Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis

Journal of Peptide Research

Volumn 60, Issue 5, 2002, Pages 247-256

  Sun, Y M ^a   Liu, W ^a   Zhu, R H ^a   Wang, D C ^a   Goudet, C ^b   Tytgat, J ^b  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

BmK M1; Disulfide bridge; Mutagenesis analysis; Mutant; Scorpion toxin

Indexed keywords

BUTHUS MARTENSII KARSCH M1 TOXIN; SCORPION VENOM; SODIUM CHANNEL; UNCLASSIFIED DRUG; BMK M1 NEUROTOXIN; CYSTINE; INSECT PROTEIN; NEUROTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DISULFIDE BOND; FATALITY; IN VIVO STUDY; MALE; MOUSE; MUTAGENESIS; MUTATIONAL ANALYSIS; NEUROTOXICITY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SCORPION; TOXICITY; TOXIN ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CIRCULAR DICHROISM; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; MOLECULAR GENETICS; NERVE CELL; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; XENOPUS;

ANIMALIA; BUTHUS; INVERTEBRATA; MESOBUTHUS MARTENSII; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCORPIONES;

AMINO ACID SEQUENCE; ANIMALS; CIRCULAR DICHROISM; CYSTINE; INSECT PROTEINS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEURONS; NEUROTOXINS; PROTEIN CONFORMATION; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT; SODIUM CHANNELS; XENOPUS;

EID: 0036829766     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2002.21021.x     Document Type: Article

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