Use of cloned and expressed human UDP-glucuronosyltransferases for the assessment of human drug conjugation and identification of potential drug interactions

Drug Metabolism and Disposition

Volumn 29, Issue 1, 2001, Pages 48-53

  Ethell, Brian T ^a   Beaumont, Kevin ^b   Rance, David J ^b   Burchell, Brian ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; PHENOL DERIVATIVE; PROPOFOL; UK 156037; UK 157147; UK 157261; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN V 79; DRUG COMPETITION; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BENZOPYRANS; CELL LINE; CLONING, MOLECULAR; CRICETINAE; DRUG INTERACTIONS; GLUCURONOSYLTRANSFERASE; HUMANS; SULFONES;

EID: 0035149349     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases
2. Specificity of UDP-glucuronosyltransferases and xenobiotic glucuronidation
3. The uridine diphosphate glucuronosyltransferase multigene family: Function and regulation. Conjugation-deconjugation reactions in drug metabolism and toxicity
4. Human UGT2B7 catalyses morphine glucuronidation
5. Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family
6. Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol
7. A universal radiochemical high performance liquid chromatographic assay for the determination of UDP-glucuronosyltransferase activity
8. Stable expression of two human UDP-glucuronosyltransferase cDNAs in V79 cell culture
9. Expressed human UGT1*4 catalyzes the formation of quaternary ammonium linked glucuronides
10. Stable expression of a human liver UDP-glucuronosyltranslerase (UGT2B15) with activity towards steroid and xenobiotic substrates
11. Heterologous expression of human drug metabolizing enzymes
12. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid containing drugs
13. Propofol: A review of its pharmacodynamic and pharmacokinetic properties and use as an intraveous anaesthetic
14. Glucuronidation of propofol in microsomal fractions from various tissues and species including humans: Effect of different drugs
15. Protein measurement with the Folin phenol reagent
16. The UDP glycosyltransferase gene superfamily: Recommended nomenclature based on evolutionary divergence
17. Drug glucuronidation by human renal UDP-glucuronosyltransferases
18. cDNA cloning and characterization of the human UDP-glucuronosyltransferase UGT1A3
19. The human UDP glucuronosyltransferase UGT1A10 glucuronidates mycophenolic acid
20. Validation and use of cloned expressed human drug-metabolizing enzymes in heterologous cells for analysis of drug metabolism and drug-drug interactions
21. Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation
22. The expression of UDP-glucuronosyltransferases of the UGT1 family in human liver and kidney in response to drugs
23. Characterisation of a human bilirubin UDP-glucuronosyltransferase stably expressed in hamster lung fibroblast cell cultures
24. Drug and xenobiotic glucuronidation catalysed by cloned human liver UDP-glucuronosyltransferases stably expressed in tissue culture cell lines
25. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronsyltransferase cDNA family