Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Oggl) in human type 2 diabetes

BMC Endocrine Disorders

Volumn 2, Issue , 2002, Pages

  Tyrberg, Björn ^a   Anachkov, Kamen A ^b   Dib, Sergio A ^c   Wang Rodriguez, Jessica ^a   Yoon, Kun Ho ^d   Levine, Fred ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MILITARY MEDICAL ACADEMY   (Bulgaria)

^c FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^d The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

8 OXOGUANOSINE DNA GLYCOSYLASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOPLASM; DISEASE DURATION; DNA DAMAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCORING SYSTEM;

EID: 3042652948     PISSN: 14726823     EISSN: None     Source Type: Journal    
DOI: 10.1186/1472-6823-2-2     Document Type: Article

References (46)

1. Tyrberg B, Levine F: Current and future treatment strategies for type 2 diabetes: the β-cell as a therapeutic target. Curr Opin Investig Drugs 2001, 2:1568-1574
2. Finegood DT, Scaglia L, Bonner-Weir S: Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 1995, 44:249-256
3. Sorenson RL, Brelje TC: Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 1997, 29:301-307
4. Kahn BB: Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 1998, 92:593-6
5. Farnier M, Picard S: Diabetes: Statins, Fibrates, or Both? Curr Atheroscler Rep 2001, 3:19-28
6. Eizirik DL, Korbutt GS, Hellerström C: Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest 1992, 90:1263-1268
7. Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY: Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 2001, 50:1683-90
8. Höppener JW, Ahrén B, Lips CJ: Islet amyloid and type 2 diabetes mellitus. N Engl J Med 2000, 343:411-9
9. Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC: The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 1999, 48:491-8
10. Zhou YP, Grill VE: Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994, 93:870-6
11. Cnop M, Hannaert JC, Hoorens A, Eizirik DL, Pipeleers DG: Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation. Diabetes 2001, 50:1771-7
12. Donath MY, Gross DJ, Cerasi E, Kaiser N: Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 1999, 48:738-44
13. Tyrberg B, Eizirik DL, Hellerström C, Pipeleers DG, Andersson A: Human pancreatic β-cell DNA-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro. Endocrinology 1996, 137:5694-5699
14. Ling Z, Pipeleers DG: Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest 1996, 98:2805-2812
15. Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, Cerasi E, Melloul D: Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 1999, 48:1230-1236
16. Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP: In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes 1999, 48:1995-2000
17. Mandrup-Poulsen T, Bendtzen K, Nielsen JH, Bendixen G, Nerup J: Cytokines cause functional and structural damage to isolated islets of Langerhans. Allergy 1985, 40:424-9
18. Rabinovitch A, Sumoski W, Rajotte RV, Warnock GL: Cytotoxic effects of cytokines on human pancreatic islet cells in monolayer culture. J Clin Endocrinol Metab 1990, 71:152-6
19. Arnush M, Heitmeier MR, Scarim AL, Marino MH, Manning PT, Corbett JA: IL-1 produced and released endogenously within human islets inhibits beta cell function. J Clin Invest 1998, 102:516-26
20. Rabinovitch A, Suarez WL, Thomas PD, Strynadka K, Simpson I: Cytotoxic effects of cytokines on rat islets: evidence for involvement of free radicals and lipid peroxidation. Diabetologia 1992, 35:409-413
21. Brenner HH, Burkart V, Rothe H, Kolb H: Oxygen radical production is increased in macrophages from diabetes prone BB rats. Autoimmunity 1993, 15:93-98
22. Rabinovitch A, Suarez-Pinzon W, Strynadka K, Lakey J, Rajotte R: Human pancreatic islet β-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrinol Metab 1996, 81:3197-3202
23. Delaney CA, Tyrberg B, Bouwens L, Vaghef H, Hellman B, Eizirik DL: Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death. FEBS Lett 1996, 394:300-306
