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Volumn 8, Issue 11, 2005, Pages 1471-1480

Laboratory models of alcoholism: Treatment target identification and insight into mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; SEROTONIN;

EID: 27644564011     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1581     Document Type: Review
Times cited : (85)

References (100)
  • 1
    • 0031014559 scopus 로고    scopus 로고
    • Cellular and molecular neuroscience of alcoholism
    • Diamond, I. & Gordon, A.S. Cellular and molecular neuroscience of alcoholism. Physiol. Rev. 77, 1-20 (1997).
    • (1997) Physiol. Rev. , vol.77 , pp. 1-20
    • Diamond, I.1    Gordon, A.S.2
  • 2
    • 6344228776 scopus 로고    scopus 로고
    • The search for genes contributing to the low level of response to alcohol: Patterns of findings across studies
    • Schuckit, M.A., Smith, T.L. & Kalmijn, J. The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. Alcohol. Clin. Exp. Res. 28, 1449-1458 (2004).
    • (2004) Alcohol. Clin. Exp. Res. , vol.28 , pp. 1449-1458
    • Schuckit, M.A.1    Smith, T.L.2    Kalmijn, J.3
  • 3
    • 11044219969 scopus 로고    scopus 로고
    • Alcoholism: Genes and mechanisms
    • Oroszi, G. & Goldman, D. Alcoholism: genes and mechanisms. Pharmacogenomics 5, 1037-1048 (2004).
    • (2004) Pharmacogenomics , vol.5 , pp. 1037-1048
    • Oroszi, G.1    Goldman, D.2
  • 4
    • 0036415294 scopus 로고    scopus 로고
    • Genetic contributions to addiction
    • Crabbe, J.C. Genetic contributions to addiction. Annu. Rev. Psychol. 53, 435-462 (2002).
    • (2002) Annu. Rev. Psychol. , vol.53 , pp. 435-462
    • Crabbe, J.C.1
  • 5
    • 17644440887 scopus 로고    scopus 로고
    • Neurobiological correlates of the disposition and maintenance of alcoholism
    • Heinz, A., Schafer, M., Higley, J.D., Krystal, J.H. & Goldman, D. Neurobiological correlates of the disposition and maintenance of alcoholism. Pharmacopsychiatry 36 (Suppl.) S255-S258 (2003).
    • (2003) Pharmacopsychiatry , vol.36 , Issue.SUPPL.
    • Heinz, A.1    Schafer, M.2    Higley, J.D.3    Krystal, J.H.4    Goldman, D.5
  • 6
    • 0034968655 scopus 로고    scopus 로고
    • Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors
    • Weiss, F. et al. Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. Ann. NY Acad. Sci. 937, 1-26 (2001).
    • (2001) Ann. NY Acad. Sci. , vol.937 , pp. 1-26
    • Weiss, F.1
  • 7
    • 17744412210 scopus 로고    scopus 로고
    • Alcohol actions on GABA(A) receptors: From protein structure to mouse behavior
    • Ueno, S. et al. Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior. Alcohol. Clin. Exp. Res. 25, 76S-81S (2001).
    • (2001) Alcohol. Clin. Exp. Res. , vol.25
    • Ueno, S.1
  • 8
    • 0036890466 scopus 로고    scopus 로고
    • Elevated levels of GluR1 in the midbrain: A trigger for sensitization to drugs of abuse?
    • Carlezon, W.A., Jr. & Nestler, E.J. Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci. 25, 610-615 (2002).
    • (2002) Trends Neurosci. , vol.25 , pp. 610-615
    • Carlezon Jr., W.A.1    Nestler, E.J.2
  • 9
    • 0037526206 scopus 로고    scopus 로고
    • N-methyl-D-aspartate glutamate receptors and alcoholism: Reward, dependence, treatment, and vulnerability
    • Krystal, J.H., Petrakis, I.L., Mason, G., Trevisan, L. & D'Souza, D.C. N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacol. Ther. 99, 79-94 (2003).
    • (2003) Pharmacol. Ther. , vol.99 , pp. 79-94
    • Krystal, J.H.1    Petrakis, I.L.2    Mason, G.3    Trevisan, L.4    D'Souza, D.C.5
  • 10
    • 4644365351 scopus 로고    scopus 로고
    • Molecular mechanisms of drug addiction
    • Nestler, E.J. Molecular mechanisms of drug addiction. Neuropharmacology 47. Suppl 1, 24-32 (2004).
