Alcohols and neurotransmitter gated ion channels: Past, present and future

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 3, 1997, Pages 267-282

  Lovinger, David M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT3 receptor; Ethanol; GABA(A) receptor; Glutamate receptors; Integral membrane proteins; Nicotinic Receptor; NMDA receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; CATION CHANNEL; GLUTAMATE RECEPTOR; ION CHANNEL; IONOTROPIC RECEPTOR; MEMBRANE PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER RECEPTOR; NICOTINIC RECEPTOR; PURINE P2X RECEPTOR; SEROTONIN 3 RECEPTOR;

ANESTHESIA; CHEMICAL STRUCTURE; DRUG MECHANISM; HUMAN; INTOXICATION; NONHUMAN; PROTEIN DOMAIN; REVIEW;

ANIMALS; ETHANOL; HUMANS; ION CHANNEL GATING; ION CHANNELS; LIGANDS; NEUROTRANSMITTER AGENTS; RECEPTORS, NEUROTRANSMITTER;

EID: 0030929015     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005051     Document Type: Review

References (173)

1. Abadji V, Raines DE, Dalton LA, Miller KW (1994) Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol. Biochim Biophys Acta 1194:25-34
2. - current in mouse hippocampal and cortical neurons. Eur J Pharmacol 187:127-130
3. Akabas MH, Kaufmann C, Archdeacon P, Karlin A (1994) Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit. Neuron 13:919-927
4. Akabas MH, Stauffer DA, Xu M, Karlin A (1995) Acetylcholine receptor channel structure probed in cysteine substitution mutants. Science 258:307-310
5. Allan AM, Harris RA (1986) Gamma-aminobutyric acid and alcohol actions: neurochemical studies of long sleep and short sleep mice. Life Sci 39:2005-2015
6. Altenbach C, Yang K, Farrens DL, Farahbakhsh ZT, Khorana HG, Hubbell WL (1996) Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: A site-directed spin-labeling study. Biochemstry 35:470-478
7. Barann M, Ruppert K, Göthert M, Bönisch H (1995) Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells. Naunyn-Schmiedeberg's Arch Pharmacol 352:149-156
8. Barnes JM, Henley JM (1992) Molecular characteristics of excitatory amino acid receptors. Prog Neurobiol 39:113-133
9. Bennett JA, Dingledine R (1995) Topology profile for a glutamate receptor: three transmembrane domains and a channel-lining reentrant membrane loop. Neuron 14:373-384
10. Bradley RJ, Peper K, Sterz R (1980) Post synaptic effects of ethanol at the frog neuromuscular junction. Nature 284:60-62
11. Bradley RJ, Sterz R, Peper K (1984) The effects of alcohols and diols at the nicotinic acetylcholine receptor of the neuromuscular junction. Brain Res 295:101-112
12. Briley MS, Changeux JP (1977) Isolation and purification of the nicotinic acetylcholine receptor and its functional reconstitution into a membrane environment. Internat Rev Neurobiol 20:31-63
13. Buller AL, Larson HC, Morrisett RA, Monaghan DT (1995) Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Mol Pharmacol 48:717-723
14. Celentano JJ, Gibbs TT, Farb DH (1988) Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons. Brain Res 455:377-380
15. Charnet P, Labarca C, Leonard RJ, Vogelaar J, Czyzyk L, Gouin A, Davidson N, Lester HA (1990) An open-channel blocker interacts with adjacent tunrs of alpha-helices in the nicotinic acetylcholine receptor. Neuron 4:87-95
16. Chu B, Anantharam V, Treistman SN (1995) Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators. J Neurochem 65:140-148
17. Couturier S, Bertrand D, Matter JM, Hernandez MC, Bertrand S, Millar N, Valera S, Barkas T, Ballivet M (1990) A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX. Neuron 5:847-856
18. Covarrubias M, Vyas TB, Escobar L, Wei A (1995) Alcohols inhibit a cloned potassium channel at a discrete saturable site. J Biol Chem 270:408-416
