Definition by specific antisense oligonucleotides of a role for protein kinase Cα in expression of differentiation markers in normal and neoplastic mouse epidermal keratinocytes

Molecular Carcinogenesis

Volumn 18, Issue 1, 1997, Pages 44-53

  Lee, Yun Sil ^a   Dlugosz, Andrzej A ^a   McKay, Robert ^b   Dean, Nicholas M ^b   Yuspa, Stuart H ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

antisense oligonucleotides; differentiation; keratinocytes; protein kinase C; ras

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CALCIUM; FILAGGRIN; ISOENZYME; PROTEIN KINASE C;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN CELL; KERATINOCYTE; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; ANTIGENS, DIFFERENTIATION; CALCIUM; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CELLS, CULTURED; CYTOSKELETON; ENZYME INDUCTION; ENZYME INHIBITORS; EPIDERMIS; GENES, RAS; ISOENZYMES; KERATINOCYTES; KERATINS; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDES, ANTISENSE; ORNITHINE DECARBOXYLASE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; SOLUBILITY; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

MURINAE;

EID: 0031034522     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199701)18:1<44::AID-MC6>3.0.CO;2-R     Document Type: Article

References (64)

1. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614, 1992.
2. Stabel S, Parker PJ. Protein kinase C. Pharmacol Ther 51:71-95, 1991.
3. Azzi A, Boscoboinik D, Hensey C. The protein kinase C family. Eur J Biochem 208:547-557, 1992.
4. Goodnight J, Mischak H, Mushinski JF. Selective involvement of protein kinase C isozymes in differentiation and neoplastic transformation. Adv Cancer Res 64:159-209, 1994.
5. Mehrel T, Hohl D, Rothnagel JA, et al. Identification of a major keratinocyte cell envelope protein, loricrin. Cell 61:1103-1112, 1990.
6. Kartasova T, Darwiche N, Kohno Y, et al. Sequence and expression patterns of mouse SPR1: Correlation of expression with epithelial function. J Invest Dermatol 106:294-304, 1996.
7. Kim IG, Gorman JJ, Park SC, Chung SI, Steinert PM. The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse. J Biol Chem 268:12682-12690, 1993.
8. Rice RH, Mehrpouyan M, O'Callahan W, Parenteau NL, Rubin AL. Keratinocyte transglutaminase: Differentiation marker and member of an extended family. Epithelial Cell Biol 1:128-137, 1992.
9. Fuchs E, Byrne C. The epidermis: Rising to the surface. Curr Opin Genet Dev 4:725-736, 1994.
10. Dlugosz AA, Yuspa SH. Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C. J Cell Biol 120:217-225, 1993.
11. K) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium. J Invest Dermatol 102:409-414, 1994.
12. Yuspa SH, Hennings H, Tucker RW, et al. The regulation of differentiation in normal and neoplastic keratinocytes. In: Howley P, Broker T (eds), Papillomaviruses, UCLA Symposia and Molecular and Cellular Biology, New Series. Alan R. Liss, Inc., New York, 1990, pp. 211-222.
13. Yuspa SH, Kilkenny AE, Steinert PM, Roop DR. Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro. J Cell Biol 109:1207-1217, 1989.
14. Denning MF, Dlugosz AA, Williams EK, Szallasi Z, Blumberg PM, Yuspa SH. Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ 6:149-157, 1995.
15. Malmquist KG, Carlsson L-E, Forslind B, Roomans GM, Akselsson KR. Proton and electron microprobe analysis of human skin. Nuclear Instruments and Methods in Physics Research 3:611-617, 1984.
16. Menon GK, Grayson S, Elias PM. Ionic calcium reservoirs in mammalian epidermis: Ultrastructural localization by ion-capture cytochemistry. J Invest Dermatol 84:508-512, 1985.
17. Menon GK, Elias PM. Ultrastructural localization of calcium in psoriatic and normal human epidermis. Arch Dermatol 127:57-63, 1991.
18. 2+-mediated inositol lipid metabolism in normal and neoplastic epidermal cells. Carcinogenesis 9:1033-1038, 1988.
