A mutation in human topoisomerase II α whose expression is lethal in DNA repair-deficient yeast cells

Journal of Biological Chemistry

Volumn 279, Issue 25, 2004, Pages 25947-25954

  Walker, Jerrylaine V ^a   Nitiss, Karin C ^a   Jensen, Lars H ^b   Mayne, Christopher ^a   Hu, Tao ^c   Jensen, Peter B ^d   Sehested, Maxwell ^b   Hsieh, Tao ^c   Nitiss, John L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Rigshospitalet   (Denmark)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d FINSEN LABORATORY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CATALYSIS; DNA; DRUG PRODUCTS; MUTAGENESIS;

BINDING DOMAINS; MUTATIONS;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ASPARAGINE; ASPARTIC ACID; BIS(DIOXOPIPERAZINE) DERIVATIVE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); MUTANT PROTEIN; PIPERAZINEDIONE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CELL TRANSFORMATION; CONTROLLED STUDY; COVALENT BOND; DNA CLEAVAGE; DNA PROTEIN COMPLEX; DNA REPAIR; DNA STRUCTURE; DRUG TARGETING; GENETIC RECOMBINATION; HUMAN; LETHALITY; MOLECULAR STABILITY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; TEMPERATURE SENSITIVE MUTANT; YEAST CELL;

ADENOSINE TRIPHOSPHATE; ALLELES; ANTIGENS, NEOPLASM; ASPARAGINE; ASPARTIC ACID; DNA; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROLYSIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OLIGONUCLEOTIDES; PIPERAZINES; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; SACCHAROMYCES;

BACTERIA (MICROORGANISMS);

EID: 2942715083     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312314200     Document Type: Article

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