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Volumn 33, Issue 22, 2005, Pages 7000-7010

Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE; POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RIBONUCLEASE; SMALL NUCLEAR RNA; TRANSCRIPTION FACTOR;

EID: 29244459405     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki997     Document Type: Article
Times cited : (60)

References (41)
  • 1
    • 5444225805 scopus 로고    scopus 로고
    • Elongation by RNA polymerase II: The short and long of it
    • Sims,R.J.,III, Belotserkovskaya,R. and Reinberg,D. (2004) Elongation by RNA polymerase II: The short and long of it. Genes Dev., 18, 2437-2468.
    • (2004) Genes Dev. , vol.18 , pp. 2437-2468
    • Sims III, R.J.1    Belotserkovskaya, R.2    Reinberg, D.3
  • 2
    • 15744388341 scopus 로고    scopus 로고
    • A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation
    • Barboric,M. and Peterlin,B.M. (2005) A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation. PLoS Biol., 3, e76.
    • (2005) PLoS Biol. , vol.3
    • Barboric, M.1    Peterlin, B.M.2
  • 3
    • 0034111019 scopus 로고    scopus 로고
    • P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II
    • Price,D.H. (2000) P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol. Cell. Biol., 20, 2629-2634.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2629-2634
    • Price, D.H.1
  • 4
    • 0037102566 scopus 로고    scopus 로고
    • CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C.elegans embryo
    • Shim,E.Y., Walker,A.K., Shi,Y. and Blackwell,T.K. (2002) CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C.elegans embryo. Genes Dev., 16, 2135-2146.
    • (2002) Genes Dev. , vol.16 , pp. 2135-2146
    • Shim, E.Y.1    Walker, A.K.2    Shi, Y.3    Blackwell, T.K.4
  • 5
    • 0035943710 scopus 로고    scopus 로고
    • Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
    • Chao,S.H. and Price,D.H. (2001) Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. J. Biol. Chem., 276, 31793-31799.
    • (2001) J. Biol. Chem. , vol.276 , pp. 31793-31799
    • Chao, S.H.1    Price, D.H.2
  • 6
    • 3242769187 scopus 로고    scopus 로고
    • Cellular control of gene expression by T-type cyclin/CDK9 complexes
    • Garriga,J. and Grana,X. (2004) Cellular control of gene expression by T-type cyclin/CDK9 complexes. Gene, 337, 15-23.
    • (2004) Gene , vol.337 , pp. 15-23
    • Garriga, J.1    Grana, X.2
  • 7
    • 18144371989 scopus 로고    scopus 로고
    • HEXIM2, a HEXIM1 related protein, regulates P-TEFb through association with 7SK
    • Byers,S.A., Price,J.P., Cooper,J.J., Li,Q. and Price,D.H. (2005)HEXIM2, a HEXIM1 related protein, regulates P-TEFb through association with 7SK. J. Biol. Chem., 280, 16360-16367.
    • (2005) J. Biol. Chem. , vol.280 , pp. 16360-16367
    • Byers, S.A.1    Price, J.P.2    Cooper, J.J.3    Li, Q.4    Price, D.H.5
  • 10
    • 0035891288 scopus 로고    scopus 로고
    • 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes
    • Nguyen,V.T., Kiss,T., Michels,A.A. and Bensaude,O. (2001) 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature, 414, 322-325.
    • (2001) Nature , vol.414 , pp. 322-325
    • Nguyen, V.T.1    Kiss, T.2    Michels, A.A.3    Bensaude, O.4
  • 11
    • 0035891271 scopus 로고    scopus 로고
    • The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
    • Yang,Z., Zhu,Q., Luo,K. and Zhou,Q. (2001)The7SKsmall nuclearRNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature, 414, 317-322.
    • (2001) Nature , vol.414 , pp. 317-322
    • Yang, Z.1    Zhu, Q.2    Luo, K.3    Zhou, Q.4
  • 12
    • 18144422796 scopus 로고    scopus 로고
    • Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive P-TEFb complexes for control of transcription
    • Yik,J.H., Chen,R., Pezda,A.C. and Zhou,Q. (2005) Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive P-TEFb complexes for control of transcription. J. Biol. Chem., 280, 16368-16376.