19. Punnonen K, Denning M, Lee E, Li L, Rhee SG, Yuspa SH. Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes. J Invest Dermatol 101:719-726, 1993.
20. Tang W, Ziboh VA, Isseroff R, Martinez D. Turnover of inositol phospholipids in cultured murine keratinocytes: Possible involvement of inositol triphosphate in cellular differentiation. J Invest Dermatol 90:37-43, 1988.
21. Wirth PJ, Yuspa SH, Thorgeirsson SS, Hennings H. Induction of common patterns of polypeptide synthesis and phosphorylation by calcium and 12-O-tetradecanoylphorbol-13-acetate in mouse epidermal cell culture. Cancer Res 47:2831-2838, 1987.
22. Lichti U, Yuspa SH. Modulation of tissue and epidermal transglutaminases in mouse epidermal cells after treatment with 12-O-tetradecanoylphorbol-13-acetate and/or retinoic acid in vivo and in culture. Cancer Res 48:74-81, 1988.
23. Roop DR, Huitfeldt H, Kilkenny A, Yuspa SH. Regulated expression of differentiation-associated keratins in cultured epidermal cells detected by monospecific antibodies to unique peptides of mouse epidermal keratins. Differentiation 35:143-150, 1987.
24. Cheng C, Kilkenny AE, Roop D, Yuspa SH. The v-ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes. Mol Carcinog 3:363-373, 1990.
25. Huitfeldt HS, Heyden A, Clausen OPF, Thrane EV, Roop D, Yuspa SH. Altered regulation of growth and expression of differentiation-associated keratins in benign mouse skin tumors. Carcinogenesis 12:2063-2067, 1991.
26. Mamrack MD, Klein-Szanto AJP, Reiners JJ, Slaga TJ. Alteration in the distribution of the epidermal protein filaggrin during two-stage chemical carcinogenesis in the SENCAR mouse skin. Cancer Res 44:2634-2641, 1984.
27. Ziboh VA, Isseroff RR, Pandey R. Phospholipid metabolism in calcium-regulated differentiation in cultured murine keratinocytes. Biochem Biophys Res Commun 122:1234-1240, 1984.
28. Lee E, Punnonen K, Cheng C, Glick A, Dlugosz A, Yuspa SH. Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: Relationship of phosphatidylinositol turnover and cytokine stimulation to the transformed phenotype. Carcinogenesis 13:2367-2373, 1992.
29. Ha genes are mediated by protein kinase C-α. Cancer Res 54:6413-6420, 1994.
30. Gold L. Oligonucleotides as research, diagnostic, and therapeutic agents. J Biol Chem 270:13581-13584, 1995.
31. Stein CA, Cheng YC. Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261:1004-1012, 1993.
32. Wagner RW. Gene inhibition using antisense oligodeoxynucleotides. Nature 372:333-335, 1994.
33. Dean NM, McKay R. Inhibition of protein kinase C-α expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides. Proc Natl Acad Sci USA 91:11762-11766, 1994.
34. Dean NM, McKay R, Condon TP, Bennett CF. Inhibition of protein kinase C-α expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters. J Biol Chem 269:16416-16424, 1994.
35. McKay R, Cummins LL, Graham MJ, et al. Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-α by the incorporation of 2′-O-propyl modifications. Nucleic Acids Res 24:411-417, 1996.
36. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19:245-254, 1980.
37. Roop DR, Lowy DR, Tambourin PE, et al. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 323:822-824, 1986.
38. Ha oncogene and form papillomas in skin grafts on athymic nude mouse hosts. Cancer Res 48:165-169, 1988.
39. Huff CA, Yuspa SH, Rosenthal D. Identification of control elements 3′ to the human keratin 1 gene that regulate cell type and differentiation-specific expression. J Biol Chem 268:377-384, 1993.
40. Harper JR, Greenhalgh DA, Yuspa SH. Expression of transfected DNA by primary murine keratinocytes. J Invest Dermatol 91:150-153, 1988.
41. Nakadate T, Jeng AY, Blumberg PM. Effect of phospholipid on substrate phosphorylation by a catalytic fragment of protein kinase C. J Biol Chem 262:11507-11513, 1987.
42. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1976.
43. Kazanietz MG, Areces LB, Bahador A, et al. Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent PKC isozymes. Mol Pharmacol 44:298-307, 1993.
