Insulin-like growth factor I treatment for cerebellar ataxia: Addressing a common pathway in the pathological cascade?

Brain Research Reviews

Volumn 50, Issue 1, 2005, Pages 134-141

  Fernandez, A M ^a   Carro, E M ^a   Lopez Lopez, C ^a   Torres Aleman, I ^a  

^a INSTITUTO CAJAL   (Spain)

Author keywords

Cerebellar ataxia; Insulin like growth factor I; Neurodegeneration; Neurotrophic factor; Therapy

Indexed keywords

SOMATOMEDIN C;

ATAXIA TELANGIECTASIA; BINDING AFFINITY; BLOOD LEVEL; BRAIN DYSFUNCTION; CEREBELLAR ATAXIA; CEREBELLUM ATROPHY; CEREBELLUM DISEASE; DEGENERATIVE DISEASE; HEART DISEASE; HUMAN; IMMUNE DEFICIENCY; MORBIDITY; MOTOR DYSFUNCTION; NERVE CELL LESION; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; REVIEW;

ANIMALS; CEREBELLAR ATAXIA; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MODELS, BIOLOGICAL; NEUROPROTECTIVE AGENTS;

EID: 27744535546     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2005.05.003     Document Type: Review

References (74)

1. M.A. Aberg, N.D. Aberg, H. Hedbacker, J. Oscarsson, and P.S. Eriksson Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus J. Neurosci. 20 2000 2896 2903
2. A. Adem, S.S. Jossan, R. d'Argy, P.G. Gillberg, A. Nordberg, B. Winblad, and V. Sara Insulin-like growth factor 1 (IGF-1) receptors in the human brain: quantitative autoradiographic localization Brain Res. 503 1989 299 303
3. F. Aguado, F. Sanchez-Franco, J. Rodrigo, L. Cacicedo, and R. Martinez-Murillo Insulin-like growth factor I-immunoreactive peptide in adult human cerebellar Purkinje cells: co-localization with low-affinity nerve growth factor receptor Neuroscience 59 1994 641 650
4. R.L. Albin Dominant ataxias and Friedreich ataxia: an update Curr. Opin. Neurol. 16 2003 507 514
5. R. Artuch, A. Aracil, A. Mas, C. Colome, M. Rissech, E. Monros, and M. Pineda Friedreich's ataxia: idebenone treatment in early stage patients Neuropediatrics 33 2002 190 193
6. P.F. Backeljauw, and L.E. Underwood Therapy for 6.5-7.5 years with recombinant insulin-like growth factor I in children with growth hormone insensitivity syndrome: a clinical research center study J. Clin. Endocrinol. Metab. 86 2001 1504 1510
7. K.D. Beck, L. Powell-Braxton, H.R. Widmer, J. Valverde, and F. Hefti Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons Neuron 14 1995 717 730
8. J. Berciano Ataxia and genetics Med. Clin. (Barc.) 115 2000 135 136
9. J. Berciano, J. Infante, I. Mateo, and O. Combarros Hereditary ataxias and paraplegias: a clinicogenetic review Neurologia 17 2002 40 51
10. C.A. Bondy Transient IGF-I gene expression during the maturation of functionally related central projection neurons J. Neurosci. 11 1991 3442 3455
11. S. Boonen, C. Rosen, R. Bouillon, A. Sommer, M. McKay, D. Rosen, S. Adams, P. Broos, J. Lenaerts, J. Raus, D. Vanderschueren, and P. Geusens Musculoskeletal effects of the recombinant human IGF-I/IGF binding protein-3 complex in osteoporotic patients with proximal femoral fracture: a double-blind, placebo-controlled pilot study J. Clin. Endocrinol. Metab. 87 2002 1593 1599
12. V. Brower IGF in the clinic Nat. Biotechnol. 16 1998 601 602
13. K. Burk, A. Melms, J.B. Schulz, and J. Dichgans Effectiveness of intravenous immunoglobin therapy in cerebellar ataxia associated with gluten sensitivity Ann. Neurol. 50 2001 827 828
14. S. Busiguina, A.M. Fernandez, V. Barrios, R. Clark, D.L. Tolbert, J. Berciano, and I. Torres-Aleman Neurodegeneration is associated to changes in serum insulin-like growth factors Neurobiol. Dis. 7 2000 657 665
