Defective repair in COPD: The American hypothesis

Long-Term Intervention in Chronic Obstructive Pulmonary Disease

Volumn , Issue , 2004, Pages 165-200

  Rennard, Stephen ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

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EID: 28244494336     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (229)

1. Celli BR, Snider GL, Heffner J, Tiep B, Ziment I, Make B, Braman S, Olsen G, Phillips Y. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152:S77-S120.
2. Siafakas, NM, Vermeire P, Pride NB, Paoletti P, Gibson J, Howard P, Yernault JC, Decramer M, Higenbottam T, Postma DS, Rees J. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). Eur Respir J 1995; 8:1398-1420.
3. Peat JK, Woolcock AJ, Cullen K. Rate of decline of lung function in subjects with asthma. Eur J Respir Dis 1987; 70:171-179.
4. Lange P, Parner J, Vestbo J, Schnor P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339:1194-1200.
5. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. 2003
6. Niewoehner DE. Anatomic and pathophysiological correlations in COPD. In: Baum GL et al. eds. Textbook of Pulmonary Diseases. Philadelphia:Lippincott-Raven, 1998: 823-842.
7. Orie NG, Sluiter HJ, DeVries K, Tammeling GJ, Witkop J. The host factor in bronchitis. In: Orie NGM, Sluiter HJ, eds. Bronchitis, An International Symposium. Assen, Netherlands, 1961: 43-59.
8. Burrows B. Airways obstructive disease: pathogenetic mechanisms and natural histories of the disorders. Med Clin North Am 1990; 74:547-560.
9. Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise RA. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 153:1802-1811.
10. Ulrik CS, Backer V. Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma. Eur Respir J 1999; 14:892-6.
11. Fletcher C, Peto R, Tinker C, Speizer FE. The Natural History of Chronic Bronchitis and Emphysema. New York: Oxford University Press, 1976: 1-272.
12. Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Am J Respir Crit Care Med 1996; 153:1530-1535.
13. Donaldson GC, Seemungal TAR, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57:847-852.
14. Paupe J. Immunotherapy with an oral bacterial extract (OM-85 BV) for upper respiratory infections. Respiration 1991; 58:150-154.
15. Martin RJ, Pak J, Moore EG. Overnight theophylline concentrations and effects on sleep and lung function in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992; 145:540-544.
16. McElvaney NG, Crystal RG. Proteases and lung injury. In: Crystal RG, West JB, eds. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven, 1997: 2205-2218.
17. McElvaney NG, Crystal RG. Antiproteases and lung defense. In: Crystal RG, et al., eds. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven, 1997: 2219-2235.
18. Lucey EC, Stone PJ, Snider GL. Consequences of proteolytic injury. In: Crystal RG, et al., eds. The Lung: Scientific Foundations. Philadelphia: Lippincott-Raven, 1997; 2237-2250.
19. Hautamaki, RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997; 277:2002-2004.
20. Rahman I, MacNee W. Role of oxidants/antioxidants in smoking induced lung disease. Free Radic Biol Med 1996; 21:669-681.
21. Brassart B, Randoux A, Hornebeck W, Emonard H. Regulation of matrix metalloproteinase-2 (gelatinase A, MMP-2), membrane type matrix metalloproteinase-1 (MT1-MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression by elastin derived peptides in human HT-1080 fibrosarcoma cell line. Clin Exp Metastasis 1998; 16:489-500.
22. Nadel JA. Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies. Chest 2000; 117:386S-389S.
23. Liebow AA. Pulmonary emphysema with special reference to vascular changes. Am Rev Respir Dis 1959; 80:67-93.
24. Rennard SI. COPD: overview of definitions, epidemiology and factors influencing its development. Chest 1998; 113:235S-241S.
25. Wilhelm DL. Regeneration of tracheal epithelium. J Pathol Bacteriol 1953; 55:543-550.
26. Lane BP, Gordon R. Regeneration of rat tracheal epithelium after mechanical injury. Exp Biol Med 1974; 145:1139-1144.
27. Keenan KP, Combs JW, McDowell EM. Regeneration of hamster tracheal epithelium after mechanical injury. Virchows Arch 1982; 41:193-214.
28. Shimizu T, Nishihara M, Kawaguchi S, Sakakura Y. Expression of phenotypic markers during regeneration of rat tracheal epithelium following mechanical injury. Am J Respir Cell Mol Biol 1994; 11:85-94.
29. Erjefalt JS, Persson CG. Airway epithelial repair: breathtakingly quick and multipotentially pathogenic. Thorax 1997; 52:1010-1012.
30. Boers JE. Composition and Proliferation of Normal Human Tracheobronchial Mucosa. Maastricht: Masstricht Universitaire Pers, 1997: 134.
31. Persson CGA, Erjefalt JS, Andersson M, Greiff L, Svensson C. Extravasation, lamina propria flooding ande lumenal entry of bulk plasma exudate in mucosal defence, inflammation and repair. Pulm Pharmacol 1996; 9:129-139.
32. Lane BP, Gordon R. Regeneration of rat tracheal epithelium after mechanical injury. Proc Soc Exp Biol Med 1974; 145:1139-1144.
33. Erjefalt J. Airway Epithelial Shedding: Morphological and Functional Aspects In Vivo. Lund, Sweden, 1996.
34. McDowell EM, Newkirk C, Coleman B. Development of hamster tracheal epithelium: I. A quantitative morphologic study in the fetus. Anat Rec 1985; 213:429-447.