    • (2005) J. Biol. Chem. , vol.280 , pp. 16368-16376
    • Yik, J.H.1    Chen, R.2    Pezda, A.C.3    Zhou, Q.4
  • 13
    • 0242361319 scopus 로고    scopus 로고
    • Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA
    • Yik,J.H., Chen,R., Nishimura,R., Jennings,J.L., Link,A.J. and Zhou,Q. (2003) Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. Mol. Cell, 12, 971-982.
    • (2003) Mol. Cell , vol.12 , pp. 971-982
    • Yik, J.H.1    Chen, R.2    Nishimura, R.3    Jennings, J.L.4    Link, A.J.5    Zhou, Q.6
  • 14
    • 2342423586 scopus 로고    scopus 로고
    • Phosphorylation of RNA polymerase II in cardiac hypertrophy: Cell enlargement signals converge on cyclinT/Cdk9
    • Kulkarni,P.A., Sano,M. and Schneider,M.D. (2004) Phosphorylation of RNA polymerase II in cardiac hypertrophy: Cell enlargement signals converge on cyclinT/Cdk9. Recent Prog. Horm. Res., 59, 125-139.
    • (2004) Recent Prog. Horm. Res. , vol.59 , pp. 125-139
    • Kulkarni, P.A.1    Sano, M.2    Schneider, M.D.3
  • 15
    • 0036851825 scopus 로고    scopus 로고
    • Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy
    • Sano,M., Abdellatif,M., Oh,H., Xie,M., Bagella,L., Giordano,A., Michael,L.H., DeMayo,F.J. and Schneider,M.D. (2002) Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy. Nature Med., 8, 1310-1317.
    • (2002) Nature Med. , vol.8 , pp. 1310-1317
    • Sano, M.1    Abdellatif, M.2    Oh, H.3    Xie, M.4    Bagella, L.5    Giordano, A.6    Michael, L.H.7    DeMayo, F.J.8    Schneider, M.D.9
  • 16
    • 21644468867 scopus 로고    scopus 로고
    • Identification of a dimeric Cyclin T-binding domain in HEXIM1 and biochemical analysis of its binding competition with HIV-1 Tat
    • Schulte,A., Czudnochowski,N., Barboric,M., Schonichen,A., Blazek,D., Peterlin,B.M. and Geyer,M. (2005) Identification of a dimeric Cyclin T-binding domain in HEXIM1 and biochemical analysis of its binding competition with HIV-1 Tat. J. Biol. Chem., 280, 24968-24977.
    • (2005) J. Biol. Chem. , vol.280 , pp. 24968-24977
    • Schulte, A.1    Czudnochowski, N.2    Barboric, M.3    Schonichen, A.4    Blazek, D.5    Peterlin, B.M.6    Geyer, M.7
  • 17
    • 0036133174 scopus 로고    scopus 로고
    • Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes
    • Taube,R., Lin,X., Irwin,D., Fujinaga,K. and Peterlin,B.M. (2002) Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol. Cell. Biol., 22, 321-331.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 321-331
    • Taube, R.1    Lin, X.2    Irwin, D.3    Fujinaga, K.4    Peterlin, B.M.5
  • 18
    • 0037322883 scopus 로고    scopus 로고
    • Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells
    • Ouchida,R., Kusuhara,M., Shimizu,N., Hisada,T., Makino,Y., Morimoto,C., Handa,H., Ohsuzu,F. and Tanaka,H. (2003) Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells, 8, 95-107.
    • (2003) Genes Cells , vol.8 , pp. 95-107
    • Ouchida, R.1    Kusuhara, M.2    Shimizu, N.3    Hisada, T.4    Makino, Y.5    Morimoto, C.6    Handa, H.7    Ohsuzu, F.8    Tanaka, H.9
  • 19
    • 29244474416 scopus 로고    scopus 로고
    • Interplay between 75K sn RNA and oppositely charged regions in HEXIMA direct the inhibition of P-TEFb
    • doi: 10.1038/sj.emboj.7600883
    • Barboric,M., Kohoutek,J., Price,J.P., Blazek,D., Price,D.H. and Peterlin,B.M. (2005) Interplay between 75K sn RNA and oppositely charged regions in HEXIMA direct the inhibition of P-TEFb. EMBOJ., doi: 10.1038/ sj.emboj.7600883.
    • (2005) EMBO J.
