Modulating Protein Kinase C

Advances in Pharmacology

Volumn 44, Issue C, 1998, Pages 91-145

  Mochly Rosen, Daria ^a   Kauvar, Lawrence M ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Terrapin Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 27644504484     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60126-X     Document Type: Article

References (301)

1. Acs G., Lee J., Marquez V.E., Wang S., Milne G.W.A., Du L., Lewin N.E., and Blumberg P.M. Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids. J. Neurochem. 65 (1995) 301-308
2. Acs P., Szallasi Z., Kazanietz M.G., and Blumberg P.M. Differential activation of PKC isozymes by 14-3-3ζ protein. Biochem. Biophys. Res. Commum. 216 (1995) 103-109
3. Aitken A., Howell S., Jones D., Madrazo J., Martin H., Patel Y., and Robinson K. Post-translationally modified 14-3-3 isoforms and inhibition of protein kinase C. Mol. Cell. Biochem. 149/150 (1995) 41-49
4. Akimoto K., Mizuno K., Osada S., Hirai S., Tanuma S., Suzuki K., and Ohno S. A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J. Biol. Chem. 269 (1994) 12677-12683
5. Akimoto K., Takahashi R., Moriya S., Nishioka N., Takayanagi J., Kimura K., Fukui Y., Osada S., Mizuno K., Hirai S., Kazlauskas A., and Ohno S. EGF or PDGF receptors activate atypical PKC-lambdathrough phosphatidylinositol 3-kinase. EMBO J. 15 (1996) 788-798
6. Alessi D.R. The protein kinase C inhibitors Ro 31-8220 and GF-109203X are equally potent inhibitors of MAPKAP kinase-lb (Rsk-2) and p70 S6 kinase. FEBS Lett. 402 (1997) 121-123
7. Alexander D.R., Hexham J.M., Lucas S.C., Graves J.D., Cantrell D.A., and Crumpton M.J. A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes. Biochem. J. 260 (1989) 893-901
8. Alkan S.S., Rutschmann S., Grogg D., and Erb P. Effects of a new protein kinase C inhibitor CGP 41251 on T cell functions: Inhibition of activation, growth, and target cell killing. Cell. Immunol. 150 (1993) 137-148
9. Amano M., Mukai H., Ono Y., Chihara K., Matsui T., Hamajima Y., Okawa K., Iwamatsu A., and Kaibuchi K. Identification of a putative target for Rho as the serinethreonine kinase protein kinase N. Science 271 (1996) 648-650
10. Atkinson M.R., Kamberov E.S., Weiss R.L., and Ninfa A.J. Reversible uridylylation of the Escherichia coli PII signal transduction protein regulates its ability to stimulate the dephosphorylation of the transcription factor nitrogen regulator I (NRI or NtrC). J. Biol. Chem. 269 (1994) 28288-28293
11. Azzi A., Boscoboinik D., and Hensey C. The protein kinase C family. Eur. J. Biochem. 208 (1992) 547-557
12. Bacskai B.J., Wallen P., Lev-Ram V., Grillner S., and Tsien R.Y. Activity-related calcium dynamics in lamprey motoneurons as revealed by video-rate confocal microscopy. Neuron 14 (1995) 19-28
13. Baier G., Telford D., Giampa L., Goggeshall K.M., Baier-Bitterlich G., Isakov N., and Altman A. Molecular cloning and characterization of PKCθ, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268 (1993) 5997-6004
14. Baier G., Vaier-Bitterlich G., Meller N., Coggeshall K.M., Giampa L., Telford D., Isakov N., and Altman A. Expression and biochemical characterization of human protein kinase Cθ. Eur. J. Biochem. 225 (1994) 195-203
15. Barja P., Alavi-Nassab A., Turck C.W., and Freire-Moar J. Inhibition of T cell activation by protein kinase C pseudosubstrates. Cell. Immunol. 153 (1994) 28-38
16. Basu A. The potential of protein kinase C as a target for anticancer treatment. Pharmacol. Ther. 59 (1993) 257-280
17. Bell R.M., and Burns D.J. Lipid activation of protein kinase C. J. Biol. Chem. 266 (1991) 4661-4664
18. Beltman J., McCormick F., and Cook S.J. The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. J. Biol. Chem. 271 (1996) 27018-27024
19. Berra E., Diaz-Meco T., Lozano J., Frutos S., Municio M.M., Sanchez P., Sanz L., and Moscat J. Evidence for a role of MEK and MAPK during signal transduction by protein kinase Cζ. EMBO J. 14 (1995) 6157-6163
20. Berry N., Ase K., Kikkawa U., Kishimoto A., and Nishizuka Y. Human T cell activation by phorbol esters and diacylglycerol analogues. J. Biol. Chem. 143 (1989) 1407-1413
21. Berry N., and Nishizuka Y. Protein kinase C and T cell activation. Eur. J. Biochem. 189 (1990) 205-214
22. Bindseil K.U., Hug P., Peter H.H., Petersen F., and Roggo B.E. Balmoralmycin, a new angucyclinone, and two related biosynthetic shunt products containing a novel ring system. J. Antibiot. 48 (1995) 457-461
23. Birchall A.M., Bishop J., Bradshaw D., Cline A., Coffey J., Elliott L.H., Gibson V.M., Greenham A., Hallam T.J., Harris W., Hill C.H., Hutchings A., Lamont A.G., Lawton G., Lewis E.J., Maw A., Nixon J.S., Pole D., Wadsworth J., and Wilkinson S.E. Ro 32-0432, a selective and orally active inhibitor of protein kinase C prevents T-cell activation. J. Pharmacol. Exp. Ther. 268 (1994) 922-929
24. Blackshear P.J. The MARCKS family of cellular protein kinase C substrates. J. Biol. Chem. 268 (1993) 1501-1504
25. Blest A.D., Stowe S., Carter M., and Tsukitani Y. Manipulation of phototransductive membrane turnover by crab photoreceptors in vitro: Effects of two protein kinase activators, SC-9 and phorbol ester in the presence of a protein phosphatase inhibitor, okadaic acid. J. Comp. Physiol. [A] 170 (1992) 189-199
26. Blumberg P.M., Acs G., Acs P., Areces L.B., Kazanietz M.G., Lewin N.E., and Szallasi Z. Protein kinase C in cell signaling: Strategies for the development of selective inhibitors. Agents Actions [Suppl.] 47 (1995) 87-100
27. Blumberg P.M., Acs G., Areces L.B., Kazanietz M.G., Lewin N.E., and Szallasi Z. Protein kinase C in signal transduction and carcinogenesis. Prog. Clin. Biol. Res. 387 (1994) 3-19
28. Boneh A. Possible role for protein kinase C in the pathogenesis of inborn errors of metabolism. J. Cell. Biochem. 59 (1995) 27-32
29. Borner C., Eppenberger U., Wyss R., and Fabbro D. Continuous synthesis of two protein kinase C-related proteins after down-regulation by phorbol esters. Proc. Natl. Acad. Sci. USA 85 (1988) 2110-2114
30. Boros C., Hamilton S.M., Katz B., and Kulanthaivel P. Comparison of balanol from Verticillium balanoides and ophiocordin from Cordyceps ophioglossoides. J. Antibiot. 47 (1994) 1010-1016
31. Bosca L., and Moran F. Circular dichroism analysis of ligand-induced conformational changes in protein kinase C. Biochem. J. 290 (1993) 827-832
32. Boscoboinik D., Szewczyk A., and Azzi A. α-Tocopherol (Vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Arch. Biochem. Biophys. 286 (1991) 264-269
33. Bossemeyer D. Protein kinases-Structure and function. FEBS Lett. 369 (1995) 57-61
34. Bradshaw D., Hill C.H., Nixon J.S., and Wilkinson S.E. Therapeutic potential of protein kinase C inhibitors. Agents Actions 38 (1993) 135-147
35. Budworth J., and Gescher A. Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors. FEBS Lett. 362 (1995) 139-142