35. Plopper CG, Alley JL, Weir AJ. Differentiation of tracheal epithelium during fetal lung maturation in the rhesus monkey Macaca mulatta. Am J Anat 1986; 175:59-71.
36. Plopper CG, Mariassy AT, Wilson DW, Alley JL, Nishio SJ, Nettesheim P. Comparison of nonciliated tracheal epithelial cells in six mammalian species:ultrastructure and population densities. Exp Lung Res 1983; 5:281-294.
37. Robbins RA, Rennard SI. Biology of airway epithelial cells. In: Crystal RG, et al. (eds) The Lung: Scientific Foundations Second Edition, Philadelphia:Lippincott-Raven, 1997: 445-457.
38. Borthwick DW, Shahbazian M, Krantz QT, Dorin JR, Randell SH. Evidence for stem-cell niches in the tracheal epithelium. Am J Respir Cell Mol Biol 2001; 24:662-670.
39. Brody AR, Hook GER, Cameron GS, Jetten AM, Butterick CJ, Nettesheim P. The differentiation capacity of Clara cells isolated from the lungs of rabbits. Lab Invest 1987; 57:219.
40. Hook GER, Brody AR, Cameron GS, Jetten AM, Gilmore LB, Nettesheim P. Repopulation of denuded tracheas by Clara cells isolated from the lungs of rabbits. Exp Lung Res 1987; 12:311-329.
41. Shoji S, Ertl RF, Linder J, Koizumi S, Duckworth WC, Rennard SI. Bronchial epithelial cells respond to insulin and insulin-like growth factor-I as a chemoattractant. Am J Respir Cell Mol Biol 1990; 2:53-557.
42. Shoji S, Ertl RF, Linder J, Romberger DJ, Rennard SI. Bronchial epithelial cells produce chemotactic activity for bronchial epithelial cells: possible role for fibronectin in airway repair. Am Rev Respir Dis 1990; 141:218-225.
43. Rickard KA, Taylor J, Rennard SI, Spurzem JR. Migration of bovine bronchial epithelial cells to extracellular matrix components. Am J Respir Cell Mol Biol 1993; 8:63-68.
44. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, Fauci AS. Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83:4167-4171.
45. Roberts AB. Molecular and cell biology of TGF-beta. Miner Electrolyte Metab 1998 24:111-119.
46. Sacco O, Romberger D, Rizzino A, Beckmann J, Rennard SI, Spurzem JR. Spontaneous production of transforming growth factor beta 2 by primary culture of bronchial epithelial cells: effects on cell behavior in vitro. J Clin Invest 1992; 90:1379-1385.
47. Mio T, Liu X, Adachi Y, Striz I, Skold CM, Romberger DJ, Spurzem JR, Illig MG, Ertl R, Rennard SI. Human bronchial epithelial cells modulate collagen gel contraction by fibroblasts. Am J Phys 1998; 274:L119-L126.
48. Romberger DJ, Beckmann JD, Claassen L, Ertl RF, Rennard SI. Modulation of fibronectin production of bovine bronchial epithelial cells by transforming growth factor-beta. Am J Respir Cell Mol Biol 1992; 7:149-155.
49. Wang A, Cohen DS, Palmer E, Sheppard D. Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor. J Biol Chem 1991; 266:15558-15560.
50. Ruoslahti E. Fibronectin and its receptors. Annu Rev Biochem 1988; 57:375-413.
51. Savla U, Appel HJ, Sporn PH, Waters CM. Prostaglandin E(2) regulates wound closure in airway epithelium. Am J Physiol Lung Cell Mol Physiol 2001; 280:L421-431.
52. Kim JS, McKinnis VS, White SR. Migration of guinea pig airway epithelial cells in response to bombesin analogues. Am J Respir Cell Mol Biol 1997; 16:259-266.
53. Kim JS, McKinnis VS, Adams K, White SR. Proliferation and repair of guinea pig tracheal epithelium after neuropeptide depletion and injury in vivo. Am J Physiol 1997; 273:L1235-1241.
54. Erjefalt JS, Erjefalt I, Sundler F, Persson CGA. Microcirculation-derived factors in airway epithelial repair in vivo. Microvasc Res 1994; 48:161-178.
55. Zahm JM, Chevillard M, Puchelle E. Wound repair of human surface respiratory epithelium. Am J Respir Cell Mol Biol 1991; 5:242-248.
56. Herard AL, Zahm JM, Pierrot D, Hinnrasky J, Fuchey C, Puchelle E. Epithelial barrier integrity during in vitro wound repair of the airway epithelium. Am J Respir Cell Mol Biol 1996; 15:624-632.
57. Kim JS, McKinnis VS, Nawrocki A, White SR. Stimulation of migration and wound repair of guinea-pig airway epithelial cells in response to epidermal growth factor. Am J Respir Cell Mol Biol 1998; 18:66-74.
58. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, Davies DE. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 2000; 14:1362-1374.
59. Ito H, Rennard SI, Spurzem JR. Mononuclear cell conditioned medium enhances bronchial epithelial cell migration but inhibits attachment to fibronectin. J Lab Clin Med 1996; 127:494-503.
60. Zahm JM, Debordeaux C, Raby B, Klossek JM, Bonnet N, Puchelle E. Motogenic effect of recombinant HGF on airway epithelial cells during the in vitro wound repair of the respiratory epithelium. J Cell Physiol 2000; 185:447-453.
