Brain/blood distribution described by a combination of partition coefficient and molecular mass

International Journal of Pharmaceutics

Volumn 145, Issue 1-2, 1996, Pages 9-16

  Kaliszan, Roman ^a   Markuszewski, Michał ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Brain blood distribution; Bulkiness parameters; Log P; Partition coefficients; Polarity parameters; Quantitative; Structure activity relationships (QSAR)

Indexed keywords

1 (2 CHLOROETHYL) 3 (2,6 DIOXO 3 PIPERIDYL) 1 NITROSOUREA; ASCORBIC ACID; BLEOMYCIN; CARMUSTINE; CREATININE; CYTOSINE; DIANHYDROGALACTITOL; DOXORUBICIN; EPIPODOPHYLLOTOXIN; FLUOROURACIL; GALACTITOL; GLYCEROL; LOMUSTINE; MANNITOL; METODICLOROFEN; METRONIDAZOLE; MISONIDAZOLE; MITOLACTOL; PHENOBARBITAL; PROCARBAZINE; PROPYLENE GLYCOL; PYRIMETHAMINE; SODIUM CHLORIDE; SPIROMUSTINE; SUCROSE; TEGAFUR; THIOUREA; UREA; VINCRISTINE; WATER;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY PERMEABILITY; DRUG DISTRIBUTION; HUMAN; IN VITRO STUDY; MATHEMATICAL MODEL; MOLECULAR WEIGHT; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THEORY;

EID: 0030573058     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04712-6     Document Type: Article

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