Novel protein targets for organophosphorus compounds

Chemico-Biological Interactions

Volumn 119-120, Issue , 1999, Pages 503-511

  Richards, Paul ^a   Johnson, Martin ^a   Ray, David ^a   Walker, Colin ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

Acetylcholonesterase; DFP; Di isopropyl phophorofluoridate; Diazinon; Dichlorvos; Organophosphorus pesticide; Paraoxon

Indexed keywords

ACETYLCHOLINESTERASE; CLOFENVINFOS; DICHLORVOS; DIMPYLATE; DYFLOS; ORGANOPHOSPHATE PESTICIDE; PARAOXON;

ANIMAL TISSUE; BRAIN HOMOGENATE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; NEUROTOXICITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; TARGET CELL; THIN LAYER CHROMATOGRAPHY;

ANIMALS; BINDING SITES; BRAIN; CALCIUM; CHROMATOGRAPHY, THIN LAYER; HYDROGEN-ION CONCENTRATION; ISOFLUROPHATE; NERVE TISSUE PROTEINS; ORGANOPHOSPHORUS COMPOUNDS; PRECIPITATION; RATS; TRITIUM;

EID: 0033064117     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(99)00064-2     Document Type: Conference Paper

References (11)

1. Gallo M.A., Lawryk N.J. Organic phosphorus pesticides, Ch. 16. Haips W.J., Laws E.R. Handbook of Toxicology. 2:1991;920-929 Academic Press, London.
2. Peedicayil J., Ernest K., Thomas M., Kanagasabathy A.S., Stepher P.M. The effects of organophosphorus compounds on serum pseudocholinesterase levels in a group of industrial workers. Hum. Exp. Toxicol. 10:1991;275-278.
3. Johnson M.K. A phosphorylation site in brain and the delayed neurotoxic effect of some organophosporus compounds. Biochem. J. 111:1969;487-495.
4. Williams D.J., Johnson M.K. Gel-electrophoretic identification of hen brain neurotoxic esterase, labelled with tritiated di-isopropyl phosphorofluoridate. Biochem. J. 199:1981;323-333.
5. Stephens R., Spurgeon A. Neuropsychological effects of long-term exposure to organophosphates in sheep-dip. Lancet. 345:1995;1135-1139.
6. O'Brien S.J., Campbell D.M., Morris G.P. Letters to the Editor. Lancet. 345:1995;1631-1633.
7. O'Neill J.J. Non-cholinesterase effects of anticholinesterases. Fundam. Appl. Toxicol. 1:1981;154-160.
8. Aldridge W.N. Organophosphorus compounds: Molecular basis for their biological properties. Sci. Prog. Oxf. 67:1981;131-147.
9. Ellman G.L., Courtney K.D., Andreas V., Featherstone R.M. A new and rapid coluorimetric determination of acetylcholinesterase activity. Biochem. Pharm. 7:1961;88-95.
10. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 277:1970;680-685.
11. Khyse-Anderson J. Electroblotting of multiple gels. A simple apparatus without buffer tanks for rapid transfer of proteins from polyacrylamide gels to nitrocellulose. J. Biochem. Biophys. Methods. 10:1984;203-209.