    • (2004) Neuropharmacology , vol.47 , Issue.1 SUPPL. , pp. 24-32
    • Nestler, E.J.1
  • 11
    • 4444300234 scopus 로고    scopus 로고
    • The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement
    • Gonzales, R.A., Job, M.O. & Doyon, W.M. The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement. Pharmacol. Ther. 103, 121-146 (2004).
    • (2004) Pharmacol. Ther. , vol.103 , pp. 121-146
    • Gonzales, R.A.1    Job, M.O.2    Doyon, W.M.3
  • 12
    • 27644454004 scopus 로고    scopus 로고
    • Is there a common molecular pathway for addiction?
    • Nestler, E.J. Is there a common molecular pathway for addiction? Nat. Neurosci. 8, 1445-1449 (2005).
    • (2005) Nat. Neurosci. , vol.8 , pp. 1445-1449
    • Nestler, E.J.1
  • 13
    • 0345274805 scopus 로고    scopus 로고
    • Genetic basis of ethanol reward
    • ed. Maldonado, R. Humana, Totowa, New Jersey
    • Cunningham, C.L. & Phillips, T.J. Genetic basis of ethanol reward. in Molecular Biology of Drug Addiction (ed. Maldonado, R.) 263-294 (Humana, Totowa, New Jersey, 2003).
    • (2003) Molecular Biology of Drug Addiction , pp. 263-294
    • Cunningham, C.L.1    Phillips, T.J.2
  • 15
    • 7044249270 scopus 로고    scopus 로고
    • Festina lente: Late night thoughts on high-throughput screening of mouse behavior
    • Crabbe, J.C. & Morris, R.G.M. Festina lente: Late night thoughts on high-throughput screening of mouse behavior. Nat. Neurosci. 7, 1175-1179 (2004).
    • (2004) Nat. Neurosci. , vol.7 , pp. 1175-1179
    • Crabbe, J.C.1    Morris, R.G.M.2
  • 17
    • 0034064407 scopus 로고    scopus 로고
    • Chemical properties of alcohols and their protein binding sites
    • Dwyer, D.S. & Bradley, R.J. Chemical properties of alcohols and their protein binding sites. Cell. Mol. Life Sci. 57, 265-275 (2000).
    • (2000) Cell. Mol. Life Sci. , vol.57 , pp. 265-275
    • Dwyer, D.S.1    Bradley, R.J.2
  • 20
    • 4544260511 scopus 로고    scopus 로고
    • Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors
    • Carpenter-Hyland, E.P., Woodward, J.J. & Chandler, L.J. Chronic ethanol induces synaptic but not extrasynaptic targeting of NMDA receptors. J. Neurosci. 24, 7859-7868 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 7859-7868
    • Carpenter-Hyland, E.P.1    Woodward, J.J.2    Chandler, L.J.3
  • 21
    • 0033986985 scopus 로고    scopus 로고
    • Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal
    • Thomas, M.P. & Morrisett, R.A. Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal. Neuropharmacology 39, 218-226 (2000).
    • (2000) Neuropharmacology , vol.39 , pp. 218-226
    • Thomas, M.P.1    Morrisett, R.A.2
  • 22
    • 0030929015 scopus 로고    scopus 로고
    • Alcohols and neurotransmitter gated ion channels: Past, present and future
    • Lovinger, D.M. Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn Schmiedebergs Arch. Pharmacol. 356, 267-282 (1997).
    • (1997) Naunyn Schmiedebergs Arch. Pharmacol. , vol.356 , pp. 267-282
    • Lovinger, D.M.1
  • 24
    • 0036675420 scopus 로고    scopus 로고
    • GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions?
    • Aguayo, L.G., Peoples, R.W., Yeh, H.H. & Yevenes, G.E. GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions? Curr. Top. Med. Chem. 2, 869-885 (2002).
    • (2002) Curr. Top. Med. Chem. , vol.2 , pp. 869-885
    • Aguayo, L.G.1    Peoples, R.W.2    Yeh, H.H.3    Yevenes, G.E.4
  • 25
    • 1842328604 scopus 로고    scopus 로고
    • Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors
    • Mihic, S.J. et al. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389, 385-389 (1997).
    • (1997) Nature , vol.389 , pp. 385-389
    • Mihic, S.J.1
  • 26
    • 0036326314 scopus 로고    scopus 로고
    • Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol
    • Sundstrom-Poromaa, I. et al. Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nat. Neurosci. 5, 721-722 (2002).
