Structural implications on the interaction of scorpion α-like toxins with the sodium channel receptor site inferred from toxin iodination and pH-dependent binding

Journal of Neurochemistry

Volumn 75, Issue 4, 2000, Pages 1735-1745

  Gilles, Nicolas ^a,b,c,d   Krimm, Isabelle ^a,b,c,d   Bouet, Francoise ^a,b,c,d   Froy, Oren ^a,b,c,d   Gurevitz, Michael ^a,b,c,d   Lancelin, Jean Marc ^a,b,c,d   Gordon, Dalia ^a,b,c,d  

^a DIF   (France)

^b UNIVERSITÉ LYON 1   (France)

^c TEL AVIV UNIVERSITY   (Israel)

^d Sigyn Pharmaceuticals Ltd   (Israel)

Author keywords

Cockroach; Insect sodium channel; Locust; pH dependent binding; Scorpion toxin; Toxin iodination

Indexed keywords

HISTIDINE; LEUCINE; PHENYLALANINE; SCORPION VENOM; SODIUM CHANNEL; TYROSINE;

ARTICLE; BINDING AFFINITY; BRAIN SYNAPTOSOME; COCKROACH; CONTROLLED STUDY; DRUG BINDING; DRUG METABOLISM; IODINATION; LOCUST; NERVE CELL MEMBRANE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTON TRANSPORT; RAT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING, COMPETITIVE; GRASSHOPPERS; HYDROGEN-ION CONCENTRATION; IODINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEUROTOXINS; PERIPLANETA; PROTEIN STRUCTURE, TERTIARY; SCORPION VENOMS; SODIUM CHANNELS; SYNAPTOSOMES; TYROSINE;

BLATTARIA; HEXAPODA; INSECTA; LEIURUS; LEIURUS QUINQUESTRIATUS HEBRAEUS; MAMMALIA; SCORPIONES;

EID: 0033812147     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751735.x     Document Type: Article

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