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Volumn 83, Issue 7, 2005, Pages 605-616

Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis

Author keywords

Colon; Cyclooxygenase; Esophagus; Myofibroblast; PGE synthase; Prostaglandin E2; Proteinase activated receptor; Small intestine

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FURA 2; FURA 2 ACETOXYMETHYL ESTER; MICROSOME ENZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PEPTIDE; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROTEINASE ACTIVATED RECEPTOR 2; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCINE; TRYPSIN; UNCLASSIFIED DRUG;

EID: 27744480379     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y05-046     Document Type: Article
Times cited : (21)

References (66)
  • 1
    • 0033965542 scopus 로고    scopus 로고
    • Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2
    • Akers, I.A., Parsons, M., Hill, M.R., Hollenberg, M.D., Sanjar, S., Laurent, G.J., et al. 2000. Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2. Am. J. Physiol. 278: L193-L201.
    • (2000) Am. J. Physiol. , vol.278
    • Akers, I.A.1    Parsons, M.2    Hill, M.R.3    Hollenberg, M.D.4    Sanjar, S.5    Laurent, G.J.6
  • 3
    • 0029143543 scopus 로고
    • Morphological evidence of mast cell degranulation in an animal model of acid-induced esophageal mucosal injury
    • Barclay, R.L., Dinda, P.K., Morris, G.P., and Paterson, W.G. 1995. Morphological evidence of mast cell degranulation in an animal model of acid-induced esophageal mucosal injury. Dig. Dis. Sci. 40: 1651-1658.
    • (1995) Dig. Dis. Sci. , vol.40 , pp. 1651-1658
    • Barclay, R.L.1    Dinda, P.K.2    Morris, G.P.3    Paterson, W.G.4
  • 4
    • 0033565430 scopus 로고    scopus 로고
    • Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha
    • Barrios-Rodiles, M., Tiraloche, G., and Chadee, K. 1999. Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha. J. Immunol. 163: 963-969.
    • (1999) J. Immunol. , vol.163 , pp. 963-969
    • Barrios-Rodiles, M.1    Tiraloche, G.2    Chadee, K.3
  • 5
    • 0030470167 scopus 로고    scopus 로고
    • Trypsin stimulates proteinase-activated receptor-2-dependent and-independent activation of mitogen-activated protein kinases
    • Belham, C.M., Tate, R.J., Scott, P.H., Pemberton, A.D., Miller, H.R., Wadsworth, R.M., et al. 1996. Trypsin stimulates proteinase-activated receptor-2-dependent and-independent activation of mitogen-activated protein kinases. Biochem. J. 320 (Pt. 3): 939-946.
    • (1996) Biochem. J. , vol.320 , Issue.PART 3 , pp. 939-946
    • Belham, C.M.1    Tate, R.J.2    Scott, P.H.3    Pemberton, A.D.4    Miller, H.R.5    Wadsworth, R.M.6
  • 6
    • 0024340055 scopus 로고
    • Immune system control of rat and rabbit colonic electrolyte transport. Role of prostaglandins and enteric nervous system
    • Bern, J.M., Sturbaum, C.W., Karayalcin, S.S., Berschneider, H.M., Wachsman, J.T., and Powell, D.W. 1989. Immune system control of rat and rabbit colonic electrolyte transport. Role of prostaglandins and enteric nervous system. J. Clin. Invest. 83: 1810-1820.
    • (1989) J. Clin. Invest. , vol.83 , pp. 1810-1820
    • Bern, J.M.1    Sturbaum, C.W.2    Karayalcin, S.S.3    Berschneider, H.M.4    Wachsman, J.T.5    Powell, D.W.6
  • 7
    • 0026594777 scopus 로고
    • Fibroblasts modulate intestinal secretory responses to inflammatory mediators
    • Berschneider, H.M., and Powell, D.W. 1992. Fibroblasts modulate intestinal secretory responses to inflammatory mediators. J. Clin. Invest. 89: 484-489.
    • (1992) J. Clin. Invest. , vol.89 , pp. 484-489
    • Berschneider, H.M.1    Powell, D.W.2
  • 8
    • 0029929603 scopus 로고    scopus 로고
    • Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
    • Bohm, S.K., Kong, W., Bromme, D., Smeekens, S.P., Anderson, D.C., Connolly, A., et al. 1996. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J. 314 (Pt 3): 1009-1016.