61. Waters CM, Savla U. Keratinocyte growth factor accelerates wound closure in airway epithelium during cyclic mechanical strain. J Cell Physiol 1999; 181:424-432.
62. Rickard KA, Taylor J, Spurzem JR, Rennard SI. Extracellular matrix and bronchial epithelial cell migration. Chest 1992; 01:17S-18S.
63. Yokosaki Y, Matsuura N, Sasaki T, Murakami I, Schneider H, Higashiyama S, Saitoh Y, Yamakido M, Taooka Y, Sheppard D. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J Biol Chem 1999; 274:36328-36334.
64. Dunsmore SE, Saarialho-Kere UK, Roby JD, Wilson CL, Matrisian LM, Welgus HG, Parks WC. Matrilysin expression and function in airway epithelium. J Clin Invest 1998; 102:1321-1331.
65. Buissson AC, Gilles C, Polette M, Zahm JM, Birembaut P, Tournier JM. Wound repair-induced expression of a stromelysins is associated with the acquisition of a mesenchymal phenotype in human respiratory epithelial cells. Lab Invest 1996; 74:658-669.
66. Legrand C, Gilles C, Zahm JM, Polette M, Buisson AC, Kaplan H, Birembaut P, Tournier JM. Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling. J Cell Biol 1999; 146:517-529.
67. de Bentzmann S, Polette M, Zahm JM, Hinnrasky J, Kileztky C, Bajolet O, Klossek JM, Filloux A, Lazdunski A, Puchelle E. Pseudomonas aeruginosa virulence factors delay airway epithelial wound repair by altering the actin cytoskeleton and inducing overactivation of epithelial matrix metalloproteinase-2. Lab Invest 2000; 80:209-219.
68. Legrand C, Polette M, Tournier JM, de Bentzmann S, Huet E, Monteau M, Birembaut P. uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration. Exp Cell Res 2001; 264:326-363.
69. Erjefalt JS, Erjefalt I, Sundler F, Persson GA. In vivo restitution of airway epithelium. Cell Tissue Res 1995; 281:305-316.
70. Stoker M. Effect of scatter factor on motility of epithelial cells and fibroblasts. J Cell Physiol 1989; 139:565-569.
71. White SR, Dorscheid DR, Rabe KF, Wojcik KR, Hamann KJ. Role of very late adhesion integrins in mediating repair of human airway epithelial cell monolayers after mechanical injury. Am J Respir Cell Mol Biol 1999; 20:787-796.
72. Pilewski JM, Latoche JD, Arcasoy SM, Albelda SM. Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo. Am J Physiol 1997; 273:L256-263.
73. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, et al. The integrin alpha avb6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999; 96:319-328.
74. Herard AL, Pierrot D, Hinnrasky J, Kaplan H, Sheppard D, Puchelle E, Zahm JM. Fibronectin and its alpha 5 beta 1-integrin receptor are involved in the wound-repair process of airway epithelium. Am J Physiol 196; 21:L726-L733.
75. Leir SH, Baker JE, Holgate ST, Lackie PM. Increased CD44 expression in human bronchial epithelial repair after damage or plating at low cell densities. Am J Physiol Lung Cell Mol Physiol 2000; 278:L1129-L1137.
76. de Bentzmann S, Roger P, Puchelle E. Pseudomonas aeruginosa adherence to remodelling respiratory epithelium. Eur Respir J 1996; 9:2145-2150.
77. Striz I, Mio T., Adachi Y, Heires P, Robbins RA, Spurzem JR, Illig MJ, Romberger DJ, Rennard SI. IL-4 induces ICAM-1 expression in human bronchial epithelial cells and potentiates TNF-a. Am J Physiol 1999; 277:L58-L64.
78. DeRose V, Robbins RA, Snider RM, Spurzem JR, Thiele GM, Rennard SI, Rubinstein I. Substance P increases neutrophil adhesion to bronchial epithelial cells. J Immunol 1994; 152:1339-1346.
79. Shoji S, Rickard KA, Takizawa H, Ertl RF, Linder J, Rennard SI. Lung fibroblasts produce growth stimulatory activity for bronchial epithelial cells. Am Rev Respir Dis 1990; 141:433-439.
80. Tsao MS, Zhu H, Viallet J. Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells. Exp Cell Res 1996; 223:268-273.
81. Tsao MS, Zhu H, Giaid A, Viallet J, Nakamura T, Park M. Hepatocyte growth factor/scatter factor is an autocrine factor for human normal bronchial epithelial and lung carcinoma cells. Cell Growth Differ 1993; 4:571-579.
82. Takizawa H, Beckmann J, Shoji S, Classen LR, Ertl RF, Linder J, Rennard SI. Pulmonary macrophages can stimulate cell growth of bovine bronchial epithelial cells. Am J Respir Cell Mol Biol 1990; 2:245-255.
83. Jetten AM, Vollberg TM, Nervi C, George MD. Positive and negative regulation of proliferation and differentiation in tracheobronchial epithelial cells. Am Rev Respir Dis 1990; 142:S36-S39.
84. Oyamada H, Kayaba H, Kamada Y, Kuwasaki T, Yamada Y, Kobayashi Y, Cui C, Honda K, Saito N, Chihara J. An optimal condition of bronchial cell proliferation stimulated by insulin-like growth factor-I. Int Arch Allergy Immunol 2000; 122(suppl 1):59-62.