36. Burns D.J., Bloomenthal J., Lee M.-H., and Bell R.M. Expression of the α, βII and β protein kinase C isozymes in the baculovirus-insect cell expression system. J. Biol. Chem. 265 (1990) 12044-12051
37. Cachau R.E., Erickson J.W., and Villar H.O. Novel procedure for structure refinement in homology modeling and its application to the human class Mu Glutathione S-Transferases. Protein Eng. 7 (1994) 831-839
38. Caputi A., Barindelli S., Pastorino L., Cimino M., Buxbaum J.D., Cattabeni F., and Di Luca M. Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C. J. Neurochem. 68 (1997) 2523-2529
39. Casnellie J.E. Protein kinase inhibitors: Probes for the functions of protein phosphorylation. Adv. Pharmacol. 22 (1991) 167-202
40. Cazaubon S., Bornancin F., and Parker P.J. Threonine-497 is a critical site for permissive activation of protein kinase C α. Biochem. J. 301 (1994) 443-448
41. Chan J.A., Freyer A.J., Carte B.K., Hemling M.E., Hoffmann G.A., Mattern M.R., Mentzer M.A., and Westley J.W. Protein kinase C inhibitors: Novel spirosesquiterpene aldehydes from a marine sponge Siphonodictyon coralliphagum. J. Nat. Prod. 57 (1994) 1543-1548
42. Chang J.D., Xu Y., Raychowdhury M.K., and Ware J.A. Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). J. Biol. Chem. 268 (1993) 14208-14214
43. Chapline C., Ramsay K., Klauck T., and Jaken S. Interaction cloning of protein kinase C substrates. J. Biol. Chem. 268 (1993) 6858-6861
44. 2+-dependent translocation domain with homology to PKC and GAP. Cell 65 (1991) 1043-1051
45. Crane H.M., Menaldino D.S., Jagdmann G.E.J., Darges J.W., and Buben J.A. Increasing the cellular PKC inhibitory activity of balanol: A study of ester analogs. Bioorg. Med. Chem. Lett. 5 (1995) 2133-2138
46. Csukai M., Chen C.-H., De Matteis M.A., and Mochly-Rosen D. The coatomer protein β'-COP, a selective binding protein (RACK) for Protein Kinase Cε. J. Biol. Chem. 272 (1997) 29200-29206
47. Cubitt A.B., Heim R., Adams S.R., Boyd A.E., Gross L.A., and Tsien R.Y. Understanding, improving and using green fluorescent proteins. Trends Biochem. Sci. 20 (1995) 448-455
48. Danielsen A.G., Liu F., Hosomi Y., Shii K., and Roth R.A. Activation of protein kinase C a inhibits signaling by members of the insulin receptor family. J. Biol. Chem. 270 (1995) 21600-21605
49. De B.P., Gupta S., Gupta S., and Banerjee A.K. Cellular protein kinase C isoform ζ regulates human parainfluenza virus type 3 replication. Proc. Natl. Acad. Sci. USA 92 (1995) 5204-5208
50. Dean N., McKay R., Miraglia L., Howard R., Cooper S., Giddings J., Nicklin P., Meister L., Ziel R., Geiger T., Muller M., and Fabbro D. Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression. Cancer Res. 56 (1996) 3499-3507
51. Dean N.M., and McKay R. Inhibition of protein kinase C-α expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA 91 (1994) 11762-11766
52. Dean N.M., McKay R., Condon T.P., and Bennett C.F. Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J. Biol. Chem. 269 (1994) 16416-16424
53. Defauw J.M., Murphy M.M., Jagdmann Jr. G.E., Hu H., Lampe J.W., Hollinshead S.P., Mitchell T.J., Crane H.M., Heerding J.M., Mendoza J.S., Davis J.E., Darges J.W., Hubbard F.R., and Hall S.E. Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A. J. Med. Chem. 39 (1996) 5215-5227
54. Dekker L.V., and Parker P.J. Protein kinase C-A question of specificity. Trends Biochem. Sci. 19 (1994) 73-77
55. Demers J.P., Hageman W.E., Johnson S.G., Klaubert D.H., Look R.A., and Moore J.B. Selective inhibitors of protein kinase C in a model of graft-vs-host disease. Bioorg. Med. Chem. Lett. 4 (1994) 2451-2456
56. Diaz-Meco M.T., Municio M.M., Sanchez P., Lozano J., and Moscat J. Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype λ/i and stimulates its kinase activity in vitro and in vivo. Mol. Cell. Biol. 16 (1996) 105-114
57. Dickens M., Rogers J.S., Cavanagh J., Raitano A., Zhengui X., Halpern J.R., Greenberg M.E., Sawyers C.L., and Davis R.J. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277 (1997) 693-696
58. Dietrich J., Hou X., Wegener A.M., and Geisler C. CD3-gamma contains a phosphoserine-dependent di-leucine motif involved in down regulation of the T-cell receptor. EMBO J. 13 (1994) 2156-2166
59. Disatnik M.-H., Buraggi G., and Mochly-Rosen D. Localization of protein kinase C isozymes in cardiac myocytes. Exp. Cell Res. 210 (1994) 287-297
60. Diwu Z., Zimmermann J., Meyer T., and Lown J.W. Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: Perylenequinonoid pigments. Biochem. Pharmacol. 47 (1994) 373-385
61. Durkin J.P., Tremblay R., Chakravarthy B., Mealing G., Morley P., Small D., and Song D. Evidence that the early loss of membrane protein kinase C is a necessary step in the excitatory amino acid-induced death of primary cortical neurons. J. Neurochem. 68 (1997) 1400-1412
62. Eckly-Michel A.E., Le Bec A., and Lugnier C. Chelerythrine, a protein kinase C inhibitor, interacts with cyclic nucleotide phosphodiesterases. Eur. J. Pharmacol. 324 (1997) 85-88
63. Emoto Y., Manome Y., Meinhardt G., Kisaki H., Kharbanda S., Robertson M., Ghayur T., Wong W.W., Kamen R., Weichselbaum R., and Kufe D. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J. 14 (1995) 6148-6156
64. Epand R.M. In vitro assays of protein kinase C activity. Anal. Biochem. 218 (1994) 241-247
65. Evans C.A., Lord J.M., Owen-Lynch P.J., Johnson G., Dive C., and Whetton A.D. Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line. J. Cell Sci. 18 (1995) 2591-2598
66. Faux M.C., and Scott J.D. More on target with protein phosphorylation: Conferring specificity by location. Trends Biochem. Sci. 21 (1996) 312-315
67. Ferrell Jr. J.E. Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem. Sci. 21 (1996) 460-466
68. Fisher G.J., Tavakkol A., Leach K., Burns D., Basta P., Loomis C., Griffiths C.E.M., Cooper K.D., Reynolds N.J., Elder J.T., Livneh E., and Voorhees J.J. Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: Reduced expression of protein kinase C-βII in psoriasis. J. Invest. Dermatol. 101 (1993) 553-559
69. Florin-Christensen J., Florin-Christensen M., Delfino J.M., Stegmann T., and Rasmussen H. Metabolic fate of plasma membrane diacylglycerols in NIH 3T3. J. Biol Chem. 267 (1992) 14783-14789
70. Fredenhagen A., Hug P., Sauter H., and Peter H.H. Paeciloquinones A, B, C, D, E and F: New potent inhibitors of protein tyrosine kinase produced by Paecilomyces carneus, II. Characterization and structure determination. J. Antibiot. 48 (1995) 199-204
71. Freire-Moar J., Tsutsumi A., and Barja P. Use of an antisense RNA expression system to explore functions of PKC isoenzymes in T cell activation. Ann. NY Acad. Sci. 660 (1992) 288-290
72. Fry D.W., and Bridges A.J. Inhibitors of protein tyrosine kinases. Curr. Biol. 6 (1995) 662-667
