The selectivity of scorpion α-toxins for sodium channel subtypes is determined by subtle variations at the interacting surface

Toxicon

Volumn 41, Issue 2, 2003, Pages 125-128

  Gordon, Dalia ^a   Gurevitz, Michael ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

SCORPION VENOM; SODIUM CHANNEL;

BINDING AFFINITY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SHORT SURVEY; SURFACE PROPERTY; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; MOLECULAR SEQUENCE DATA; NEUROTOXINS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RATS; SCORPION VENOMS; SCORPIONS; SODIUM CHANNELS; SURFACE PROPERTIES; SYNAPTOSOMES;

INSECTA; SCORPIONES;

EID: 0037306968     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(02)00294-5     Document Type: Short Survey

References (19)

1. Catterall W.A. Cellular and molecular biology of voltage-gated sodium channels. Physiol. Rev. 72:1992;S15-S48.
2. Catterall W.A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron. 26:2000;13-25.
3. Cestèle S., Ben Khalifa R., Pelhate M., Rochat H., Gordon D. α-Scorpion toxins binding on rat brain and insect sodium channels reveal divergent allosteric modulations by brevetoxin and veratridine. J. Biol. Chem. 270:1995;15153-15161.
4. Chen H., Heinemann S.H. Interaction of scorpion α-toxins with cardiac sodium channels: binding properties and enhancement of slow inactivation. J. Gen. Physiol. 117:2001;505-518.
5. Chen H., Lu S.-Q., Leipold E., Gordon D., Hansel A., Heinemann S.H. Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3. Eur. J. Neurosci. 16:2002;1-5.
6. Gilles N., Blanchet B., Shichor I., Zaninetti M., Lotan I., Bertrand D., Gordon D. A scorpion α-like toxin active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons. J. Neurosci. 19:1999;8730-8739.
7. Gilles N., Chen H., Wilson H., Legall F., Montoya G., Molgo J., Schönherr R., Nicholson G., Heinemann S.H., Gordon D. Scorpion α- and α-like toxins differentially interact with sodium channels in mammalian CNS and periphery. Eur. J. Neurosci. 12:2000;2823-2832.
8. Gilles N., Leipold E., Chen H., Heinemann S.H., Gordon D. Effect of depolarization on binding kinetics of scorpion α-toxin highlights conformational changes of rat brain sodium channels. Biochemistry. 40:2001;14576-14584.
9. Gilles N., Harrison G., Karbat I., Gurevitz M., Nicholson G., Gordon D. Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider δ-atracotoxin. Eur. J. Biochem. 269:2002;1500-1510.
10. Goldin A.L. Diversity of mammalian voltage-gated sodium channels. Ann. NY Acad. Sci. 868:1999;38-50.
11. Gordon D. Sodium channels as targets for neurotoxins: mode of action and interaction of neurotoxins with receptor sites on sodium channels. Lazarowici P., Gutman Y. Toxins and Signal Transduction. 1997;119-149 Harwood Press, Amsterdam.
12. Gordon D., Martin-Eauclaire M.F., Cestèle S., Kopeyan C., Carlier E., Ben Khalifa R., Pelhate M., Rochat H. Scorpion toxins affecting sodium current inactivation bind to distinct homologous receptor sites on rat brain and insect sodium channels. J. Biol. Chem. 271:1996;8034-8045.
13. Gordon D., Savarin P., Gurevitz M., Zinn-Justin S. Functional anatomy of scorpion toxins affecting sodium channels. J. Toxicol. Toxin. Rev. 17:1998;131-158.
14. Gordon D., Gilles N., Bertrand D., Molgo J., Nicholson G.M., Sauviat M.P., Benoit E., Shichor I., Lotan I., Gurevitz M., Kallen R.G., Heinemann S.H. Scorpion toxins differentiating among neuronal sodium channel subtypes: nature's guide for design of selective drugs. Menez A. Perspectives in Molecular Toxinology. 2002;215-238 Wiley, Chichester, England.
15. Gurevitz M., Gordon D., Ben-Natan S., Turkov M., Froy O. Diversification of neurotoxins by C-tail 'wiggling' - a scorpion recipe for survival. FASEB J. 15:2001;1201-1205.
16. Gurevitz M., Zilberberg N., Froy O., Turkov M., Wilunsky R., Karbat I., Anglister J., Shaanan B., Pelhate M., Adams M.E., Gilles N., Gordon D. Diversification of toxic sites on a conserved protein scaffold - a scorpion recipe for survival. Menez A. Perspectives in Molecular Toxinology. 2002;239-253 Wiley, Chichester, England.
17. Martin-Eauclaire M.F., Couraud F. Scorpion neurotoxins: effects and mechanisms. Chang L.W., Dyer R.S. Handbook on Neurotoxicology. 1995;683-716 Marcel Dekker, New York.
18. + Channels. Eur. J. Biochem. 264:1999;287-300.
19. Rogers J.C., Qu Y., Tanada T.N., Scheuer T., Catterall W.A. Molecular determinants of high affinity binding of α-scorpion toxin and sea anemone toxin in the S3-S4 extracellular loop in domain IV of the sodium channel α subunit. J. Biol. Chem. 271:1996;15950-15962.