    • (1996) Biochem. J. , vol.314 , Issue.PART 3 , pp. 1009-1016
    • Bohm, S.K.1    Kong, W.2    Bromme, D.3    Smeekens, S.P.4    Anderson, D.C.5    Connolly, A.6
  • 10
    • 0035215713 scopus 로고    scopus 로고
    • Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle
    • Chambers, L.S., Black, J.L., Poronnik, P., and Johnson, P.R. 2001. Functional effects of protease-activated receptor-2 stimulation on human airway smooth muscle. Am. J. Physiol. 281: L1369-L1378.
    • (2001) Am. J. Physiol. , vol.281
    • Chambers, L.S.1    Black, J.L.2    Poronnik, P.3    Johnson, P.R.4
  • 11
    • 0000153591 scopus 로고
    • Intestinal water and electrolyte transport: Mechanisms of physiological and adaptive responses
    • Edited by L.R. Johnson. Raven Press, New York
    • Chang, E.B., and Rao, M.C. 1994. Intestinal water and electrolyte transport: mechanisms of physiological and adaptive responses. In Physiology of the Gastroinestinal Tract. Edited by L.R. Johnson. Raven Press, New York. pp. 2027-2081.
    • (1994) Physiology of the Gastroinestinal Tract , pp. 2027-2081
    • Chang, E.B.1    Rao, M.C.2
  • 12
    • 0035933736 scopus 로고    scopus 로고
    • The 3′-untranslated region of murine cyclooxygenase-2 contains multiple regulatory elements that alter message stability and translational efficiency
    • Cok, S.J., and Morrison, A.R. 2001. The 3′-untranslated region of murine cyclooxygenase-2 contains multiple regulatory elements that alter message stability and translational efficiency. J. Biol. Chem. 276: 23179-23185.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23179-23185
    • Cok, S.J.1    Morrison, A.R.2
  • 13
    • 0032529228 scopus 로고    scopus 로고
    • The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: Tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells
    • Compton, S.J., Cairns, J.A., Holgate, S.T., and Walls, A.F. 1998. The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells. J. Immunol. 161: 1939-1946.
    • (1998) J. Immunol. , vol.161 , pp. 1939-1946
    • Compton, S.J.1    Cairns, J.A.2    Holgate, S.T.3    Walls, A.F.4
  • 15
    • 0036444721 scopus 로고    scopus 로고
    • Restricted ability of human mast cell tryptase to activate proteinase- Activated receptor-2 in rat aorta
    • Compton, S.J., McGuire, J.J., Saifeddine, M., and Hollenberg, M.D. 2002. Restricted ability of human mast cell tryptase to activate proteinase- activated receptor-2 in rat aorta. Can. J. Physiol. Pharmacol. 80: 987-992.
    • (2002) Can. J. Physiol. Pharmacol. , vol.80 , pp. 987-992
    • Compton, S.J.1    McGuire, J.J.2    Saifeddine, M.3    Hollenberg, M.D.4
  • 16
    • 1842414265 scopus 로고    scopus 로고
    • Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor
    • Corvera, C.U., Déry, O., McConalogue, K., Böhm, S.K., Khitin, L.M., Caughey, G.H., et al. 1997. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor. J. Clin. Invest. 100: 1383-1393.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1383-1393
    • Corvera, C.U.1    Déry, O.2    McConalogue, K.3    Böhm, S.K.4    Khitin, L.M.5    Caughey, G.H.6
  • 17
    • 0028031081 scopus 로고
    • Protease-activated receptors start a family
    • Coughlin, S.R. 1994. Protease-activated receptors start a family. Proc. Natl. Acad. Sci. U.S.A. 91: 9200-9202.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 9200-9202
    • Coughlin, S.R.1
  • 19
    • 0034319114 scopus 로고    scopus 로고
    • Thrombin induces IL-6 but not TNFalpha secretion by mouse mast cells: Threshold-level thrombin receptor and very low level FcepsilonRI signaling synergistically enhance IL-6 secretion
    • Gordon, J.R., Zhang, X., Stevenson, K., and Cosford, K. 2000. Thrombin induces IL-6 but not TNFalpha secretion by mouse mast cells: threshold-level thrombin receptor and very low level FcepsilonRI signaling synergistically enhance IL-6 secretion. Cell. Immunol. 205: 128-135.
    • (2000) Cell. Immunol. , vol.205 , pp. 128-135
    • Gordon, J.R.1    Zhang, X.2    Stevenson, K.3    Cosford, K.4
  • 20
    • 0034611078 scopus 로고    scopus 로고
    • Histopathology of reflux-induced esophageal and supraesophageal injuries
    • Haggitt, R.C. 2000. Histopathology of reflux-induced esophageal and supraesophageal injuries. Am. J. Med. 108(Suppl 4a): 109S-111S.