15. G. Buyse, L. Mertens, G. Di Salvo, I. Matthijs, F. Weidemann, B. Eyskens, W. Goossens, N. Goemans, G.R. Sutherland, and J.L. Van Hove Idebenone treatment in Friedreich's ataxia: neurological, cardiac, and biochemical monitoring Neurology 60 2003 1679 1681
16. C. Carrascosa, I. Torres-Aleman, C. Lopez-Lopez, E. Carro, L. Espejo, S. Torrado, and J.J. Torrado Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration Biomaterials 25 2004 707 714
17. E. Carro, and I. Torres-Aleman Insulin-like growth factor I and Alzheimer's disease: therapeutic prospects? Expert Rev. Neurotherapeutics 4 2003 79 86
18. E. Carro, A. Nunez, S. Busiguina, and I. Torres-Aleman Circulating insulin-like growth factor I mediates effects of exercise on the brain J. Neurosci. 20 2000 2926 2933
19. E. Carro, J.L. Trejo, S. Busiguina, and I. Torres-Aleman Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy J. Neurosci. 21 2001 5678 5684
20. E. Carro, J.L. Trejo, T. Gomez-Isla, D. LeRoith, and I. Torres-Aleman Serum insulin-like growth factor I regulates brain amyloid-beta levels Nat. Med. 8 2002 1390 1397
21. H.K. Chen, P. Fernandez-Funez, S.F. Acevedo, Y.C. Lam, M.D. Kaytor, M.H. Fernandez, A. Aitken, E.M. Skoulakis, H.T. Orr, J. Botas, and H.Y. Zoghbi Interaction of akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1 Cell 113 2003 457 468
22. W. Chen, K.V. Salojin, Q.S. Mi, M. Grattan, T.C. Meagher, P. Zucker, and T.L. Delovitch Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes Endocrinology 145 2004 627 638
23. R.G. Clark Recombinant human insulin-like growth factor I (IGF-I): risks and benefits of normalizing blood IGF-I concentrations Horm. Res. 62 Suppl. 1 2004 93 100
24. A.J. D'Ercole, P. Ye, and G. Gutierrez-Ospina Use of transgenic mice for understanding the physiology of insulin-like growth factors Horm. Res. 45 Suppl. 1 1996 5 7
25. G. De Michele, G. Coppola, S. Cocozza, and A. Filla A pathogenetic classification of hereditary ataxias: is the time ripe? J. Neurol. 251 2004 913 922
26. F. de Pablo, and E.J. de la Rosa The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors Trends Neurosci. 18 1995 143 150
27. A.M. Fernandez, A. Gonzalez de la Vega, and I. Torres-Aleman Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxia Proc. Natl. Acad. Sci. U. S. A. 95 1998 1253 1258
28. E. Giovannucci Nutrition, insulin, insulin-like growth factors and cancer Horm. Metab. Res. 35 2003 694 704
29. A. Grahnen, K. Kastrup, U. Heinrich, M. Gourmelen, M.A. Preece, M.A. Vaccarello, J. Guevara-Aguirre, R.G. Rosenfeld, and A. Sietnieks Pharmacokinetics of recombinant human insulin-like growth factor I given subcutaneously to healthy volunteers and to patients with growth hormone receptor deficiency Acta Paediatr., Suppl. 82 Suppl. 391 1993 9 13
30. M. Grilli, G.F. Toninelli, D. Uberti, P. Spano, and M. Memo Alzheimer's disease linking neurodegeneration with neurodevelopment Funct. Neurology 18 2003 145 148
31. J.F. Gusella, and M.E. MacDonald Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease Nat. Rev., Neurosci. 1 2000 109 115
32. A.E. Harding Clinical features and classification of inherited ataxias Adv. Neurol. 61 1993 1 14
33. S. Humbert, E.A. Bryson, F.P. Cordelieres, N.C. Connors, S.R. Datta, S. Finkbeiner, M.E. Greenberg, and F. Saudou The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt Dev. Cell 2 2002 831 837
