Molecular mechanisms of drug addiction

Neuropharmacology

Volumn 47, Issue SUPPL. 1, 2004, Pages 24-32

  Nestler, Eric J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

8710; Cocaine; CREB; Drug abuse; FosB; Opiates

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN DEPENDENT KINASE 5 INHIBITOR; ENZYME INHIBITOR; PROTEIN FOS; PROTEIN FOSB DELTA; ROSCOVITINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

BRAIN REGION; DRIVE; DRUG ABUSE; DRUG DEPENDENCE; DRUG EXPOSURE; DRUG TOLERANCE; DRUG WITHDRAWAL; EMOTION; GENE EXPRESSION; GENE TARGETING; HUMAN; MEDICAL RESEARCH; MOLECULAR DYNAMICS; NONHUMAN; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL; REVIEW; REWARD;

EID: 4644365351     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2004.06.031     Document Type: Article

References (61)

1. Ang E., Chen J.S., Zagouras P., Magna H., Holland J., Schaeffer E., Nestler E.J. Induction of NFκB in nucleus accumbens by chronic cocaine administration. J. Neurochem. 79:2001;221-224
2. Baker D.A., McFarland K., Lake R.W., Shen H., Tang X.C., Toda S., Kalivas P.W. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat. Neurosci. 6:2003;743-749
3. Barrot M., Olivier J.D.A., Perrotti L.I., Impey S., Storm D.R., Neve R.L., Zachariou V., Nestler E.J. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc. Natl. Acad. Sci. USA. 99:2002;11435-11440
4. Berke J.D., Hyman S.E. Addiction, dopamine, and the mole cular mechanisms of memory. Neuron. 25:2000;515-532
5. Bibb J.A., Chen J.S., Taylor J.R., Svenningsson P., Nishi A., Snyder G.L., Yan Z., Sagawa Z.K., Ouimet C.C., Nairn A.C., Nestler E.J., Greengard P. Cdk5 regulates action of chronic cocaine. Nature. 410:2001;376-380
6. Carle T., Ulery P.G., Nestler E.J. Absence of conserved Fos family C-terminal domain in ΔFosB may contribute to its unique stability. Soc. Neurosci. Abs. 29:2003;856
7. Carlezon W.A. Jr, Thome J., Olson V.G., Lane-Ladd S.B., Brodkin E.S., Hiroi N., Duman R.S., Neve R.L., Nestler E.J. Regulation of cocaine reward by CREB. Science. 282:1998;2272-2275
8. Chao J.R., Ni Y.G., Bolanos C.A., Chen J.S., Rahman Z., DiLeone R.J., Olson V.G., Nestler E.J. Characterization of the mouse adenylyl cyclase type VIII gene promoter: regulation by cAMP and CREB. Eur. J. Neurosci. 16:2002;1284-1294
9. Chen J.S., Nye H.E., Kelz M.B., Hiroi N., Nakabeppu Y., Hope B.T., Nestler E.J. Regulation of ΔFosB and FosB-like proteins by electroconvulsive seizure (ECS) and cocaine treatments. Mol. Pharmacol. 48:1995;880-889
10. Chen J., Kelz M.B., Hope B.T., Nakabeppu Y., Nestler E.J. Chronic FRAs: stable variants of ΔFosB induced in brain by chronic treatments. J. Neurosci. 17:1997;4933-4941
11. Chen J.S., Zhang Y.J., Kelz M.B., Steffen C., Ang E.S., Zeng L., Nestler E.J. Induction of cyclin-dependent kinase 5 in hippocampus by chronic electroconvulsive seizures: role of ΔFosB. J. Neurosci. 20:2000;8965-8971
12. Colby C.R., Whisler K., Steffen C., Nestler E.J., Self D.W. ΔFosB enhances incentive for cocaine. J. Neurosci. 23:2003;2488-2493
13. Cole R.L., Konradi C., Douglass J., Hyman S.E. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron. 14:1995;813-823
14. Ehrlich M.E., Sommer J., Canas E., Unterwald E.M. Periadolescent mice show enhanced DeltaFosB upregulation in response to cocaine and amphetamine. J. Neurosci. 22:2002;9155-9159
15. Georgescu D., Zachariou V., Barrot M., Mieda M., Willie J.T., Eisch A.J., Yanagisawa M., Nestler E.J., DiLeone R.J. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J. Neurosci. 23:2003;3106-3111
16. Graybiel A.M., Moratalla R., Robertson H.A. Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proc. Natl. Acad. Sci. USA. 87:1990;6912-6916