    • (2002) Nat. Neurosci. , vol.5 , pp. 721-722
    • Sundstrom-Poromaa, I.1
  • 27
    • 0345598083 scopus 로고    scopus 로고
    • Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-am inobutyric acid type A receptors at low concentrations known to affect humans
    • Wallner, M., Hanchar, H.J. & Olsen, R.W. Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-am inobutyric acid type A receptors at low concentrations known to affect humans. Proc. Natl. Acad. Sci. USA 100, 15218-15223 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15218-15223
    • Wallner, M.1    Hanchar, H.J.2    Olsen, R.W.3
  • 28
    • 14544274549 scopus 로고    scopus 로고
    • Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity
    • Hanchar, H.J., Dodson, P.D., Olsen, R.W., Otis, T.S. & Wallner, M. Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. Nat. Neurosci. 8, 339-345 (2005).
    • (2005) Nat. Neurosci. , vol.8 , pp. 339-345
    • Hanchar, H.J.1    Dodson, P.D.2    Olsen, R.W.3    Otis, T.S.4    Wallner, M.5
  • 29
    • 4644326916 scopus 로고    scopus 로고
    • Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons
    • Wei, W., Faria, L.C. & Mody, I. Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons. J. Neurosci. 24, 8379-8382 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 8379-8382
    • Wei, W.1    Faria, L.C.2    Mody, I.3
  • 30
    • 0027392921 scopus 로고
    • Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor
    • Korpi, E.R., Kleingoor, C., Kettenmann, H. & Seeburg, P.H. Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor. Nature 361, 356-359 (1993).
    • (1993) Nature , vol.361 , pp. 356-359
    • Korpi, E.R.1    Kleingoor, C.2    Kettenmann, H.3    Seeburg, P.H.4
  • 31
    • 12244283698 scopus 로고    scopus 로고
    • Molecular characterization of new polymorphisms at the β2, α1, γ2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotype
    • Congeddu, E. et al. Molecular characterization of new polymorphisms at the β2, α1, γ2 GABA(A) receptor subunit genes associated to a rat nonpreferring ethanol phenotype. Brain Res. Mol. Brain Res. 110, 289-297 (2003).
    • (2003) Brain Res. Mol. Brain Res. , vol.110 , pp. 289-297
    • Congeddu, E.1
  • 32
    • 3142730923 scopus 로고    scopus 로고
    • Behavioral characterization of alcohol-tolerant and alcohol-nontolerant rat lines and an F(2) generation
    • Radcliffe, R.A. et al. Behavioral characterization of alcohol-tolerant and alcohol-nontolerant rat lines and an F(2) generation. Behav. Genet. 34, 453-463 (2004).
    • (2004) Behav. Genet. , vol.34 , pp. 453-463
    • Radcliffe, R.A.1
  • 33
    • 0030615289 scopus 로고    scopus 로고
    • Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: Lack of effect on responses to ethanol, pentobarbital, and general anesthetics
    • Homanics, G.E. et al. Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol. Pharmacol. 51, 588-596 (1997).
    • (1997) Mol. Pharmacol. , vol.51 , pp. 588-596
    • Homanics, G.E.1
  • 34
    • 20444382383 scopus 로고    scopus 로고
    • The tipsy terminal: Presynaptic effects of ethanol
    • Siggins, G.R., Roberto, M. & Nie, Z. The tipsy terminal: presynaptic effects of ethanol. Pharmacol. Ther. 107, 80-98 (2005).
    • (2005) Pharmacol. Ther. , vol.107 , pp. 80-98
    • Siggins, G.R.1    Roberto, M.2    Nie, Z.3
  • 35
    • 9344236027 scopus 로고    scopus 로고
    • Ethanol potentiation of GABAergic synaptic transmission may be self-limiting: Role of presynaptic GABA(B) receptors
    • Ariwodola, O.J. & Weiner, J.L. Ethanol potentiation of GABAergic synaptic transmission may be self-limiting: role of presynaptic GABA(B) receptors. J. Neurosci. 24, 10679-10686 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 10679-10686
    • Ariwodola, O.J.1    Weiner, J.L.2
  • 36
    • 1942425652 scopus 로고    scopus 로고
    • Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability
    • Carta, M., Mameli, M. & Valenzuela, C.F. Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability. J. Neurosci. 24, 3746-3751 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 3746-3751
    • Carta, M.1    Mameli, M.2    Valenzuela, C.F.3
  • 37
    • 1542377428 scopus 로고    scopus 로고
    • Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors
    • Nie, Z. et al. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science 303, 1512-1514 (2004).
