Virus-ligand interactions: Identification and characterization of ligand binding by NMR spectroscopy

Journal of the American Chemical Society

Volumn 125, Issue 1, 2003, Pages 14-15

  Benie, Andrew J ^a   Moser, Rosita ^b   Bäuml, Englbert ^a   Blaas, Dieter ^b   Peters, Thomas ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; LIGAND; POLYAMINE; PROTON; RECEPTOR PROTEIN; RNA; VIRUS PROTEIN;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN RHINOVIRUS; IRRADIATION; LIGAND BINDING; METHODOLOGY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PARTICLE SIZE; PATHOGENESIS; PICORNAVIRUS; PROTON NUCLEAR MAGNETIC RESONANCE; SEROTYPE; VIRUS; VIRUS TITRATION;

ANTIVIRAL AGENTS; BINDING SITES; HUMANS; ISOXAZOLES; KINETICS; LIGANDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RHINOVIRUS; SUBSTRATE SPECIFICITY;

EID: 0037425531     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja027691e     Document Type: Article

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20. 6-DMSO at pH 7.4. Saturation was performed at - 10 ppm for the reference spectrum and at - 10 and - 1 ppm for the difference spectrum. The spectra shown Figures 2 and 3 were obtained with a field strength of 12.1 T (500 MHz). The titration experiment with compound 2 was performed at a field strength of 16 T (700 MHz).