Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a <1 Centimorgan Interval of Murine Chromosome 4: Identification of Mpdz as a Candidate Gene

Journal of Neuroscience

Volumn 22, Issue 9, 2002, Pages 3730-3738

  Fehr, Christoph ^a,c   Shirley, Renee L ^a   Belknap, John K ^a,b   Crabbe, John C ^a,b   Buck, Kari J ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Barbiturate; C57BL 6J; Convulsion; DBA 2J; Ethanol; Interval specific congenic strain; PDZ domain; Physiological dependence; Quantitative trait locus; Recombinant progeny testing; Seizure

Indexed keywords

ALCOHOL; BARBITURIC ACID DERIVATIVE; PENTETRAZOLE; PENTOBARBITAL; CARRIER PROTEIN; MPDZ PROTEIN, MOUSE;

ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; CHROMOSOME 4; CONGENIC STRAIN; DRUG DEPENDENCE; DRUG WITHDRAWAL; FEMALE; GENE LOCUS; HAPLOTYPE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN VARIANT; SEIZURE; SEQUENCE ANALYSIS; STIMULUS RESPONSE; ANIMAL; CHROMOSOME MAP; DNA SEQUENCE; GENE; GENETIC MARKER; GENETIC PREDISPOSITION; GENETICS; HOSPITALIZATION; INBREEDING; MOLECULAR GENETICS; MOUSE STRAIN; PHENOTYPE; QUANTITATIVE TRAIT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; WITHDRAWAL SYNDROME;

ALLELES; ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CHROMOSOME MAPPING; ETHANOL; FEMALE; GENES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; INBREEDING; MALE; MICE; MICE, CONGENIC; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; PENTOBARBITAL; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; SEQUENCE ANALYSIS, DNA; SEVERITY OF ILLNESS INDEX; SEX FACTORS; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0036584950     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-09-03730.2002     Document Type: Article

References (50)

