Structure-activity relationship of an α-toxin Bs-Tx28 from scorpion (Buthus sindicus) venom suggests a new α-toxin subfamily

Archives of Biochemistry and Biophysics

Volumn 445, Issue 1, 2006, Pages 81-94

  Ali, Syed Abid ^a,b   Wang, Bingxian ^b,c   Alam, Mehtab ^a   Beck, Alexander ^b   Stoeva, Stanka ^b   Voelter, Wolfgang ^b   Abbasi, Atiya ^a   Duszenko, Michael ^b  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Holburn Biomedical Corporation   (Canada)

Author keywords

Neurotoxin; Afferent nerve discharge; Killer necklace; Peptidyl inhibitors; Scorpions; Sodium channel; Venoms

Indexed keywords

ALPHA TOXIN; AMINO ACID; ANDROCTONUS AUSTRALIS HECTOR TOXIN II; BUTHOTUS JUDAICUS ALPHA INSECT TOXIN; BUTHUS MARTENSII TOXIN M4; BUTHUS SINDICUS TOXIN 28; CYSTEINE; INSECT VENOM; LEIURUS QUINQUESTRIATUS HEBRAEUS ALPHA INSECT TOXIN; LEIURUS QUINQUESTRIATUS HEBRAEUS TOXIN IV; LEIURUS QUINQUESTRIATUS QUINQUESTRIATUS TOXIN IV; NEUROTOXIN; ODONTOBUTHUS DORIAE TOXIN 1; SCORPION VENOM; SODIUM CHANNEL; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; BUTHOTUS JUDAICUS; BUTHUS SINDICUS; DEGRADATION; ELECTROSPRAY MASS SPECTROMETRY; HYDROPHOBICITY; INSECT; LIQUID CHROMATOGRAPHY; MAMMAL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; ODONTHOBUTHUS DORIAE; PAKISTAN; PHYLOGENY; PRIORITY JOURNAL; RAT; SCORPION; SENSORY NERVE CONDUCTION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; TOXIN STRUCTURE;

ACTION POTENTIALS; AMINO ACID SEQUENCE; ANIMALS; BLATTELLIDAE; CIRCULAR DICHROISM; GASTROINTESTINAL MOTILITY; JEJUNUM; LETHAL DOSE 50; MESENTERIC ARTERIES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROTOXINS; PHYLOGENY; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; SCORPION VENOMS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNEL BLOCKERS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TETRODOTOXIN;

ANDROCTONUS AUSTRALIS HECTOR; ANIMALIA; HEXAPODA; HOTTENTOTTA JUDAICUS; INSECTA; LEIURUS QUINQUESTRIATUS; LEIURUS QUINQUESTRIATUS HEBRAEUS; LEIURUS QUINQUESTRIATUS QUINQUESTRIATUS; MAMMALIA; MESOBUTHUS MARTENSII; MESOBUTHUS TAMULUS SINDICUS; SCORPIONES;

EID: 29244468286     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2005.10.016     Document Type: Article

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