17. Guitart X., Thompson M.A., Mirante C.K., Greenberg M.E., Nestler E.J. Regulation of CREB phosphorylation by acute and chronic morphine in the rat locus coeruleus. J. Neurochem. 58:1992;1168-1171
18. Hiroi N., Brown J., Haile C., Ye H., Greenberg M.E., Nestler E.J. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc. Natl. Acad. Sci. USA. 94:1997;10397-10402
19. Hope B.T., Nye H.E., Kelz M.B., Self D.W., Iadarola M.J., Nakabeppu Y., Duman R.S., Nestler E.J. Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron. 13:1994;1235-1244
20. Hyman S.E., Malenka R.C. Addiction and the brain: the neurobiology of compulsion and its persistence. Nat. Rev. Neurosci. 2:2001;695-703
21. Jentsch J.D., Olausson P., Nestler E.J., Taylor J.R. Stimulation of protein kinase A activity in the rat amygdala enhances reward-related learning. Biol. Psychiatry. 52:2002;111-118
22. Josselyn S.A., Shi C.J., Carlezon W.A. Jr., Neve R.L., Nestler E.J., Davis M. Long-term memory is facilitated by CREB overexpression in the amygdala. J. Neurosci. 21:2001;2404-2412
23. Kelz M.B., Chen J.S., Carlezon W.A., Whisler K., Gilden L., Beckmann A.M., Steffen C., Zhang Y.-J., Marotti L., Self D.W., Tkatch R., Baranauskas G., Surmeier D.J., Neve R.L., Duman R.S., Picciotto M.R., Nestler E.J. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature. 401:1999;272-276
24. Koob G.F., Maldonado R., Stimus L. Neural substrates of opiate withdrawal. Trends Neurosci. 15:1992;186-191
25. Lane-Ladd S.B., Pineda J., Boundy V., Pfeuffer T., Krupinski J., Aghajanian G.K., Nestler E.J. CREB (cAMP response element binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. J. Neurosci. 17:1997;7890-7901
26. Mackler S.A., Homan Y.X., Korutla L., Conti A.C., Blendy J.A. The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and zinc finger protein, is regulated by AP1. Neuroscience. 121:2003;355-361
27. Maldonado R., Blendy J.A., Tzavara E., Gass P., Roques B.P., Hanoune J., Schutz G. Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science. 273:1996;657-659
28. Mayr B., Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2:2001;599-609
29. McClung C.A., Nestler E.J. Regulation of gene expression and cocaine reward by CREB and ΔFosB. Nat. Neurosci. 6:2003;1208-1215
30. Moratalla R., Elibol B., Vallejo M., Graybiel A.M. Network-level changes in expression of inducible Fos-Jun proteins in the striatum during chronic cocaine treatment and withdrawal. Neuron. 17:1996;147-156
31. Morgan J.I., Curran T. Immediate-early genes: ten years on. Trends Neurosci. 18:1995;66-67
32. Nestler E.J. Molecular basis of long-lived neural plasticity to drugs of abuse. Nat. Rev. Neurosci. 2:2001a;119-128
33. Nestler E.J. Molecular neurobiology of addiction. Am. J. Addict. 201:2001b;201-217
34. Nestler E.J., Aghajanian G.K. Molecular and cellular basis of addiction. Science. 278:1997;58-63
35. Nestler E.J., Hope B.T., Widnell K.L. Drug addiction: a model for the molecular basis of neural plasticity. Neuron. 11:1993;995-1006
36. Nestler E.J., Hyman S.E., Malenka R.C. Molecular Basis of Neuropharmacology. 2001a;McGraw-Hill, New York
37. Nestler E.J., Barrot M., Self D.W. ΔFosB: a molecular switch for addiction. Proc. Natl. Acad. Sci. USA. 98:2001b;11042-11046
38. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., Monteggia L.M. Neurobiology of depression. Neuron. 34:2002;13-25
39. Newton S.S., Thome J., Wallace T., Shirayama Y., Dow A., Schlesinger L., Duman C.H., Sakai N., Chen J.S., Neve R., Nestler E.J., Duman R.S. Inhibition of CREB or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J. Neurosci. 22:2002;10883-10890