24. Hadjivassiliou V, Green MH, James RF, Swift SM, Clayton HA, Green IC: Insulin secretion, DNA damage, and apoptosis in human and rat islets of Langerhans following exposure to nitric oxide, peroxynitrite, and cytokines. Nitric Oxide 1998, 2:429-41
25. Lakey JR, Suarez-Pinzon WL, Strynadka K, Korbutt GS, Rajotte RV, Mabley JG, Szabo C, Rabinovitch A: Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells. Lab Invest 2001, 81:1683-92
26. Zou MH, Shi C, Cohen RA: High Glucose via Peroxynitrite Causes Tyrosine Nitration and Inactivation of Prostacyclin Synthase That Is Associated With Thromboxane/Prostaglandin H(2) Receptor-Mediated Apoptosis and Adhesion Molecule Expression in Cultured Human Aortic Endothelial Cells. Diabetes 2002, 51:198-203
27. Singh R, Barden A, Mori T, Beilin L: Advanced glycation end-products: a review. Diabetologia 2001, 44:129-46
28. Tajiri Y, Möller C, Grill V: Long-term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits B cell function. Endocrinology 1997, 138:273-80
29. Vijg J: Somatic mutations and aging: a re-evaluation. Mutat Res 2000, 447:117-35
30. Kagawa Y, Cha SH, Hasegawa K, Hamamoto T, Endo H: Regulation of energy metabolism in human cells in aging and diabetes: FoF(1), mtDNA, UCP, and ROS. Biochem Biophys Res Commun 1999, 266:662-76
31. Koyama M, Wada R, Sakuraba H, Mizukami H, Yagihashi S: Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. Am J Pathol 1998, 153:537-45
32. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S: Reduced beta-cell mass and expression of oxidative stressrelated DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia 2002, 45:85-96
33. Tyrberg B, Andersson A, Borg LAH: Species differences in susceptibility of transplanted and cultured pancreatic islets to the β-cell toxin alloxan. Gen Comp Endocrinol 2001, 122:238-251
34. Anonymous: Figure 1.35. Photobleaching profiles of cells stained with Alexa Fluor 488 or fluorescein conjugates. Access: January, 14, 2002. Molecular Probes, Inc. 2001 [http://www.probes.com/handbook/figures/0842.html]
35. Verjat T, Dhenaut A, Radicella JP, Araneda S: Detection of 8-oxoG DNA glycosylase activity and OGG1 transcripts in the rat CNS. Mutat Res 2000, 460:127-38
36. Lin LH, Cao S, Yu L, Cui J, Hamilton WJ, Liu PK: Up-regulation of base excision repair activity for 8-hydroxy-2′-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion. J Neurochem 2000, 74:1098-105
37. Saitoh T, Shinmura K, Yamaguchi S, Tani M, Seki S, Murakami H, Nojima Y, Yokota J: Enhancement of OGG1 protein AP lyase activity by increase of APEX protein. Mutat Res 2001, 486:31-40
38. Takahashi S, Hirose M, Tamano S, Ozaki M, Orita S, Ito T, Takeuchi M, Ochi H, Fukada S, Kasai H, Shirai T: Immunohistochemical detection of 8-hydroxy-2′-deoxyguanosine in paraffin-embedded sections of rat liver after carbon tetrachloride treatment. Toxicol Pathol 1998, 26:247-52
39. Agudelo S, Portus M: Leishmania antigen nonspecific binding to avidin in biotin-avidin immunoassays. Clin Diagn Lab Immunol 2000, 7:717-8
40. Ishida T, Hippo Y, Nakahori Y, Matsushita I, Kodama T, Nishimura S, Aburatani H: Structure and chromosome location of human OGG1. Cytogenet Cell Genet 1999, 85:232-6
41. Nishioka K, Ohtsubo T, Oda H, Fujiwara T, Kang D, Sugimachi K, Nakabeppu Y: Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol Biol Cell 1999, 10:1637-52
42. de Souza-Pinto NC, Hogue BA, Bohr VA: DNA repair and aging in mouse liver: 8-oxodG glycosylase activity increase in mitochondrial but not in nuclear extracts. Free Radic Biol Med 2001, 30:916-23
43. Suh Y, Lee KA, Kim WH, Han BG, Vijg J, Park SC: Aging alters the apoptotic response to genotoxic stress. Nat Med 2002, 8:3-4
44. Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, Epe B, Seeberg E, Lindahl T, Barnes DE: Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A 1999, 96:13300-5
45. de Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA: Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res 2001, 61:5378-81
46. Osterod M, Hollenbach S, Hengstler JG, Barnes DE, Lindahl T, Epe B: Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis 2001, 22:1459-63