19. Czajkowski C, Karlin A (1995) Structure of the nicotinic receptor acetylcholine binding site - identification fo acidic residues in the δ subunit within 0.9 nm of the α subunit binding site disulfide. J Biol Chem 270:3160-3164
20. Dani JA (1993) Structure, diversity, and ionic permeability of neuronal and muscle acetylcholine receptors. EXS 66:47-59
21. Dani JA, Mayer ML (1995) Structure and function of glutamate and nicotinic acetylcholine receptors. Curr Opin Neurobiol 5:310-317
22. De Fiebre CM, Meyer EM (1996) The α7 neuronal nicotinic receptor subtype is inhibited by ethanol. Alcohol: Clin Exper Res 20:55A
23. Dennis M, Giraudat J, Kotzyba-Hibert F, Goeldner M, Hirth C, Chang JY, Lazure C, Chretien M, Changeux JP (1988) Amino acids of the Torpedo marmorata acetylcholine receptor subunit labeled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry 27:2346-2357
24. Devenyi P, Harrison ML (1985) Prevention of alcohol withdrawal seizures with oral diazepam loading. Can Med Assoc J 132:798-800
25. Deitrich RA, Dunwiddie TV, Harris RA, Erwin VG (1989) Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev 41:489-537
26. 2+ in dissociated brain cells. Brain Res 499:383-387
27. Dildy-Mayfield JE, Harris RA (1992a) Acute and chronic ethanol alters the function of hippocampal kainate receptors expressed in Xenopus oocytes. J Neurochem 58:1569-1572
28. Dildy-Mayfield JE, Harris RA (1992b) Comparison of ethanol sensitivity of rat brain kainate, DL-a-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 262:487-494
29. Dildy-Mayfield JE, Harris RA, (1995) Ethanol inhibits kainate responses of glutamate receptors expressed in Xenopus oocytes: role of calcium and protein kinase C. J Neurosci 15:3162-3171
30. A and glutamate receptors: relation to in vivo effects. Br J Pharmacol 118:378-384
31. Dilger JP, Brett RS (1991) Actions of volatile anesthetics and alcohols on cholinergic receptor. In: Rubin E. Miller KW, Roth SR (eds) Molecular and cellular mechanisms of alcohol and anesthetics. Ann NY Acad Sci 625:616-627
32. 3 R-A subunit expressed in Xenopus laevis oocytes. Neuropharmacology 33:473-482
33. 3 receptors. Br J Pharmacol 114:1641-1651
34. Eisele J-L, Bertrand S, Galzi J-L, Devillers-Thiery A, Changeux J-P, Bertrand D (1993) Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature 366:479-483
35. 3 receptor-activated current. Soc Neurosci Abstr 20:1127
36. - channels in rat bipolar cells. Nature 361:159-162
37. Fink K, Göthert M (1996) Both ethanol and ifenprodil inhibit NMDA-evoked release of various neurotransmitters at different, yet proportional potency: potential relation to NMDA receptor subunit composition. Naunyn-Schmiedeberg's Arch Pharmacol 353:1-8
38. Firestone LL, Sauter J-F, Braswell LM, Miller KW (1986) Actions of general anesthetics on acetylcholine receptor-rich membranes from Torpedo californica. Anesthesiology 64:694-702
39. Forman SA, Righi DL, Miller KW (1989) Ethanol increases agoinst affinity for nicotinic receptors from Torpedo. Biochim Biophys Acta 987:95-103
40. Forman SA, Miller KW, Yellen G (1995) A discrete site for general anesthetics on a postsynaptic receptor. Mol Pharmacol 48:574-581
41. Franks NP, Lieb WR (1985) Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects. Nature 316:349-351
42. Franks NP, Lieb WR (1994) Molecular and cellular mechanisms of general anaesthesia. Nature 367:607-614
43. Galzi JL, Revah F, Black D, Goeldner M, Hirth C, Changeux J-P (1990) Identification of a novel amino acid α-Tyr93 within the active site of the acetylcholine receptor by photoaffinity labelling: additional evidence for a three loop model of the acetylcholine binding site. J Biol Chem 265:430-437
44. Galzi JL, Revah F, Bessis A, Changeux JP (1991) Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain. Ann Rev Pharmacol Toxicol 31:37-72