44. Dlugosz AA, Mischak H, Mushinski JF, Yuspa SH. Transcripts encoding protein kinase C α, δ, ε, ζ, and η are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells. Mol Carcinog 5:286-292, 1992.
45. Ha gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J Biol Chem 268:26079-26081, 1993.
46. Phillips WA, Fujiki T, Rossi MW, Korchak HM, Johnston RB Jr. Influence of calcium on the subcellular distribution of protein kinase C in human neutrophils: Extraction conditions determine partitioning of histone-phosphorylating activity and immunoreactivity between cytosol and particulate fractions. J Biol Chem 264:8361-8365, 1989.
47. Roop DR, Cheng CK, Toftgard R, Stanley JR, Steinert PM, Yuspa SH. The use of cDNA clones and monospecific antibodies as probes to monitor keratin gene expression. Ann N Y Acad Sci 455:426-435, 1985.
48. Phillips MA, Stewart BE, Qin Q, et al. Primary structure of keratinocyte transglutaminase. Proc Natl Acad Sci USA 87:9333-9337, 1990.
49. Jetten AM, Ganong BR, Vandenbark GR, Shirley JE, Bell RM. Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding. Proc Natl Acad Sci USA 82:1941-1945, 1985.
50. Verma AK, Pong RC, Erickson D. Involvement of protein kinase C activation in ornithine decarboxylase gene expression in primary culture of newborn mouse epidermal cells and in skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 46:6149-6155, 1986.
51. Mills KJ, Smart RC. Comparison of epidermal protein kinase C activity, ornithine decarboxylase induction and DNA synthesis stimulated by TPA or dioctanoylglycerol in mouse strains with differing susceptiblity to TPA-induced tumor promotion. Carcinogenesis 10:833-838, 1989.
52. Fischer SM, Lee ML, Maldve RE, et al. Association of protein kinase C activation with induction of ornithine decarboxylase in murine but not human keratinocyte cultures. Mol Carcinog 7:228-237, 1993.
53. Stein CA, Tonkinson JL, Zhang LM, et al. Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells. Biochemistry 32:4855-4861, 1993.
54. Marte BM, Meyer T, Stabel S, et al. Protein kinase C and mammary cell differentiation: Involvement of protein kinase C α in the induction of β-casein expression. Cell Growth Differ 5:239-247, 1994.
55. Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF. Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-α and -δ and not by protein kinase C-β∥, -ε, -ζ, and -η. J Biol Chem 268:20110-20115, 1993.
56. 1 cells. Mol Endocrinol 4:59-68, 1990.
57. Yuspa SH, Poirier MC. Chemical carcinogenesis: From animal models to molecular models in one decade. Adv Cancer Res 50:25-70, 1988.
58. Preiss J, Loomis CR, Bishop WR, Stein R, Neidel JE, Bell RM. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras-and sis-transformed normal rat kidney cells. J Biol Chem 261:8597-8600, 1986.
59. Fleischman LF, Chahwala SB, Cantley L. ras-transformed cells: Altered levels of phosphatidylinositol-4,5-biphosphate and catabolites. Science 231:407-410, 1986.
60. Spina A, Chiosi E, Illiano G, Berlingieri MT, Fusco A, Grieco M. Protein kinase C activities are increased in rat thyroid epithelial cells expressing v-ras genes. Biochem Biophys Res Commun 157:1093-1103, 1988.
61. Molloy CJ, Laskin JD. Specific alterations in keratin biosynthesis in mouse epidermis in vivo and in explant culture following a single exposure to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 47:4674-4680, 1987.
62. Toftgard R, Yuspa SH, Roop DR. Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 45:5845-5850, 1985.
63. Darmon M, Delescluse C, Semat A, Bernard B, Bailly J, Prunieras M. A keratin of fetal skin is reexpressed in human keratinocytes transformed by SV40 virus or treated with the tumor promoter TPA. Exp Cell Res 154:315-319, 1984.
64. Pankov R, Umezawa A, Maki R, Der CJ. Oncogene activation of human keratin 18 transcription via the ras signal transduction pathway. Proc Natl Acad Sci USA 91:873-877, 1994.