Oligomerization of G-protein-coupled receptors: Lessons from the yeast Saccharomyces cerevisiae

Eukaryotic Cell

Volumn 4, Issue 12, 2005, Pages 1963-1970

  Overton, Mark C ^a   Chinault, Sharon L ^a   Blumer, Kendall J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPOLYMER; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; METABOLISM; SACCHAROMYCES CEREVISIAE; SHORT SURVEY; SIGNAL TRANSDUCTION;

BIOPOLYMERS; DIMERIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GTP-BINDING PROTEINS; MODELS, MOLECULAR; RECEPTORS, G-PROTEIN-COUPLED; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 29144466481     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.4.12.1963-1970.2005     Document Type: Short Survey

References (116)

1. Ayoub, M. A., C. Couturier, E. Lucas-Meunier, S. Angers, P. Fossier, M. Bouvier, and R. Jockers. 2002. Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J. Biol. Chem. 277:21522-21528.
2. Baker, E. K., N. J. Colley, and C. S. Zuker. 1994. The cyclophilin homolog NinaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin. EMBO J. 13:4886-4895.
3. Batlle, M., A. Lu, D. A. Green, Y. Xue, and J. P. Hirsch. 2003. Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth. J. Cell Sci. 116:701-710.
4. Benkirane, M., D. Y. Jin, R. F. Chun, R. A. Koup, and K. T. Jeang. 1997. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J. Biol. Chem. 272:30603-30606.
5. Bermak, J. C., M. Li, C. Bullock, and Q. Y. Zhou. 2001. Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat. Cell Biol. 3:492-498.
6. Blumer, K. J., J. E. Reneke, and J. Thorner. 1988. The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae. J. Biol. Chem. 263:10836-10842.
7. Bockaert, J., and J. P. Pin. 1999. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 18:1723-1729.
8. Burkholder, A. C., and L. H. Hartwell. 1985. The yeast alpha-factor receptor: structural properties deduced from the sequence of the STE2 gene. Nucleic Acids Res. 13:8463-8475.
9. Calver, A. R., M. J. Robbins, C. Cosio, S. Q. Rice, A. J. Babbs, W. D. Hirst, I. Boyfield, M. D. Wood, R. B. Russell, G. W. Price, A. Couve, S. J. Moss, and M. N. Pangalos. 2001. The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling. J. Neurosci. 21:1203-1210.
10. Carrillo, J. J., J. F. Lopez-Gimenez, and G. Milligan. 2004. Multiple interactions between transmembrane helices generate the oligomeric alpha1b-adrenoceptor. Mol. Pharmacol. 66:1123-1137.
11. Chabre, M., and M. le Maire. 2005. Monomeric G-protein-coupled receptor as a functional unit. Biochemistry 44:9395-9403.
12. Chapple, J. P., and M. E. Cheetham. 2003. The chaperone environment at the cytoplasmic face of the endoplasmic reticulum can modulate rhodopsin processing and inclusion formation. J. Biol. Chem. 278:19087-19094.
13. Chinault, S. L., M. C. Overton, and K. J. Blumer. 2004. Subunits of a yeast oligomeric G protein-coupled receptor are activated independently by agonist but function in concert to activate G protein heterotrimers. J. Biol. Chem. 279:16091-16100.
14. Cornea, A., J. A. Janovick, G. Maya-Nunez, and P. M. Conn. 2001. Gonadotropin-releasing hormone receptor microaggregation. Rate monitored by fluorescence resonance energy transfer. J. Biol. Chem. 276:2153-2158.
15. Dohlman, H. G. 2002. G proteins and pheromone signaling. Annu. Rev. Physiol. 64:129-152.
16. Dohlman, H. G., and J. W. Thorner. 2001. Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu. Rev. Biochem. 70:703-754.
17. Dosil, M., K. A. Schandel, E. Gupta, D. D. Jenness, and J. B. Konopka. 2000. The C terminus of the Saccharomyces cerevisiae α-factor receptor contributes to the formation of preactivation complexes with its cognate G protein. Mol. Cell. Biol. 20:5321-5329.
18. Duthey, B., S. Caudron, J. Perroy, B. Bettler, L. Fagni, J. P. Pin, and L. Prezeau. 2002. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J. Biol. Chem. 277:3236-3241.