45. Galzi JL, Devillers-Thiery A, Hussy N, Bertrand S, Changeux JP (1992) Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature 359:500-505
46. Galzi JL, Changeux JP (1995) Neuronal nicotinic receptors: molecular organization and regulations. Neuropharmacology 34:563-582
47. Gage PW, McBurney RN, Schneider GT (1975) Effects of some aliphatic alcohols on the conduction change caused by a quantum of acetylcholine at the toad end-plate. J Physiol (Lond) 244:409-429
48. Goldstein DB (1986) Effect of alcohol on cellular membranes. Ann Emer Med 15:1013-1018
49. Gonzales RA, Hoffman PL (1991) Receptor-gated ion channels may be selective CNS targets for ethanol. Trends Pharmacol Sci 12:1-3
50. Gopalakrishnan M, Buisson B, Tourna E, Giordano, T, Campbell, JE, Hu IC, Donnelly-Roberts D, Arneric SP, Bertrand D, Sullivan JP (1995) Stable expression and pharmacological properties of the human α7 nicotinic acetylcholine receptor. Eur J Pharmacol Mol Pharmacol Sect 290:237-246
51. Göthert M, Fink K (1989) Inhibition of N-methyl-D-aspartate (-NMDA)-and 1-glutamate-induced noradrenaline and acetylcholine release in the rat brain by EtOH. Naunyn Sehmiedeberg's Arch Pharmacol 340:516-521
52. Göthert M, Thielecke G (1976) Inhbition by ethanol of noradrenaline output from peripheral sympathetic nerves: possible interaction of ethanol with neuronal receptor. Eur J Pharmacol 37:321-328
53. Green T, Stauffer KA, Lummis SCR (1995) Expression of recombinant homo-oligomeric 5-hydroxytryptamine3 receptors provides new insights into their maturation and structure. J Biol Chem 270:6056-6061
54. A responses in cells stably transfected with receptor subunits. Alcohol Clin Exp Res 19:226-232
55. Harrison NL, Kugler JL, Jones MV, Greenblat EP, Pritchett DB (1993) Positive modulation of human γ-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane. Mol Pharmacol 44:628-632
56. 3 receptors in NCB-20 cells and in rat cerebral membranes. Alcohol Clin Exp Res 15:775-778
57. Hoffman PL, Rabe CS, Moses F, Tabakoff B (1989) N-methyl-D-aspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production. J Neurochem 52:1937-1940
58. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Ann Rev Neurosci 17:31-108
59. Hollmann M, O'Shea-Greenfield A, Rogers SW, Heinemann S (1989) Cloning by functional expression of a member of the glutamate receptor family. Nature 342:643-648
60. Hollmann M, Maron C, Heinemann S (1994) N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 13:1331-1343
61. 3 receptor A subunit. Eur J Pharmacol 245:187-192
62. Hubbell WL, Altenbach C (1994) Site directed spin-labeling of membrane proteins. In: White S (ed) Membrane protein structure: experimental approaches. Oxford Press, Oxford, pp 224-248
63. Hucho F, Layer P, Kiefer HR, Bandini G (1976) Photoaffinity labeling and quaternary structure of the acetylcholine receptor from Torpedo californica. Proc Natl Acad Sci USA 73:2624-2628
64. Hucho F, Gorne-Tschelnokow U, Strecker A (1994) Beta-structure in the membrane-spanning part of the nicotinic acetylcholine receptor (or how helical are transmembrane helices?). Trends Biochem Sci 19:383-387
65. Hucho F, Tsetlin VI, Machold J (1996) The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor. Eur J Biochem 239:539-557
66. Hughes TE (1995) Transmembrane topology of the glutamate receptors. A tale of novel twists and turns. J Mol Neurosci 5:211-217
67. Imoto K, Busch C, Sakmann B, Mishina M, Konno T, Nakai J, Bujo H, Mori Y, Fukuda K, Numa S (1988) Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature 335:645-648
68. 3 receptor blockade: A preliminary study in healthy male volunteers. Psychopharmacology 112:142-144
69. Karlin A (1993) Structure of nicotinic acetylcholine receptors. Curr Opin Neurobiol 3:299-309