    • Barboric, M.1    Kohoutek, J.2    Price, J.P.3    Blazek, D.4    Price, D.H.5    Peterlin, B.M.6
  • 20
    • 0033729426 scopus 로고    scopus 로고
    • Generation of deletion and point mutations with one primer in a single cloning step
    • Makarova,O., Kamberov,E. and Margolis,B. (2000) Generation of deletion and point mutations with one primer in a single cloning step. Biotechniques, 29, 970-972.
    • (2000) Biotechniques , vol.29 , pp. 970-972
    • Makarova, O.1    Kamberov, E.2    Margolis, B.3
  • 21
    • 0032102906 scopus 로고    scopus 로고
    • Computational approaches to identify leucine zippers
    • Bornberg-Bauer,E., Rivals,E. and Vingron,M. (1998) Computational approaches to identify leucine zippers. Nucleic Acids Res., 26, 2740-2746.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 2740-2746
    • Bornberg-Bauer, E.1    Rivals, E.2    Vingron, M.3
  • 24
    • 0041344534 scopus 로고    scopus 로고
    • Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy
    • Sorkina,T., Doolen,S., Galperin,E., Zahniser,N.R. and Sorkin,A. (2003) Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy. J. Biol. Chem., 278, 28274-28283.
    • (2003) J. Biol. Chem. , vol.278 , pp. 28274-28283
    • Sorkina, T.1    Doolen, S.2    Galperin, E.3    Zahniser, N.R.4    Sorkin, A.5
  • 25
    • 0036721022 scopus 로고    scopus 로고
    • Homomultimerization of the Coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy
    • van Kuppeveld,F.J.M., Melchers,W.J.G., Willems,P.H.G.M. and Gadella,T.W.J.,Jr (2002) Homomultimerization of the Coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy. J. Virol., 76, 9446-9456.
    • (2002) J. Virol. , vol.76 , pp. 9446-9456
    • van Kuppeveld, F.J.M.1    Melchers, W.J.G.2    Willems, P.H.G.M.3    Gadella Jr., T.W.J.4
  • 26
    • 0037012847 scopus 로고    scopus 로고
    • Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
    • Zacharias,D.A., Violin,J.D., Newton,A.C. and Tsien,R.Y. (2002) Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science, 296, 913-916.
    • (2002) Science , vol.296 , pp. 913-916
    • Zacharias, D.A.1    Violin, J.D.2    Newton, A.C.3    Tsien, R.Y.4
  • 27
    • 2942628287 scopus 로고    scopus 로고
    • A human immunodeficiency virus type 1 tat-like arginine-rich RNA-'binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SKsnRNA-mediated inactivation of P-TEFb
    • Yik,J.H.N., Chen,R.C., Pezda,A.C., Samford,C.S. and Zhou,Q. (2004) A human immunodeficiency virus type 1 tat-like arginine-rich RNA-'binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SKsnRNA-mediated inactivation of P-TEFb. Mol. Cell. Biol., 24, 5094-5105.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 5094-5105
    • Yik, J.H.N.1    Chen, R.C.2    Pezda, A.C.3    Samford, C.S.4    Zhou, Q.5
  • 28
    • 0035252931 scopus 로고    scopus 로고
    • Coiled coils: A highly versatile protein folding motif
    • Burkhard,P., Stetefeld,J. and Strelkov,S.V. (2001) Coiled coils: A highly versatile protein folding motif. Trends Cell Biol., 11, 82-88.
    • (2001) Trends Cell Biol. , vol.11 , pp. 82-88
    • Burkhard, P.1    Stetefeld, J.2    Strelkov, S.V.3
  • 29
    • 0031892994 scopus 로고    scopus 로고
    • Dimerization as a regulatory mechanism in signal transduction
    • Klemm,J.D., Schreiber,S.L. and Crabtree,G.R. (1998) Dimerization as a regulatory mechanism in signal transduction. Annu. Rev. Immunol., 16, 569-592.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 569-592
    • Klemm, J.D.1    Schreiber, S.L.2    Crabtree, G.R.3
  • 30
    • 0032548918 scopus 로고    scopus 로고
    • A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop specific binding to TAR RNA
    • Wei,P., Garber,M.E., Fang,S.-M., Fischer,W.H. and Jones,K.A. (1998) A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop specific binding to TAR RNA. Cell, 92, 451-462.