73. Fujiki H., Tanaka Y., Miyake R., Kikkawa U., Nishizuka Y., and Sugimura T. Activation of calcium-activated, phospholipid-dependent protein kinase (protein kinase C) by new classes of tumor promoters: Teleocidin and debromoaplysiatoxin. Biochem. Biophys. Res. Commun. 120 (1984) 339-343
74. Fujise A., Mizuno K., Ueda Y., Osada S., Hirai S., Takayanagi A., Shimizu N., Owada M.K., Nakajima H., and Ohno S. Specificity of the high affinity interaction of protein kinase C with a physiological substrate, myristoylated alanine-rich protein kinase C substrate. J. Biol. Chem. 269 (1994) 31642-31648
75. Fusaki N., Matsuda S., Nishizumi H., Umemori H., and Yamamoto T. Physical and functional interactions of protein tyrosine kinases, p59fyn and ZAP-70, in T cell signaling. J. Immunol. 156 (1996) 1369-1377
76. Gailani D., Fisher T.C., Mills D.C., and Macfarlane D.E. P47 phosphoprotein of blood platelets (pleckstrin) is a major target for phorbol ester-induced protein phosphorylation in intact platelets, granulocytes, lymphocytes, monocytes and cultured leukaemic cells: Absence of P47 in non-haematopoietic cells. Br. J. Haematol. 74 (1990) 192-202
77. Garcia-Rocha M., Avila J., and Lozano J. The zeta isozyme of protein kinase C binds to tubulin through the pseudosubstrate domain. Exp. Cell Res. 230 (1997) 1-8
78. Geiges D., Meyer T., Marte B., Vanek M., Weissgerber G., Stabel S., Pfeilschifter J., Fabbro D., and Huwiler A. Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. Biochem. Pharmacol. 53 (1997) 865-875
79. Ghalayini A.J., Koutz C.A., Wetsel W.C., Hannun Y.A., and Anderson R.E. Immunolocalization of PKC zeta in rat photoreceptor inner segments. Curr. Eye Res. 13 (1994) 145-150
80. Ghayur T., Hugunin M., Talanian R.V., Ratnofsky S., Quinlan C., Emoto Y., Pandey P., Datta R., Huang Y., Kharbanda S., Allen H., Kamen R., Wong W., and Kufe D. Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J. Exp. Med. 184 (1996) 2399-2404
81. Gilbert B.A., Lim Y.-H., Ding J., Badwey J.A., and Rando R.R. Farnesyl thiotriazole, a potent neutrophil agonist and structurally novel activator of protein kinase C. Biochem. 34 (1995) 3916-3920
82. Girgert R., Schweizer P., Bock I., Narr R., and Bruchelt G. Cytotoxicity of ether phospholipid BM41.440 on neuroblastoma cells. J. Cancer Res. Clin. Oncol. 121 (1995) 262-266
83. Godson C., Bell K.S., and Insel P.A. Inhibition of expression of protein kinase C α by antisense cDNA inhibits phorbol ester-mediated arachidonate release. J. Biol. Chem. 268 (1993) 11946-11950
84. Goldbeter A., and Koshland D.E.J. Ultrasensitivity in biochemical systems controlled by covalent modification. J. Biol. Chem. 259 (1984) 14441-14447
85. Goldsmith E.J., and Cobb M.H. Protein kinases. Curr. Opin. in Struct. Biol. 4 (1994) 833-840
86. Goldstein D.R., Cacace A.M., and Weinstein I.B. Overexpression of protein kinase C βI in the SW480 colon cancer cell line causes growth suppression. Carcinogenesis 16 (1995) 1121-1126
87. Goodnight J., Mischak H., Kolch W., and Mushinski J.F. Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. J. Biol. Chem. 270 (1995) 9991-10001
88. Gray M., Mochly-Rosen D., Honbo N., and Karliner J. Isozyme specific activation of protein kinase C in a rat cardiac myocyte model of ischemic preconditioning. Circulation 92 (1995) 1-137
89. Gschwendt M., Muller H.-J., Kielbassa K., Zang R., Kittstein W., Rincke G., and Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 199 (1994) 93-98
90. Hannun Y.A., and Bell R.M. Aminoacridines, potent inhibitors of protein kinase C. J. Biol. Chem. 263 (1988) 5124-5131
91. Hannun Y.A., and Bell R.M. Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243 (1989) 500-507
92. Hannun Y.A., and Obeid L.M. Ceramide: An intracellular signal for apoptosis. Trends Biochem. Sci. 20 (1995) 73-77
93. Harris R.A., McQuilken S.J., Paylor R., Abeliovich A., Tonegawa S., and Wehner J.M. Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of g-aminobutyrate type A receptors. Proc. Natl. Acad. Sci. USA 92 (1995) 3658-3662
94. Hashimoto K., Whitehurst C.E., Matsubara T., Hirohata K., and Lipsky P.E. Immunomodulatory effects of therapeutic gold compounds. Gold sodium thiomalate inhibits the activity of T cell protein kinase C. J. Clin. Invest. 89 (1992) 1839-1848
95. Hasler C.M., Acs G., and Blumberg P.M. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 52 (1992) 202-208
96. Heikkila J., Jalava A., and Eriksson K. The selective protein kinase C inhibitor GF 109203X inhibits phorbol ester-induced morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. Biochem. Biophys. Res. Commun. 197 (1993) 1185-1193
97. Herbert J.M., Augereau J.M., Gleye J., and Maffrand J.P. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophy. Res. Commun. 172 (1990) 993-999
98. Hertz J., Krogh A., and Palmer R.G. Introduction to the Theory of Neural Computation (1991), Addison-Wesley, Redwood City, CA
99. Hill C.H. The design and synthesis of selective protein kinase C inhibitors. In: King F.D. (Ed). Medicinal Chemistry: Principles and Practice (1994), Royal Society of Chemistry, Cambridge, UK. 226-240
100. Hommel U., Zurini M., and Luyten M. Solution structure of a cysteine rich domain of rat protein kinase C. Struct. Biol. 1 (1994) 383-387
101. Hornung R.L., Pearson J.W., Beckwith M., and Longo D.L. Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: In vitro versus in vivo activity. Cancer Res. 52 (1992) 101-107
102. House C., and Kemp B.E. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238 (1987) 1726-1728
103. Housey G.M., Johnson M.D., Hsiao W.L.W., O'Brian C.A., Murphy J.P., Kirschmeier P., and Weinstein I.B. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell 52 (1988) 343-354
104. Huang C.-Y.F., and Ferrell Jr. J.E. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 93 (1996) 10078-10083
105. Hubbard S.R., Bishop W.R., Kirschmeier P., George S.J., Cramer S.P., and Hendrickson W.A. Identification and characterization of zinc binding sites in protein kinase C. Science 254 (1991) 1776-1779
106. Hug R., and Sarre T.F. Protein kinase C isozymes: Divergence in signal transduction?. Biochem. J. 291 (1993) 329-343
107. Hundle B., McMahon T., Dadgar J., Chen C.-H., Mochly-Rosen D., and Messing R.O. An inhibitory fragment derived from ε Protein Kinase C prevents enhancement of nerve growth factor responses by ethanol and phorbol esters. J. Biol. Chem. 272 (1996) 15028-15035
108. Hundle B., McMahon T., Dadgar J., and Messing R.O. Overexpression of protein kinase C ε enhances nerve growth factor-induced phosphorylation of mitogen-activated protein kinases and neurite outgrowth. J. Biol. Chem. 270 (1995) 30134-30140
109. Hundle B., McMahon T., Dadgar J., Mochly-Rosen D., and Messing R.O. PKC ε specifically modulates NGF-induced neurite outgrowth. FASEB J. 9 (1995) A1407
110. Ichikawa S., Hatanaka H., Takeuchi Y., Ohno S., and Inagaki F. Solution structure of cysteine-rich domain of protein kinase C alpha. J. Biochem. (Tokyo) 117 (1995) 566-574