70. A/benzodiazepine receptor from rat cerebellum. J Neurochem 63:371-374
71. Kofuji P, Wang J.B, Moss SJ, Huganir RL, Burt DR (1991) Generation of two forms of the γ-aminobutyric acid receptorA γ2-subunit in mice by alternative splicing. J Neurochem 56:713-715
72. Koltchine V, Anantharam V, Wilson A, Bayley H, Treistman SN (1993) Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol. Neurosci Lett 152:13-16
73. Konno T, Busch C, Von Kitzing E, Imoto K, Wang F, Nakai J, Mishina M, Numa S, Sakmann B (1991) Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel. Proc Royal Soc Lond - Biol Sci 244:69-79
74. Kuner T, Schoepfer R, Korpi ER (1993) Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. Neuroreport 5:297-300
75. Kuryatove A, Laube B, Betz H, Kuhse J (1994) Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding site proteins. Neuron 12:1291-1300
76. Kusama T, Wang T-L, Guggino WB, Cutting GR, Uhl GR (1993) GABA ρ2 receptor pharmacological profile: GABA recognition site similarities to ρ1. Eur J Pharmacol 245:83-84
77. Kuusinen A, Arvola M, Keinänen K (1995) Molecular dissection of the agonist binding site of an AMPA receptor. EMBO J 14:6327-6332
78. Labarca C, Nowak MW, Zhang H, Tang L, Deshpande P, Lester HA (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376:514-516
79. Lal R, Yu L (1993) Atomic force microscopy of cloned nicotinic acetylcholine receptor expressed in Xenopus oocytes. Proc Natl Acad Sci USA 90:7280-7284
80. A receptor function: molecular and physiological determinants. Adv Biochem Psychopharmacol 47:269-279
81. Leonard RJ, Labarca CQ Charnet P, Davidson N, Lester HA (1988) Evidence that the membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science 242:1578-1581
82. Li C, Peoples RW, Weight FF (1994) Alcohol action on a neuronal membrane receptor: Evidence for a direct interaction with the receptor protein. Proc Natl Acad Sci 91:8200-8204
83. Lima-Landman MTR, Albuquerque EX (1989) Ethanol potentiates and blocks NMDA-activated single-channel currents in rat hippocampal pyramidal cells. FEBS Lett 247:61-67
84. Lindstrom J (1995) Nicotinic acetylcholine receptors. In: North RA (ed) Handbook of receptors and channels: ligand- and voltage-gated ion channels. CRC Press, Boca Raton, pp 153-175
85. Liu Y, Dilger JP, Vidai AM (1994) Effects of alcohols and volatile anesthetics on the activation of nicotinic acetylcholine receptor channels. Mol Pharmacol 45:1235-1241
86. 3 receptor-mediated ion current in NCB-20 neuroblastoma cells. Neurosci Lett 122:54-56
87. Lovinger DM (1993) High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells. Neurosci Lett 159:83-87
88. Lovinger DM (1995) Developmental decrease in ethanol sensitivity of NMDA receptors on cortical neurons: Relation to the actions of ifenprodil. J Pharmacol Exp Ther 274:164-172
89. Lovinger DM (1996) Ethanol and the NMDA Receptor. In: Soyka M (ed) Acamprosate in relapse prevention of alcoholism. Springer, Berlin, pp 1-26
90. 3 receptors. In: Alling C, Diamond I, Leslie SW, Sun GY, Wood WG (eds) Alcohol, cell membranes and signal transduction in brain. Plenum Press, New York pp 157-168
91. 3 receptor-mediated ion current in neuroblastoma cells and adult mammalian neurons. Mol Pharmacol 40:263-270
92. 3 receptor-mediated ion current in nodose ganglion neurons from adult rat. J Pharmacol Exper Therap 264:1097-1103
93. 3RA receptors expressed in a mammalian cell line. Neuropharmacology 33:1567-1572
94. Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243:1721-1724
95. Lovinger DM, White G, Weight FF (1990) NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J Neurosci 10:1372-1379
96. A receptors in hippocampal neurons. J Pharmacol Exp Therap 264:1097-1103
97. Luetje CW, Piattoni M, Patrick J (1993) Mapping of ligand binding sites of neuronal nicotinic acetylcholine receptors using chimeric alpha subunits. Mol Pharmacol 44:657-666