85. Aoshiba K, Rennard SI, S. JR. Fibronectin supports bronchial epithelial cell adhesion and survival in the absence of growth factors. Am J Phys 1997; 273:L684-693.
86. Whitcutt MJ, Adler KB, Wu R. A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells. In Vitro Cell Dev Biol 1988; 24:420.
87. Takeyama K, Dabbagh K, Lee HM, Agusti C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 1999; 96:3081-3086.
88. Guzman K, Randell SH, Nettesheim P. Epidermal growth factor regulates expression of the mucous phenotype of rat tracheal epithelial cells. Biochem Biophys Res Commun 1995; 217:412-418.
89. Hill AT, Bayley D, Stockley RA. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. Am J Respir Crit Care Med 1999; 160:893-889.
90. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol 2000; 164:1546-1552.
91. Vesely KR, Hyde DM, Stovall MY, Harkema JR, Green JF, Schelegle ES. Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. J Appl Physiol 1999; 86:951-962.
92. Shoji S, Rickard KA, Ertl RF, Robbins RA, Linder J, Rennard SI. Bronchial epithelial cells produce lung fibroblast chemotactic factor: fibronectin. Am J Respir Cell Mol Biol 1989; 1:13-20.
93. Harrison NK, Dawes KE, Kwon OJ, Barnes PJ, Laurent GJ, Chung KF. Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis. Am J Physiol 1995; 268:L278-L283.
94. Endo T, Uchida Y, Matsumoto H, Suzuki N, Nomura A, Hirata F, Hasegawa S. Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines. Biochem Biophys Res Commun 1992; 14:1594-1599.
95. Shimizu S, Gabazza EC, Hayashi T, Ido M, Adachi Y, Suzuki K. Thrombin stimulates the expression of PDGF in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2000:L503-510.
96. Varga J, Rosenbloom J, Jimenez SA. Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and III collagen and fibronectin mRNAs in normal human dermal fibroblasts. J Biochem 1987; 247:597-604.
97. Postlethwaite AE, Keski-Oja J, Balian G, Kang AH. Induction of fibroblast chemotaxis by fibronectin: Localization of the chemotactic region to a 140,000 molecular weight non-gelatin binding fragment. J Exp Med 1980; 153:494-499.
98. Gauss-Muller E, Kleinman HK, Martin GR, Schiffmann E. Role of attachment factors and attractants in fibroblast chemotaxis. J Lab Clin Med 1980; 96:1071-1080.
99. Cardoso WV. Molecular regulation of lung development. Annu Rev Physiol 2001; 63:471-494.
100. Holgate ST, Davies DE, Lackie PM, Wilson SJ, Puddicombe SM, Lordan JL. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J Allergy Clin Immunol 2000; 104:193-204.
101. Hicks W Jr, Sigurdson L, Gabalski E, Hard R, Hall L, 3rd, Gardella J, Powers C, Kumar N, Lwebuga-Mukasa J. Does cartilage down-regulate growth factor expression in tracheal epithelium? Arch Otolaryngol Head Neck Surg 1999; 125:1239-1243.
102. Vignola, AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, la-Rocca AM, Bellia V, Bonsignore G, Bousquet J. Transforming growth factor-beta expression in mucosal biopsies in asthama and chronic bronchitis. Am J Respir Crit Care Med 1997; 156:591-599.
103. Aubert J-D, Dalal BI, Bai TR, Roberts CR, Hayashi S, Hogg JC. Transforming growth factor beta-1 gene expression in human airways. Thorax 1994; 49:225-232.
104. Romberger D, Daughton D, Claassen L, Ertl R, Ghafouri M, Robbins RA, Von Essen SG, Thompson AB, Rennard SI. Increased fibronectin in bronchial lavage fluid of chronic bronchitis. Am Rev Respir Dis 1992; 145:A761.
105. Sofia M, Mormile M, Faraone S, Carratu P, Alifano M, Di Benedetto G, Carratu L. Increased 24-hour endothelin-1 urinary excretion in patients with chronic obstructive pulmonary disease. Respiration 1994; 61:263-268.
106. Chalmers GW, Macleod KJ, Sriram S, Thomson LJ, McSharry C, Stack BH, Thomson NC. Sputum endothelin-1 is increased in cystic fibrosis and chronic obstructive pulmonary disease. Eur Respir J 1999; 13:1288-1292.
107. Tomaki M, Ichinose M, Miura M, Hirayama Y, Yamauchi H, Nakajima N, Shirato K. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis. Am J Respir Crit Care Med 1995; 151:613-617.
108. Chanez P, Springall D, Vignola AM, Moradoghi-Hattvani A, Polak JM, Godard P, Bousquet J. Bronchial mucosal immunoreactivity of sensory neuropeptides in severe airway diseases. Am J Respir Crit Care Med 1998; 158:985-990.
109. Sofia M, Maniscalco M. Endothelin in acute exacerbations of COPD. Thorax 2001; 56:819.
110. Polzin A, Pletz M, Erbes R, Raffenberg M, Mauch H, Wagner S, Arndt G, Lode H. Procalcitonin as a diagnostic tool in lower respiratory tract infections and tuberculosis. Eur Respir J 2003; 21:939-943.
111. Takuwa N, Takuwa Y, Yanagisawa M, Yamashita K, Masaki T. A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts. J Biol Chem 1989; 264:7856-7861.