40. Norrholm S.D., Bibb J.A., Nestler E.J., Ouimet C.C., Taylor J.R., Greengard P. Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of the neuronal kinase Cdk5. Neuroscience. 116:2003;19-22
41. O'Donovan K.J., Tourtellotte W.G., Millbrandt J., Baraban J.M. The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience. Trends Neurosci. 22:1999;167-173
42. Olausson P., Jentsch J.D., Nestler E.J., Taylor J.R. Enhanced incentive motivation for food in ΔFosB overexpressing mice. Soc. Neurosci. Abs. 28:2002;502
43. Olson V.G., Wolf D., Russell D., Hughes T., Neve R.L., Nestler E.J. Regulation of drug reward by CREB in ventral midbrain. Soc. Neurosci. Abs. 27:2001;977
44. Peakman M.C., Colby C., Perrotti L.I., Tekumalla P., Carle T., Ulery P., Chao J., Duman C., Steffen C., Monteggia L., Allen M.R., Stock J.L., Duman R.S., McNeish J.D., Barrot M., Self D.W., Nestler E.J., Schaeffer E. Inducible, brain region specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res. 970:2003;73-86
45. Pliakas A.M., Carlson R.R., Neve R.L., Konradi C., Nestler E.J., Carlezon W.A. Jr. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated CREB expression in the nucleus accumbens. J. Neurosci. 21:2001;7397-7403
46. Robinson T.E., Kolb B. Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J. Neurosci. 17:1997;8491-8497
47. Sakai N., Thome J., Chen J.S., Kelz M.B., Steffen C., Nestler E.J., Duman R.S. Inducible and brain region specific CREB transgenic mice. Mol. Pharmacol. 61:2002;1453-1464
48. Shaw-Lutchman T.Z., Barrot M., Wallace T., Gilden L., Zachariou V., Impey S., Duman R.S., Storm D., Nestler E.J. Regional and cellular mapping of CRE-mediated transcription during naltrexone-precipitated morphine withdrawal. J. Neurosci. 22:2002;3663-3672
49. Shaw-Lutchman S.Z., Impey S., Storm D., Nestler E.J. Regulation of CRE-mediated transcription in mouse brain by amphetamine. Synapse. 48:2003;10-17
50. Shaywitz A.J., Greenberg M.E. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68:1999;821-861
51. Shippenberg T.S., Rea W. Sensitization to the behavioral effects of cocaine: modulation by dynorphin and kappa-opioid receptor agonists. Pharmacol. Biochem. Behav. 57:1997;449-455
52. Thomas M.J., Beurrier C., Bonci A., Malenka R.C. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nat. Neurosci. 4:2001;1217-1223
53. Ulery P.G., Carle T., Nestler E.J. Role of phosphorylation on ΔFosB protein stability. Soc. Neurosci. Abs. 29:2003;777
54. Walters C.L., Blendy J.A. Different requirements for cAMP response element binding protein in positive and negative reinforcing properties of drugs of abuse. J. Neurosci. 21:2001;9438-9444
55. Walters C.L., Kuo Y.C., Blendy J.A. Differential distribution of CREB in the mesolimbic dopamine reward pathway. J. Neurochem. 87:2003;1237-1244
56. Werme M., Messer C., Olson L., Gilden L., Thorén P., Nestler E.J., Brené S. ΔFosB regulates wheel running. J. Neurosci. 22:2002;8133-8138
57. White F.J., Hu X.T., Zhang X.-F., Wolf M.E. Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system. J. Pharmacol. Exp. Ther. 273:1995;445-454
58. Williams J.T., Christie M.J., Manzoni O. Cellular and synaptic adaptations mediating opioid dependence. Physiol. Rev. 81:2001;299-343
59. Young S.T., Porrino L.J., Iadarola M.J. Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. Proc. Natl. Acad. Sci. USA. 88:1991;1291-1295
60. Yao W.D., Gainetdinov R.R., Arbuckle M.I., Sotnikova T.D., Cyr M., Beaulieu J.M., Torres G.E., Grant S.G., Caron M.G. Identification of PSD-95 as a regulator of dop amine-mediated synaptic and behavioral plasticity. Neuron. 41:2004;625-638
61. Zachariou V., Berton O., Perrotti L.I., Nestler E.J. ΔFosB in the nucleus accumbens modulates morphine reward, tolerance, and dependence. Soc. Neurosci. Abs. 29:2003;112