98. Machu TK, Harris RA (1994) Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes. J Pharmacol Exp Therap 271:898-905
99. A receptor. J Neurochem 61:375-377
100. 3 receptor, a serotonin-gated ion channel. Science 254:432-437
101. Martin M, Czajkowski C, Karlin A (1996) The contributions of aspartyl residues in the acetylcholine receptor gamma and delta subunits to the binding of agonists and competitive antagonists. J Biol Chem 271:13497-13503
102. Marszalec W, Kurata Y, Hamilton BJ, Carter DB, Narahashi T (1994) Selective effects of alcohols on gamma-aminobutyric acid A receptor subunits expressed in human embryonic kidney cells. J Pharmacol Exp Ther 269:157-163
103. Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR, Harris RA (1996) A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors. Mol Pharmacol 50:402-406
104. Masood K, Wu C, Brauneis U, Weight FF (1994) Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol Pharmacol 45:324-329
105. Mehta AK, Ticku MK (1988) Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves g-aminobutyric acidA-gated chloride channels. J Pharmacol Exp Ther 246:558-564
106. Meyer H (1901) Zur theorie der alkolnarkose der einfluss wechselnder temperatur auf wirkungsstarke und theilungscoefficient der narcotica. Naunyn-Schmiedeberg's Arch Exp Pathol Pharmacol 46:338-346
107. Mihic SJ, Harris RA (1996) Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics. J Pharmacol Exp Ther 277:411-416
108. A receptor-mediated currents: lack of subunit specificity. Eur J Pharmacol 268:209-214
109. Miller KW (1993) Multiple actions of ethanol on acetylcholine receptors. In: Alling C, Diamond I, Leslie SW, Sun GY, Wood WG (eds) Alcohol, cell membranes, and signal transduction in brain. Plenum, New York, pp 83-96
110. Mirshahi T, Woodward JJ (1995) Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg2+-insensitive mutants. Neuropharmacology 34:347-355
111. Moriyoshi K, Masayuki M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354:31-37
112. Middleton RE, Cohen JB (1991) Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label. Biochemistry 30:6987-6997
113. Mishina M, Tobimatsu T, Imoto K, Tanaka K, Fujita Y, Fukuda K, Kurasaki M, Takahashi H, Morimoto Y, Hirose T, Inayama S, Takahashi T, Kuno M, Numa S. (1985) Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis. Nature 313:364-369
114. Mullins LJ (1954) Some physical mechanisms of narcosis. Chem Rev 54:289-323
115. Murrell RD, Haydon DA (1991) Actions of n-alcohols on nicotinic receptor ion channels in cultured rat muscle cells. In: Rubin, E, Miller, KW and Roth, SH (eds) Molecular and cellular mechanisms of alcohol and anesthetics. Ann NY Acad Sci 625:365-374
116. Nakahiro M, Arakawa O, Narahashi T (1991) Modulation of gamma-aminobutyric acid receptor-channel complex by alcohols. J Pharmacol Exp Ther 259:235-240
117. Nakanishi S (1994) The molecular diversity of glutamate receptors. Prog Clin Biol Res 390:85-98
118. A receptor determined by electron microscopic image analysis. J Neurochem 62:815-818
119. North RA (1996) Families of ion channels with two hydrophobic segments. Curr Opin Cell Biol 8:474-483
120. O'Hara PJ, Sheppard PO, Thogersen H, Venezia D, Haldeman BA, McGrane V, Houamed KM, Thomsen C, Gilbert TL, Mulvihill ER (1993) The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 11:41-52
121. Okada K (1967) Effects of alcohols and acetone on the neuromuscular junction of frog. Jpn J Physiol 17:245-261
122. Overton E (1896) Uber die osmotischem eigenschaften der zelle in ihrer betdeurtung dur die toxikologie und pharmakolgie. Z Physikal Chem 22:189-209