34. B.K. Kaspar, J. Llado, N. Sherkat, J.D. Rothstein, and F.H. Gage Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model Science 301 2003 839 842
35. I.A. Klement, P.J. Skinner, M.D. Kaytor, H. Yi, S.M. Hersch, H.B. Clark, H.Y. Zoghbi, and H.T. Orr Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice Cell 95 1998 41 53
36. E.C. Lai, K.J. Felice, B.W. Festoff, M.J. Gawel, D.F. Gelinas, R. Kratz, M.F. Murphy, H.M. Natter, F.H. Norris, and S.A. Rudnicki Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo-controlled study. The North America ALS/IGF-I Study Group Neurology 49 1997 1621 1630
37. C.H. Lang, G.J. Nystrom, and R.A. Frost Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFalpha Growth Horm. IGF Res. 11 2001 250 260
38. X. Lin, and R.F. Bulleit Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells Brain Res. Dev. Brain Res. 99 1997 234 242
39. R.L. Margolis The spinocerebellar ataxias: order emerges from chaos Curr. Neurol. Neurosci. Rep. 2 2002 447 456
40. C. Mariotti, A. Solari, D. Torta, L. Marano, C. Fiorentini, and S. Di Donato Idebenone treatment in Friedreich patients: one-year-long randomized placebo-controlled trial Neurology 60 2003 1676 1679
41. J.L. Marks, D. Porte Jr., and D.G. Baskin Localization of type I insulin-like growth factor receptor messenger RNA in the adult rat brain by in situ hybridization Mol. Endocrinol. 5 1991 1158 1168
42. P. Mitchell Cancelled IGF-1 trials bode ill for diabetic patients Lancet 350 1997 1606
43. J.W. Moll, S.C. Henzen-Logmans, F.G. Van der Meche, and C.H. Vecht Early diagnosis and intravenous immune globulin therapy in paraneoplastic cerebellar degeneration J. Neurol. Neurosurg. Psychiatry 56 1993 112
44. S.S. Nahm, T.C. Frank, M.D. Browning, J.M. Sepulvado, J.K. Hiney, and L.C. Abbott Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner Neurobiol. Dis. 14 2003 157 165
45. A. Nunez, E. Carro, and I. Torres-Aleman Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons J. Neurophysiol. 89 2003 3008 3017
46. S. Peretz, R. Jensen, R. Baserga, and P.M. Glazer ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response Proc. Natl. Acad. Sci. U. S. A. 98 2001 1676 1681
47. S.L. Perlman Cerebellar ataxia Curr. Treat. Options Neurol. 2 2000 215 224
48. M.N. Pollak, E.S. Schernhammer, and S.E. Hankinson Insulin-like growth factors and neoplasia Nat. Rev., Cancer 4 2004 505 518
49. B.E. Pulford, L.R. Whalen, and D.N. Ishii Peripherally administered insulin-like growth factor-I preserves hindlimb reflex and spinal cord noradrenergic circuitry following a central nervous system lesion in rats Exp. Neurol. 159 1999 114 123
50. K.L. Quick, and L.L. Dugan Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia Ann. Neurol. 49 2001 627 635
51. P. Rustin The use of antioxidants in Friedreich's ataxia treatment Expert Opin. Investig. Drugs 12 2003 569 575
52. M.O. Savage, C. Camacho-Hubner, D.B. Dunger, M.B. Ranke, R.J. Ross, and R.G. Rosenfeld Is there a medical need to explore the clinical use of insulin-like growth factor I? Growth Horm. IGF. Res. 11 Suppl. A 2001 S65 S69
53. H. Seznec, D. Simon, C. Bouton, L. Reutenauer, A. Hertzog, P. Golik, V. Procaccio, M. Patel, J.C. Drapier, M. Koenig, and H. Puccio Friedreich ataxia: the oxidative stress paradox Hum. Mol. Genet. 14 2005 463 474
54. T. Shimohata, O. Onodera, and S. Tsuji Interaction of expanded polyglutamine stretches with nuclear transcription factors leads to aberrant transcriptional regulation in polyglutamine diseases Neuropathology 20 2000 326 333
