BDNF regulates primary dendrite formation in cortical neurons via the PI3-kinase and MAP kinase signaling pathways

Journal of Neurobiology

Volumn 62, Issue 2, 2005, Pages 278-288

  Dijkhuizen, Paul A ^a,b   Ghosh, Anirvan ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Amsterdam Molecular Therapeutics   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cortex; Dendrite; MAP kinase; Neurotrophin; PI3 kinase; Pyramidal neuron

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NEUROTROPHIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN SLICE; CELL CULTURE; DENDRITE; ENZYME ACTIVATION; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; TISSUE CULTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL COUNT; CELLS, CULTURED; CEREBRAL CORTEX; DENDRITES; DRUG INTERACTIONS; EMBRYO; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCENT ANTIBODY TECHNIQUE; GREEN FLUORESCENT PROTEINS; NEURONS; RATS; RATS, LONG-EVANS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 11844272669     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/neu.20100     Document Type: Article

References (43)

1. Atwal JK, Massie B, Miller FD, Kaplan DR. 2000. The TrkB-Shc site signals neuronal survival and local axon growth via MEK and P13-kinase. Neuron 27:265-277.
2. Baker RE, Dijkhuizen PA, van Pelt J, Verhaagen J. 1997. Growth of pyramidal, but not non-pyramidal, dendrites in long-term organotypic explants of neonatal rat neocortex chronically exposed to neurotrophin-3. Eur J Neurosci 10:1037-1044.
3. Datta SR, Brunet A, Greenberg ME. 1999. Cellular survival: a play in three Akts. Genes Dev 13:2905-2927.
4. Davies SP, Reddy H, Caivano M, Cohen P. 2000. Specific-ity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
5. Duncia JV, Santella JB III, Higley CA, Pitts WJ, Wityak J, Frietze WE, Rankin FW, Sun JH, Earl RA, Tabaka AC, Teleha CA, Blom KF, Favata MF, Manos EJ, Daulerio AJ, Stradley DA, Horiuchi K, Copeland RA, Scherle PA, Trzaskos JM, Magolda RL, Trainor GL, Wexler, RR, Hobbs FW, Olson RE. 1998. MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett 8:2839-2844.
6. Fruman DA, Meyers RE, Cantley LC. 1998. Phosphoinositide kinases. Annu Rev Biochem 67:481-507.
7. Gray A, Van Der Kaay J, Downes CP. 1999. The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo. Biochem J 15:929-936.
8. Gundersen GG, Cook TA. 1999. Microtubules and signal transduction. Curr Opin Cell Biol 11:81-94.
9. Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD, Krishna UM, Falck JR, White MA, Broek D. 1998. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-560.
10. Horch HW, Katz LC. 2002. BDNF release from single cells elicits local dendritic growth in nearby neurons. Nat Neurosci 5:1177-1184.
11. Horch HW, Kruttgen A, Portbury S, Katz LC. 1999. Destabilization of cortical dendrites and spines by BDNF. Neuron 23:353-364.
12. Hoshi M, Ohta K, Gotoh Y, Mori A, Murofushi H, Sakai H, Nishida E. 1992. Mitogen-activated-protein-kinase-catalyzed phosphorylation of microtubule-associated proteins, microtubule-associated protein 2 and microtubule-assocated protein 4, induces an alteration in their function. Eur J Biochem 203:43-52.
13. Huang EJ, Reichardt LF. 2001. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736.
14. Jin W, Lo TM, Loh HH, Thayer SA. 1994. U73122 inhibits phospholipase C-dependent calcium mobilization in neuronal cells. Brain Res 642:237-243.
15. Juraska JM, Fifkova E. 1979. A golgi study of the early postnatal development of the visual cortex of the hooded rat. J Comp Neurol 183:247-256.
16. Kaplan DR, Miller FD. 2000. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 10:381-391.
17. Kjoller L, Hall A. 1999. Signaling to Rho GTPases. Exp Cell Res 253:166-179.
