Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A

Journal of Medicinal Chemistry

Volumn 39, Issue 26, 1996, Pages 5215-5227

  Defauw, Jean M ^a   Murphy, Marcia M ^a   Jagdmann Jr , G Erik ^a   Hu, Hong ^a   Lampe, John W ^a   Hollinshead, Sean P ^a   Mitchell, Thomas J ^a   Crane, Heidi M ^a   Heerding, Julia M ^a   Mendoza, José S ^a   Davis, Jefferson E ^a   Darges, James W ^a   Hubbard, Frederick R ^a   Hall, Steven E ^a  

^a Sphinx Pharmaceuticals Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BALANOL; CASEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOENZYME; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE;

ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUTROPHIL; NONHUMAN;

ANIMALS; AZEPINES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; HUMANS; HYDROXYBENZOIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN KINASE C; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 12644287559     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960581w     Document Type: Article

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