1. Bailey DW (1981) Recombinant inbred strains and bilineal congenic strains. In: The mouse in biomedical research (Foster HL, Small JD, Fox JG, eds), pp 223-239. New York: Academic.
2. 2 receptor in the pentobarbital anesthetized mouse model. Brain Res Bull 21:887-891.
3. Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (2001) Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J Biol Chem 276:12974-12982.
4. Belknap JK, Hitzemann R, Crabbe JC, Phillips TJ, Buck KJ, Williams RW (2001) QTL analysis and genome-wide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits. Behav Genet 31:5-15.
5. Buck KJ, Metten P, Belknap JK, Crabbe JC (1997) Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. J Neurosci 17:3946-3955.
6. Buck KJ, Metten P, Belknap JK, Crabbe JC (1999) Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. Mamm Genome 10:431-437.
7. Buck KJ, Rademacher BLS, Metten P, Crabbe JC (2002) Mapping murine loci for physical dependence on ethanol. Psychopharmacology 160:398-407.
8. Cadoret RJ, Cain CA, Grove WM (1980) Development of alcoholism in adoptees raised apart from alcoholic biologic relatives. Arch Gen Psychiatry 37:561-563.
9. Chou PY, Fasman GD (1978) Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol 47:45-148.
10. Cicila GT, Garrett MR, Lee SJ, Liu J, Dene H, Rapp JP (2001) High-resolution mapping of the blood pressure QTL on chromosome 7 using dahl rat congenic strains. Genomics 72:51-60.
11. Crabbe JC, Merrill C, Belknap JK (1991) Acute dependence on depressant drugs is determined by common genes in mice. J Pharmacol Exp Ther 257:663-667.
12. Crabbe JC, Phillips TJ, Gallaher EJ, Crawshaw LI, Mitchell SR (1996) Common genetic determinants of the ataxic and hypothermic effects of ethanol in BXD/Ty recombinant inbred mice: genetic correlations and quantitative trait loci. J Pharmacol Exp Ther 277:624-632.
13. Daniels GM, Buck KJ (2002) Expression profiling identifies strain-specific changes associated with ethanol withdrawal in mice. Genes Brain Behav 1:35-45.
14. Darvasi A (1997) Interval-specific congenic strains (ISCS): an experimental design for mapping a QTL into a 1 centiMorgan interval. Mamm Genome 8:163-167.
15. Darvasi A (1998) Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18:19-24.
16. Dean RB, Dixon WJ (1951) Simplified statistics for small numbers of observations. Anal Chem 23:636-638.
17. Dietrich W, Katz H, Lincoln SE, Shin H, Friedman J, Dracopoli N, Lander ES (1992) A genetic map of the mouse suitable for typing intraspecific crosses. Genetics 131:423-447.
18. DSM-IV (1994) Diagnostic and statistical manual of mental disorders, Ed 4 (First MB, ed). Washington, DC: American Psychiatric Association.
19. Ferraro TN, Golden GT, Smith GG, St Jean P, Schork NJ, Mulholland N, Ballas C, Schill J, Buono RJ, Berrettini WH (1999) Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice. J Neurosci 19:6733-6739.
20. Frankel D, Khanna JM, LeBlanc AE, Kalant H (1975) Effect of p-chlorophenylalanine on the acquisition of tolerance to ethanol and pentobarbital. Psychopharmacology 44:247-252.
21. Friedman HJ (1980) Assessment of physical dependence on and withdrawal from ethanol in animals. In: Alcohol tolerance and dependence (Rigter H, Crabbe JC, eds), pp 93-121. Amsterdam: Elsevier.
22. Gallaher EJ, Jones GE, Belknap JK, Crabbe JC (1996) Identification of genetic markers for initial sensitivity and rapid tolerance to ethanol-induced ataxia using quantitative trait locus analysis in BXD recombinant inbred mice. J Pharmacol Exp Ther 277:604-612.
23. Garnier J, Osguthorpe DJ, Robson B (1978) Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol 120:97-120.
24. Gatch MB, Wallis CJ, Lal H (2000) Effects of ritanserin on ethanol withdrawal-induced anxiety in rats. Alcohol 21:11-17.
25. Goldman D (1993) Recent developments in alcoholism: genetic transmission. Recent Dev Alcohol 11:231-248.
26. Goldstein DB, Pal N (1971) Alcohol dependence produced in mice by inhalation of ethanol: grading the withdrawal system. Science 172:288-290.
27. 2 receptor binding and 5-HT uptake in mouse brain: developmental changes and the relationship to audiogenic seizure susceptibility in DBA/2J mice. Brain Res Dev Brain Res 45:257-263.
28. Khanna JM, Le AD, Kalant H, LeBlanc AE (1980) Role of serotonin (5-HT) in tolerance to ethanol and barbiturates. Adv Exp Med Biol 126:181-195.
29. Lal H, Prather PL, Rezazadeh SM (1993) Potential role of 5-HT1C and/or 5-HT2 receptors in the mianserin-induced prevention of anxiogenic behaviors occurring during ethanol withdrawal. Alcohol Clin Exp Res 17:411-417.
30. Lander ES, Botstein D (1989) Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199.
31. Lander ES, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
32. LeMarquand D, Pihl RO, Benkelfat C (1994a) Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol Psychiatry 36:326-327.
33. LeMarquand D, Pihl RO, Benkelfat C (1994b) Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol Psychiatry 36:395-421.
34. Lyons PA, Armitage N, Argentina F, Denny P, Hill NJ, Lord CJ, Wilusz MB, Peterson LB, Wicker LS, Todd JA (2000) Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Res 10:446-453.
35. Malke H, Steiner K, Gase K, Frank C (2000) Expression and regulation of the streptokinase gene. Methods 21:111-124.
36. Mancini A, Koch A, Stefan M, Niemann H, Tamura T (2000) The direct association of the multiple PDZ domain containing proteins (MUPP1) with the human cKit C-terminus is regulated by tyrosine kinase activity. FEBS Lett 482:54-58.
37. McCaul ME, Turkkan JS, Svikis DS, Bigelow GE (1991) Alcohol and secobarbital effects as a function of familial alcoholism: extended intoxication and increased withdrawal effects. Alcohol Clin Exp Res 15:94-101.
38. Metten P, Crabbe JC (1994) Common genetic determinants of severity of withdrawal from ethanol, pentobarbital and diazepam in inbred mice. Behav Pharmacol 5:533-547.
39. Nadeau JH, Frankel WN (2000) The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. Nat Genet 25:381-384.
40. Neumann PE, Collins RL (1991) Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proc Natl Acad Sci USA 88:5408-5412.
41. Newlin DB, Pretorius MB (1990) Sons of alcoholics report greater hangover symptoms than sons of nonalcoholics: a pilot study. Alcohol Clin Exp Res 14:713-716.
42. Prather PL, Rezazadeh SM, Lan H (1991) Mianserin in the treatment of ethanol withdrawal in the rat: prevention of behaviors indicative of anxiety. Psychopharmacol Bull 27:285-289.
43. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK (1990) Comorbidity of mental disorders with alcohol and other drug abuse. results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264:2511-2518.
44. Reich T, Hinrichs A, Culverhouse R, Bierut L (1999) Genetic studies of alcoholism and substance dependence. Am J Hum Genet 65:599-605.
45. Schuckit MA, Goodwin DA, Winokur G (1972) A study of alcoholism in half siblings. Am J Psychiatry 128:1132-1136.
46. Semenova TP, Ticku MK (1992) Effects of 5-HT receptor antagonists on seizure susceptibility and locomotor activity in DBA/2 mice. Brain Res 588:229-236.
47. Sheng M, Sala C (2001) PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 24:1-29.
48. Sokal RR, Rohlf FJ (1981) Biometry. San Francisco: Freeman.
49. Strahlendorf JC, Lee M, Netzeband JG, Strahlendorf HK (1988) Pentobarbital augments serotonin-mediated inhibition of cerebellar Purkinje cells. Neuroscience 27:107-115.
50. Ullmer C, Schmuck K, Figge A, Lubbert H (1998) Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett 424:63-68.