    • (2000) Am. J. Med. , vol.108 , Issue.SUPPL. 4A
    • Haggitt, R.C.1
  • 21
    • 0032061273 scopus 로고    scopus 로고
    • Protease-activated receptors and their role in IL-6 and NF-IL-6 expression in human gingival fibroblasts
    • Hou, L., Ravenall, S., Macey, M.G., Harriott, P., Kapas, S., and Howells, G.L. 1998. Protease-activated receptors and their role in IL-6 and NF-IL-6 expression in human gingival fibroblasts. J. Periodontal Res. 33: 205-211.
    • (1998) J. Periodontal Res. , vol.33 , pp. 205-211
    • Hou, L.1    Ravenall, S.2    Macey, M.G.3    Harriott, P.4    Kapas, S.5    Howells, G.L.6
  • 22
    • 0035854794 scopus 로고    scopus 로고
    • Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung
    • Huang, C., De Sanctis, G.T., O'Brien, P.J., Mizgerd, J.P., Friend, D.S., Drazen, J.M., et al. 2001. Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. J. Biol. Chem. 276: 26276-26284.
    • (2001) J. Biol. Chem. , vol.276 , pp. 26276-26284
    • Huang, C.1    De Sanctis, G.T.2    O'Brien, P.J.3    Mizgerd, J.P.4    Friend, D.S.5    Drazen, J.M.6
  • 24
    • 0033594963 scopus 로고    scopus 로고
    • Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
    • Jakobsson, P.J., Thoren, S., Morgenstern, R., and Samuelsson, B. 1999. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acad. Sci. U.S.A. 96: 7220-7225.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 7220-7225
    • Jakobsson, P.J.1    Thoren, S.2    Morgenstern, R.3    Samuelsson, B.4
  • 25
    • 0015612519 scopus 로고
    • Release of histamine from mast cells by vasoactive peptides
    • Johnson, A.R., and Erdos, E.G. 1973. Release of histamine from mast cells by vasoactive peptides. Proc. Soc. Exp. Biol. Med. 142: 1252-1256.
    • (1973) Proc. Soc. Exp. Biol. Med. , vol.142 , pp. 1252-1256
    • Johnson, A.R.1    Erdos, E.G.2
  • 27
    • 0030667055 scopus 로고    scopus 로고
    • Protease-activated receptors: Development of agonists selective for receptors triggered by either thrombin (PAR1) or trypsin (PAR2)
    • Kawabata, A., Saifeddine, M., Al Ani, B., and Hollenberg, M.D. 1997. Protease-activated receptors: development of agonists selective for receptors triggered by either thrombin (PAR1) or trypsin (PAR2). Proc. West Pharmacol. Soc. 40: 49-51.
    • (1997) Proc. West Pharmacol. Soc. , vol.40 , pp. 49-51
    • Kawabata, A.1    Saifeddine, M.2    Al Ani, B.3    Hollenberg, M.D.4
  • 28
    • 16544388034 scopus 로고    scopus 로고
    • Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells
    • Kawabe, A., Shimada, Y., Soma, T., Maeda, M., Itami, A., Kaganoi, J., et al. 2004. Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. Life Sci. 75: 21-34.
    • (2004) Life Sci. , vol.75 , pp. 21-34
    • Kawabe, A.1    Shimada, Y.2    Soma, T.3    Maeda, M.4    Itami, A.5    Kaganoi, J.6
  • 30
    • 0031690095 scopus 로고    scopus 로고
    • Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse
    • Koshikawa, N., Hasegawa, S., Nagashima, Y., Mitsuhashi, K., Tsubota, Y., Miyata, S., et al. 1998. Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse. Am. J. Pathol. 153: 937-944.
    • (1998) Am. J. Pathol. , vol.153 , pp. 937-944
    • Koshikawa, N.1    Hasegawa, S.2    Nagashima, Y.3    Mitsuhashi, K.4    Tsubota, Y.5    Miyata, S.6
  • 31
    • 0035146812 scopus 로고    scopus 로고
    • Role of PGE(2) in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea
    • Lan, R.S., Knight, D.A., Stewart, G.A., and Henry, P.J. 2001. Role of PGE(2) in protease-activated receptor-1, -2 and -4 mediated relaxation in the mouse isolated trachea. Br. J. Pharmacol. 132: 93-100.