111. Inoue M., Kishimoto A., Takai Y., and Nishizuka Y. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J. Biol. Chem. 252 (1977) 7610-7616
112. Isakov N., Galron D., Mustelin T., Pettit G.R., and Altman A. Inhibition of phorbol ester-induced T cell proliferation by bryostatin is associated with rapid degradation of protein kinase C. J. Immunol. 150 (1993) 1195-1204
113. Ishii H., Jirousek M.R., Koya D., Takagi C., Xia P., Clermont A., Bursell S.-E., Kern T.S., Ballas L.M., Heath W.F., Stramm L.E., Feener E.P., and King G.L. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor. Science 272 (1996) 728-731
114. Ison A.J., MacEwan D.J., Johnson M.S., Clegg R.A., Connor K., and Mitchell R. Evidence for a distinct H7-resistant form of protein kinase C in rat anterior pituitary gland. FEBS Lett. 329 (1993) 199-204
115. Issandou M., Faucher C., Bayard F., and Darbon J.M. Opposite effects of tamoxifen on in vitro protein kinase C activity and endogenous protein phosphorylation in intact MCF-7 cells. Cancer Res. 50 (1990) 5845-5850
116. Jacobson M.D. Reactive oxygen species and programmed cell death. Trends Biomed. Sci. 21 (1996) 83-86
117. Jacobson M.D., and Raff M.C. Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374 (1995) 814-816
118. Jaken S., Leach K., and Klauck T. Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts. J. Cell Biol. 109 (1989) 697-704
119. Jayson G.C., Crowther D., Prendiville J., McGown A.T., Scheid C., Stern P., Young R., Brenchley P., Chang J., Owens S., and Pettit G.R. A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion. Br. J. Cancer 72 (1995) 461-468
120. Jerusalinsky D., Quillfeldt J.A., Walz R., Da Silva R.C., Medina J.H., and Izquierdo I. Post-training intrahippocampal infusion of protein kinase C inhibitors causes amnesia in rats. Behav. Neural Biol. 61 (1994) 107-109
121. Johannes F.-J., Prestle J., Dieterich S., Oberhagemann P., Link G., and Pfizenmaier K. Characterization of activators and inhibitors of protein kinase C μ. Eur. J. Biochem. 227 (1995) 303-307
122. Johnson J.A., Adak S., and Mochly-Rosen D. Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes. Life Sci. 57 (1995) 1027-1038
123. Johnson J.A., and Mochly-Rosen D. Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. Circ. Res. 76 (1995) 654-663
124. Johnson J.A., Gray M.O., Chen C.-H., and Mochly-Rosen D. A protein kinase C inhibitor as an isozyme-selective antagonist of cardiac function. J. Biol. Chem. 271 (1996) 24962-24966
125. Kaibuchi K., Fukumoto Y., Oku N., and Takai Y. Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C. J. Biol. Chem. 264 (1989) 13489-13496
126. Kameyama K., Haga K., Haga T., Kontani K., Katada T., and Fukada Y. Activation by G protein βy subunits of β-adrenergic and muscarinic receptor kinase. J. Biol. Chem. 268 (1993) 7753-7758
127. Kashiwada Y., Huang L., Ballas L.M., Jiang J.B., Janzen W.P., and Lee K.-H. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J. Med. Chem. 37 (1994) 195-200
128. Kauvar L.M. Peptide mimetic drugs: A comment on progress and prospects. Nat. Biotechnol. 14 (1996) 709
129. Kauvar L.M., Higgins D.L., Villar H.O., Sportsman J.R., Engqvist-Goldstein A., Bukar R., Bauer K.E., Dilley H., and Rocke D.M. Predicting ligand binding to proteins by affinity fingerprinting. Chem. Biol. 2 (1995) 107-118
130. Kazanietz M.G., Bustelo X.R., Barbacid M., Kolch W., Mischak H., Wong G., Pettit G.R., Bruns J.D., and Blumberg P.M. Zinc finger domains and phorbol ester pharmacophore. J. Biol. Chem. 269 (1994) 11590-11594
131. Kazanietz M.G., Krausz K.W., and Blumberg P.M. Differential irreversible insertion of protein kinase C into phosophlipid vesicles by phorbol esters and related activators. J. Biol. Chem. 267 (1992) 20878-20886
132. Kazanietz M.G., Wang S., Milne G.W.A., Lewin N.E., Liu H.L., and Blumberg P.M. Residues in the second cysteine-rich region of protein kinase C δ relevant to phorbol ester binding as revealed by site-directed mutagenesis. J. Biol. Chem. 270 (1995) 21852-21859
133. Kelleher D., and Long A. Development and characterization of a protein kinase C β-isozyme-deficient T-cell line. FEBS Lett. 301 (1992) 310-314
134. Kennelly P.J., and Krebs E.G. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J. Biol. Chem. 266 (1991) 15555-15558
135. Kikkawa U., and Nishizuka Y. The role of protein kinase C in transmembrane signalling. Ann. Rev. Cell Biol. 2 (1986) 149-178
136. Kleinschroth J., Hartenstein J., Rudolph C., and Schachtele C. Novel indolocarbazole protein kinase C inhibitors with improved biochemical physicochemical properties. Bioorg. Med. Chem. Lett. 5 (1995) 55-60
137. Knopf J.L., Lee M.H., Sultzman L.A., Kriz R.W., Loomis C.R., Hewick R.M., and Bell R.M. Cloning and expression of multiple protein kinase C cDNAs. Cell 46 (1986) 491-502
138. Konishi H., Kuroda S., and Kikkawa U. The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C ζ. Biochem. Biophys. Res. Commun. 205 (1994) 1770-1775
139. Kraft A.S., Anderson W.B., Cooper H., and Sando J.J. Decrease in cytosolic calcium/phospholipid dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells. J. Biol. Chem. 257 (1982) 13193-13196
140. Kubo K., Ohno S., Matsumoto S., Yahara I., and Suzuki K. A novel yeast gene coding for a putative protein kinase. Gene 76 (1989) 177-180
141. Kulanthaivel P., Hallock Y.F., Boros C., Hamilton S.M., Janzen W.P., Ballas L.M., Loomis C.R., and Jiang J.B. Balanol: A novel and potent inhibitor of protein kinase C from the fungus. Verticillium balanoides. J. Am. Chem. Soc. 115 (1993) 6452-6453
142. Kupfer H., Monks C.R.F., and Kupfer A. Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: Immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions. J. Exp. Biol. 179 (1994) 1507-1515
143. Kwon Y.-G., Mendelow M., and Lawrence D.S. The active site substrate specificity of protein kinase C. J. Biol. Chem. 269 (1994) 4839-4844
144. Land M., Islas-Trejo A., Freedman J.H., and Rubin C.S. Structure and expression of a novel, neuronal protein kinase C (PKC1B) from Caenorhabditis elegans. J. Biol. Chem. 269 (1994) 9234-9244
145. Lee H.W., Smith L., Pettit G.R., and Smith J.B. Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblasts. Mol. Pharmacol. 51 (1997) 439-447
146. Lee J., Marquez V.E., Blumberg P.M., Krausz K.W., and Kazanietz M.G. Conformationally constrained analogues of diacylglycerol (DAG)-II. Differential interaction of δ-lactones and δ-lactones with protein kinase C (PKC). Bioorg. Med. Chem. 1 (1993) 119-123
147. Lee J., Wang S., Milne G.W.A., Sharma R., Lewin N.E., Blumberg P.M., and Marquez V.E. Conformationally constrained analogues of diacylglycerol, 11: ultrapotent protein kinase C ligands based on a chiral 5-substituted tetrahydro-2-furanone template. J. Med. Chem. 39 (1996) 29-35
