Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system

Drug Discovery Today: TARGETS

Volumn 1, Issue 6, 2002, Pages 206-213

  Katugampola, Sidath ^a   Davenport, Anthony ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GHRELIN; MELANIN CONCENTRATING HORMONE; MOTILIN; NEUROMEDIN U 25; NOCICEPTIN; OREXIN A; OREXIN B; PROLACTIN RELEASING FACTOR; RELAXIN; UROCORTIN III; UROTENSIN II;

CARDIOVASCULAR SYSTEM; GENE SEQUENCE; GENE TARGETING; GENETIC ANALYSIS; GENETIC CODE; HUMAN; IMMUNOREACTIVITY; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PREDICTION; PROTEOMICS; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW;

EID: 3042712521     PISSN: 17418372     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1477-3627(02)02276-6     Document Type: Review

References (59)

1. Wilson, S. and Bergsma, D. (2000) Orphan G-protein coupled receptors: novel drug targets for the pharmaceutical industry. Drug Des. Discov. 17, 105-114
2. Marchese, A. et al. (1999) Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends Pharmacol. Sci. 20, 370-375
3. Civelli, O. et al. (2001) Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. Trends Neurosci. 24, 230-237
4. Howard, A.D. et al. (2001) Orphan G-protein-coupled receptors and natural ligand discovery. Trends Pharmacol. Sci. 22, 132-140
5. Lee, D.K. et al. (2001) Orphan G protein coupled receptors in the CNS. Curr. Opin. Pharmacol. 1, 31-39
6. 1)apelin-13 is a novel radioligand for localising the APJ orphan receptor in human and rat tissue with evidence for a vasoconstrictor role in man. Br. J. Pharmacol. 132, 1255-1260
7. 9]- ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: upregulation of receptors with atherosclerosis. Br. J. Pharmacol. 134, 143-149
8. Katugampola, S.D. et al. (2002) Discovery of recently adopted orphan receptors for apelin, urotensin-II and ghrelin identified using novel radioligands and functional role in the human cardiovascular system. Can. J. Physiol. Pharmacol. 80, 1-6
9. Lee, D.K. et al. (2000) Characterization of apelin, the ligand for the APJ receptor. J. Neurochem. 74, 34-41
10. Raddatz, R. et al. (2000) Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J. Biol. Chem. 275, 32452-32459
11. Lin, B. et al. (2000) Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension. Life Sci. 66, PL99-104
12. Chen, C.T. et al. (2000) Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R692-R697
13. Ames, R.S. et al. (1999) Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 401, 282-286
14. Sullivan, K.A. et al. (1997) Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors. Biochem. Biophys. Res. Commun. 233, 823-828
15. Lee, D.K. et al. (1999) Discovery of a receptor related to the galanin receptors. FEBS Lett. 446, 103-107
16. Ohtaki, T. et al. (2001) Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 411, 613-617
17. Wang, J.H. and Hewick, R.M. (1999) Proteomics in drug discovery. Drug Discov. Today 4, 129-133
18. Strohman, R. (1994) Epigenesis: the missing beat in biotechnology? Nat. Biotechnol. 12, 156-164
19. Lembo, P.M. et al. (2002) Proenkephalin A gene products activate a new family of sensory neuron - specific GPCRs. Nat. Neurosci. 5, 201-209
20. Tatemoto, K. et al. (1998) Isolation and characterisation of a novel endogenous peptide ligand for the human APJ receptor. Biochem. Biophys. Res. Commun. 251, 471-476
21. Maguire, J.J. et al. (2000) Orphan-receptor ligand human urotensin II: receptor localisation in human tissues and comparison of vasoconstrictor responses with endothelin-1. Br. J. Pharmacol. 131, 441-446
22. Ivell, R. (2002) Endocrinology. This hormone has been relaxing too long! Science 127, 637-638
23. Tan, Y.Y. et al. (1999) Quantitative autoradiography studies of relaxin binding in rat atria, uterus and cerebral cortex: characterisation and effects of oestrogen treatment. Br. J. Pharmacol. 127, 91-98
24. Maguire, J.J. and Davenport, A.P. (2002) Is urotensin-II the new endothelin? Br. J. Pharmacol. 137, 579-588
25. Flohr, S. et al. (2002) Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II. J. Med. Chem. 25, 1799-1805
26. Kojima, M. et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656-660
27. Muccioli, G. et al. (2002) Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur. J. Pharmacol. 440, 235-254