19. Eichinger, L., J. A. Pachebat, G. Glockner, M. A. Rajandream, R. Sucgang, M. Berriman, J. Song, R. Olsen, K. Szafranski, Q. Xu, B. Tunggal, S. Kummerfeld, M. Madera, B. A. Konfortov, F. Rivero, A. T. Bankier, R. Lehmann, N. Hamlin, R. Davies, P. Gaudet, P. Fey, K. Pilcher, G. Chen, D. Saunders, E. Sodergren, P. Davis, A. Kerhornou, X. Nie, N. Hall, C. Anjard, L. Hemphill, N. Bason, P. Farbrother, B. Desany, E. Just, T. Morio, R. Rost, C. Churcher, J. Cooper, S. Haydock, N. van Driessche, A. Cronin, I. Goodhead, D. Muzny, T. Mourier, A. Pain, M. Lu, D. Harper, R. Lindsay, H. Hauser, K. James, M. Quiles, M. Madan Babu, T. Saito, C. Buchrieser, A. Wardroper, M. Felder, M. Thangavelu, D. Johnson, A. Knights, H. Loulseged, K. Mungall, K. Oliver, C. Price, M. A. Quail, H. Urushihara, J. Hernandez, E. Rabbinowitsch, D. Steffen, M. Sanders, J. Ma, Y. Kohara, S. Sharp, M. Simmonds, S. Spiegler, A. Tivey, S. Sugano, B. White, D. Walker, J. Woodward, T. Winckler, Y. Tanaka, G. Shaulsky, M. Schleicher, G. Weinstock, A. Rosenthal, E. C. Cox, R. L. Chisholm, R. Gibbs, W. F. Loomis, M. Platzer, R. R. Kay, J. Williams, P. H. Dear, A. A. Noegel, B. Barrell, and A. Kuspa. 2005. The genome of the social amoeba Dictyostelium discoideum. Nature 435:43-57.
20. Eilers, M., V. Hornak, S. O. Smith, and J. B. Konopka. 2005. Comparison of class A and D G protein-coupled receptors: common features in structure and activation. Biochemistry 44:8959-8975.
21. El-Asmar, L., J. Y. Springael, S. Ballet, E. U. Andrieu, G. Vassart, and M. Parmentier. 2005. Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers. Mol. Pharmacol. 67:460-469.
22. Filipek, S., K. A. Krzysko, D. Fotiadis, Y. Liang, D. A. Saperstein, A. Engel, and K. Palczewski. 2004. A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem. Photobiol. Sci. 3:628-638.
23. Fisher, R. D., B. Wang, S. L. Alam, D. S. Higginson, H. Robinson, W. I. Sundquist, and C. P. Hill. 2003. Structure and ubiquitin binding of the ubiquitin-interacting motif. J. Biol. Chem. 278:28976-28984.
24. Floyd, D. H., A. Geva, S. P. Bruinsma, M. C. Overton, K. J. Blumer, and T. J. Baranski. 2003. C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast. J. Biol. Chem. 278:35354-35361.
25. Foord, S. M., and F. H. Marshall. 1999. RAMPs: accessory proteins for seven transmembrane domain receptors. Trends Pharmacol. Sci. 20:184-187.
26. Fotiadis, D., Y. Liang, S. Filipek, D. Saperstein, A., A. Engel, and K. Palczewski. 2004. The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett. 564:281-288.
27. Fotiadis, D., Y. Liang, S. Filipek, D. A. Saperstein, A. Engel, and K. Palczewski. 2003. Atomic-force microscopy: rhodopsin dimers in native disc membranes. Nature 421:127-128.
28. Fredriksson, R., and H. B. Schioth. 2005. The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol. Pharmacol. 67:1414-1425.
29. Galvez, T., B. Duthey, J. Kniazeff, J. Blahos, G. Rovelli, B. Bettler, L. Prezeau, and J. P. Pin. 2001. Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J. 20:2152-2159.
30. George, S. R., B. F. O'Dowd, and S. P. Lee. 2002. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat. Rev. Drug Discov. 1:808-820.
