Proteomics-based target identification: Bengamides as a new class of methionine aminopeptidase inhibitors

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52964-52971

  Towbin, Harry ^a   Bair, Kenneth W ^a   DeCaprio, James A ^b   Eck, Michael J ^b   Kim, Sunkyu ^a   Kinder, Frederick R ^a   Morollo, Anthony ^b   Mueller, Dieter R ^a   Schindler, Patrick ^a   Song, Hyun Kyu ^b   Van Oostrum, Jan ^a   Versace, Richard W ^a   Voshol, Hans ^a   Wood, Jeanette ^a   Zabludoff, Sonya ^a,c   Phillips, Penny E ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CRYSTALLIZATION; ELECTROPHORESIS; POLYPEPTIDES; RNA; SIGNALING; SUBSTRATES; TUMORS;

PROTEOMICS; SIGNALING PATHWAYS;

ENZYME INHIBITION;

BENGAMIDE DERIVATIVE; ENZYME INHIBITOR; LAF 153; LAF 389; METHIONYL AMINOPEPTIDASE; METHIONYL AMINOPEPTIDASE INHIBITOR; NATURAL PRODUCT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEOMICS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TUMOR GROWTH; TWO DIMENSIONAL GEL ELECTROPHORESIS;

14-3-3 PROTEINS; AMINOPEPTIDASES; ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; AZEPINES; BINDING SITES; CELL DIVISION; CELL LINE, TUMOR; CLONING, MOLECULAR; COBALT; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; GLYCOPROTEINS; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEOME; RNA, SMALL INTERFERING; SESQUITERPENES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TYROSINE 3-MONOOXYGENASE;

EID: 9144222006     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309039200     Document Type: Article

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