55. P. Stattin, S. Rinaldi, C. Biessy, U.H. Stenman, G. Hallmans, and R. Kaaks High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based nonscreened cohort J. Clin. Oncol. 22 2004 3104 3112
56. H. Thoenen, and M. Sendtner Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches Nat. Neurosci. 5 2002 1046 1050 (Suppl.)
57. D.L. Tolbert, and B.R. Clark GDNF and IGF-I trophic factors delay hereditary Purkinje cell degeneration and the progression of gait ataxia Exp. Neurol. 183 2003 205 219
58. I. Torres-Aleman Serum growth factors and neuroprotective surveillance Mol. Neurobiol. 21 2000 153 160
59. I. Torres-Aleman, and A.M. Fernandez The Role of Insulin-like Growth Factors in Human Neurodegeneration 1998 Springer Publishing Co. 131 149
60. I. Torres-Aleman, S. Pons, and L.M. Garcia-Segura Climbing fiber deafferentation reduces insulin-like growth factor I (IGF-I) content in cerebellum Brain Res. 564 1991 348 351
61. I. Torres-Aleman, S. Pons, and M.A. Arevalo The insulin-like growth factor I system in the rat cerebellum: developmental regulation and role in neuronal survival and differentiation J. Neurosci. Res. 39 1994 117 126
62. I. Torres-Aleman, V. Barrios, A. Lledo, and J. Berciano The insulin-like growth factor I system in cerebellar degeneration Ann. Neurol. 39 1996 335 342
63. J.L. Trejo, E. Carro, A. Nunez, and I. Torres-Aleman Sedentary life impairs self-reparative processes in the brain: the role of serum insulin-like growth factor-I Rev. Neurosci. 13 2002 365 374
64. J.L. Trejo, E. Carro, E. Garcia-Galloway, and I. Torres-Aleman Role of insulin-like growth factor I signaling in neurodegenerative diseases J. Mol. Med. 82 2004 156 162
65. G.A. Werther, M. Abate, A. Hogg, H. Cheesman, B. Oldfield, D. Hards, P. Hudson, B. Power, K. Freed, and A.C. Herington Localization of insulin-like growth factor-I mRNA in rat brain by in situ hybridization-relationship to IGF-I receptors Mol. Endocrinol. 4 1990 773 778
66. N. Wilczak, R.A. de Vos, and J. De Keyser Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosis Lancet 361 2003 1007 1011
67. A. Wong, J. Yang, P. Cavadini, C. Gellera, B. Lonnerdal, F. Taroni, and G. Cortopassi The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis Hum. Mol. Genet. 8 1999 425 430
68. S.M. Woodall, B.H. Breier, U. O'Sullivan, and P.D. Gluckman The effect of the frequency of subcutaneous insulin-like growth factor-1 administration on weight gain in growth hormone deficient mice Horm. Metab. Res. 23 1991 581 584
69. S. Yakar, J.L. Liu, B. Stannard, A. Butler, D. Accili, B. Sauer, and D. LeRoith Normal growth and development in the absence of hepatic insulin-like growth factor I Proc. Natl. Acad. Sci. U. S. A. 96 1999 7324 7329
70. P. Ye, Y. Xing, Z. Dai, and A.J. D'Ercole In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors Brain Res. Dev. Brain Res. 95 1996 44 54
71. H. Zhang, and D. Yee The therapeutic potential of agents targeting the type I insulin-like growth factor receptor Expert Opin. Investig. Drugs 13 2004 1569 1577
72. W. Zhang, B. Ghetti, and W.H. Lee Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice Brain Res. Dev. Brain Res. 98 1997 164 176
73. J. Zhong, J. Deng, J. Phan, S. Dlouhy, H. Wu, W. Yao, P. Ye, A.J. D'Ercole, and W.H. Lee Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice J. Neurosci. Res. 4 2005 481 490
74. H.Y. Zoghbi, and H.T. Orr Glutamine repeats and neurodegeneration Annu. Rev. Neurosci. 23 2000 217 247