NMR reporter screening for the detection of high-affinity ligands

Angewandte Chemie - International Edition

Volumn 41, Issue 18, 2002, Pages 3420-3423

  Jahnke, Wolfgang ^a   Floersheim, Philipp ^a   Ostermeier, Christian ^a   Zhang, Xiaolu ^a   Hemmig, Rene ^a   Hurth, Konstanze ^a   Uzunov, Doncho P ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Drug design; High throughput screening; Inhibitors; NMR spectroscopy; Structure activity relationships

Indexed keywords

NUCLEAR MAGNETIC RESONANCE; ORGANIC COMPOUNDS; PROTEINS;

LIGANDS;

CHEMICAL ANALYSIS;

2 ACETYLBENZOFURAN; 2-ACETYLBENZOFURAN; 3 HYDROXYSTEROID DEHYDROGENASES; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 5 ALPHA 3 ALPHA HYDROXYSTEROID DEHYDROGENASE; 5 ALPHA-3 ALPHA-HYDROXYSTEROID DEHYDROGENASE; BENZOFURAN DERIVATIVE; ENZYME INHIBITOR; LIGAND; PROTEIN;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; HUMAN; LIGAND BINDING; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; SYNTHESIS;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; BENZOFURANS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PROTEINS;

EID: 0037119648     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20020916)41:18<3420::AID-ANIE3420>3.0.CO;2-E     Document Type: Article

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