123. Patrick J, Sequela P, Vernino S, Amador M, Luetje C, Dani JA (1993) Functional diversity of neuronal nicotinic acetylcholine receptors. Prog Brain Res 98:113-120
124. Peoples RW, Weight FF (1992) Ethanol inhibition of N-methyl-D-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine. Brain Res 571:342-344
125. Peoples RW, Weight FF (1994) Trichloroethanol potentiation of gamma-aminobutyric acid-activated chloride current in mouse hippocampal neurones. Br J Pharmacol 113:555-563
126. Peoples RW, Weight FF (1995) Cutoff in potency implicates alcohol inhibition of N-methyl-D-aspartate receptors in alcohol intoxication. Proc Natl Acad Sci, USA 92:2825-2829
127. Pettinati HM (1996) Use of serotonin selective pharmacotherapy in the treatment of alcohol dependence. Alcohol Clin Exper Res 20:23A-29A
128. Popp RL, Lickteig RL, Browning MD, Lovinger DM (1996) NMDA receptor subunit composition and EtOH sensitivity in primary neuronal cultures. Soc Neurosci Abstr 22:470
129. A receptor subunit for benzodiazepine pharmacology. Nature 338:582-585
130. Puchacz E, Buisson B, Bertrand D, Lukas RJ (1994) Functional expression of nicotinic acetylcholine receptors containing rat α7 subunits in human Sh-SY5Y neuroblastoma cell. FEBS Lett 354:155-159
131. Rabe CS, Tabakoff B (1990) Glycine site-directed agonists reverse the action of ethanol at the N-methyl-D-aspartate receptor. Mol Pharmacol 38:753-757
132. Raines DE, Rankin SE, Miller KW (1995) General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations. Anesthesiology 82:276-287
133. Revah F, Bertrand D, Galzi J-L, Devillers-Thiery A, Mulle C, Hussy N, Bertrand S, Balliver M, Changeux J-P (1991) Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature 353:846-849
134. Roche KW, Raymond LA, Blackstone C, Huganir RL (1994) Transmembrane topology of the glutamate receptor subunit GluR6. J Biol Chem 269:11679-11682
135. A receptor complex from rat cerebral cortex and hippocampus. Mol Brain Res 25:225-233
136. Samson HH, Harris RA (1992) Neurobiology of alcohol abuse. Trends Pharmacol Sci 13:206-211
137. Sanna E, Harris RA (1993) Recent developments in alcoholism: neuronal ion channels. Recent Dev Alcohol 11:169-186
138. Schoepfer R, Conroy WG, Whiting P, Gore M, Lindstrom J (1990) Brain α-bungarotoxin-binding protein cDNAs and mAbs reveal subtypes of this branch of the ligand-gated ion channel superfamily. Neuron 5:35-48
139. Schoepfer R, Monyer H, Sommer B, Wisden W, Sprengel R, Kuner T, Lomeli H, Herb A, Kohler M, Burnashev N, et al. (1994) Molecular biology of glutamate receptors. Prog Neurobiol 42:353-357
140. Seguela P, Haghighi A, Soghomonian JJ, Cooper E (1996) A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. J Neurosci 16:448-455
141. Seeburg PH (1993) The molecular biology of mammalian glutamate receptor channels. Trends Pharmacol Sci 14:297-302
142. Sellers EM, Naranjo CA, Harrison M, Devenyi P, Roach C, Sykori K (1983) Diazepam loading: simplified treatment of alcohol withdrawal. Clin Pharmacol Ther 34:822-826
143. 3 antagonist ondansetron in alcohol abuse and dependence. Alcohol Clin Exper Res 18:879-885
144. Sheng M, Cummings J, Roldan LA, Jan YN, Jan LY (1994) Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368:144-147
145. Shimada S, Cutting G, Uhl GR (1992) γ-Aminobutyric acid A or C receptor? γ-Aminobutyric acid ρ1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-inesnsitive γ-aminobutyric acid responses in Xenopus oocytes. Mol Pharmacol 41:683-687
146. A receptor function and ethanol. FEBS Lett 324:140-142
147. Simson PE, Criswell HE, Johnson KB, Hicks RE, Breese GR (1991) Ethanol inhibits NMDA-evoked electrophysiological activity in vivo. J Pharmacol Exp Ther 257:225-231
148. Sine SM, Kreienkamp H-J, Bren N, Maeda R, Taylor P (1995) Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine α-conotoxin M1 selectivity. Neuron 15:205-211
