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Volumn 45, Issue 9, 2002, Pages 1799-1805

Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II

(6) Flohr, Stefanie a Kurz, Michael a Kostenis, Evi a Brkovich, Alexandre b Fournier, Alain b Klabunde, Thomas a

a SANOFI AVENTIS DEUTSCHLAND GMBH (Germany)

b INRS INSTITUT ARMAND FRAPPIER (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 CARBAMIMIDOYLBENZYL) 4 METHYL 1H INDOLE 2 CARBOXYLIC ACID (NAPHTHALEN 1 YLMETHYL)AMIDE; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG; UROTENSIN II; UROTENSIN II RECEPTOR; UROTENSIN II RECEPTOR ANTAGONIST;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; CHO CELL; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PATHOPHYSIOLOGY; PEPTIDE ANALYSIS; PHARMACOPHORE; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

AMINO ACID SUBSTITUTION; ANIMALS; CALCIUM; CHO CELLS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; DATABASES, FACTUAL; FLUOROMETRY; HUMANS; INDOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NAPHTHALENES; PEPTIDE FRAGMENTS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; UROTENSINS;

EID: 0037171726 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm0111043 Document Type: Article

Times cited : (181)

References (30)

1
- 0032428160
- Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord
- (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 15803-15808
- Coulouarn, Y.¹ Lihrmann, I.² Jegou, S.³ Anouar, Y.⁴ Tostivint, H.⁵ Beauvillain, J.C.⁶ Conlon, J.M.⁷ Bern, H.A.⁸ Vaudry, H.⁹

2
- 0023929923
- Functional receptors for fish neuropeptide urotensin II in major rat arteries
- (1988) Eur. J. Pharmacol. , vol.149 , pp. 61-66
- Itoh, H.¹ McMaster, D.² Lederis, K.³

3
- 0032580152
- A molecular time scale for vertebrate evolution
- (1998) Nature , vol.392 , pp. 917-920
- Kumar, S.¹ Hedges, S.B.²

4
- 0033575930
- Human Urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
- (1999) Nature , vol.401 , pp. 282-286
- Ames, R.S.¹ Sarau, H.M.² Chambers, J.K.³ Willette, R.N.⁴ Aiyar, N.V.⁵ Romanic, A.M.⁶ Louden, C.S.⁷ Foley, J.J.⁸ Sauermelch, C.F.⁹ Coatney, R.W.¹⁰ Ao, Z.¹¹ Glover, G.J.¹² Wilson, S.¹³ McNulty, D.E.¹⁴ Ellis, C.E.¹⁵ Elshourbagy, N.A.¹⁶ Shabon, U.¹⁷ Trill, J.J.¹⁸ Hay, D.W.P.¹⁹ Ohlstein, E.H.²⁰ Bergsma, D.J.²¹ Douglas, S.A.²² more..

5
- 0033539884
- Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
- (1999) Biochem. Biophys. Res. Commun. , vol.266 , pp. 174-178
- Liu, Q.¹ Pong, S.-S.² Zeng, Z.³ Zhang, Q.⁴ Howard, A.D.⁵ Williams, D.L.⁶ Davidoff, M.⁷ Wang, R.⁸ Austin, C.P.⁹ McDonald, T.P.¹⁰ Bai, C.¹¹ George, S.R.¹² Evans, J.F.¹³ Caskey, C.T.¹⁴

6
- 0033547450
- Urotensin II is the endogenous ligand of a G-protein coupled orphan receptor SENT (GPR 14)
- (1999) Biochem. Biophys. Res. Commun. , vol.265 , pp. 123-129
- Mori, M.¹ Sugo, T.² Abe, M.³ Shimomura, Y.⁴ Kurihara, M.⁵ Kitada, C.⁶ Kikuchi, K.⁷ Shintani, Y.⁸ Kurokawa, T.⁹ Onda, H.¹⁰ Nishimura, O.¹¹ Fujino, M.¹²

