Sphingosine kinase 1 is a negative regulator of CD4+ Th1 cells

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 6580-6588

  Yang, Jianfei ^a   Castle, Brian E ^a   Hanidu, Adedayo ^a   Stevens, Lisa ^a   Yu, Yang ^a   Li, Xiang ^a   Stearns, Carol ^a   Papov, Vladimir ^a   Rajotte, Daniel ^a   Li, Jun ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CCL22 CHEMOKINE; CD4 ANTIGEN; CHEMOKINE; GAMMA INTERFERON; HLA DO ANTIGEN; HLA DO11.10 ANTIGEN; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE; REGULATOR PROTEIN; SMALL INTERFERING RNA; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; T LYMPHOCYTE RECEPTOR; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM MOBILIZATION; CELL MIGRATION; CELL PROLIFERATION; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FEMALE; GENE DISRUPTION; GENE EXPRESSION; GENE OVEREXPRESSION; HELPER CELL; IMMUNITY; INFLAMMATION; MOUSE; NONHUMAN; PHOSPHORYLATION AND DEPHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TH0 CELL; TH1 CELL; TH2 CELL;

EID: 27744470509     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.6580     Document Type: Article

References (47)

1. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348-2357.
2. Murphy, K. M., W. Ouyang, J. D. Farrar, J. Yang, S. Ranganath, H. Asnagli, M. Afkarian, and T. L. Murphy. 2000. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18: 451-494.
3. + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J. Immunol. 157: 1261-1270.
4. Bouma, G., and W. Strober. 2003. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3: 521-533.
5. Manoury-Schwartz, B., G. Chiocchia, N. Bessis, O. Abehsira-Amar, F. Batteux, S. Muller, S. Huang, M. C. Boissier, and C. Fournier. 1997. High susceptibility to collagen-induced arthritis in mice lacking IFN-γ receptors. J. Immunol. 158: 5501-5506.
6. van den Berg, W. B. 2002. Is there a rationale for combined TNF and IL-1 blocking in arthritis? Clin. Exp. Rheumatol. 20(Suppl. 27): S21-S25.
7. Papadakis, K. A., and S. R. Targan. 2000. Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 51: 289-298.
8. Spiegel, S., and S. Milstien. 2003. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 4: 397-407.
9. Pitson, S. M., P. A. Moretti, J. R. Zebol, H. E. Lynn, P. Xia, M. A. Vadas, and B. W. Wattenberg. 2003. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation. EMBO J. 22: 5491-5500.
10. 2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem. 277: 17255-17262.
11. Pettus, B. J., J. Bielawski, A. M. Porcelli, D. L. Reames, K. R. Johnson, J. Morrow, C. E. Chalfant, L. M. Obeid, and Y. A. Hannun. 2003. The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α. FASEB J. 17: 1411-1421.
12. Yoshimoto, T., M. Furuhata, S. Kamiya, M. Hisada, H. Miyaji, Y. Magami, K. Yamamoto, H. Fujiwara, and J. Mizuguchi. 2003. Positive modulation of IL-12 signaling by sphingosine kinase 2 associating with the IL-12 receptor β1 cytoplasmic region. J. Immunol. 171: 1352-1359.
13. Billich, A., F. Bornancin, P. Devay, D. Mechtcheriakova, N. Urtz, and T. Baumruker. 2003. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J. Biol. Chem. 278: 47408-47415.
14. Rosen, H., and J. Liao, 2003. Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. Curr. Opin. Chem. Biol. 1: 461-468.
15. Mandala, S., R. Hajdu, J. Bergstrom, E. Quackenbush, J. Xie, J. Milligan, R. Thornton, G. J. Shei, D. Card, C. Keohane, et al. 2002. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296: 346-349.
16. Matloubian, M., C. G. Lo, G. Cinamon, M. J. Lesneski, Y. Xu, V. Brinkmann, M. L. Allende, R. L. Proia, and J. G. Cyster. 2004. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427: 355-360.
17. Graeler, M., G. Shankar, and E. J. Goetzl. 2002. Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. J. Immunol. 169: 4084-4087.
18. Dorsam, G., M. H. Graeler, C. Seroogy, Y. Kong, J. K. Voice, and E. J. Goetzl. 2003. Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. J. Immunol. 171: 3500-3507.
19. lo thymocytes in vivo. Science 250: 1720-1723.
20. Yang, J., H. Zhu, T. L. Murphy, W. Ouyang, and K. M. Murphy. 2001. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat. Immunol. 2: 157-164.
21. Ouyang, W., S. H. Ranganath, K. Weindel, D. Bhattacharya, T. L. Murphy, W. C. Sha, and K. M. Murphy. 1998. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9: 745-755.
22. Pitson, S. M., P. A. Moretti, J. R. Zebol, R. Zareie, C. K. Derian, A. L. Darrow, J. Qi, R. J. D'Andrea, C. J. Bagley, M. A. Vadas, et al. 2002. The nucleotide-binding site of human sphingosine kinase 1. J. Biol. Chem. 277: 49545-49553.