    • (1998) Cell , vol.92 , pp. 451-462
    • Wei, P.1    Garber, M.E.2    Fang, S.-M.3    Fischer, W.H.4    Jones, K.A.5
  • 31
    • 0033986157 scopus 로고    scopus 로고
    • Interactions between equine cyclin T1, Tat and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1
    • Taube,R., Fujinaga,K., Irwin,D., Wimmer,J., Geyer,M. and Peterlin,B.M. (2000) Interactions between equine cyclin T1, Tat and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1. J. Virol., 74, 892-898.
    • (2000) J. Virol. , vol.74 , pp. 892-898
    • Taube, R.1    Fujinaga, K.2    Irwin, D.3    Wimmer, J.4    Geyer, M.5    Peterlin, B.M.6
  • 32
    • 7044272278 scopus 로고    scopus 로고
    • The crystal structure of a high affinity RNA stem-loop complexes with the bacteriophage MS2 capsid: Further challenges in the modeling of ligand-RNA interactions
    • Horn,W.T., Convery,M.A., Stonehouse,N.J., Adams,C.J., Liljas,L., Phillips,S.E.V. and Stockley,P.G. (2004) The crystal structure of a high affinity RNA stem-loop complexes with the bacteriophage MS2 capsid: Further challenges in the modeling of ligand-RNA interactions. RNA, 10, 1776-1782.
    • (2004) RNA , vol.10 , pp. 1776-1782
    • Horn, W.T.1    Convery, M.A.2    Stonehouse, N.J.3    Adams, C.J.4    Liljas, L.5    Phillips, S.E.V.6    Stockley, P.G.7
  • 33
    • 0030968219 scopus 로고    scopus 로고
    • Role of the coat protein-RNA interaction the life cycle of bacteriophage MS2
    • Peabody,D.S. (1997) Role of the coat protein-RNA interaction the life cycle of bacteriophage MS2. Mol. Gen. Genet., 254, 358-364.
    • (1997) Mol. Gen. Genet. , vol.254 , pp. 358-364
    • Peabody, D.S.1
  • 35
    • 23344437022 scopus 로고    scopus 로고
    • Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186
    • Li,Q., Price,J.P., Byers,S.A., Cheng,D., Peng,J. and Price,D.H. (2005) Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. J. Biol. Chem., 280, 28819-28826.
    • (2005) J. Biol. Chem. , vol.280 , pp. 28819-28826
    • Li, Q.1    Price, J.P.2    Byers, S.A.3    Cheng, D.4    Peng, J.5    Price, D.H.6
  • 36
    • 2542493861 scopus 로고    scopus 로고
    • Ablation of the CLP-1gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death
    • Huang,F., Wagner,M. and Siddiqui,M.A. (2004) Ablation of the CLP-1gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death. Mech. Dev., 121, 559-572.
    • (2004) Mech. Dev. , vol.121 , pp. 559-572
    • Huang, F.1    Wagner, M.2    Siddiqui, M.A.3
  • 38
    • 12544251219 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells
    • Shan,B., Zhou,Y., Chin,D., Morris,C.A., Morris,G.F. and Lasky,J.A. (2005) Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells. J. Biol. Chem., 280, 1103-1111.
    • (2005) J. Biol. Chem. , vol.280 , pp. 1103-1111
    • Shan, B.1    Zhou, Y.2    Chin, D.3    Morris, C.A.4    Morris, G.F.5    Lasky, J.A.6
  • 40
    • 24644486087 scopus 로고    scopus 로고
    • The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1
    • Wittmann,B.M., Fujinaga,K., Deng,H., Ogba,N. and Montano,M.M. (2005) The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. Oncogene, 36, 5576-5588.
    • (2005) Oncogene , vol.36 , pp. 5576-5588
    • Wittmann, B.M.1    Fujinaga, K.2    Deng, H.3    Ogba, N.4    Montano, M.M.5
  • 41
    • 0042014234 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors
    • Wittmann,B.M., Wang,N. and Montano,M.M. (2003) Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors. Cancer Res., 63, 5151-5158.
    • (2003) Cancer Res. , vol.63 , pp. 5151-5158
    • Wittmann, B.M.1    Wang, N.2    Montano, M.M.3


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