7
- 0033202995
- Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction
- (1999) Nat. Cell Biol. , vol.1 , pp. 381-385
- Nothacker, H.-P.¹ Wang, Z.² McNeill, A.M.³ Saito, Y.⁴ Merten, S.⁵ O'Dowd, B.⁶ Duckles, S.P.⁷ Civelli, O.⁸

8
- 0023226879
- Complex effects of Gillichthys urotensin II on rat aortic strips
- (1987) Br. J. Pharmacol. , vol.91 , pp. 205-212
- Gibson, A.¹

9
- 0033638718
- Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmorset and cynomolgus monkey
- (2000) Br. J. Pharmacol. , vol.131 , pp. 1262-1274
- Douglas, S.A.¹ Sulpizio, A.C.² Piercy, V.³ Sarau, H.M.⁴ Ames, R.S.⁵ Aiyar, N.V.⁶ Ohlstein, E.H.⁷ Willette, R.N.⁸

10
- 0013023197
- Contractile responses to human urotensin-II in rat and human pulmonary arteries: Effect of endothelial factors and chronic hypoxia in the rat
- (2000) Br. J. Pharmacol. , vol.130 , pp. 201-204
- MacLean, M.R.¹ Alexander, D.² Stirrat, A.³ Gallagher, M.⁴ Douglas, S.A.⁵ Ohlstein, E.H.⁶ Morecroft, I.⁷ Polland, K.⁸

11
- 0033776533
- Orphan-receptor ligand human urotensin II: Receptor localization in human tissue and comparison of vasoconstrictor responses
- (2000) Br. J. Pharmacol. , vol.131 , pp. 441-446
- Maguire, J.J.¹ Kuc, R.E.² Davenport, A.P.³

12
- 0023145815
- Contraction of major artery segments of rat by fish neuropeptide urotensin II
- (1987) Am. Phys. Soc. , vol.252
- Ithoh, H.¹ Itoh, Y.² River, J.³ Lederis, K.⁴

13
- 0025013524
- Molecular modeling and design of analogues of the peptide hormone urotensin II
- (1990) Biochem. Soc. Trans. , vol.18 , Issue.5-8 , pp. 918-919
- Perkins, T.D.J.¹ Bansal, S.² Barlow, D.J.³

14
- 0032561511
- Rapid identification of subtype-selective agoinsts of the somatostatin receptor through combinatorial chemistry
- (1998) Science , vol.282 , pp. 737-740
- Rohrer, S.P.¹

15
- 0032758539
- Synthesis and structure-activity investigation of novel vasopressin hypotensive peptide agonists
- (1999) J. Pept. Sci. , vol.5 , pp. 472-490
- Manning, M.¹ Stoev, S.² Cheng, L.L.³ Wo, N.C.⁴ Chan, W.Y.⁵

16
- 0024490127
- Melanin concentrating hormone analogues: Contraction of the cyclic structure
- (1989) Life Sci. , vol.44 , pp. 451-457
- Lebl, M.¹ Hruby, V.J.² Castrucci, A.³ Hadley, M.E.⁴

17
- 0035957992
- Structure-activity relationship studies of melanin-concentrating hormone (MCH)-related peptide ligands at SLC-1, the human MCH receptor
- (2001) J. Biol. Chem. , vol.276 , pp. 13554-13562
- Audinot, V.¹ Beauverger, P.² Lahaye, C.³ Suply, T.⁴ Rodriguez, M.⁵ Ouvry, C.⁶ Lamamy, V.⁷ Imbert, J.⁸ Rique, H.⁹ Nahon, J.L.¹⁰ Galizzi, J.P.¹¹ Canet, E.¹² Levens, N.¹³ Fauchère, J.L.¹⁴ Boutin, J.A.¹⁵