23. Ancellin, N., C. Colmont, J. Su, Q. Li, N. Mittereder, S. S. Chae, S. Stefansson, G. Liau, and T. Hla. 2002. Extracellular export of sphingosine kinase-1 enzyme: sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J. Biol. Chem. 277: 6667-6675.
24. Chen, X. L., J. Y. Grey, S. Thomas, F. H. Qiu, R. M. Medford, M. A. Wasserman, and C. Kunsch. 2004. Sphingosine kinase-1 mediates TNF-α-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow. Am. J. Physiol. 287: H1452-H1458.
25. Bektas, M., P. S. Jolly, C. Muller, J. Eberle, S. Spiegel, and C. C. Geilen. 2005. Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression. Oncogene 24: 178-187.
26. Elbashir, S. M., J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
27. Li, X., P. E. Massa, A. Hanidu, G. W. Peet, P. Aro, A. Savitt, S. Mische, J. Li, and K. B. Marcu. 2002. IKKα, IKKβ, and NEMO/IKKγ are each required for the NF-κB-mediated inflammatory response program. J. Biol. Chem. 277: 45129-45140.
28. Li, X., and X. Wang. 2000. Application of real-time polymerase chain reaction for the quantitation of interleukin-1β mRNA upregulation in brain ischemic tolerance. Brain Res. Brain Res. Protoc. 5: 211-217.
29. 2+, calcineurin, and NF-AT. Cell 96: 611-614.
30. Brummelkamp, T. R., R. Bernards, and R. Agami. 2002. A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
31. Bidere, N., H. K. Lorenzo, S. Carmona, M. Laforge, F. Harper, C. Dumont, and A. Senik. 2003. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J. Biol. Chem. 278: 31401-31411.
32. Soumelis, V., P. A. Reche, H. Kanzler, W. Yuan, G. Edward, B. Homey, M. Gilliet, S. Ho, S. Antonenko, A. Lauerma, et al. 2002. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3: 673-680.
33. Sekiya, T., M. Miyamasu, M. Imanishi, H. Yamada, T. Nakajima, M. Yamaguchi, T. Fujisawa, R. Pawankar, Y. Sano, K. Ohta, et al. 2000. Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells. J. Immunol. 165: 2205-2213.
34. Alferink, J., I. Lieberam, W. Reindl, A. Behrens, S. Weiss, N. Huser, K. Gerauer, R. Ross, A. B. Reske-Kunz, P. Ahmad-Nejad, et al. 2003. Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J. Exp. Med. 197: 585-599.
35. Zhang, S., N. W. Lukacs, V. A. Lawless, S. L. Kunkel, and M. H. Kaplan. 2000. Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4. J. Immunol. 165: 10-14.
36. + T cells. J. Immunol. 170: 3662-3670.
37. Cinamon, G., M. Matloubian, M. J. Lesneski, Y. Xu, C. Low, T. Lu, R. L. Proia, and J. G. Cyster. 2004. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nat. Immunol. 5: 713-720.
38. + regulatory T cells. J. Exp. Med. 194: 847-853.
39. Andrew, D. P., N. Ruffing, C. H. Kim, W. Miao, H. Heath, Y. Li, K. Murphy, J. J. Campbell, E. C. Butcher, and L. Wu. 2001. C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential. J. Immunol. 166: 103-111.
40. Simons, F. E., Y. Shikishima, G. Van Nest, J. J. Eiden, and K. T. HayGlass. 2004. Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA. J. Allergy Clin. Immunol. 113: 1144-1151.
41. Kawasaki, S., H. Takizawa, H. Yoneyama, T. Nakayama, R. Fujisawa, M. Izumizaki, T. Imai, O. Yoshie, I. Homma, K. Yamamoto, et al. 2001. Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J. Immunol. 166: 2055-2062.
42. Berin, M. C., M. B. Dwinell, L. Eckmann, and M. F. Kagnoff. 2001. Production of MDC/CCL22 by human intestinal epithelial cells. Am. J. Physiol. 280: G1217-G1226.
43. Idzko, M., E. Panther, S. Corinti, A. Morelli, D. Ferrari, Y. Herouy, S. Dichmann, M. Mockenhaupt, P. Gebicke-Haerter, F. Di Virgilio, et al. 2002. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J. 16: 625-627.
44. Jin, Y., E. Knudsen, L. Wang, Y. Bryceson, B. Damaj, S. Gessani, and A. A. Maghazachi. 2003. Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. Blood 101: 4909-4915.
45. Delon, C., M. Manifava, E. Wood, D. Thompson, S. Krugmann, S. Pyne, and N. T. Ktistakis. 2004. Sphingosine kinase 1 is an intracellular effector of phosphatidic acid. J. Biol. Chem. 279: 44763-44774.
46. Gijsbers, S., S. Asselberghs, P. Herdewijn, and P. P. Van Veldhoven. 2002. 1-O-hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase. Biochim. Biophys. Acta 1580: 1-8.
47. Allende, M. L., T. Sasaki, H. Kawai, A. Olivera, Y. Mi, G. Echten-Deckert, R. Hajdu, M. Rosenbach, C. A. Keohane, S. Mandala, et al. 2004. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J. Biol. Chem. 279: 52487-52492.