    • (2004) Science , vol.303 , pp. 1512-1514
    • Nie, Z.1
  • 38
    • 0037222831 scopus 로고    scopus 로고
    • Invertebrate models of drug abuse
    • Wolf, F.W. & Heberlein, U. Invertebrate models of drug abuse. J. Neurobiol. 54, 161-178 (2003).
    • (2003) J. Neurobiol. , vol.54 , pp. 161-178
    • Wolf, F.W.1    Heberlein, U.2
  • 39
    • 23844531242 scopus 로고    scopus 로고
    • The hangover gene defines a stress pathway required for ethanol tolerance development
    • Scholz, H., Franz, M. & Heberlein, U. The hangover gene defines a stress pathway required for ethanol tolerance development. Nature 436, 845-847 (2005).
    • (2005) Nature , vol.436 , pp. 845-847
    • Scholz, H.1    Franz, M.2    Heberlein, U.3
  • 40
    • 0036850986 scopus 로고    scopus 로고
    • Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila
    • Rodan, A.R., Kiger, J.A., Jr. & Heberlein, U. Functional dissection of neuroanatomical loci regulating ethanol sensitivity in Drosophila. J. Neurosci. 22, 9490-9501 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 9490-9501
    • Rodan, A.R.1    Kiger Jr., J.A.2    Heberlein, U.3
  • 41
    • 0034656653 scopus 로고    scopus 로고
    • High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice
    • Thiele, T.E. et al. High ethanol consumption and low sensitivity to ethanol-induced sedation in protein kinase A-mutant mice. J. Neurosci. 20, RC75, 1-6 (2000).
    • (2000) J. Neurosci. , vol.20
    • Thiele, T.E.1
  • 42
    • 0037076671 scopus 로고    scopus 로고
    • βγ dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption
    • Yao, L. et al. βγ dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell 109, 733-743 (2002).
    • (2002) Cell , vol.109 , pp. 733-743
    • Yao, L.1
  • 43
    • 0031691884 scopus 로고    scopus 로고
    • LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster
    • Kim, M.S., Repp, A. & Smith, D.P. LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster. Genetics 150, 711-721 (1998).
    • (1998) Genetics , vol.150 , pp. 711-721
    • Kim, M.S.1    Repp, A.2    Smith, D.P.3
  • 44
    • 0041819527 scopus 로고    scopus 로고
    • Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster
    • Kruse, S.W., Zhao, R., Smith, D.P. & Jones, D.N. Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster. Nat. Struct. Biol. 10, 694-700 (2003).
    • (2003) Nat. Struct. Biol. , vol.10 , pp. 694-700
    • Kruse, S.W.1    Zhao, R.2    Smith, D.P.3    Jones, D.N.4
  • 45
    • 0842281552 scopus 로고    scopus 로고
    • Revisiting the odorant-binding protein LUSH of Drosophila melanogaster: Evidence for odour recognition and discrimination
    • Zhou, J.J. et al. Revisiting the odorant-binding protein LUSH of Drosophila melanogaster: evidence for odour recognition and discrimination. FEBS Lett. 558, 23-26 (2004).
    • (2004) FEBS Lett. , vol.558 , pp. 23-26
    • Zhou, J.J.1
  • 46
    • 0346335778 scopus 로고    scopus 로고
    • A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans
    • Davies, A.G. et al. A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. Cell 115, 655-666 (2003).
    • (2003) Cell , vol.115 , pp. 655-666
    • Davies, A.G.1
  • 48
    • 16644366598 scopus 로고    scopus 로고
    • Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster
    • Corl, A.B., Rodan, A.R. & Heberlein, U. Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat. Neurosci. 8, 18-19 (2005).
    • (2005) Nat. Neurosci. , vol.8 , pp. 18-19
    • Corl, A.B.1    Rodan, A.R.2    Heberlein, U.3
  • 49
    • 0141920607 scopus 로고    scopus 로고
    • Zebra fish: An uncharted behavior genetic model
    • Gerlai, R. Zebra fish: an uncharted behavior genetic model. Behav. Genet. 33, 461-468 (2003).
    • (2003) Behav. Genet. , vol.33 , pp. 461-468
    • Gerlai, R.1
  • 50
    • 1542270267 scopus 로고    scopus 로고
    • Acute effects of alcohol on larval zebrafish: A genetic system for large-scale screening
    • Lockwood, B., Bjerke, S., Kobayashi, K. & Guo, S. Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacol. Biochem. Behav. 77, 647-654 (2004).
