Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance

Toxicology

Volumn 181-182, Issue , 2002, Pages 453-456

  Miners, John O ^a   McKinnon, Ross A ^b   Mackenzie, Peter I ^a  

^a FLINDERS MEDICAL CENTRE   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Genetic polymorphism; Glucuronidation; UDP glucuronosyltransferase

Indexed keywords

BILIRUBIN; GLUCURONOSYLTRANSFERASE; XENOBIOTIC AGENT;

CATALYSIS; GENETIC POLYMORPHISM; GILBERT DISEASE; GLUCURONIDATION; HUMAN; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TOXICOLOGY;

EID: 0037184841     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00449-3     Document Type: Article

References (20)

1. Ando Y., Saka H., Ando M., et al. Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis. Cancer Res. 60:2000;6921-6926.
2. Beutler E., Gelbart T., Demina A. Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc. Natl. Acad. Sci. USA. 95:1998;8170-8174.
3. Bhasker C.R., McKinnon W., Stone A.N., et al. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. Pharmacogenetics. 10:2000;679-685.
4. Bosma P.J., Roy Chowdhury J., Bakker C., et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. N. Eng. J. Med. 333:1995;1171-1175.
5. Burchell B., Hume R. Molecular genetic basis of Gilbert syndrome. J. Gastroenterol. Hepatol. 14:1999;960-966.
6. Ciotti M., Marrone A., Potter C., Owens I.S. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications. Pharmacogenetics. 7:1997;485-495.
7. Grant D.J., Bell D.A. Bilirubin UDP-glucuronosyltransferase 1A1 gene polymorphisms: susceptibility to oxidative damage and cancer? Mol. Carcinogen. 29:2000;198-204.
8. Guillemette C., Ritter J.K., Auyeung D.J., Kessler F.K., Houseman D.E. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics. 10:2000;629-644.
9. Iyer L., Hall D., Das S., et al. Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism. Clin. Pharmacol. Ther. 65:1999;576-582.
10. Jin C.-J., Miners J.O., Lillywhite K.J., Mackenzie P.I. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem. Biophys. Res. Commun. 194:1993a;496-503.
11. Jin C.-J., Miners J.O., Lillywhite K.J., Mackenzie P.I. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J. Pharmacol. Exp. Ther. 264:1993b;475-479.
12. Lampe J.W., Bigler J., Horner N.K., Potter J.D. UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: Relationships to serum bilirubin concentrations. Pharmacogenetics. 9:1999;341-349.
13. Lampe J.W., Bigler J., Bush A.C., Potter J.D. Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y) and UGT2B15(D85Y). Cancer Epidemiol. (Biomarkers Prevention). 9:2000;329-333.
14. Levesque E., Beaulieu M., Green M.D., Tephly T.R., Belanger A., Hum D.W. Isolation and characterisation of UGT2B15(Y85): A UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics. 7:1997;317-325.
15. Levesque E., Beaulieu M., Hum D.W., Belanger A. Characterisation and substrate specificity of UGT2B4(E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics. 9:1999;207-216.
16. Mackenzie P.I., Owens I.S., Burchell B., et al. The UDP-glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence. Pharmacogenetics. 7:1997;255-269.
17. McLeod S.L., Nowell S., Plaxco J., Lang N.P. An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer. Ann. Surg. Oncol. 7:2000;777-782.
18. Miners J.O., Mackenzie P.I. Drug glucuronidation in humans. Pharmacol. Ther. 51:1991;347-369.
19. Owens I.S., Ritter J.K. Gene structure of the human UGT1 locus creates diversity in isozyme structure, substrate specificity and regulation. Prog. Nucleic Acid Res. Mol. Biol. 51:1995;305-338.
20. Posner J., Cohen A.F., Land G., Winton C., Peck A.W. The pharmacokinetics of lamotrigine (BW430C) in healthy subjects with unconjugated hyperbilirubinaemia (Gilbert's syndrome). Br. J. Clin. Pharmacol. 28:1989;117-120.