148. Lee J., Sharma R., Wang S., Milne G.W.A., Lewin N.E., Szallasi Z., Blumberg P.M., George C., and Marquez V.E. Conformationally constrained analogues of diacylglycerol, 12: Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-l,4-lactone template. J. Med. Chem. 39 (1996) 36-45
149. Lee J.C., and Adams J.L. Inhibitors of serine/threonine kinases. Curr. Biol. 6 (1995) 657-661
150. Lee Y.S., Dlugosz A.A., McKay R., Dean N.M., and Yuspa S.H. Definition by specific antisense oligonucleotides of a role for protein kinase C alpha in expression of differentiation markers in normal and neoplastic mouse epidermal keratinocytes. Mol. Carcinog. 18 (1997) 44-53
151. Lehel C., Olah Z., Jakab G., and Anderson W.B. Protein kinase C ε is localized to the Golgi via its zinc-finger domain and modulates Golgi function. Proc. Natl. Acad. Sci. USA 92 (1995) 1406-1410
152. Leitges M., Schmedt C., Guinamard R., Davoust J., Schaal S., Stabel S., and Tarakhovsky A. Immunodeficiency in protein kinase C β-deficient mice. Science 273 (1996) 788-791
153. Levin D.E., Fields F.O., Kunisawa R., Bishop J.M., and Thorner J. A candidate protein kinase C gene PKC1, is required for the S. cerevisae cell cycle. Cell 62 (1990) 213-224
154. Lim L. n-Chimaerin and neuronal signal transduction mechanisms. Biochem. Soc. Trans. 20 (1992) 611-614
155. Liscovitch M., and Cantley L.C. Lipid second messengers. Cell 77 (1994) 329-334
156. Loomis C.R., and Bell R.M. Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C. J. Biol. Chem. 263 (1988) 1682-1692
157. Lopez I., Burns D.J., and Lambeth J.D. Regulation of phospholipase D by protein kinase C in human neutrophils. J. Biol. Chem. 270 (1995) 19465-19472
158. Lucas M., and Sanchez-Margalet V. Protein kinase C involvement in apoptosis. Gen. Pharmacol. 26 (1995) 881-887
159. Luo J.-H., and Weinstein I.B. Calcium-dependent activation of protein kinase C. J. Biol. Chem. 268 (1993) 23580-23584
160. Macdonald R.L. Ethanol, γ-aminobutyrate type A receptors and protein kinase C phosphorylation. Proc. Natl. Acad. Sci. USA 92 (1995) 3633-3635
161. Mahoney C.W., Azzi A., and Huang K.-P. Effects of suramin, an anti-human immunodeficiency virus reverse transcriptase agent, on protein kinase C. J. Biol. Chem. 265 (1990) 5424-5428
162. Malinow R., Schulman H., and Tsien R.W. Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP. Science 245 (1989) 862-866
163. Malmberg A.B., Chen C., Tonegawa S., and Basbaum A.I. Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ. Science 278 (1997) 279-283
164. Manji H.K., Etcheberrigaray R., Chen G., and Olds J.L. Lithium decreases membrane-associated protein kinase C in hippocampus: Selectivity for the α isozyme. J. Neurochem. 61 (1993) 2303-2310
165. Martiny-Baron G., Kazanietz M.G., Mischak H., Blumberg P.M., Kochs G., Hug H., Marme D., and Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J. Biol. Chem. 268 (1993) 9194-9197
166. 2+-independent protein kinase C from fission yeast. J. Biol. Chem. 268 (1993) 7401-7406
167. McAlpine J.B., Karwowski J.P., Jackson M., Mullally M.M., Hochlowski J.E., Premachandran U., and Burres N.S. MLR-52, (4'-demethylamino-4'5'-dihydroxystaurosporine), a new inhibitor of protein kinase C with immunosuppressive activity. J. Antibiot. 47 (1994) 281-288
168. McKay R.A., Cummins L.L., Graham M.J., Lesnik E.A., Owens S.R., Winniman M., and Dean N.M. Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-α by the incorporation of 2'-O-propyl modifications. Nucleic Acids Res. 24 (1996) 411-417
169. McKeithan T.W. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92 (1995) 5042-5046
170. Meller N., Liu Y.-C., Collins T.L., Bonnefoy-Berard N., Baier G., Isakov N., and Altman A. Direct interaction between protein kinase C-θ (PKCθ) and 14-3-3ζ in T-cells: Overexpression results in inhibition of PKCθ translocation and function. Mol. Cell. Biol. 16 (1996) 5782-5791
171. Merchenthaler I., Liposits Z., Reid J.J., and Wetsel W.C. Light and electron microscopic immunocytochemical localization of PKC delta immunoreactivity in the rat central nervous system. J. Comp. Neurol. 336 (1993) 378-799
172. Merrill A.H.J., Nimkar S., Menaldino D., Hannun Y.A., Loomis C., Bell R.M., Tyagi S.R., Lambeth J.D., Stevens V.L., Hunter R., and Liotta D.C. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 28 (1989) 3138-3145
173. Meyer T., Regenass U., Fabbro D., Alteri E., Rosel J., Muller M., Caravatti G., and Matter A. A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int. J. Cancer 43 (1989) 851-856
174. Mischak H., Goodnight J., Henderson D.W., Osada S., Ohno S., and Mushinski J.F. Unique expression pattern of protein kinase C-θ high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms. FEBS Lett. 326 (1993) 51-55
175. Mischak H., Goodnight J., Kolch W., Martiny-Baron G., Schaechtle C., Kazanietz M.G., Blumberg P.M., Pierce J.H., and Mushinski J.F. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence and tumorigenicity. J. Biol. Chem. 268 (1993) 6090-6096
176. Mizuno K., Noda K., Ueda Y., Hanaki H., Saido T.C., Ikuta T., Kuroki T., Tamaoki T., Hirai S., Osada S., and Ohno S. UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC family. FEBS Lett. 359 (1995) 259-261
177. Mizuno K., Saido T.C., Ohno S., Tamaoki T., and Suzuki K. Staurosporine-related compounds, K252a and UCN-01, inhibit both cPKC and nPKC. FEBS Lett. 330 (1993) 114-116
178. Mochly-Rosen D. Localization of protein kinases by anchoring proteins: A theme in signal transduction. Science 268 (1995) 247-251
179. Mochly-Rosen D., Khaner H., and Lopez J. Identification of intracellular receptor proteins for activated protein kinase C. Proc. Natl. Acad. Sci. USA 88 (1991) 3997-4000
180. Mochly-Rosen D., Khaner H., Lopez J., and Smith B.L. Intracellular receptors for activated protein kinase C; identification of a binding site for the enzyme. J. Biol. Chem. 266 (1991) 14866-14868
181. Mochly-Rosen D., Miller K.G., Scheller R.H., Khaner H., Lopez J., and Smith B.L. p65 fragments, homologous to the C2 region of protein kinase C., bind to the intracellular receptors for protein kinase C. Biochemistry 31 (1992) 8120-8124
182. Mogi A., Hatai M., Soga H., Takenoshita S., Nagamachi Y., Fujimoto J., Yamamoto T., Yokota J., and Yaoi Y. Possible role of protein kinase C in the regulation of intracellular stability of focal adhesion kinase in mouse 3T3 cells. FEBS Lett. 373 (1995) 135-140
183. Monks C.R., Kupfer H., Tamir I., Barlow A., and Kupfer A. Selective modulation of protein kinase C-theta during T-cell activation. Nature 385 (1997) 83-86
184. Morawetz R., Lendenfeld T., Mischak H., Muhlbauer M., Gruber F., Goodnight J., de Graaff L.H., Visser J., Mushinski J.F., and Kubicek C.P. Cloning and characterisation of genes (pkc1 and pkcA) encoding protein kinase C homologues from. Trichoderma reesei and Aspergillus niger. Mol. Gen. Genet. 250 (1996) 17-28
185. Mori T., Takai Y., Minakuchi R., Yu B., and Nishizuka Y. Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase. J. Biol. Chem. 255 (1990) 8378-8390