    • (2004) Pharmacol. Biochem. Behav. , vol.77 , pp. 647-654
    • Lockwood, B.1    Bjerke, S.2    Kobayashi, K.3    Guo, S.4
  • 51
    • 4644269845 scopus 로고    scopus 로고
    • Ethanol effects on the developing zebrafish: Neurobehavior and skeletal morphogenesis
    • Carvan, M.J., III, Loucks, E., Weber, D.N. & Williams, F.E. Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis. Neurotoxicol. Teratol. 26, 757-768 (2004).
    • (2004) Neurotoxicol. Teratol. , vol.26 , pp. 757-768
    • Carvan III, M.J.1    Loucks, E.2    Weber, D.N.3    Williams, F.E.4
  • 52
    • 0004767755 scopus 로고    scopus 로고
    • Genetic strategies in preclinical substance abuse research
    • eds. Bloom, F.E. & Kupfer, D.J. Lippincott, Williams & Wilkins, Philadelphia
    • Browman, K.E., Crabbe, J.C. & Li, T.K. Genetic strategies in preclinical substance abuse research. in Psychopharmacology: The Fourth Generation of Progress (eds. Bloom, F.E. & Kupfer, D.J.) (Lippincott, Williams & Wilkins, Philadelphia, 2000).
    • (2000) Psychopharmacology: The Fourth Generation of Progress
    • Browman, K.E.1    Crabbe, J.C.2    Li, T.K.3
  • 53
    • 0036751424 scopus 로고    scopus 로고
    • Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference
    • Murphy, J.M. et al. Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. Behav. Genet. 32, 363-388 (2002).
    • (2002) Behav. Genet. , vol.32 , pp. 363-388
    • Murphy, J.M.1
  • 54
    • 0032466081 scopus 로고    scopus 로고
    • Animal models of alcoholism: Neurobiology of high alcohol-drinking behavior in rodents
    • McBride, W.J. & Li, T.K. Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit. Rev. Neurobiol. 12, 339-369 (1998).
    • (1998) Crit. Rev. Neurobiol. , vol.12 , pp. 339-369
    • McBride, W.J.1    Li, T.K.2
  • 55
    • 4344633808 scopus 로고    scopus 로고
    • Pharmacogenetic studies of alcohol self-administration and withdrawal
    • Crabbe, J.C. & Phillips, T.J. Pharmacogenetic studies of alcohol self-administration and withdrawal. Psychopharmacology (Berl.) 174, 539-560 (2004).
    • (2004) Psychopharmacology (Berl.) , vol.174 , pp. 539-560
    • Crabbe, J.C.1    Phillips, T.J.2
  • 56
    • 0038587645 scopus 로고    scopus 로고
    • Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: A European perspective
    • Soyka, M. & Chick, J. Use of acamprosate and opioid antagonists in the treatment of alcohol dependence: a European perspective. Am. J. Addict. 12 Suppl 1, S69-S80 (2003).
    • (2003) Am. J. Addict. , vol.12 , Issue.1 SUPPL.
    • Soyka, M.1    Chick, J.2
  • 57
    • 0034071789 scopus 로고    scopus 로고
    • Neuropharmacological treatments for alcoholism: Scientific basis and clinical findings
    • Johnson, B.A. & Ait-Daoud, N. Neuropharmacological treatments for alcoholism: scientific basis and clinical findings. Psychopharmacology (Berl.) 149, 327-344 (2000).
    • (2000) Psychopharmacology (Berl.) , vol.149 , pp. 327-344
    • Johnson, B.A.1    Ait-Daoud, N.2
  • 58
    • 0028278185 scopus 로고
    • Genetic animal models of alcohol and drug abuse
    • Crabbe, J.C., Belknap, J.K. & Buck, K.J. Genetic animal models of alcohol and drug abuse. Science 264, 1715-1723 (1994).
    • (1994) Science , vol.264 , pp. 1715-1723
    • Crabbe, J.C.1    Belknap, J.K.2    Buck, K.J.3
  • 60
    • 0036584950 scopus 로고    scopus 로고
    • Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: Identification of Mpdz as a candidate gene
    • Fehr, C., Shirley, R.L., Belknap, J.K., Crabbe, J.C. & Buck, K.J. Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J. Neurosci. 22, 3730-3738 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 3730-3738
    • Fehr, C.1    Shirley, R.L.2    Belknap, J.K.3    Crabbe, J.C.4    Buck, K.J.5
  • 61
    • 27644441537 scopus 로고    scopus 로고
    • Identifying genes affecting addiction risk in animal models
    • eds. Madras, B. et al. Cold Spring Harbor Press, in press
    • Crabbe, J.C. Identifying genes affecting addiction risk in animal models. in The Cell Biology of Addiction (eds. Madras, B. et al.) (Cold Spring Harbor Press, in press).