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 93-100
    • Lan, R.S.1    Knight, D.A.2    Stewart, G.A.3    Henry, P.J.4
  • 32
    • 0034055979 scopus 로고    scopus 로고
    • Role of constitutive cyclooxygenase-2 in prostaglandin-dependent secretion in mouse colon in vitro
    • MacNaughton, W.K., and Cushing, K. 2000. Role of constitutive cyclooxygenase-2 in prostaglandin-dependent secretion in mouse colon in vitro. J. Pharmacol. Exp. Ther. 293: 539-544.
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 539-544
    • MacNaughton, W.K.1    Cushing, K.2
  • 33
    • 0032444937 scopus 로고    scopus 로고
    • Role of nitric oxide in inflammation-induced suppression of secretion in a mouse model of acute colitis
    • MacNaughton, W.K., Lowe, S.S., and Cushing, K. 1998. Role of nitric oxide in inflammation-induced suppression of secretion in a mouse model of acute colitis. Am. J. Physiol. 275: G1353-G1360.
    • (1998) Am. J. Physiol. , vol.275
    • MacNaughton, W.K.1    Lowe, S.S.2    Cushing, K.3
  • 34
    • 0031408125 scopus 로고    scopus 로고
    • Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2
    • Mahida, Y.R., Beltinger, J., Makh, S., Göke, M., Gray, T., Podolsky, D.K., et al. 1997. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2. Am. J. Physiol. 273: G1341-G1348.
    • (1997) Am. J. Physiol. , vol.273
    • Mahida, Y.R.1    Beltinger, J.2    Makh, S.3    Göke, M.4    Gray, T.5    Podolsky, D.K.6
  • 35
    • 0028823347 scopus 로고
    • Monophasic luminal release of prostaglandin E2 in patients with reflux esophagitis under the impact of acid and acid/pepsin solutions. Its potential pathogenetic significance
    • Marcinkiewicz, M., Sarosiek, J., Edmunds, M., Scheurich, J., Weiss, P., and McCallum, R.W. 1995. Monophasic luminal release of prostaglandin E2 in patients with reflux esophagitis under the impact of acid and acid/pepsin solutions. Its potential pathogenetic significance. J. Clin. Gastroenterol. 21: 268-274.
    • (1995) J. Clin. Gastroenterol. , vol.21 , pp. 268-274
    • Marcinkiewicz, M.1    Sarosiek, J.2    Edmunds, M.3    Scheurich, J.4    Weiss, P.5    McCallum, R.W.6
  • 36
    • 0033049460 scopus 로고    scopus 로고
    • Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF- β3
    • McKaig, B.C., Makh, S.S., Hawkey, C.J., Podolsky, D.K., and Mahida, Y.R. 1999. Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF- β3. Am. J. Physiol. 276: G1087-G1093.
    • (1999) Am. J. Physiol. , vol.276
    • McKaig, B.C.1    Makh, S.S.2    Hawkey, C.J.3    Podolsky, D.K.4    Mahida, Y.R.5
  • 37
  • 39
    • 0016593938 scopus 로고
    • Effect of prostaglandin E2 on esophageal motility in man
    • Mukhopadhyay, A., Rattan, S., and Goyal, R.K. 1975. Effect of prostaglandin E2 on esophageal motility in man. J. Appl. Physiol. 39: 479-481.
    • (1975) J. Appl. Physiol. , vol.39 , pp. 479-481
    • Mukhopadhyay, A.1    Rattan, S.2    Goyal, R.K.3
  • 42
    • 0026735231 scopus 로고
    • DNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase
    • O'Banion, M.K., Winn, V.D., and Young, D.A. 1992. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A. 89: 4888-4892.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 4888-4892
    • O'Banion, M.K.1    Winn, V.D.2    Young, D.A.3
  • 43
    • 0031445618 scopus 로고    scopus 로고
    • Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease
    • Oberg, S., Peters, J.H., DeMeester, T.R., Chandrasoma, P., Hagen, J.A., Ireland, A.P., et al. 1997. Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastroesophageal reflux disease. Ann. Surg. 226: 522-530.
    • (1997) Ann. Surg. , vol.226 , pp. 522-530
    • Oberg, S.1    Peters, J.H.2    Demeester, T.R.3    Chandrasoma, P.4    Hagen, J.A.5    Ireland, A.P.6
  • 44
    • 0031935935 scopus 로고    scopus 로고
    • Role of mast cell-derived mediators in acid-induced shortening of the esophagus
    • Paterson, W.G. 1998. Role of mast cell-derived mediators in acid-induced shortening of the esophagus. Am. J. Physiol. 274: G385-G388.