112. Peacock AJ, Shock A, Gray AJ, Reeves JT, Chmabers R, Laurent GJ. The effect of endothelin-1 on the growth and chemotaxis of fibroblasts. Eur Respir J 1990; 3:336S.
113. Ziche M, Morbidelli L, Pacini M, Dolara P, Maggi CA. NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins. Br J Pharmacol 1990; 100:11-14.
114. Kahler CM, Herold M, Wiedermann CJ. Substance P: a competence factor for human fibroblast proliferation that induces the release of growth-regulatory arachidonic acid metabolites. J Cell Physiol 1993; 156:579-587.
115. Philpps RP, Borrello MA, Blieden TM. Fibroblast heterogeneity in the periodontium and other tissues. J Periodont Res 1997; 32:159-165.
116. Torry DJ, Richards CD, Podor TJ, Gauldie J. Anchorage-independent colony growth of pulmonary fibroblasts derived from fibrotic human lung tissue. J Clin Invest 1994; 93:1525-1532.
117. Botstein GR, Sherer GK, Leroy EC. Fibroblast selection in scleroderma. Arthritis Rheum 1982; 25:189-195.
118. Torry DJ, Richards CD, Podor TJ, Gauldie J. Modulation of the anchorageindependent phynotype of human lung fibroblasts obtained from fibrotic tissue following culture with retinoid and corticosteriod. Exp Lung Res 1996; 22:231-244.
119. Kawamoto M, Matsunami T, Ertl RF, Fukuda Y, Ogawa M, Spurzem JR, Yamanaka N, Rennard SI. Selective migration of a-smooth muscle actinpositive myofibroblasts toward fibronectin in the Boyden’s blindwell chamber. Clin Sci 1997; 93:355-362.
120. Bitterman PB, Wewers MD, Rennard SI, Adelberg S, Crystal RG. Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J Clin Invest 1986; 77:700-708.
121. Diaz A, Munoz E, Johnston R, Korn JH, Jimenez SA. Regulation of human lung fibroblast alpha 1 procollagen gene expression by tumor necrosis factor alpha, interleukin-1 beta, and prostaglandin E2. J Biol Chem 1993; 268:10364-10371.
122. Sempowski GD, Derdak S, Phipps RP. Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets. J Cell Physiol 1996; 167:290-296.
123. Epler GR, Colby T, McLoud TC, Carrington CB, Gaensler EA. Bronchiolitis obliterans organizing pneumonia. N Engl J Med 1985; 312:152-158.
124. Costabel U, Guzman J, Teschler H. Bronchiolitis obliterans with organizing pneumonia: outcome. Thorax 1995; 50:S59-S64.
125. King TE. Bronchiolitis. In: Schwarz MI, King TE, eds. Interstitial Lung Disease. St. Louis, MO, Mosby-Year Book, 1993:463-495.
126. Kawamoto M, Romberger DJ, Nakamura Y, Tate L, Ertl RF, Spurzem JR, Rennard SI. Modulation of fibroblast type I collagen and fibronectin production by bovine bronchial epithelial cells. Am J Respir Cell Mol Biol 1995; 12:425-433.
127. Nakamura Y, Tate L, Ertl RF, Kawamoto M, Mio T, Adachi Y, et al. Bronchial epithelial cells regulate fibroblast proliferation. Am J Physiol 1995; 269:L377-L387.
128. Matsuba K, Wright JL, Wiggs BR, Pare PD, Hogg JC. The changes in airways structure associated with reduced forced expiratory volume in one second. Eur Respir J 1989; 2:834-839.
129. Kuwano K, Bosken CH, Pare PD, Bai TR, Wiggs BR, Hogg JC. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 148:1220-1225.
130. Salvato G. Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 2001; 56:902-906.
131. Vrugt B, Wilson S, Bron A, Holgate ST, Djukanovic R, Aalbers R. Bronchial angiogenesis in severe glucocorticoid-dependent asthma. Eur Respir J 2000; 15:1014-1021.
132. Hogg JC. Chronic obstructive pulmonary disease: an overview of pathology and pathogenesis. Novartis Found Symp 2001; 234:4-26.
133. McDonald DM. Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med 2001; 164:S39-45.
134. Cavarra E, Martorana PA, Bartalesi B, Fineschi S, Gambelli F, Lucattelli M, Ortiz L, Lungarella G. Genetic deficiency of alpha1-PI in mice influences lung responses to bleomycin. Eur Respir J 2001; 17:474-480.
135. Michelson PH, Tigue M, Panos RJ, Sporn PH. Keratinocyte growth factor stimulates bronchial epithelial cell proliferation in vitro and in vivo. Am J Physiol 1999; 277:L737-742.
136. Ohmichi H, Matsumoto K, Nakamura T. In vivo mitogenic action of HGF on lung epithelial cells: pulmotrophic role in lung regeneration. Am J Physiol 1996; 270:L1031-1039.
137. Adamson IYR, Bakowska J. Relationship of keratinocyte growth factor and hepatocyte growth factor levels in rat lung lavage fluid to epithelial cell regeneration after bleomycin. Am J Pathol 1999; 155:949-954.
138. Dohi M, Hasegawa T, Yamamoto K, Marshall BC. Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis. Am J Respir Crit Care Med 2000; 162:2302-2307.
139. Panoskaltsis-Mortari A, Taylor PA, Rubin JS, Uren A, Welniak LA, Murphy WJ, Farrell CL, Lacey DL, Blazar BR. Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury. Blood 2000; 96:4350-4356.