28. Wiley, K.E. and Davenport, A.P. (2002) Comparison of vasodilators in human mammary artery: ghrelin is a potent physiological antagonist of endothelin-1. Br. J. Pharmacol. 136, 1146-1152
29. Chemelli, R.M. et al. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437-451
30. Szabo, Z. et al. (2001) Use of positron emission tomography to study AT1 receptor regulation in vivo. J. Am. Soc. Nephrol. 12, 1350-1358
31. Reinscheid, R.K. et al. (1995) Orphanin FQ: a neuropeptide that activates an opioid like G protein-coupled receptor. Science 210, 792-794
32. Sakurai, T. et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585
33. Hinuma, S. et al. (1998) A prolactin-releasing peptide in the brain. Nature 393, 272-276
34. Chambers, J. et al. (1999) Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature 400, 261-265
35. Feighner, S.D. et al. (1999) Receptor for motilin identified in the human gastrointestinal system. Science 284, 2184-2188
36. Usdin, T.B. et al. (1999) TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nat. Neurosci. 2, 941-943
37. Howard, A.D. et al. (2000) Identification of receptors for neuromedin U and its role in feeding. Nature 406, 70-74
38. An, S. et al. (2001) Identification and characterization of a melanin-concentrating hormone receptor. Proc. Natl. Acad. Sci. U. S. A. 98, 7576-7581
39. Lewis, K. et al. (2001) Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc. Natl. Acad. Sci. U. S. A. 98, 7570-7575
40. Hsu, S.Y. et al. (2002) Activation of orphan receptors by the hormone relaxin. Science 295, 671-674
41. Hosoya, M. et al. (2000) Molecular and functional characteristics of APJ: tissue distribution of mRNA and interaction with endogenous ligand, apelin. J. Biol. Chem. 275, 21061-21067
42. Satoh, F. et al. (2000) Characterization and distribution of prolactin releasing peptide (PrRP) binding sites in the rat-evidence for a novel binding site subtype in cardiac and skeletal muscle. Br. J. Pharmacol. 129, 1787-1793
43. Hill, J. et al. (2001) Molecular cloning and functional characterization of MCH2, a novel human MCH receptor. J. Biol. Chem. 276, 20125-20129
44. Strunz, A. et al. (1975) Analysis of the motor effects of 13-norleucine motilin on the rabbit, guineapig, rat, and human alimentary tract in-vitro. Gastroenterology 68, 1485-1491
45. Perrin, M.H. and Vale, W.W. (1999) Corticotropin releasing factor receptors and their ligand family. Ann. New York Acad. Sci. 885, 312-328
46. Salis, M.B. et al. (2000) Studies of the cardiovascular effects of nociceptin and related peptides. Peptides 21, 985-993
47. Arihara, Z. et al. (2000) Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastoma. Peptides 21, 565-570
48. Takahashi, K. et al. (1995) Melanin-concentrating hormone in human and rat. Neuroendocrinology 61, 493-498
49. Christofides, N.D. et al. (1979) Release of motilin by oral and intravenous nutrients in man. Gut 20, 102-106
50. Totsune, K. et al. (2001) Role of urotensin II in patients on dialysis. Lancet 358, 810-811
51. Fawzi, A.B. et al. (1997) Nociceptin activation of the human ORL1 receptor expressed in Chinese hamster ovary cells: functional homology with opioid receptors. Eur. J. Pharmacol. 336, 233-242
52. Langmead, C.J. et al. (2000) Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. Br. J. Pharmacol. 131, 683-688
53. Miller, P. et al. (2000) Motilin receptors in the human antrum. Am. J. Physiol. Gastrointest. Liver Physiol. 278, G18-23
54. Higelin, J. et al. (2001) 125I-Antisauvagine-30: a novel and specific high-affinity radioligand for the characterization of corticotropin-releasing factor type 2 receptors. Neuropharmacology 40, 114-122
55. Burnside, J.L. et al. (2000) Species differences in the efficacy of compounds at the nociceptin receptor (ORL1). Peptides 21, 1147-1154
56. Smart, D. et al. (2000) The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors. Br. J. Pharmacol. 129, 1289-1291
57. + signalling induced by motilin and erythromycin in the circular smooth muscle of human colon. Neurogastroenterol. Motil. 13, 27-35
58. Kotani, M. et al. (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J. Biol. Chem. 276, 34631-34636
59. Hsu, S.Y. and Hsueh, A.J. (2001) Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat. Med. 7, 605-611