18
- 0008878160
- Structure-function study of the urotensin-II peptide: Elucidation of features required for potent agonist activity
- Chicago, IL, 2001; American Chemical Society: Washington, DC; MEDI-232
- (2001) Abstracts of Papers, 222nd American Chemical Society National Meeting
- Kinney, W.A.¹ Almond H.R., Jr.² Maryanoff, B.E.³ Qi, J.⁴ Smith, C.E.⁵ Santulli, R.J.⁶ De Garavilla, L.⁷ Andrade-Gordon, P.⁸ Cho, D.S.⁹ Everson, A.M.¹⁰ Feinstein, M.A.¹¹ Leung, P.A.¹²

19
- 0003919736
- Wiley: New York
- (1986) NMR of Proteins Nucleic Acids
- Wüthrich, K.¹

20
- 0028208429
- NMR and dynamical simulated annealing studies on the solution conformation of urotensin II
- (1994) Biochim. Biophys. Acta , vol.1199 , pp. 115-122
- Bhaskaran, R.¹ Arunkumar, A.I.² Yu, C.³

21
- 0031024171
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
- (1997) Adv. Drug Delivery Rev. , vol.23 , pp. 3-25
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

22
- 0008884866
- Structure-based design and discovery of orally available potent nonbenzamidine factor Xa inhibitors
- San Francisco, CA, 2000; American Chemical Society: Washington, DC; MEDI-160
- (2000) Book of Abstracts, 219th American Chemical Society National Meeting
- Lam, P.Y.S.¹ Li, R.² Clark, C.G.³ Pinto, D.J.⁴ Alexander, R.S.⁵ Rossi, K.A.⁶ Knapp, R.M.⁷ Wong, P.C.⁸ Aungst, B.J.⁹ Bai, S.A.¹⁰ Wright, M.R.¹¹ Wexler, R.R.¹²

23
- 0008930302
- Discovery of aminoquinazoline and aminoindazole P1 side chains as benzamidine mimics for Fxa inhibitors
- MEDI-050
- (2001) Abstr. Pap. - Am. Chem. Soc. , vol.221
- Li, R.¹ Clark, C.G.² Rossi, K.A.³ Wang, P.C.⁴ Luettgen, J.M.⁵ Aungst, B.J.⁶ Bai, S.A.⁷ Knabb, R.M.⁸ Wexler, R.R.⁹ Lam, P.Y.S.¹⁰

24
- 0035855285
- Arginine mimetics
- (2001) Tetrahedron , vol.57 , pp. 7073-7105
- Masic, L.P.¹ Kikelj, D.²

25
- 0033606951
- Lead generation using pharmacophore mapping and three-dimensional database searching: Application to mucscarinic M3 receptor antagonists
- (1999) J. Med. Chem. , vol.42 , pp. 3210-3216
- Marriott, D.P.¹ Dougall, I.G.² Meghani, P.³ Liu, Y.-J.⁴ Flower, D.R.⁵

26
- 0021114895
- 1H spin-spin coupling constants in proteins
- (1983) Biochem. Biophys. Res. Commun. , vol.113 , pp. 967-974
- Marion, D.¹ Wüthrich, K.²

27
- 5144233105
- MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy
- (1985) J. Magn. Reson. , vol.65 , pp. 355-360
- Bax, A.¹ Davis, D.G.²

28
- 0011491177
- Structure determination of a tetrasaccharide: Transient nuclear overhauser effects in the rotating frame
- (1984) J. Am. Chem. Soc. , vol.106 , pp. 811-813
- Bothner-By, A.A.¹ Stephens, R.L.² Lee, J.³ Warren, C.D.⁴ Jeanloz, J.W.⁵

29
- 0001240703
- Frequency offset effects and their elimination in NMR rotating frame cross-relaxation spectroscopy
- (1987) J. Magn. Reson. , vol.75 , pp. 261-271
- Griesinger, C.¹ Ernst, R.R.²

30
- 84988115618
- Validation of the general purpose tripos 5.2 force field
- (1989) J. Comput. Chem. , vol.10 , pp. 982-1012
- Clark, M.¹ Cramer R.D. III² Van Opdenbosch, N.³

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