    • (1998) Am. J. Physiol. , vol.274
    • Paterson, W.G.1
  • 46
    • 0037335786 scopus 로고    scopus 로고
    • Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons
    • Reed, D.E., Barajas-Lopez, C., Cottrell, G., Velazquez-Rocha, S., Dery, O., et al. 2003. Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. J. Physiol. (Cambridge, U.K.), 547: 531-542.
    • (2003) J. Physiol. (Cambridge, U.K.) , vol.547 , pp. 531-542
    • Reed, D.E.1    Barajas-Lopez, C.2    Cottrell, G.3    Velazquez-Rocha, S.4    Dery, O.5
  • 47
    • 0025351930 scopus 로고
    • Morphological alterations in tryptic esophagitis: An experimental light microscopic and scanning and transmission electron microscopic study in rabbits
    • Salmo, J.A., Lehto, V.P., Myllarniemi, H.S., and Kivilaakso, E.O. 1990. Morphological alterations in tryptic esophagitis: an experimental light microscopic and scanning and transmission electron microscopic study in rabbits. J. Surg. Res. 49: 14-17.
    • (1990) J. Surg. Res. , vol.49 , pp. 14-17
    • Salmo, J.A.1    Lehto, V.P.2    Myllarniemi, H.S.3    Kivilaakso, E.O.4
  • 48
    • 0029021942 scopus 로고
    • Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes
    • Santulli, R.J., Derian, C.K., Darrow, A.L., Tomko, K.A., Eckardt, A.J., Seiberg, M., et al. 1995. Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proc. Natl. Acad. Sci. U.S.A. 92: 9151-9155.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 9151-9155
    • Santulli, R.J.1    Derian, C.K.2    Darrow, A.L.3    Tomko, K.A.4    Eckardt, A.J.5    Seiberg, M.6
  • 49
    • 0029149212 scopus 로고
    • What is the secretory potential of submucosal mucous glands within the human gullet in health and disease?
    • Sarosiek, J., and McCallum, R.W. 1995. What is the secretory potential of submucosal mucous glands within the human gullet in health and disease? Digestion, 56(Suppl. 1): 15-23.
    • (1995) Digestion , vol.56 , Issue.SUPPL. 1 , pp. 15-23
    • Sarosiek, J.1    McCallum, R.W.2
  • 50
    • 0031850771 scopus 로고    scopus 로고
    • Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts
    • Schechter, N.M., Brass, L.F., Lavker, R.M., and Jensen, P.J. 1998. Reaction of mast cell proteases tryptase and chymase with protease activated receptors (PARs) on keratinocytes and fibroblasts. J. Cell. Physiol. 176: 365-373.
    • (1998) J. Cell. Physiol. , vol.176 , pp. 365-373
    • Schechter, N.M.1    Brass, L.F.2    Lavker, R.M.3    Jensen, P.J.4
  • 51
    • 0037404447 scopus 로고    scopus 로고
    • PAR1-dependent and independent increases in COX-2 and PGE2 in human colonic myofibroblasts stimulated by thrombin
    • Seymour, M.L., Zaidi, N.F., Hollenberg, M.D., and MacNaughton, W.K. 2003. PAR1-dependent and independent increases in COX-2 and PGE2 in human colonic myofibroblasts stimulated by thrombin. Am. J. Physiol. 284: C1185-C1192.
    • (2003) Am. J. Physiol. , vol.284
    • Seymour, M.L.1    Zaidi, N.F.2    Hollenberg, M.D.3    MacNaughton, W.K.4
  • 52
    • 0034102269 scopus 로고    scopus 로고
    • Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure
    • Shirvani, V.N., Ouatu-Lascar, R., Kaur, B.S., Omary, M.B., and Triadafilopoulos, G. 2000. Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. Gastroenterology, 118: 487-496.
    • (2000) Gastroenterology , vol.118 , pp. 487-496
    • Shirvani, V.N.1    Ouatu-Lascar, R.2    Kaur, B.S.3    Omary, M.B.4    Triadafilopoulos, G.5
  • 53
    • 0031870032 scopus 로고    scopus 로고
    • Role of intestinal mast cells in modulating gastrointestinal pathophysiology
    • Stenton, G.R., Vliagoftis, H., and Befus, A.D. 1998. Role of intestinal mast cells in modulating gastrointestinal pathophysiology. Ann. Allergy Asthma Immunol. 81: 1-13.