140. Geiser T, Jarreau PH, Atabai K, Matthay MA. Interleukin-1b augments in vitro alveolar epithelial repair. Am J Physiol Lung Cell Mol Physiol 2000; 279:L1184-L1190.
141. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13:9-22.
142. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000; 106:1311-1319.
143. Kasahara Y, Tuder RM, Cool CD, Lynch DA, Flores SC, Voelkel NF. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. Am J Respir Crit Care Med 2001; 163:737-744.
144. Watkins RH, D’Angio CT, Ryan RM, Patel A, Maniscalco WM. Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol 1999; 276:L858-L867.
145. Sakao S, Tatsumi K, Hashimoto T, Igari H, Shino Y, Shirasawa H, Kuriyama T. Vascular endothelial growth factor and the risk of smokingrelated COPD Chest 2003; 124:323-327.
146. Snider G, Lucey E, Stone P. Animal models of emphysema. Am Rev Respir Dis 1986; 133:149-169.
147. Shapiro SD, Endicott SK, Province MA, Pierce JA, Campbell EJ. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J Clin Invest 1991; 87:1828-1834.
148. Stone PJ, Morris SM, Thomas KM, Schuhwerk K, Mitchelson A. Repair of elastase-digested elastic fibers in acellular matrices by replating with neonatal rat-lung lipid interstitial fibroblasts or other elastogenic cell types. Am J Respir Cell Mol Biol 1997; 17:289-301.
149. Morris SM, Thomas KM, Rich CB, Stone PJ. Degradation and repair of elastic fibers in rat lung interstitial fibroblast cultures. Anat Rec 1998; 250:397-407.
150. Senior RM, Tegner H, Kuhn C, Ohlsson K, Starcher BC, Pierce JA. The induction of pulmonary emphysema with human leukocyte elastase. Am Rev Respir Dis 1977; 116:469-475.
151. Karlinsky JB, Fredette J, Davidovits G. The balance of lung connective tissue elements in elastase-induced emphysema. J Lab Clin Med 1983; 102:151-162.
152. Kuhn C, Yu SY, Chraplyvy M. The induction of emphysema with elastase: II. Changes in connective tissue. Lab Invest 1976; 34:372-380.
153. Cardoso WV, Sekhon HS, Hyde DM, Thurlbeck WM. Collagen and elastin in human pulmonary emphysema. Am Rev Respir Dis 1993; 147:975-981.
154. Pierce JA, Hocott JB, Ebert RV. The collagen ad elastin content of the lung in emphysema. Ann Intern Med 1961; 55:210-221.
155. Lang MR, Fiaux GW, Gillooly M, Stewart JA, Hulmes DJS, Lamb D. Collagen content of alveolar wall tissue in emphysematous and nonemphysematous lungs. Thorax 1994; 49:319-326.
156. Vlahovic G, Russell ML, Mercer RR, Crapo JD. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am J Respir Crit Care Med 1999; 160:2086-2092.
157. Kawakami M, Takizawa T. Distribution of pores within alveoli in the human lung. J Appl Physiol 1987; 63:1866-1870.
158. Menkes H, Traystman R, Terry P. Collateral ventilation. Fed Proc 1979; 38:22-26.
159. Gillett NA, Gerlach RF, Muggenburg BA, Harkema JR, Griffith WC, Mauderly JL. Relationship between collateral flow resistance and alveolar pores in the aging beagle dog. Exp Lung Res 1989; 15:709-719.
160. Port CD, Ketels KV, Coffin DL, Kane P. A comparative study of experimental and spontaneous emphysema. J Toxicol Environ Health 1977; 2:589-604.
161. Takaro T, Gaddy LR, Parra S. Thin alveolar epithelial partitions across connective tissue gaps in the alveolar wall of the human lung: ultrastructural observations. Am Rev Respir Dis 1982; 126:326-331.
162. Sahebjami H, Wirman JA. Emphysema-like changes in the lungs of starved rats. Am Rev Respir Dis 1981; 124:619-624.
163. Parra SC, Gaddy LR, Takaro T. Early ultrastructural changes in papaininduced experimental emphysema. Lab Invest 1980; 42:277-289.
164. Mazzone RW, Kornblau S. Size of pores of Kohn: influence of transpulmonary and vascular pressures. J Appl Physiol 1981; 51:739-745.
165. Adamson IYR, Bowden DH. Derivation of Type 1 epithelium from Type 2 cells in the developing rat lung. Lab Invest 1975; 32:736.
166. Mason RJ, Shannon JM. Alveolar type II cells. In: Crystal RG, West JB eds. The Lung: Scientific Foundations, 2nd ed. Philadelphia: Lippincott-Raven, 1997, 543-555.
167. Massaro G, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 1997; 3:675-677.
168. Massaro GD, Massaro D. Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am J Physiol 1996; 270:L305-L310.
169. Kuhn C, Starcher BC. The effect of lathyrogens on the evolution of elastaseinduced emphysema. Am Rev Respir Dis 1980; 122:453-460.
170. O’Dell BL, Kilburn KH, McKenzie WN, Thurston RJ. The lung of the copper-deficient rat. A model for developmental pulmonary emphysema. Am J Pathol 1978; 91:413-432.
171. Soskel NT, Watanabe S, Hammond E, Sandberg LB, Renzetti AD, Crapo JD. A copper-deficient, zinc-supplemented diet produces emphysema in pigs. Am Rev Respir Dis 1982; 126:316-325.