186. Morris P.B., Hida T., Blackshear P.J., Klintworth G.K., and Swain J.L. Tumorpromoting phorbol esters induce angiogenesis in vivo. Am. J. Physiol. 254 (1988) C318-C322
187. Mukai H., and Ono Y. A novel protein kinase with leucine zipper-like sequences: Its catalytic domain is highly homologous to that of protein kinase C. Biochem. Biophys. Res. Commun. 199 (1994) 897-904
188. Muller G., Ayoub M., Storz P., Rennecke J., Fabbro D., and Pfizenmaier K. PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14 (1995) 1961-1969
189. Muramatsu M.A., Kaibuchi K., and Arai K.I. A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester. Mol. Cell. Biol. 9 (1989) 831-836
190. Nakanishi H., Brewer K.A., and Exton J.H. Activation of the ζ isozyme oi protein kinase C by phosphatidylinositol 3, 4, 5-trisphosphate. J. Biol. Chem. 268 (1993) 13-16
191. Nassar N., Horn G., Herrmann C., Scherer A., McCormick F., and Wittinghofer A. The 2.2Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Rafl in complex with RaplA and a GTP analogue. Nature 375 (1995) 554-560
192. Neer E.J., Schmidt C.J., Nambudripad R., and Smith T.F. The ancient regulatory-protein family of WD-repeat proteins. Nature 371 (1994) 297-300
193. Nel A.E., Taylor L.K., Kumar G.P., Gupta S., Wang S.C., Williams K., Liao O., Swanson K., and Landreth G.E. Activation of a novel serine/threonine kinase that phosphorylates c-fos upon stimulation of T and B lymphocytes via antigen and cytokine receptors. J. Immunol. 152 (1994) 4347-4357
194. Newman R.H., Carpenter E., Freement P.S., Blundell T.L., and Parker P.J. Microcrystals of the βI isoenzyme of protein kinase C: An electron microscopic study. Biochem. J. 2948 (1994) 391-393
195. Newton A.C. Protein kinase C: Structure, function and regulation. J. Biol. Chem. 270 (1995) 28495-28498
196. Newton A.C. Protein Kinase C: Seeing two domains. Curr. Biol. 5 (1995) 973-977
197. Newton A.C., and Keranen L.M. Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes. Biochemistry 33 (1994) 6651-6658
198. Nishikawa K., Toker A., Johannes F.J., Songyang Z., and Cantley L.C. Determination of the specific substrate sequence motifs of protein kinase C isozymes. J. Biol. Chem. 272 (1997) 952-960
199. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J. 9 (1995) 484-496
200. Norris V., Baldwin T.J., Sweeney S.T., Williams P.H., and Leach K.L. A protein kinase C-like activity in Escherichia coli. Mol. Microbiol. 5 (1991) 2977-2981
201. O'Brian C.A., Housey G.M., and Weinstem I.B. Binding of protein kinase C to naphthalenesulfonamide and phenothiazine agarose columns: Evidence for direct interactions of protein kinase C and cationic amphiphilic inhibitors of the enzyme. Biochem. Pharmacol. 36 (1987) 4179-4181
202. O'Brian C.A., and Ward N.E. Biology of the protein kinase C family. Cancer Metastasis Rev. 8 (1989) 199-214
203. Ogita K., Miyamoto S., Koide H., Iwai T., Oka M., Ando K., Kishimoto A., Ikeda K., Fukami Y., and Nishizuka Y. Protein kinase C in Saccharomyces cerevisae: Comparison with the mammalian enzyme. Proc. Natl. Acad. Sci. USA 87 (1990) 5011-5015
204. Oh E.S., Woods A., and Couchman J.R. Syndecan-4 proteoglycan regulates the distribution and activity of protein kinase C. J. Biol. Chem. 272 (1997) 8133-8136
205. Ohno S., Akita Y., Hata A., Osada S., Kubo K., Konno Y., Akimoto K., Mizuno K., Saido T., Kuroki T., et al. Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC., conventional cPKC and novel nPKC. Adv. Enzyme Regul. 31 (1991) 287-303
206. Ohno S., Kawasaki H., Imajoh S., Suzuki K., Inagaki M., Yokokura H., Sakoh T., and Hidaka H. Tissue-specific expression of three distinct types of rabbit protein kinase C. Nature 325 (1987) 161-166
207. Ohshima S., Yanagisawa M., Katoh A., Fujii T., Sano T., Matsukuma S., Furumai T., Fujiu M., Watanabe K., Yokose K., Arisawa M., and Okuda T. Fusarium merismoides CORDA NR 6356; the source of the protein kinase C inhibitor, azepinostatin. J. Antibiot. 47 (1994) 639-647
208. Ohno S., Konno Y., Akita Y., Yano A., and Suzuki K. A point mutation at the putative ATP-binding site of protein kinase C a abolishes the kinase activity and renders it down-regulation-insensitive. J. Biol. Chem. 265 (1990) 6296-6300
209. Okajima S., Mizoguchi A., Tamaik K., Hirasawa Y., and Ide C. Distribution of protein kinase C (α, β, δ subtypes) in normal nerve fibers and in regenerating growth cones of the rat peripheral nervous system. Neuroscience 66 (1995) 645-654
210. Orita S., Sasaki T., Naito A., Komuro R., Ohtsuka T., Maeda M., Suzuki H., Igarashi H., and Takai Y. Doc2: A novel brain protein having two repeated C2-like domains. Biochem. Biophys. Res. Commun. 206 (1995) 439-448
211. Orr J.W., Keranen L.M., and Newton A.C. Reversible exposure of the pseudosubstrate domain of protein kinase C by phosphatidylserine and diacylglycerol. J. Biol. Chem. 267 (1992) 15263-15266
212. Orr J.W., and Newton A.C. Requirement for negative charge on "activation loop" of protein kinase C. J. Biol. Chem. 269 (1994) 27715-27718
213. Orr J.W., and Newton A.C. Intrapeptide regulation of protein kinase C. J. Biol. Chem. 269 (1994) 8383-8387
214. Paigen K. Acid hydrolases as models of genetic control. Annu. Rev. Genet. 13 (1979) 417-466
215. Palmer R.H., Ridden J., and Parker P.J. Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family. Eur. J. Biochem. 227 (1995) 344-351
216. Parissenti A.M., Kim S.A., Colantonio C.M., Snihura A.L., and Schimmer B.P. Regulatory domain of human protein kinase C a dominantly inhibits protein kinase C 01-regulated growth and morphology in Saccharomyces cerevisiae. J. Cell Physiol. 166 (1996) 609-617
217. Parissenti A.M., Kirwan A.F., Kim S.A., Colantonio C.M., and Schimmer B.P. Molecular strategies for the dominant inhibition of protein kinase C. Endocr. Res. 22 (1996) 621-630
218. Parker P.J., Coussens L., Totty N., Rhee L., Young S., Chen E., Stabel S., Waterfield M.D., and Ullrich A. The complete primary structure of protein kinase C-The major phorbol ester receptor. Science 233 (1986) 853-859
219. Pascale A., Fortino I., Govoni S., Trabucchi M., Wetsel W.C., and Battaini F. Functional impairment in protein kinase C by RACK1 (receptor for activated C kinase 1) deficiency in aged rat brain cortex. J. Neurochem. 67 (1996) 2471-2477
220. Pavlakovic G., Eyer C.L., and Isom G.E. Neuroprotective effects of PKC inhibition against chemical hypoxia. Brain Res. 676 (1995) 205-211
221. Pears C., Stabel S., Cazaubon S., and Parker P.J. Studies on the phosphorylation of protein kinase C-α. Biochem. J. 283 (1992) 515-518
222. Perin M.S., Fried V.A., Mignery G.A., Jahn R., and Sudhof T.C. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345 (1990) 260-263
223. Perlmutter R.M., Levin S.D., Appleby M.W., Anderson S.J., and Alberola-Ila J. Regulation of lymphocyte function by protein phosphorylation. Annu. Rev. Immunol. 11 (1993) 451-499