    • The Cell Biology of Addiction
    • Crabbe, J.C.1
  • 62
    • 10444266005 scopus 로고    scopus 로고
    • Molecular genetics of substance abuse vulnerability: Remarkable recent convergence of genome scan results
    • Uhl, G.R. Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. Ann. NY Acad. Sci. 1025, 1-13 (2004).
    • (2004) Ann. NY Acad. Sci. , vol.1025 , pp. 1-13
    • Uhl, G.R.1
  • 63
    • 0034892846 scopus 로고    scopus 로고
    • Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice
    • Hood, H.M., Belknap, J.K., Crabbe, J.C. & Buck, K.J. Genomewide search for epistasis in a complex trait: Pentobarbital withdrawal convulsions in mice. Behav. Genet. 31, 93-100 (2001).
    • (2001) Behav. Genet. , vol.31 , pp. 93-100
    • Hood, H.M.1    Belknap, J.K.2    Crabbe, J.C.3    Buck, K.J.4
  • 64
    • 0037678719 scopus 로고    scopus 로고
    • Chromosomal loci influencing chronic alcohol withdrawal severity
    • Bergeson, S.E. et al. Chromosomal loci influencing chronic alcohol withdrawal severity. Mammal. Genome 14, 454-463 (2003).
    • (2003) Mammal. Genome , vol.14 , pp. 454-463
    • Bergeson, S.E.1
  • 65
    • 0035400051 scopus 로고    scopus 로고
    • Genetical genomics: The added value from segregation
    • Jansen, R.C. & Nap, J.P. Genetical genomics: the added value from segregation. Trends Genet. 17, 388-391 (2001).
    • (2001) Trends Genet. , vol.17 , pp. 388-391
    • Jansen, R.C.1    Nap, J.P.2
  • 66
    • 6344290144 scopus 로고    scopus 로고
    • On the integration of alcohol-related quantitative trait loci and gene expression analyses
    • Hitzemann, R. et al. On the integration of alcohol-related quantitative trait loci and gene expression analyses. Alcohol. Clin. Exp. Res. 28, 1437-1448 (2004).
    • (2004) Alcohol. Clin. Exp. Res. , vol.28 , pp. 1437-1448
    • Hitzemann, R.1
  • 67
    • 0037780558 scopus 로고    scopus 로고
    • Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors
    • Tabakoff, B., Bhave, S.V. & Hoffman, P.L. Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. J. Neurosci. 23, 4491-4498 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 4491-4498
    • Tabakoff, B.1    Bhave, S.V.2    Hoffman, P.L.3
  • 68
    • 20144386111 scopus 로고    scopus 로고
    • Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    • Chesler, E.J. et al. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat. Genet. 37, 233-242 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 233-242
    • Chesler, E.J.1
  • 69
    • 20144383240 scopus 로고    scopus 로고
    • Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
    • Bystrykh, L. et al. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat. Genet. 37, 225-232 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 225-232
    • Bystrykh, L.1
  • 70
    • 20144377218 scopus 로고    scopus 로고
    • Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
    • Hubner, N. et al. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat. Genet. 37, 243-253 (2005).
    • (2005) Nat. Genet. , vol.37 , pp. 243-253
    • Hubner, N.1
  • 71
    • 4644340512 scopus 로고    scopus 로고
    • Gamma-Aminobutyric acid A receptor subunit mutant mice: New perspectives on alcohol actions
    • Boehm, S.L., II et al. gamma-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions. Biochem. Pharmacol. 68, 1581-1602 (2004).
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1581-1602
    • Boehm II, S.L.1
  • 72
    • 24944442520 scopus 로고    scopus 로고
    • Neurocircuitry in alcoholism: A substrate of disruption and repair
    • Sullivan, E.V. & Pfefferbaum, A. Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology (Berl) 180, 583-594 (2005).
    • (2005) Psychopharmacology (Berl) , vol.180 , pp. 583-594
    • Sullivan, E.V.1    Pfefferbaum, A.2
  • 73
    • 21444439411 scopus 로고    scopus 로고
    • Examining personality and alcohol expectancies using functional magnetic resonance imaging (fMRI) with adolescents
    • Anderson, K.G., Schweinsburg, A., Paulus, M.P., Brown, S.A. & Tapert, S. Examining personality and alcohol expectancies using functional magnetic resonance imaging (fMRI) with adolescents. J. Stud. Alcohol 66, 323-331 (2005).