    • (1998) Ann. Allergy Asthma Immunol. , vol.81 , pp. 1-13
    • Stenton, G.R.1    Vliagoftis, H.2    Befus, A.D.3
  • 54
    • 0031802130 scopus 로고    scopus 로고
    • Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells
    • Strong, S.A., Pizarro, T.T., Klein, J.S., Cominelli, F., and Fiocchi, C. 1998. Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells. Gastroenterology, 114: 1244-1256.
    • (1998) Gastroenterology , vol.114 , pp. 1244-1256
    • Strong, S.A.1    Pizarro, T.T.2    Klein, J.S.3    Cominelli, F.4    Fiocchi, C.5
  • 55
    • 0034693050 scopus 로고    scopus 로고
    • Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis
    • Tanioka, T., Nakatani, Y., Semmyo, N., Murakami, M., and Kudo, I. 2000. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J. Biol. Chem. 275: 32775-32782.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32775-32782
    • Tanioka, T.1    Nakatani, Y.2    Semmyo, N.3    Murakami, M.4    Kudo, I.5
  • 56
    • 0030916991 scopus 로고    scopus 로고
    • Phenotypic characterization of an intestinal subepithelial myofibroblast cell line
    • Valentich, J.D., Popov, V., Saada, J.I., and Powell, D.W. 1997. Phenotypic characterization of an intestinal subepithelial myofibroblast cell line. Am. J. Physiol. 272: C1513-C1524.
    • (1997) Am. J. Physiol. , vol.272
    • Valentich, J.D.1    Popov, V.2    Saada, J.I.3    Powell, D.W.4
  • 57
    • 0032560576 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2 (PAR2)-activating peptides: Identification of a receptor distinct from PAR2 that regulates intestinal transport
    • Vergnolle, N., MacNaughton, W.K., Al Ani, B., Saifeddine, M., Wallace, J.L., and Hollenberg, M.D. 1998. Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc. Natl. Acad. Sci. U.S.A. 95: 7766-7771.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 7766-7771
    • Vergnolle, N.1    MacNaughton, W.K.2    Al Ani, B.3    Saifeddine, M.4    Wallace, J.L.5    Hollenberg, M.D.6
  • 59
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu, T.K., Hung, D.T., Wheaton, V.I., and Coughlin, S.R. 1991. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell, 64: 1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4
  • 60
    • 0033594911 scopus 로고    scopus 로고
    • Nonsteroid drug selectivities for cyclooxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
    • Warner, T.D., Giuliano, F., Vojnovic, I., Bukasa, A., Mitchell, J.A., and Vane, J.R. 1999. Nonsteroid drug selectivities for cyclooxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc. Natl. Acad. Sci. U.S.A. 96: 7563-7568.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 7563-7568
    • Warner, T.D.1    Giuliano, F.2    Vojnovic, I.3    Bukasa, A.4    Mitchell, J.A.5    Vane, J.R.6
  • 61
    • 0032528178 scopus 로고    scopus 로고
    • Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas
    • Wilson, K.T., Fu, S., Ramanujam, K.S., and Meltzer, S.J. 1998. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res. 58: 2929-2934.
    • (1998) Cancer Res. , vol.58 , pp. 2929-2934
    • Wilson, K.T.1    Fu, S.2    Ramanujam, K.S.3    Meltzer, S.J.4
  • 62
    • 0025754779 scopus 로고
    • Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
    • Xie, W.L., Chipman, J.G., Robertson, D.L., Erikson, R.L., and Simmons, D.L. 1991. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. U.S.A. 88: 2692-2696.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 2692-2696
    • Xie, W.L.1    Chipman, J.G.2    Robertson, D.L.3    Erikson, R.L.4    Simmons, D.L.5
  • 66
    • 0031952157 scopus 로고    scopus 로고
    • Increased levels of prostaglandins and nitric oxide in esophageal mucosa of children with reflux esophagitis
    • Zicari, A., Corrado, G., Cavaliere, M., Frandina, G., Rea, P., Pontieri, G., et al. 1998. Increased levels of prostaglandins and nitric oxide in esophageal mucosa of children with reflux esophagitis. J. Pediatr. Gastroenterol. Nutr. 26: 194-199.
    • (1998) J. Pediatr. Gastroenterol. Nutr. , vol.26 , pp. 194-199
    • Zicari, A.1    Corrado, G.2    Cavaliere, M.3    Frandina, G.4    Rea, P.5    Pontieri, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.