINE; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; INTERFERON TYPE II; LUNG NEOPLASMS; POLYMERASE CHAIN REACTION; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; TIME FACTORS;

EID: 0037621450     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401157     Document Type: Article

References (34)

1. Greenlee RT, Murray T, Bolden S and Wingo PA (2000) Cancer statistics, 2000. CA Cancer J. Clin. 50: 7-33.
2. Wistuba II, Gazdar AF and Minna JD (2001) Molecular genetics of small cell lung carcinoma. Semin. Oncol. 28: 3-13.
3. Prins J, De Vries EG and Mulder NH (1993) The myc family of oncogenes and their presence and importance in small-cell lung carcinoma and other tumour types. Anticancer Res. 13: 1373-1385
4. Brodeur GM Seeger RC Schwab M Varmus HE and Bishop JM (1984) Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224: 1121-1124
5. Kaufmann SH and Earnshaw WC (2000) Induction of apoptosis by cancer chemotherapy. Exp. Cell Res. 256: 42-49
6. Daniel PT, Wieder T, Sturm I and Schulze-Osthoff K (2001) The kiss of death: promises and failures of death receptors and ligands in cancer therapy. Leukemia 15: 1022-1032.
7. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH and Peter ME (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17: 1675-1687
8. Jiang SX, Sato Y, Kuwao S and Kameya T (1995) Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomas. J. Pathol. 177: 135-138
9. Ziegler A, Luedke GH, Fabbro D, Altmann KH and Zangemeister-Wittke U (1997) Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence. J. Natl. Cancer Inst. 89: 1027-1036
10. Fisher MJ, Virmani AK, Wu L, Aplenc R, Harper JC, Powell SM, Rebbeck TR, Sidransky D, Gazdar AF and El Deiry WS (2001) Nucleotide substitution in the ectodomain of trail receptor dr4 is associated with lung cancer and head and neck cancer. Clin. Cancer Res. 7: 1688-1697
11. Joseph B, Ekedahl J, Sirzen F, Lewensohn R and Zhivotovsky B (1999) Differences in expression of pro-caspases in small cell and non-small cell lung carcinoma. Biochem. Biophys. Res. Commun. 262: 381-387
12. Zhang XD, Franco AV, Nguyen T, Gray CP and Hersey P (2000) Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells. J. Immunol. 164: 3961-3970
13. Sirzen F, Zhivotovsky B, Nilsson A, Bergh J and Lewensohn R (1998) Higher spontaneous apoptotic index in small cell compared with non-small cell lung carcinoma cell lines; lack of correlation with Bcl-2/Bax. Lung Cancer 22: 1-13
14. Hopkins-Donaldson S, Bodmer JL, Bourloud KB, Brognara CB, Tschopp J and Gross N (2000) Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res. 60: 4315-4319
15. Peli J, Schroter M, Rudaz C, Hahne M, Meyer C, Reichmann E and Tschopp J (1999) Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas. EMBO J. 18: 1824-1831
16. Fulda S and Debatin KM (2002) IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway. Oncogene 21: 2295-2308
17. Bernassola F, Scheuerpflug C, Herr I, Krammer PH, Debatin KM and Melino, G (1999) Induction of apoptosis by IFNgamma in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit. Cell Death Differ. 6: 652-660
18. Lee SH, Shin MS, Kim HS, Lee HK, Park WS, Kim SY, Lee JH, Han SY, Park JY, Oh RR, Kang CS, Kim KM, Jang JJ, Nam SW, Lee JY and Yoo NJ (2001) Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma. Oncogene 20: 399-403
19. Natoli G, Ianni A, Costanzo A, De Petrillo G, Ilari I, Chirillo P, Balsano, C and Levrero M (1995) Resistance to Fas-mediated apoptosis in human hepatoma cells. Oncogene 11: 1157-1164
20. Ibrahim SM, Ringel J, Schmidt C, Ringel B, Muller P, Koczan D, Thiesen HJ and Lohr M (2001) Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death, Pancreas 23: 72-79
21. Imler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE and Tschopp J (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388: 190-195
22. Grotzer MA, Eggert A, Zuzak TJ, Janss AJ, Marwaha S, Wiewrodt BR, Ikegaki N, Brodeur GM and Phillips PC (2000) Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression. Oncogene 19: 4604-4610
23. Santourlidis S, Warskulat U, Florl AR, Maas S, Pulte T, Fischer J, Muller W and Schulz WA (2001) Hypermethylation of the tumor necrosis factor receptor superfamily 6 (APT1, Fas, CD95/Apo-1) gene promoter at rel/nuclear factor kappaB sites in prostatic carcinoma. Mol. Carcinog. 32: 36-43
24. Wu WG, Soria JC, Wang L, Kemp BL and Mao L (2000) TRAIL-R2 is not correlated with p53 status and is rarely mutated in non-small cell lung cancer. Anticancer Res. 20: 4525-4529
25. Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M and Tschopp J (2000) The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr. Biol. 10: 640-648
26. Esteller M, Corn PG, Baylin SB and Herman JG (2001) A gene hypermethylation profile of human cancer. Cancer Res. 61: 3225-3229
27. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm f, Look AT, Lahti JM and Kidd VJ (2000) Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat. Med. 6: 529-535
28. Beltinger C, Bohler T, Karawajew L, Ludwig WD, Schrappe M and Debatin KM (1998) Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia. Br. J. Haematol. 102: 722-728
29. Esteller M, Sanchez-Cespedes M, Rosell R, Sidransky D, Baylin SB and Herman JG (1999) Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res. 59: 67-70
30. MacLeod AR and Szyf M (1995) Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. J. Biol. Chem. 270: 8037-8043
31. Shimizu M, Fontana A, Takeda Y, Yagita H, Yoshimoto T and Matsuzawa A (1999) Induction of antitumor immunity with Fas/APO-1 ligand (CD95L)-transfected neuroblastoma neuro-2a cells. J. Immunol. 162: 7350-7357
32. Goodwin G and Baylin SB (1982) Relationships between neuroendocrine differentiation and sensitivity to gamma-radiation in culture line OH-1 of human small cell lung carcinoma. Cancer Res. 42: 1361-1367
33. Kaufmann SH, Mabry M, Jasti R and Shaper JH (1991) Differential expression of nuclear envelope lamins A and C in human lung cancer cell lines. Cancer Res. 51: 581-586
34. Herman JG, Graff JR, Myohanen S, Nelkin BD and Baylin SB (1996) Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93: 9821-9826