Discovery of recently adopted orphan receptors for apelin, urotensin II, and ghrelin identified using novel radioligands and functional role in the human cardiovascular system

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 5, 2002, Pages 369-374

  Katugampola, S D ^a   Maguire, J J ^a   Kuc, R E ^a   Wiley, K E ^a   Davenport, A P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apelin; Ghrelin; Human; Orphan receptor; Urotensin II

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; APELIN 13; APJ ORPHAN RECEPTOR; ENDOTHELIN 1; GHRELIN; GHS ORPHAN RECEPTOR; MESSENGER RNA; ORPHAN GPR14 RECEPTOR; RADIOLIGAND; RECEPTOR; UNCLASSIFIED DRUG; UROTENSIN II; VASOCONSTRICTOR AGENT;

ATHEROSCLEROSIS; CARDIOVASCULAR SYSTEM; CONFERENCE PAPER; CORONARY ARTERY DISEASE; DRUG EFFECT; DRUG POTENCY; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR DENSITY; SAPHENOUS VEIN GRAFT; SEQUENCE HOMOLOGY; VASOCONSTRICTION; VASODILATATION;

AMINO ACID SEQUENCE; ANIMALS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; HUMANS; MOLECULAR SEQUENCE DATA; RADIOLIGAND ASSAY; RECEPTORS, CELL SURFACE; RECEPTORS, DOPAMINE D2; RECEPTORS, G-PROTEIN-COUPLED;

EID: 0036109544     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-029     Document Type: Conference Paper

References (23)

1. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
2. Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans
3. Selective downregulation of the angiotensin II AT1-receptor subtype in failing human ventricular myocardium
4. Endothelin peptides and receptors in human atherosclerotic coronary artery and aorta
5. Growth hormone and the heart
6. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motorneurons of the spinal cord
7. Urotensin II: Fish neuropeptide catches orphan receptor
8. Effects of urotensin II in human arteries and veins of varying calibre
9. 1)Apelin-13 is a novel radioligand for localising the APJ orphan receptor in human and rat tissue with evidence for a vasoconstrictor role in man
10. 9]ghrelin, a novel radioligand for localising GHS orphan receptors in human and rat tissue; upregulation of receptors with atherosclerosis
11. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
12. Characterization of apelin, the ligand for the APJ receptor
13. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14
14. Contractile responses to urotensin-II in rat and human pulmonary arteries: Effect of endothelial factors and chronic hypoxia in the rat
15. Orphan-receptor ligand human urotensin II: Receptor localisation in human tissues and comparison of vasoconstrictor responses with endothelin-1
16. Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction
17. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11
18. Ghrelin-induced growth hormone secretion in humans
19. Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries
20. Isolation and characterisation of a novel endogenous peptide ligand for the human APJ receptor
21. The novel peptide apelin lowers blood pressure via a nitric oxide dependendent mechanism
22. Ghrelin induces adiposity in rodents
23. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion