Comparison of vasodilators in human internal mammary artery: Ghrelin is a potent physiological antagonist of endothelin-1

British Journal of Pharmacology

Volumn 136, Issue 8, 2002, Pages 1146-1152

  Wiley, Katherine E ^a   Davenport, Anthony P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CGRP; Endothelin 1; Ghrelin; GSH receptor; Human internal mammary artery; Natriuretic peptide; Orphan receptor; PAMP 12; PAMP 20; Prostanoid

Indexed keywords

ADRENOMEDULLIN; AMYLIN; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CALCITONIN GENE RELATED PEPTIDE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; NATRIURETIC PEPTIDE TYPE C; PROADRENOMEDULLIN; PROSTACYCLIN; PROSTAGLANDIN E2; VASODILATOR AGENT; PEPTIDE HORMONE;

ADULT; AGED; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTERNAL MAMMARY ARTERY; MALE; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; MAMMARY ARTERY; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; ENDOTHELIN-1; FEMALE; HUMANS; MALE; MAMMARY ARTERIES; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; PEPTIDE HORMONES; VASODILATION; VASODILATOR AGENTS;

EID: 0036687932     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704815     Document Type: Article

References (50)

1. Endothelin peptide and receptors in human atherosclerotic coronary artery and aorta
2. Characterization of the prostanoid receptors mediating constriction and relaxation of human isolated uterine artery
3. 2+-dependent, agonist-stimulated secretion of human adrenal glands
4. Characterization of excitatory prostanoid receptors in the human umbilical artery in vitro
5. The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit
6. Plasma concentrations and comparisons of brain and atrial natriuretic peptide in normal subjects and in patients with essential hypertension
7. 2 in maintaining low vascular tone in feto-placental vessels
8. Endothelin is a potent and long-lasting vasoconstrictor in men
9. Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels
10. 125I]endothelin-1 in humans, pigs, and rats: Functional relevance in humans
11. Endothelin- and neuropeptide Y-induced vasoconstriction of human epicardial coronary arteries in vitro
12. Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans
13. Bioactivity and metabolism of C-type natriuretic peptide in normal man
14. Adrenomedullin stimulates cyclic AMP formation in rat vascular smooth muscle cells
15. 9]-Ghrelin, a novel radioligand for localising GHS orphan receptor in human and rat tissue; up-regulation of receptors with atherosclerosis
16. Radioligand binding reveals chymase as the predominant enzyme for mediating tissue conversion of angiotensin I in the normal human heart
17. 2 of isolated human uterine arteries
18. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
19. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
20. Increased plasma proadrenomedullin N-terminal 20 peptide in patients with essential hypertension
21. Purification and characterization of PAMP-12 (PAMP[9-20]) in porcine adrenal medulla as a major endogenous biologically active peptide
22. Calcitonin gene-related peptide in patients with and without early reperfusion after acute myocardial infarction
23. Endothelin has biological actions at pathophysiological concentrations
24. ATP-sensitive potassium channels mediate vasodilatation produced by calcitonin gene-related peptide in human internal mammary but not gastroepiploic arteries
25. Endothelin converting enzyme (ECE) activity in human vascular smooth muscle
26. (1-31), in human mammary and coronary arteries in vitro
27. Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction
28. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers
29. Comparison of vasodilator potency of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human
30. Potent and long-lasting vasodilatory effects of adrenomedullin in humans - Comparisons between normal subjects and patients with chronic heart failure
31. Relaxant effect of human brain natriuretic peptide on human artery and vein tissue
32. Potent contractile actions of prostanoid EP3-receptor agonists on human isolated pulmonary artery
33. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis
34. Evidence using immunoelectron microscopy for regulated and constitutive pathways in the transport and release of endothelin
35. Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart
36. Imbalance between the endothelial cell-derived contracting factors prostacyclin and angiotensin II and nitric oxide/cyclic GMP in human primary varicosis
37. 2+ mobilization, in bovine aortic endothelial cells
38. Human coronary arteriolar dilation to adrenomedullin: Role of nitric oxide and K+ channels
39. Treatment of heart failure guided by plasma amino terminal brain natriuretic peptide (N-BNP) concentrations
40. Prostanoid receptors involved in the relaxation of human pulmonary vessels
41. Immunoreactive proadrenomedullin N-terminal 20 peptide in human tissue, plasma and urine
42. Amylin-induced relaxation of the perfused mesenteric arterial bed: Meditation by calcitonin gene-related peptide receptors
43. From gene to function: Discovery of vasodilator properties of novel endogenous ligands to orphan receptors in human arteries
44. Nitric oxide-mediated modulation of the endothelin-1 signalling pathway in the human cardiovascular system
45. Physiological antagonism of endothelin-1 in human conductance and resistance coronary artery
46. Functional response of apelin-13, the novel endogenous ligand for the orphan receptor APJ, in human artery: Comparison with natriuretic peptides
47. 2-terminal 20 peptide (PAMP)
48. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
49. Different effects of endothelin-1 on cAMP- and cGMP-mediated vascular relaxation in human arteries and veins: Comparison with norepinephrine
50. Coronary vasodilator effects of BNP: Mechanisms of action in coronary conductance and resistance arteries