    • (2005) J. Stud. Alcohol , vol.66 , pp. 323-331
    • Anderson, K.G.1    Schweinsburg, A.2    Paulus, M.P.3    Brown, S.A.4    Tapert, S.5
  • 74
    • 0034877477 scopus 로고    scopus 로고
    • Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): Long-term characterization of sex and individual differences
    • Vivian, J.A. et al. Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): long-term characterization of sex and individual differences. Alcohol. Clin. Exp. Res. 25, 1087-1097 (2001).
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 1087-1097
    • Vivian, J.A.1
  • 75
    • 0346994781 scopus 로고    scopus 로고
    • Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone
    • Middaugh, L.D., Szumlinski, K.K., Van Patten, Y., Marlowe, A.L. & Kalivas, P.W. Chronic ethanol consumption by C57BL/6 mice promotes tolerance to its interoceptive cues and increases extracellular dopamine, an effect blocked by naltrexone. Alcohol. Clin. Exp. Res. 27, 1892-1900 (2003).
    • (2003) Alcohol. Clin. Exp. Res. , vol.27 , pp. 1892-1900
    • Middaugh, L.D.1    Szumlinski, K.K.2    Van Patten, Y.3    Marlowe, A.L.4    Kalivas, P.W.5
  • 76
    • 0038308863 scopus 로고    scopus 로고
    • Schedule-induced ethanol self-administration in DBA/2J and C57BL/6J mice
    • Mittleman, G., Van Brunt, C.L. & Matthews, D.B. Schedule-induced ethanol self-administration in DBA/2J and C57BL/6J mice. Alcohol. Clin. Exp. Res. 27, 918-925 (2003).
    • (2003) Alcohol. Clin. Exp. Res. , vol.27 , pp. 918-925
    • Mittleman, G.1    Van Brunt, C.L.2    Matthews, D.B.3
  • 77
    • 0000487074 scopus 로고
    • Production of polydipsia in normal rats by an intermittent food schedule
    • Falk, J.L. Production of polydipsia in normal rats by an intermittent food schedule. Science 133, 195-196 (1961).
    • (1961) Science , vol.133 , pp. 195-196
    • Falk, J.L.1
  • 78
    • 24144440383 scopus 로고    scopus 로고
    • Ataxia and c-Fos expression in mice drinking ethanol in a limited access session
    • Sharpe, A.L., Tsivkovskaia, N.O. & Ryabinin, A.E. Ataxia and c-Fos expression in mice drinking ethanol in a limited access session. Alcohol. Clin. Exp. Res. 29, 1419-1426 (2005).
    • (2005) Alcohol. Clin. Exp. Res. , vol.29 , pp. 1419-1426
    • Sharpe, A.L.1    Tsivkovskaia, N.O.2    Ryabinin, A.E.3
  • 79
    • 0034878850 scopus 로고    scopus 로고
    • Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats
    • Rodd-Henricks, Z.A. et al. Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring rats. Alcohol. Clin. Exp. Res. 25, 1140-1150 (2001).
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 1140-1150
    • Rodd-Henricks, Z.A.1
  • 80
    • 11844289551 scopus 로고    scopus 로고
    • Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice
    • Rhodes, J.S., Best, K., Belknap, J.K., Finn, D.A. & Crabbe, J.C. Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol. Behav. 84, 53-63 (2005).
    • (2005) Physiol. Behav. , vol.84 , pp. 53-63
    • Rhodes, J.S.1    Best, K.2    Belknap, J.K.3    Finn, D.A.4    Crabbe, J.C.5
  • 81
    • 16844377776 scopus 로고    scopus 로고
    • A procedure to produce high alcohol intake in mice
    • Finn, D.A. et al. A procedure to produce high alcohol intake in mice. Psychopharmacology (Berl.) 178, 471-480 (2005).
    • (2005) Psychopharmacology (Berl.) , vol.178 , pp. 471-480
    • Finn, D.A.1
  • 82
    • 23944501980 scopus 로고    scopus 로고
    • Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice
    • Cronise, K., Finn, D.A., Metten, P. & Crabbe, J.C. Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice. Pharmacol. Biochem. Behav. 81, 943-953 (2005).
    • (2005) Pharmacol. Biochem. Behav. , vol.81 , pp. 943-953
    • Cronise, K.1    Finn, D.A.2    Metten, P.3    Crabbe, J.C.4
  • 84
    • 25844463562 scopus 로고    scopus 로고
    • Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice
    • published online 7 July (doi:10.1007/s00213-005-0026-3)
    • Lopez, M.F. & Becker, H.C. Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice. Psychopharmacology (Berl.) published online 7 July 2005 (doi:10.1007/s00213-005- 0026-3).