31. Gimelbrant, A. A., S. L. Haley, and T. S. McClintock. 2001. Olfactory receptor trafficking involves conserved regulatory steps. J. Biol. Chem. 276:7285-7290.
32. Goldsmith, P. K., G. F. Fan, K. Ray, J. Shiloach, P. McPhie, K. V. Rogers, and A. M. Spiegel. 1999. Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. J. Biol. Chem. 274:11303-11309.
33. Gomes, I., B. A. Jordan, A. Gupta, C. Rios, N. Trapaidze, and L. A. Devi. 2001. G protein coupled receptor dimerization: implications in modulating receptor function. J. Mol. Med. 79:226-242.
34. Guo, W., L. Shi, and J. A. Javitch. 2003. The forth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J. Biol. Chem. 278:4385-4388.
35. Harashima, T., and J. Heitman. 2002. The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol. Cell 10:163-173.
36. Harashima, T., and J. Heitman. 2005. G{alpha} subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae. Mol. Biol Cell. 16:4557-4571.
37. Havlickova, M., L. Prezeau, B. Duthey, B. Bettler, J. P. Pin, and J. Blahos. 2002. The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor. Mol. Pharmacol. 62:343-350.
38. Helenius, A., and K. Simons. 1975. Solubilization of membranes by detergents. Biochim. Biophys. Acta 415:29-79.
39. Hicke, L. 1997. Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins. FASEB J. 11:1215-1226.
40. Hlavackova, V., C. Goudet, J. Kniazeff, A. Zikova, D. Maurel, C. Vol, J. Trojanova, L. Prezeau, J. P. Pin, and J. Blahos. 2005. Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. EMBO J. 24:499-509.
41. Hoffman, C. S. 2005. Except in every detail: comparing and contrasting G-protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Eukaryot. Cell 4:495-503.
42. Jastrzebska, B., T. Maeda, L. Zhu, D. Fotiadis, S. Filipek, A. Engel, R. E. Stenkamp, and K. Palczewski. 2004. Functional characterization of rhodopsin monomers and dimers in detergents. J. Biol. Chem. 279:54663-54675.
43. Jones, K. A., B. Borowsky, J. A. Tamm, D. A. Craig, M. M. Durkin, M. Dai, W. J. Yao, M. Johnson, C. Gunwaldsen, L. Y. Huang, C. Tang, Q. Shen, J. A. Salon, K. Morse, T. Laz, K. E. Smith, D. Nagarathnam, S. A. Noble, T. A. Branchek, and C. Gerald. 1998. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 396:674-679.
44. Kaeberlein, M., K. T. Kirkland, S. Fields, and B. K. Kennedy. 2005. Genes determining yeast replicative life span in a long-lived genetic background. Mech. Ageing Dev. 126:491-504.
45. Kaupmann, K., B. Malitschek, V. Schuler, J. Heid, W. Froestl, P. Beck, J. Mosbacher, S. Bischoff, A. Kulik, R. Shigemoto, A. Karschin, and B. Bettler. 1998. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature 396:683-687.
46. Kenworthy, A. K., and M. Edidin. 1998. Distribution of a glycosylphosphatidylinositol-anchored protein at the apical surface of MDCK cells examined at a resolution of <100 Å using imaging fluorescence resonance energy transfer. J. Cell Biol. 142:69-84.
47. Klco, J. M., T. B. Lassere, and T. J. Baranski. 2003. C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J. Biol. Chem. 278:35345-35353.
48. Konopka, J. B., S. M. Margarit, and P. Dube. 1996. Mutation of Pro-258 in transmembrane domain 6 constitutively activates the G protein-coupled alpha-factor receptor. Proc. Natl. Acad. Sci. USA 93:6764-6769.
49. Kühn, H. 1984. Interactions between photoexcited rhodopsin and light-activated enzymes in rods., p. 123-156. In N. Osborne and J. Chader (ed.), Progress in Retinal Research. Pergamon Press, Oxford, United Kingdom.
50. Kunishima, N., Y. Shimada, Y. Tsuji, T. Sato, M. Yamamoto, T. Kumasaka, S. Nakanishi, H. Jingami, and K. Morikawa. 2000. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407:971-977,
51. Ladds, G., D. K., A. Das, and J. Davey. 2005. A constitutively active GPCR retains its G protein specificity and the ability to form dimers. Mol. Microbiol. 55:482-497.