149. Slater SJ, Cox KJA, Lombardi JV, Ho C, Kelly MB, Rubin E, Stubbs CD (1993) Inhibition of protein kinase C by alcohols and anaesthetics. Nature 364:82-84
150. Snell LD, Tabakoff B, Hoffman PL (1994) Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells. Alcohol: Clin Exp Res 18:81-85
151. Stern-Bach Y, Bettler B, Hartley M, Sheppard PO, O'Hara PJ, Heinemann SF (1994) Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid binding proteins. Neuron 13:1345-1357
152. - transport in rat brain synaptoneurosomes Proc Natl Acad Sci USA 83:4071-4075
153. 2X receptors bring new structure to ligand-galed ion channels. Trends Neurosci 18:224-229
154. Tabakoff B, Hoffman PL (1995) Effect of alcohol on neurotransmitters and their receptors and enzymes. In: Begleiter H, Kissin B (eds) Alcohol and alcoholism, vol 2. Oxford University Press, New York
155. Unwin N (1993) Nicotinic acetylcholine receptor at 9 Å Resolution. J Mol Biol 229:1101-1124
156. Unwin N (1995) Acetylcholine receptor channel imaged in the open state. Nature 373:37-41
157. Villarroel A, Herlitze S, Koenen M, Sakmann B (1991) Location of a threonine residue in the alpha-suhunit M2 transmembrane segment that determines the ion flow through the acetylcholine receptor channel. Proc Royal Soc Lond - Biol Sci 243:69-74
158. A receptors expressed in Xenopus oocytes. Science 249:291-293
159. A receptor expressed in Xenopus oocytes requires 8 amino acids contained in the γ2L subunit. Neuron 7:27-33
160. A receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit. FEBS Lett 313:113-117
161. Whiting PJ, McKernan RM, Iversen LL (1990) Another mechanism for creating diversity in γ-aminobutyrate type A receptors: RNA splicing directs expression of two forms of γ2 subunit, one of which contains a protein kinase C phosphorylation site. Proc Natl Acad Sci USA 87:9966-9970
162. White G, Lovinger DM, Weight FF (1990) Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron. Brain Res 507:332-336
163. Wick MJ, Harrison NL, Mihic SJ, Ye O, Finn SE, Bhave S, Harris RA (1996) A search for sites of action of alcohols on GABA and glycine receptors. Soc Neurosci Abstr 22: 1290
164. Wo ZG, Oswald RE (1994) Transmembrane topology of two kainate receptor subunits revealed by N-glycosylation. Proc Natl Acad Sci USA 91:7154-7158
165. Wood SC, Tonner PH, Armendi AJ, Bugge B, Miller KW (1995) Channel inhibition by alkanols occurs at a binding site on the nicotinic acetylcholine receptor. Mol Pharmacol 47:121-130
166. Woodward JJ, Gonzales RA (1990) Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from rat striatal slices: reversal by glycine. J Neurochem 54:712-715
167. Wright JM, Weight FF (1992) Effects of ethanol on NMDA receptor channels in single channel recordings. Soc Neurosci Abstr 18:257
168. Wu G, Tonner PH, Miller KW (1994) Ethanol stabilizes the open channel state ot the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol 45:102-108
169. Yang X, Criswell HE, Simson P, Moy S, Breese GR (1996a) Evidence for a selective effect of ethanol on N-methyl-d-aspartate responses: ethanol affects a subtype of the ifenprodil-sensitive N-melhyl-d-aspartate receptors. J Pharmacol Exp Ther 278:114-124
170. Yang K, Farrens DL, Hubbell WL, Khorna HG (1996b) Structure and function in rhodopsin. Single cysteine substitution mutants in the cytoplasmic interhelical E-F loop region show position-specific effects in transducin activation Biochemistry 35:464-469
171. Zhang L, Yu DH, Changuex J-P, Weight FF (1996) N-terminal domain mediates alcohol action on a neurotransmitter receptor. Alcohol: Clin Exp Res 20:9A
172. 3 receptors in NCB-20 cells. Alcohol: Clin Exp Res 20:57A
173. 3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells. J Pharmacol Exp Ther 278:732-740