Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: Methoxychlor by human hepatic UDP-glucuronosyl transferases

Drug Metabolism and Disposition

Volumn 32, Issue 7, 2004, Pages 742-751

  Hazai, Eszter ^a   Gagne, Peter V ^b   Kupfer, David ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Gentest Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; CHLORPHENOTANE; COMPLEMENTARY DNA; CYTOCHROME P450; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; METHOXYCHLOR; PESTICIDE; PHENOL DERIVATIVE;

ARTICLE; CATALYST; CHIRALITY; CONJUGATION; CONTROLLED STUDY; ENANTIOSELECTIVITY; ENZYME MODIFICATION; ENZYME SUBSTRATE; ESTROGEN ACTIVITY; GLUCURONIDATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; TOXICOKINETICS;

BLOTTING, WESTERN; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROCARBONS, CHLORINATED; INSECTICIDES; MASS SPECTROMETRY; METHOXYCHLOR; MICROSOMES, LIVER; OXIDATION-REDUCTION; PHENOLS; STEREOISOMERISM; TIME FACTORS;

MAMMALIA;

EID: 3042542310     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.7.742     Document Type: Article

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