52. Lakowitz, J. R. 1983. Principles of fluorescence spectroscopy. Plenum Press, New York, N.Y.
53. Lee, S. P., B. F. O'Dowd, R. D. Rajaram, T. Nguyen, and S. R. George. 2003. D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4. Biochemistry 42:11023-11031.
54. Lefkowitz, R. J., and S. K. Shenoy. 2005. Transduction of receptor signals by beta-arrestins. Science 308:512-517.
55. Lemaire, K., S. Van de Velde, P. Van Dijck, and J. M. Thevelein. 2004. Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gprl in the yeast Saccharomyces cerevisiae. Mol. Cell 16:293-299.
56. Liang, Y., D. Fotiadis, S. Filipek, D. A. Saperstein, K. Palczewski, and A. Engel. 2003. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J. Biol. Chem. 278:21655-21662.
57. Loconto, J., F. Papes, E. Chang, L. Stowers, E. P. Jones, T. Takada, A. Kumanovics, K. Fischer Lindahl, and C. Dulac. 2003. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Cell 112:607-618.
58. Lorenz, M. C., X. Pan, T. Harashima, M. E. Cardenas, Y. Xue, J. P. Hirsch, and J. Heitman. 2000. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics 154:609-622.
59. MacKenzie, K. R., and D. M. Engelman. 1998. Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization. Proc. Natl. Acad. Sci. USA 95:3583-3590.
60. MacKenzie, K. R., J. H. Prestegard, and D. M. Engelman. 1997. A transmembrane helix dimer: structure and implications. Science 276:131-133.
61. Margeta-Mitrovic, M., Y. N. Jan, and L. Y. Jan. 2000. A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 27:97-106.
62. Martin, N. P., L. M. Leavitt, C. M. Sommers, and M. E. Dumont. 1999. Assembly of G protein-coupled receptors from fragments: identification of functional receptors with discontinuities in each of the loops connecting transmembrane segments. Biochemistry 38:682-695.
63. McVey, M., D. Ramsay, E. Kellett, S. Rees, S. Wilson, A. J. Pope, and G. Milligan. 2001. Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta-opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy. J. Biol. Chem. 276:14092-14099.
64. Mercier, J. F., A. Salahpour, S. Angers, A. Breit, and M. Bouvier. 2002. Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo-and heterodimerization by bioluminescence resonance energy transfer. J. Biol. Chem. 277:44925-44931.
65. Mesnier, D., and J. L. Baneres. 2004. Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1. J. Biol. Chem. 279:49664-49670.
66. Milligan, G., S. Wilson, and J. F. Lopez-Gimenez. 2005. The specificity and molecular basis of alpha1-adrenoceptor and CXCR chemokine receptor dimerization. J. Mol. Neurosci. 26:161-168.
67. Miwa, T., Y. Takagi, M. Shinozaki, C. W. Yun, W. A. Schell, J. R. Perfect, H. Kumagai, and H. Tamaki. 2004. Gpr1, a putative G-protein-coupled receptor, regulates morphogenesis and hypha formation in the pathogenic fungus Candida albicans. Eukaryot. Cell 3:919-931.
68. + based on green fluorescent proteins and calmodulin. Nature 388:882-887.
69. Nelson, G., J. Chandrashekar, M. A. Hoon, L. Feng, G. Zhao, N. J. Ryba, and C. S. Zuker. 2002. An amino-acid taste receptor. Nature 416:199-202.
70. Nelson, G., M. A. Hoon, J. Chandrashekar, Y. Zhang, N. J. Ryba, and C. S. Zuker. 2001. Mammalian sweet taste receptors. Cell 106:381-390.
71. Nemoto, W., and H. Toh. 2005. Prediction of interfaces for oligomerization of G-protein coupled receptors. Proteins 58:644-660.
72. Overton, M., and K. Blumer. 2002. Use of fluorescence resonance energy transfer to analyze oligomerization of G-protein-coupled receptors expressed in yeast. Methods 27:324-332.
73. Overton, M. C. 2000. GPCR structure and activation. Ph.D. dissertation. Washington University, St. Louis, Mo.
74. Overton, M. C., and K. J. Blumer. 2002. The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J. Biol. Chem. 277:41463-41472.