172. Stein J, Fenigstein H. Anatomie pathologique de la maladie de famine. In:Apfelbaum E, ed. Maladie de Famine. American Joint Distribution Committee (1946), 21-27.
173. Das RM. The effects of intermittent starvation on lung development in suckling rats. Am J Pathol 1984; 117:326-332.
174. Lechner AJ, Winston DC, Bauman JE. Lung mechanics, cellularity, and surfactant after prenatal starvation in guinea pigs. J Appl. Physiol 1986; 60:1610-1614.
175. Sahebjami H, Domino M. Effects of repeated cycles of starvation and refeeding on lungs of growing rats. J Appl Physiol 1992; 73:2349-2354.
176. Karlinsky JB, Goldstein RH, Ojserkis B, Snider GL. Lung mechanics and connective tissue levels in starvation-induced emphysema in hamsters. Am J Physiol 1986; 251:R282-R288.
177. Sahebjami H, Vassallo CL. Influence of starvation on enzyme-induced emphysema. J Appl Physiol 1980; 48:284-288.
178. Massaro D, Massaro GD, Baras A, Hoffman EP, Clerch LB. Calorie-related rapid onset of alveolar loss, regeneration, and changes in mouse lung gene expression. Am J Physiol Lung Cell Mol Physiol 2003;
179. Sahebjami H, Doers JT, Render ML, Bond TL. Anthropometric and pulmonary function test profiles of outpatients with stable chronic obstructive pulmonary disease. Am J Med 1993; 94:469-474.
180. Wilson DO, Rogers RM, Hoffman RM. Nutrition and chronic lung disease. Am Rev Repir Dis 1985; 132:1347-1365.
181. Schols AM, Slangen J, Vovovics L, Wouters EF. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157:1791-1797.
182. Donahoe M, Rogers RM, Wilson DO, et al. Oxygen consumption of the respiratory muscles in normal and in malnourished patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 1989; 140:385-391.
183. Schols AMWJ, Buurman WA, Staal-van den Brekel AJ, Dentener MA, Wouters EFM. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996; 51:819-824.
184. Keman S, Wilemse B, Tollerud DJ, Guevarra L, Schins RP, Borm PJ. Blood interleukin-8 production is increased in chemical workers with bronchitic symptoms. Am J Indust Med 1997; 32:670-673.
185. Yasuda N, Gotoh K, Minatoguchi S, Asano K, Nishigake K, Nomura M, et al. An increase of soluble fas, an inhibitor of apoptosis, associated with progession of COPD. Respir Med 1998; 92:993-999.
186. Di Francia M, Barbier D, Mege JL, Orehek J. Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1994; 150:1453-5.
187. ****#11057
188. Keatings VM, Collins PD, Scott DM, Barnes PJ. Differences in interleukin-8 and tumor necrosis factor-a in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996; 153:530-534.
189. Mueller R, Chanez P, Campbell AM, Bousquet J, Heusser C, Bullock GR. Different cytokine patterns in bronchial biopsies in asthma and chronic bronchitis. Respir Med 1996; 90:79-85.
190. Sulkowska M, Sulkowski S, Terlikowski S, Nowak HF. Tumor necrosis factor-alpha induces emphysema-like pulmonary tissue rebuilding. Changes in type II alveolar epithelial cells. Pol J Pathol 1997; 48:179-188.
191. Mauviel A, Heino J, Kahari V-M, Hartmann D-J, Loyau G, Pujol J-P, Vuorio E. Comparative effects of interleukin-1 and tumor necrosis factoralpha on collagen production and corresponding procollagen mRNA levels in human dermal fibroblasts. J Invest Dermatol 1991; 96:243-249.
192. Rapala KT, Vaha-Kreula MO, Heino JJ, Vuorio EI, Laato MK. Tumor necrosis factor alpha inhibits collagen synthesis in human and rat tissue fibroblasts. Experentia 1996; 52:70-74.
193. Laurent P, Janoff A, Kagan HM. Cigarette smoke blocks cross-linking of elastin in vitro. Am Rev Respir Dis 1983; 127:189-192.
194. Osman M. Cigarette smoke impairs elastin resynthesis in lungs of hamsters with elastase-induced emphysema. Am Rev Respir Dis 1985; 132:640-643.
195. White RR, Coggins CRE. Effects of cigarette smoke on elastase-induced emphysema. Am Rev Respir Dis 1982; 125:S214.
196. Nakamura Y, Romberger DJ, Tate L, Ertl RF, Kawamoto M, Adachi Y, Mio T, Sisson JH, Spurzem JR, Rennard SI. Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis. Am J Respir Crit Care Med 1995; 151:1497-1503.
197. Carnevali S, Nakamura Y, Mio T, Liu X, Takigawa K, Romberger DJ, Spurzem JR, Rennard SI. Cigarette smoke extract inhibits fibroblast-mediated collagen gel contraction. Am J Physiol Lung Cell Mol Physiol 1998; 274:L591-L598.
198. Cantral DE, Sisson JH, Veys T, Rennard SI, Spurzem JR. Effects of cigarette smoke extract on bovine bronchial epithelial cell attachment and migration. Am J Physiol 1995; 268:L723-L728.
199. Wang H, Liu X, Umino R, Skold CM, Zhu Y, Kohyama T, Spurzem JR, Romberger DJ, Rennard SI. Cigarette smoke inhibits human bronchial epithelial cell repair processes. Am J Respir Cell Mol Biol 2001; 25:772-779.
