The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 12, 2001, Pages 5888-5891

  Frittitta, L ^a   Baratta, R ^a   Spampinato, D ^a   Di Paola, R ^a   Pizzuti, A ^a   Vigneri, R ^a   Trischitta, V ^a  

^a GARIBALDI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; MEMBRANE PROTEIN; PROTEIN PC 1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

EID: 0035217903     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.12.8108     Document Type: Article

References (21)

1. Role of insulin resistance in human disease
2. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes metlitus
3. Putting the genes for type II diabetes on the map
4. Strategies and prospects for finding insulin resistance genes
5. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
6. PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: Relationship to insulin receptor tyrosine-kinase and whole body insulin sensitivity
7. Skeletal muscle content of membrane glycoprotein PC-1 in obesity
8. Increased adipose tissue PC-1 protein content, but not tumor necrosis factor-α gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
9. Elevated PC-1 content in cultured skin fibroblasts correlates with the decreased in vivo and in vitro insulin action in non diabetic subjects
10. Increased activity of membrane glycoprotein PC-1 in the fibroblasts from non-insulin dependent diabetes mellitus patients with insulin resistance
11. Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese woman with gestational diabetes mellitus (GDM): Evidence for increased serine/threonine phosphorylation in pregnancy and GDM
12. A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans
13. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
14. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis
15. The K121Q variant of human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians
16. 121)
17. Interpretation of results from genetic studies of multifactorial diseases
18. Genetic polymorphisms and disease
19. Insulin resistance: Interaction between obesity and a common variant of insulin receptor substrate-1
20. Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes
21. Obesity and insulin resistance