75. Overton, M. C., and K. J. Blumer. 2000. G-protein-coupled receptors function as oligomers in vivo. Current Biology 10:341-344.
76. Overton, M. C., S. L. Chinault, and K. J. Blumer. 2003. Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor. J. Biol. Chem. 278:49369-49377.
77. Pagano, A., G. Rovelli, J. Mosbacher, T. Lohmann, B. Duthey, D. Stauffer, D. Ristig, V. Schuler, I. Meigel, C. Lampert, T. Stein, L. Prezeau, J. Blahos, J. Pin, W. Froestl, R. Kuhn, J. Heid, K. Kaupmann, and B. Bettler. 2001. C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors. J. Neurosci. 21:1189-1202.
78. Palczewski, K., T. Kumasaka, T. Hori, C. A. Behnke, H. Motoshima, B. A. Fox, I. Le Trong, D. C. Teller, T. Okada, R. E. Stenkamp, M. Yamamoto, and M. Miyano. 2000. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289:739-745.
79. Park, P. S., S. Filipek, J. W. Wells, and K. Palczewski. 2004. Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry 43:15643-15656.
80. Park, P. S., and K. Palczewski. 2005. Diversifying the repertoire of G protein-coupled receptors through oligomerization. Proc. Natl. Acad. Sci. USA 102:8793-8794.
81. Parnot, C., and B. Kobilka. 2004. Toward understanding GPCR dimers. Nat. Struct. Mol. Biol. 11:691-692.
82. Parrish, W., M. Eilers, W. Ying, and J. B. Konopka. 2002. The cytoplasmic end of transmembrane domain 3 regulates the activity of the Saccharomyces cerevisiae G-protein-coupled alpha-factor receptor. Genetics 160:429-443.
83. Pausch, M. H. 1997. G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discovery. Trends Biotechnol. 15:487-494.
84. Pfleger, K. D., and K. A. Eidne. 2005. Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochem. J. 385:625-637.
85. Pierce, K. L., R. T. Premont, and R. J. Lefkowitz. 2002. Seven-transmembrane receptors. Nat. Rev. Mol. Cell Biol. 3:639-650.
86. Raicu, V., D. B. Jansma, R. J. Miller, and J. D. Friesen. 2005. Protein interaction quantified in vivo by spectrally resolved fluorescence resonance energy transfer. Biochem. J. 385:265-277.
87. Ray, K., and B. C. Hauschild. 2000. Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. J. Biol. Chem. 275:34245-34251.
88. Reneke, J. E. 1989. Genetic and functional analysis of the yeast alpha-factor receptor. Ph.D. dissertation. University of California, Berkeley, Calif.
89. Reneke, J. E., K. J. Blumer, W. E. Courchesne, and J. Thorner. 1988. The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain. Cell 55:221-234.
90. Rocheville, M., D. C. Lange, U. Kumar, R. Sasi, R. C. Patel, and Y. C. Patel. 2000. Subtypes of the somatostatin receptor assemble as functional homo-and heterodimers. J. Biol. Chem. 275:7862-7869.
91. Roess, D. A., C. J. Brady, and B. G. Barisas. 2000. Biological function of the LH receptor is associated with slow receptor rotational diffusion. Biochim. Biophys. Acta 1464:242-250.
92. Romano, C., J. K. Miller, K. Hyrc, S. Dikranian, S. Mennerick, Y. Takeuchi, M. P. Goldberg, and K. L. O'Malley. 2001. Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu5 dimerization. Mol. Pharmacol. 59:46-53.
93. Romano, C., W. L. Yang, and K. L. O'Malley. 1996. Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J. Biol. Chem. 271:28612-28616.
94. Russ, W. P., and D. M. Engelman. 2000. The GxxxG motif: a framework for transmembrane helix-helix association. J. Mol. Biol. 296:911-919.
95. Salahpour, A., S. Angers, and M. Bouvier. 2000. Functional significance of oligomerization of G-protein-coupled receptors. Trends Endocrinol. Metab. 11:163-168.
