Structure-based screening as applied to human FABP4: A highly efficient alternative to HTS for hit generation

Journal of the American Chemical Society

Volumn 124, Issue 40, 2002, Pages 11874-11880

  Van Dongen, Maria J P ^a   Uppenberg, Jonas ^a   Svensson, Stefan ^a   Lundbäck, Thomas ^b   Åkerud, Tomas ^a,c   Wikström, Mats ^a   Schultz, Johan ^a  

^a Biovitrum AB   (Sweden)

^b Biovitrum   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOGENEOUS LIGANDS;

ASSAYS; CRYSTAL STRUCTURE; DRUG PRODUCTS; FATTY ACIDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SCAFFOLDS; SCREENING;

CHEMICAL ANALYSIS;

FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 4; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTAL STRUCTURE; LIGAND BINDING; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PROTEIN BINDING; PROTEIN STRUCTURE; SCREENING TEST; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; CARRIER PROTEINS; DRUG EVALUATION, PRECLINICAL; FATTY ACID-BINDING PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEINS;

EID: 0037048588     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja017830c     Document Type: Article

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