200. Tuder RM, Wood K, Taraseviciene L, Flores SC, Voekel NF. Cigarette smoke extract decreases the expression of vascular endothelial growth factor by cultured cells and triggers apoptosis of pulmonary endothelial cells. Chest 2000; 117:241S-242S.
201. Tuder RM, Zhen L, Cho CY, Taraseviciene-Stewart L, Kasahara Y, Salvemini D, Voelkel NF, Flores SC. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am J Respir Cell Mol Biol 2003; 29:88-97.
202. Lane RE, Campbell ACP. Fatal emphysema in two men making a copper cadmium alloy. Br J Ind Med 1954; 11:118-122.
203. Driscoll KE, Hassenbein DG, Howard BW, Isfort RJ, Cody D, Tindah MH. Cloning, expression and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen. J Leukoc Biol 1995; 58:359-364.
204. Chambers RC, McAnulty RJ, Shock A, Campa JS, Tyalor AJN, Laurent GJ. Cadmium selectively inhibits fibroblast procollagen production and proliferation. Am J Physiol 1994; 267:L300-L308.
205. Chambers RC, Laurent GJ, Westergren-Thorsson G. Cadmium inhibits proteoglycan and procollagen production by cultured human lung fibroblasts. Am J Respir Cell Mol Biol 1998; 19:498-506.
206. Liu XD, Umino T, Zhu YK, Wang HJ, Spurzem JR, Romberger DJ, Rennard SI. A study on the effect of cadmium on human lung fibroblasts. Chest 2000; 117:247S.
207. Mannino DM. Personal communication.
208. Mitchell RS, Stanford RE, Johnson JM, Silvers GW, Dart G, George MS. The morphologic features of the bronchi, brochioles and alveoli in chronic airway obstruction: a clinicopathologic study. Am Rev Respir Dis 1976; 114:137-145.
209. Nagai A, West WW, Thurlbeck WM. The national institutes of health intermittent positive-pressure breathing trial: pathology studies II. Correlation between morphologic findings, clinical findings, and evidence of expiratory airflow obstruction. Am Rev Respir Dis 1985; 132:946-953.
210. Nagai A, West WW, Paul JL. The national institutes of health intermittent positive pressure breathing trial: pathology studies. Am Rev Respir Dis 1985; 132:937-945.
211. Mio T, Adachi Y, Romberger DJ, Spurzem JR, Ertl RF, Carnevali S, Rennard SI. Human bronchial epithelial cells modulate collagen gel contraction by fibroblasts. Am J Respir Crit Care Med 1995; 151:A561.
212. Kohyama T, Ertl RF, Valenti V, Spurzem J, Kawamoto M, Nakamura Y, Veys T, Allegra L, Romberger D, Rennard SI. Prostaglandin E2 inhibits fibroblast chemotaxis. Am J Physiol 2001; 281:L1257-L1263.
213. Fine A., Goldstein RH. The effect of PGE2 on the activation of quiescent lung fibroblasts. Prostaglandins 1987; 33:903-913.
214. Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, Roberts AB. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1999; 1:260-266.
215. Wang H, Liu X, Umino T, Kohyama T, Zhu YK, Wen FQ, Spurzem JR, Romberger DJ, Kim HJ, Rennard SI. Effect of cigarette smoke on fibroblastmediated gel contraction is dependent on cell density. Am J Physiol Lung Cell Mol Physiol 2003; 284:L205-213.
216. Abe S, Lauby G, Boyer C, Manouilova L, Rennard SI, Sharp JG. Lung cells transplanted to irradiated recipients generate lymphohematopoietic progeny. Am J Respir Cell Mol Biol 2003.
217. Giangreco A, Reynolds SD, Stripp BR. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol 2002; 161:173-182.
218. Hong KU, Reynolds SD, Giangreco A, Hurley CM, Stripp BR. Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. Am J Respir Cell Mol Biol 2001; 24:671-681.
219. Inayama Y, Hook GER, Brody AR, Cameron GS, Jetten AM, Gilmore LB, Gray T, Nettesheim P. The differentiation potential of tracheal basal cells. Lab Invest 1988; 58:706.
220. Johnson NF, Hubbs AF. Epithelial progenitor cells in the rat trachea. Am J Respir Cell Mol Biol 1990; 3:579-585.
221. Otto WR. Lung epithelial stem cells. J Pathol 2002; 197:527-535.
222. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105:369-377.
223. Theise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. Exp Hematol 2002; 30:1333-1338.
224. Devine SM, Cobbs C, Jennings M, Bartholomew A, Hoffman R. Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates. Blood 2003; 101:2999-3001.
225. Abe S, Lauby G, Boyer C, Rennard SI, Sharp JG. Transplanted bone marrow and bone marrow side population (SP) cells contribute progeny to the lung and liver in irradiated mice. Cytotherapy. In Press.
226. Suratt BT, Cool CD, Serls AE, Chen L, Varella-Garcia M, Shpall EJ, Brown KK, Worthen GS. Human pulmonary chimerism following hematopoietic stem cell transplantation. Am J Respir Crit Care Med 2003. In Press.
227. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A. Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development 2001; 128:5181-5188.
228. Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 2003; 100:8407-8411.
229. Laurell CB, Eriksson S. The electrophoretic alpha 1-globulin pattern of serum in alpha 1-antitrypsin deficiency. Scand J Clin Lab Invest 1963; 15:132-140.