224. Persons D.A., Wilkison W.O., Bell R.M., and Finn O.J. Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-1 cDNA. Cell 52 (1988) 447-458 1993
225. Pettit G.R. The bryostatins. Prog. Chem. Org. Nat. Prod. 57 (1991) 153-195
226. Pronin A.N., and Benovic J.L. Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C. J. Biol. Chem. 272 (1997) 3806-3812
227. Quick J., Ware J.A., and Driedger P.E. The structure and biological activities of the widely used protein kinase inhibitor H7 differ depending on the commercial source. Biochem. Biophys. Res. Commun. 187 (1992) 657-663
228. Rasmussen H.H., and Celis J.E. Evidence for an altered protein kinase C (PKC) signaling pathway in psoriasis. J. Invest. Dermatol. 101 (1993) 560-566
229. Reddy V.N., Liebman M.N., and Mavrovouniotis M.L. Qualitative analysis of biochemical reaction systems. Comput. Biol. Med. 26 (1996) 9-24
230. Reynolds N.J., Yi J.Y., Fisher G.J., Cooper K.D., Voorhees J.J., and Griffiths C.E.M. Down-regulation of Langerhans cell protein kinase C-β isoenzyme expression in inflammatory and hyperplastic dermatoses. Br. J. Dermatol. 133 (1995) 157-167
231. Reza F., Igarashi K., Tokita S., Asai K., Aoki J., Asaoka Y., Umeda M., and Inoue K. Anti-idiotypic monoclonal antibody recognizes a consensus recognition site for phosphatidylserine in phosphatidylserine-specific monoclonal antibody and protein kinase C. FEES Lett. 339 (1993) 229-233
232. Ron D., Chen C.-H., Caldwell J., Jamieson L., Orr E., and Mochly-Rosen D. Cloning of an intracellular receptor for protein kinase C; a homolog of the β subunit of G proteins. Proc. Natl. Acad. Sci. USA 91 (1994) 839-843
233. Ron D., Luo J., and Mochly-Rosen D. C2 region-derived peptides inhibit translocation and function ofβ protein kinase C. in vivo. J. Biol. Chem. 270 (1995) 24180-24187
234. Ron D., and Mochly-Rosen D. Agonists and antagonists of protein kinase C function, derived from its binding proteins. J. Biol. Chem. 269 (1994) 21395-21398
235. Ron D., and Mochly-Rosen D. An autoregulatory region in protein kinase C: The pseudoanchoring site. Proc. Natl. Acad. Sci. USA 92 (1995) 492-496
236. Rotenberg S.A., Huang M.H., Zhu J., Su L., and Riedel H. Deletion analysis of protein kinase C inactivation by calphostin C. Mol. Carcinog. 12 (1995) 42-49
237. Rozengurt E., Sinnett-Smith J., Van Lint J., and Valverde A.M. Protein kinase D (PKD): A novel target for diacylglycerol and phorbol esters. Mutat. Res. 333 (1995) 153-160
238. Ruff V.A., McGee J.E., Yem A.W., Deibel M.R., and Leach K.L. FKBP-12 is not an inhibitor of protein kinase C. Immunol. Invest. 21 (1992) 259-273
239. Ryves W.J., Evans A.T., Olivier A.R., Parker P.J., and Evans F.J. Activation of the PKC-isotypes α, βI, γ, δ, and ε by phorbol esters of different biological activities. FEBS Lett. 288 (1991) 5-9
240. Sasaki Y., Asaoka Y., and Nishizuka Y. Potentiation of diacylglycerol-induced activation of protein kinase C by lysophospholipids. Subspecies difference. FEBS Lett. 320 (1993) 47-51
241. Schaeffer E., Smith D., Mardon G., Quinn W., and Zucker C. Isolation and characterization of two new Drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. Cell 57 (1989) 403-412
242. Schwartz G.K., Haimovitz-Friedman A., Dhupar S.K., Ehleiter D., Maslak P., Lai L., Loganzo J.F., Kelsen D.P., Fuks Z., and Albino A.P. Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells. J. Natl. Cancer Inst. 87 (1995) 1394-1399
243. Seedorf K., Shearman M., and Ullrich A. Rapid and long term effects of protein kinase C on receptor tyrosine kinase phosphorylation and degradation. J. Biol. Chem. 270 (1995) 18953-18960
244. 2+ binding motif in C2 domains of synaptotagmin and protein kinase C. Science 273 (1996) 248-251
245. Sharma R., Lee J., Wang S., Milne G.W.A., Lewin N.E., Blumberg P.M., and Marquez V.E. Conformational constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template. J. Med. Chem. 39 (1996) 19-28
246. Shyy J.Y.-J., Lin M.-C., Han J., Lu Y., Petrime M., and Chien S. The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate" responsive element is involved in shear stress-induced monocyte chemotactic protein-1 gene expression. Proc. Natl. Acad. Sci. USA 92 (1995) 8069-8073
247. Sidorenko S.P., Law C.-L., Klaus S.J., Chandran K.A., Takata M., Kurosaki T., and Clark E.A. Protein kinase C;μ, associates with the B-cell antigen receptor complex and regulates lymphocyte signaling. Immunity 5 (1996) 353-363
248. Siegel J.N., June C.H., Yamada H., Rapp U.R., and Samelson L.E. Rapid activation of c-raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T-cells. J. Immunol. 151 (1993) 4116-4127
249. Sista P., Edmiston S., Darges J.W., Robinson S., and Burns D.J. A cell-based reporter assay for the identification of protein kinase C activators and inhibitors. Mol. Cell. Biochem. 141 (1994) 129-134
250. Smith B., Krushelnycky B., Mochly-Rosen D., and Berg P. The HIV nef protein associates with protein kinase C θ. J. Biol. Chem. 271 (1996) 16753-16757
251. Smith B.L., and Mochly-Rosen D. Inhibition of protein kinase C function by injection of receptors for the enzyme. Biochem. Biophys. Res. Communun. 188 (1992) 1235-1240
252. Sohn U.D., Zoukhri D., Dartt D., Sergheraert C., Harnett K.M., Behar J., and Biancani P. Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle. Mol. Pharmacol. 51 (1997) 462-470
253. Song L., and Jope R.S. Chronic lithium treatment impairs phosphatidylinositol hydrolysis in membranes from rat brain regions. J. Neurochem. 58 (1992) 2200-2206
254. 2+-independent protein kinase C's contain an amino-terminal domain similar to the C2 consensus sequence. Trends Biochem. Sci. 18 (1993) 207-208
255. Speechly-Dick M.E., Mocanu M.M., and Yellon D.M. Protein kinase C: Its role in ischemic preconditioning in the rat. Circ. Res. 75 (1994) 586-590
256. Stanwell C., Gescher A., Bradshaw T.D., and Pettit G.R. The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin in human A549 lung and MCF-7 breast carcinoma cells. Int. J. Cancer 56 (1994) 585-592
257. Staudinger J., Zhou J., Burgess R., Elledge S.J., and Olson E.N. PICK1: A nuclear binding protein and substrate for protein kinase C isolated by the two-hybrid system. J. Cell Biol. 128 (1995) 263-271
258. 2+-dependent signal transduction pathways. J. Immunol. 155 (1995) 4685-4691
259. Sullivan J.P., Connor J.R., Shearer B.G., and Burch R.M. 26-diamino-N-([l-(l- oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): A novel inhibitor of protein kinase C interacting at the regulatory domain. Mol. Pharmacol. 41 (1991) 38-44
260. 2+phospholipid-binding fold. Cell 80 (1995) 929-938
261. Swedlow J.R., Sedate J.W., and Agard D.A. Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy. Cell 73 (1993) 97-108
262. Szallasi Z., Krsmanovic L., and Blumberg P.M. Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-I mouse skin. Cancer Res. 53 (1993) 2507-2512
