Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTS): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

Drug Metabolism and Disposition

Volumn 30, Issue 11, 2002, Pages 1257-1265

  Court, Michael H ^a   Duan, Su X ^a   Guillemette, Chantal ^b   Journault, Kim ^b   Krishnaswamy, Soundararajan ^a   Von Moltke, Lisa L ^a   Greenblatt, David J ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANEDIOL; ASPARTIC ACID; EUGENOL; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B7; HYMECROMONE; ISOENZYME; NARINGENIN; OXAZEPAM; TYROSINE; UNCLASSIFIED DRUG; ANXIOLYTIC AGENT; GLUCURONIDE; UDP GLUCURONOSYLTRANSFERASE 2B15, HUMAN; UDP-GLUCURONOSYLTRANSFERASE 1A9; UDP-GLUCURONOSYLTRANSFERASE 2B15, HUMAN;

ALLELE; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; PRIORITY JOURNAL; STEREOCHEMISTRY; ADULT; ALGORITHM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; KINETICS; MALE; METABOLISM; MIDDLE AGED; STEREOISOMERISM; ULTRAVIOLET SPECTROPHOTOMETRY;

ADULT; ALGORITHMS; ALLELES; ANTI-ANXIETY AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; KINETICS; MALE; MIDDLE AGED; OXAZEPAM; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM;

EID: 0036842042     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.11.1257     Document Type: Article

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