    • (2005) Psychopharmacology (Berl.)
    • Lopez, M.F.1    Becker, H.C.2
  • 85
    • 11844276987 scopus 로고    scopus 로고
    • Anxiety-like behaviors following chronic ethanol exposure
    • Kliethermes, C.L. Anxiety-like behaviors following chronic ethanol exposure. Neurosci. Biobehav. Rev. 28, 837-850 (2005).
    • (2005) Neurosci. Biobehav. Rev. , vol.28 , pp. 837-850
    • Kliethermes, C.L.1
  • 86
    • 0041346384 scopus 로고    scopus 로고
    • A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders
    • Anguelova, M., Benkelfat, C. & Turecki, G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol. Psychiatry 8, 574-591 (2003).
    • (2003) Mol. Psychiatry , vol.8 , pp. 574-591
    • Anguelova, M.1    Benkelfat, C.2    Turecki, G.3
  • 87
    • 7744240079 scopus 로고    scopus 로고
    • Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates
    • Barr, C.S. et al. Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch. Gen. Psychiatry 61, 1146-1152 (2004).
    • (2004) Arch. Gen. Psychiatry , vol.61 , pp. 1146-1152
    • Barr, C.S.1
  • 88
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi, A. et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386-389 (2003).
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1
  • 89
    • 4344607104 scopus 로고    scopus 로고
    • Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
    • Barr, C.S. et al. Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc. Natl. Acad. Sci. USA 101, 12358-12363 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 12358-12363
    • Barr, C.S.1
  • 90
    • 12344328265 scopus 로고    scopus 로고
    • An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk
    • Hu, X. et al. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol. Clin. Exp. Res. 29, 8-16 (2005).
    • (2005) Alcohol. Clin. Exp. Res. , vol.29 , pp. 8-16
    • Hu, X.1
  • 91
    • 0242552619 scopus 로고    scopus 로고
    • Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype
    • Ozaki, N. et al. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol. Psychiat. 8, 895, 933-936 (2003).
    • (2003) Mol. Psychiat. , vol.8 , Issue.895 , pp. 933-936
    • Ozaki, N.1
  • 92
  • 93
    • 28744441117 scopus 로고    scopus 로고
    • Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism?
    • in press
    • Egli, M. Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism? Addict. Biol. (in press).
    • Addict. Biol.
    • Egli, M.1
  • 94
    • 0024535962 scopus 로고
    • Ethanol inhibits NMDA-activated ion current in hippocampal neurons
    • Lovinger, D.M., White, G. & Weight, F.F. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243, 1721-1724 (1989).
    • (1989) Science , vol.243 , pp. 1721-1724
    • Lovinger, D.M.1    White, G.2    Weight, F.F.3
  • 95
    • 3242770741 scopus 로고    scopus 로고
    • Renaissance of NMDA receptor antagonists: Do they have a role in the pharmacotherapy for alcoholism?
    • Nagy, J. Renaissance of NMDA receptor antagonists: do they have a role in the pharmacotherapy for alcoholism? IDrugs 7, 339-350 (2004).
    • (2004) IDrugs , vol.7 , pp. 339-350
    • Nagy, J.1
  • 97
    • 10444259013 scopus 로고    scopus 로고
    • Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors
    • Hungund, B.L. & Basavarajappa, B.S. Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors. Ann. NY Acad. Sci. 1025, 515-527 (2004).
    • (2004) Ann. NY Acad. Sci. , vol.1025 , pp. 515-527
    • Hungund, B.L.1    Basavarajappa, B.S.2
  • 98
    • 17844388556 scopus 로고    scopus 로고
    • Endocannabinoid control of food intake and energy balance
    • Di, M.V. & Matias,I. Endocannabinoid control of food intake and energy balance. Nat. Neurosci. 8, 585-589 (2005).
    • (2005) Nat. Neurosci. , vol.8 , pp. 585-589
    • Di, M.V.1    Matias, I.2
  • 99
    • 14344259844 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence
    • Le Foll, B. & Goldberg, S.R. Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J. Pharmacol. Exp. Ther. 312, 875-883 (2005).
    • (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 875-883
    • Le Foll, B.1    Goldberg, S.R.2
  • 100
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-Year experience from the RIO-Europe study
    • Van Gaal, L.F., Rissanen, A.M., Scheen, A.J., Ziegler, O. & Rossner, S. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365, 1389-1397 (2005).
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3    Ziegler, O.4    Rossner, S.5


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