Inhibitors of Sir2: Evaluation of Splitomicin Analogues

Journal of Medicinal Chemistry

Volumn 47, Issue 10, 2004, Pages 2635-2644

  Posakony, Jeff ^a   Hirao, Maki ^a   Stevens, Sam ^a   Simon, Julian A ^a   Bedalov, Antonio ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDRO 3H NAPHTHO[2,1 B]PYRAN 3 ONE; 3 (2 HYDROXYNAPHTH 1 YL)PROPIONAMIDE; AROMATIC COMPOUND; LACTONE; PROTEIN INHIBITOR; SILENT INFORMATION REGULATOR PROTEIN 2; SILENT INFORMATION REGULATOR PROTEIN 2 INHIBITOR; SPLITOMICIN; SPLITOMICIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION KINETICS; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HYDROLYSIS; PROTEIN PROCESSING; TOXICITY TESTING; TRANSCRIPTION REGULATION; YEAST;

HISTONE DEACETYLASES; LACTONES; NAPHTHALENES; PYRONES; SACCHAROMYCES CEREVISIAE; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2342614837     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030473r     Document Type: Article

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