18. Kuruvilla R, Ye H, Ginty DD. 2000. Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron 27;499-512.
19. Lo DC, McAllister AK, Katz LC. 1994. Neuronal transfection in brain slices using particle-mediated gene transfer. Neuron 13:1263-1268.
20. Luo L. 2000. Rho GTPases in neuronal morphogenesis. Nat Rev Neurosci 3:173-180.
21. Ma AD, Metjian A, Bagrodia S, Taylor S, Abrams CS. 1998. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac. Mol Cell Biol 18:4744-4751.
22. Markus A, Zhong J, Snider WD. 2002. Raf and Akt mediate distinct aspects of sensory axon growth. Neuron 35:65-76.
23. McAllister AK, Katz LC, Lo DC. 1996. Neurotrophin regulation of cortical dendritic growth requires activity. Neuron 17:1057-1064.
24. McAllister AK, Lo DC, Katz LC. 1995. Neurotrophins regulate dendritic growth in developing visual cortex. Neuron 15:791-803.
25. Miller MW. 1981. Maturation of rat visual cortex. I. A quantitative study of Golgi-impregnated pyramidal neurons. J Neurocytol 10:859-878.
26. Morishima-Kawashima M, Kosik KS. 1996. The pool of map kinase associates with microtubules is small but constitutively active. Mol Biol Cell 7:893-905.
27. Niblock MM, Brunso-Bechtold JK, Riddle DR. 2000. Insulin-like growth factor 1 stimulates dendritic growth in primary somatosensory cortex, J Neurosci 20:4165-4176.
28. Nimnual AS, Yatsula BA, Bar-Sagi D. 1998. Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Science 279:560-563.
29. Polleux F, Morrow T, Ghosh A. 2000. Semaphorin 3A is a chemoattractant for corticalapical dendrites. Nature 404:567-573.
30. Redmond L, Ghosh A. 2001. The role of Notch and Rho GTPase signaling in the control of dendritic development. Curr Opin Neurobiol 11:111-117.
31. Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A. 2000. Nuclear Notch1 signaling and the regulation of dendritic development. Nat Neurosci 3:30-40.
32. Reszka AA, Seger R, Diltz CD, Krebs EG, Fischer EH. 1995. Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci USA 92:8881-8885.
33. Reszka AA, Bulinski JC, Krebs EG, Fischer EH. 1997. Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions. Mol Biol Cell 8:1219-1232.
34. Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD. 1999. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science 286:2358-2361.
35. Seger R, Seger D, Reszka AA, Munar ES, Eldar-Finkelman H, Dobrowolska G, Jensen AM, Campbell JS, Fischer EH, Krebs EG. 1994. Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J Biol Chem 269:25699-25709.
36. Teruel MN, Meyer T. 2000. Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction. Cell 103:181-184.
37. Threadgill R, Bobb K, Ghosh A. 1997. Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42. Neuron 19:625-634.
38. Vaillant AR, Zanassi P, Walsh GS, Aumont A, Alonso A, Miller FD. 2002. Signaling mechanisms underlying reversible, activity-dependent dendrite formation. Neuron 34:985-998.
39. Wennstrom S, Downward J. 1999. Role of phosphoinostide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor. Mol Cell Biol 19:4279-4288.
40. Whitford KL, Marillat V, Stein E, Goodman CS, Tessier-Lavigne M, Chedotal A, Ghosh A. 2002. Regulation of cortical dendrite development by Slit-Robo interactions. Neuron 33:47-61.
41. Xing J, Ginty DD, Greenberg ME. 1996. Coupling of the Ras-MAPK pathway to gene activation of RSK2, a growth factor-regulated CREB kinase. Science 273:959-963.
42. Yacoubian TA, Lo DC. 2000. Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Nat Neurosci 3:342-349.
43. Yasui H, Katoh H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M. 2001. Differential responses to nerve growth factor and epidermal growth factor in neurite outgrowth of PC12 cells are determined by Rac1 activation systems. J Biol Chem 276:15298-15305.