263. Szamel M., Barrels F., and Resch K. Cyclosporin A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C-B. Eur. J. Immunol. 23 (1993) 3072-3081
264. Szamel M., and Resch K. T-cell antigen receptor-induced signal-transduction pathways. Activation and function of protein kinases C in T lymphocytes. Eur. J. Biochem. 228 (1995) 1-15
265. Takai Y., Kishimoto A., Inoue M., and Nishizuka Y. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum. J. Biol. Chem. 252 (1977) 7603-7609
266. Takai Y., Ogawara M., Tomono Y., Moritoh C., Imajoh-Ohmi S., Tsutsumi O., Taketani Y., and Inagaki M. Mitosis-specific phosphorylation of vimentin by protein kinase C coupled with reorganization of intracellular membranes. J. Cell Biol. 133 (1996) 141-149
267. Takekoshi S., Kambayashi Y., Nagata H., Takagi T., Yamamoto Y., and Watanabe K. Activation of protein kinase C by oxidized diacylglycerols. Biochem. Biophys. Res. Commun. 217 (1995) 654-660
268. Tamaoki T., and Nakano H. Potent and specific inhibitors of protein kinase C of microbial origin. Nat. Biotechnol. 8 (1990) 732-735
269. Tanaka C., and Nishizuka Y. The protein kinase C family for neuronal signaling. Annu. Rev. Neurosci. 17 (1994) 551-567
270. Theodore L., Derossi D., Chassaing G., Llirbat B., Kubes M., Jordan P., Chneiweiss H., Godement P., and Prochiantz A. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse. J. Neurosci. 15 (1995) 7158-7167
271. Tong G., and Nielsen J. A convergent solid-phase synthesis of actinomycin analogues- towards implementation of double-combinatorial chemistry. Bioorg. Med. Chem. 4 (1996) 693-698
272. Topper J.N., Cai J., Falb D., and Gimbrone J.M.A. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc. Natl. Acad. Sci. USA 93 (1996) 10417-10422
273. Tsopanoglou N.E., Pipili-Synetos E., and Maragoudakis M.E. Protein kinase C involvement in the regulation of angiogenesis. J. Vase. Res. 30 (1993) 202-208
274. Tsuchida A., Liu Y., Liu G.S., Cohen M.V., and Downey J.M. αl-Adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C. Circ. Res. 75 (1994) 576-585
275. Walker S.D., Murray N.R., Burns D.J., and Fields A.P. Protein kinase C chimeras: Catalytic domains of α and βII protein kinase C contain determinants for isotype-specific function. Proc. Natl. Acad. Sci. USA 92 (1995) 9156-9160
276. Wang S., Milne G.W.A., Nicklaus M.C., Marquez V.E., Lee J., and Blumberg P.M. Protein kinase C. Modeling of the binding site and prediction of binding constants. J. Med. Chem. 37 (1994) 1326-1338
277. Wang S., Zaharevitz D.W., Sharma R., Marquez V.E., Lewin N.E., Du L., Blumberg P.M., and Milne G.W.A. The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies. J. Med. Chem. 37 (1994) 4479-4489
278. Weiss A., and Littman D.R. Signal transduction by lymphocyte antigen receptors. Cell 76 (1994) 263-274
279. Wender P.A., Irie K., and Miller B.L. Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C. Proc. Natl. Acad. Sci. USA 92 (1995) 239-243
280. Wender P.A., Koehler K.F., Sharkey N.A., Del'Aquila M.L., and Blumberg P.M. Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs. Proc. Nat. Acad. Sci. USA 83 (1986) 4214-4218
281. Westermann P., Knoblich M., Maier O., Lindschau C., and Haller H. Protein kinase C bound to the Golgi apparatus supports the formation of constitutive transport vesicles. Biochem. J. 320 (1996) 651-658
282. Whitehead I., Kirk H., Tognon C., Trigo-Gonzales G., and Kay R. Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. J. Biol. Chem. 270 (1995) 18388-18395
283. Wilkinson S.E., and Hallam T.J. Protein kinase C: Is its pivotal role in cellular activation over-stated?. Trends Pharmacol. Sci. 15 (1994) 53-57
284. Wilkinson S.E., Parker P.J., and Nixon J.S. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem. J. 294 (1993) 335-337
285. William F., Wagner F., Karin M., and Kraft A.S. Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation. J. Biol. Chem. 265 (1990) 18166-18171
286. Wilson A.C. The molecular basis of evolution. Sci. Am. 253 (1985) 164-173
287. Wittinghofer A., and Herrmann C. Ras-effector interactions, the problem of specificity. FEBS Lett. 369 (1995) 52-56
288. Yamada K., Avignon A., Standaert M.L., Cooper D.R., Spencer B., and Farese R.V. Effects of insulin on the translocation of protein kinase C-6 and other protein kinase C isoforms in rat skeletal muscles. Biochem. J. 38 (1995) 177-180
289. Yang J.-M., Chin K.-V., and Hait W.N. Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells. Cancer Res. 56 (1996) 3490-3494
290. Yao L., Suzuki H., Ozawa K., Deng J., Lehel C., Fukamachi H., Anderson W.B., Kawakami Y., and Kawakami T. Interactions between protein kinase C and pleckstrin homology domains. Inhibition by phosphatidylinositol 4, 5-bisphosphate and phorbol 12-myristate 13-acetate. J. Biol. Chem. 272 (1997) 13033-13039
291. Yashpal K., Pitcher G.M., Parent A., Quirion R., and Coderre T.J. Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12, 13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C. J. Neurosci. 15 (1995) 3263-3272
292. Yazaki T., Ahmad S., Chahiavi A., Zylber-Katz E., Dean N.M., Rabkin S.D., Martuza R.L., and Glazer R.I. Treatment of glioblastoma U-87 by systemic administation of an antisense protein kinase C-α phosphorothioate oligodeoxynucleotide. Mol. Pharmacol. 50 (1996) 236-242
293. Yedovitzky M., Mochly-Rosen D., Johnson J.A., Gray M.O., Ron D., Abramovitch E., Cerasi E., and Nesher R. Translocation inhibitors define specificity of Protein Kinase C isoenzymes in pancreatic β-cells. J. Biol. Chem. 272 (1997) 1417-1420
294. Yoshioka K., Deng T., Cavigelli M., and Karin M. Antitumor promotion by phenolic antioxidants: Inhibition of AP-1 activity through induction of Fra expression. Proc. Natl. Acad. Sci. USA 92 (1995) 4972-4976
295. Ytrehus K., Liu Y., and Downey J.M. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am. J. Physiol. 266 (1994) H1145-H1152
296. Zang Q., Lu Z., Curto M., Barile N., Shalloway D., and Foster D.A. Association between v-Src and protein kinase C delta in v-Src-transformed fibroblasts. J. Biol. Chem. 272 (1997) 13275-13280
297. Zhang G., Kazanietz M.G., Blumberg P.M., and Hurley J.H. Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester. Cell 81 (1995) 917-924
298. Zhang J., Wang L., Petrin J., Bishop W.R., and Bond R.W. Characterization of site-specific mutants altered at protein kinase C beta 1 isozyme autophosphorylation sites. Proc. Natl. Acad. Sci. USA 90 (1993) 6130-6134
299. 2+ channels. Circ. Res. 80 (1997) 720-729
300. Zhou L.Y., Disatnik M.-H., Chen C.-H., Herron G.S., Mochly-Rosen D., and Karasek M.A. Differential activation of protein kinase C isozymes by phorbol ester and collagen in skin microvascular endothelial cells. J. Invest. Dermatol. 107 (1996) 248-252
301. Zimmermann M.L., and Sneden A.T. Vanicosides A and B, protein kinase C inhibitors from. Polygonum pensylvanicum. J. Nat. Prod. 57 (1994) 236-242