96. Salahpour, A., S. Angers, J. F. Mercier, M. Lagace, S. Marullo, and M. Bouvier. 2004. Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting. J. Biol. Chem. 279:33390-33397.
97. Shah, A., and L. Marsh. 1996. Role of Sst2 in modulating G protein-coupled receptor signaling. Biochem. Biophys. Res. Commun. 226:242-246.
98. Shih, S. C., D. J. Katzmann, J. D. Schnell, M. Sutanto, S. D. Emr, and L. Hicke. 2002. Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat. Cell Biol. 4:389-393.
99. Shioda, T., E. E. Nakayama, Y. Tanaka, X. Xin, H. Liu, A. Kawana-Tachikawa, A. Kato, Y. Sakai, Y. Nagai, and A. Iwamoto. 2001. Naturally occurring deletional mutation in the C-terminal cytoplasmic tail of CCR5 affects surface trafficking of CCR5. J. Virol. 75:3462-3468.
100. Springael, J. Y., E. Urizar, and M. Parmentier. 2005. Dimerization of chemokine receptors and its functional consequences. Cytokine. Growth Factor Rev.
101. Stefan, C. J., M. C. Overton, and K. J. Blumer. 1998. Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors. Mol. Biol. Cell 9:885-399.
102. Tamaki, H., C. W. Yun, T. Mizutani, T. Tsuzuki, Y. Takagi, M. Shinozaki, Y. Kodama, K. Shirahige, and H. Kumagai. 2005. Glucose-dependent cell size is regulated by a G protein-coupled receptor system in yeast Saccharomyces cerevisiae. Genes Cells 10:193-206.
103. Tanford, C., and J. A. Reynolds. 1976. Characterization of membrane proteins in detergent solutions. Biochim. Biophys. Acta 457:133-170.
104. Terrillon, S., and M. Bouvier. 2004. Roles of G-protein-coupled receptor dimerization. EMBO Rep. 5:30-34.
105. Terrillon, S., D. T., Mouillac, B., Breit, A., Ayoub, M. A., Taulan, M., Jockers, R., Barberis, C., Bouvier, M. 2003. Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis. Mol. Endocrinol. 17:677-691.
106. Thevelein, J. M., R. Gelade, I. Holsbeeks, O. Lagatie, Y. Popova, F. Rolland, F. Stolz, S. Van de Velde, P. Van Dijck, P. Vandormael, A. Van Nuland, K. Van Roey, G. Van Zeebroeck, and B. Yan. 2005. Nutrient sensing systems for rapid activation of the protein kinase A pathway in yeast. Biochem. Soc. Trans. 33:253-256.
107. Thevenin, D., T. Lazarova, M. F. Roberts, and C. R. Robinson. 2005. Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor. Protein Sci. 14:2177-2186.
108. Trettel, F., S. Di Bartolomeo, C. Lauro, M. Catalano, M. T. Ciotti, and C. Limatola. 2003. Ligand-independent CXCR2 dimerization. J. Biol. Chem. 278:40980-40988.
109. Vanoni, M., R. L. Rossi, L. Querin, V. Zinzalla, and L. Alberghina. 2005. Glucose modulation of cell size in yeast. Biochem. Soc. Trans. 33:294-296.
110. Weiner, J. L., S. C. Guttierez, and K. J. Blumer. 1993. Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway. J. Biol. Chem. 268:8070-8077.
111. White, J.H., A. Wise, M. J. Main, A. Green, N. J. Fraser, G. H. Disney, A. A. Barnes, P. Emson, S. M. Foord, and F. H. Marshall. 1998. Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396:679-682.
112. Xu, H., L. Staszewski, H. Tang, E. Adler, M. Zoller, and X. Li. 2004. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. USA 101:14258-14263.
113. Xue, Y., M. Batile, and J. P. Hirsch. 1998. GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway. EMBO J. 17:1996-2007.
114. Yesilaltay, A., and D. D. Jenness. 2000. Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis. Mol. Biol. Cell 11:2873-2884.
115. Zacharias, D. A., J. D. Violin, A. C. Newton, and R. Y. Tsien. 2002. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296:913-916.
116. Zhang, Z., S. Sun, S. J. Quinn, E. M. Brown, and M. Bai. 2001. The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions. J. Biol. Chem. 276:5316-5322.