Different protein kinase C isozymes mediate lower esophageal sphincter tone and phasic contraction of esophageal circular smooth muscle

Molecular Pharmacology

Volumn 51, Issue 3, 1997, Pages 462-470

  Sohn, Uy Dong ^b   Zoukhri, Driss ^c   Dartt, Darlene ^c   Sergheraert, Christian ^d   Harnett, Karen M ^a   Behar, Jose ^a   Biancani, Piero ^a,e  

^a RHODE ISLAND HOSPITAL   (United States)

^b Yeungnam University College of Medicine   (South Korea)

^c SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^d INSTITUT PASTEUR DE LILLE   (France)

^e BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; DIOCTANOIN; ISOENZYME; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SAPONIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CAT; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ESOPHAGUS MUSCLE; FEMALE; IMMUNOBLOTTING; LOWER ESOPHAGUS SPHINCTER; MALE; MYRISTYLATION; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION;

ANIMALS; CATS; ESOPHAGOGASTRIC JUNCTION; ESOPHAGUS; FEMALE; ISOENZYMES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA;

EID: 0000207414     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. 2+ release in the LES. Am. J. Physiol. 253:G760-G766 (1987).
2. Sohn, U. D., T. T. Chiu, K. N. Bitar, C. Hillemeier, J. Behar, and P. Biancani. Calcium requirements for ACh induced contraction of cat esophageal circular muscle cells. Am. J. Physiol. 266:G330-G338 (1994).
3. Biancani, P., K. M. Harnett, U. D. Sohn, B. Y. Rhim, J. Behar, C. Hillemeier, and K. N. Bitar. Differential signal transduction pathways in LES tone and response to ACh. Am. J. Physiol. 266:G767-G774 (1994).
4. Nishizuka, Y. Protein kinase C and lipid signaling for sustained responses. FASEB J. 9:484-496 (1995).
5. Bitar, K. N., and G. M. Makhlouf. Receptors on smooth muscle cells: characterization by contraction and specific antagonists. Am. J. Physiol. 242:G400-G407 (1982).
6. Biancani, P., M. Zabinski, M. Kerstein, and J. Behar. Lower esophageal sphincter mechanisms: anatomic and physiologic relationships of the esophagogastric junction of the cat. Gastroenterology 82:468-475 (1982).
7. Bitar, K. N., S. Stein, and G. Omann. Specific G-proteins mediate endothelin induced contraction. Life Sci. 50:2119-2124 (1992).
8. Sohn, U. D., K. M. Harnett, G. De Petris, J. Behar, and P. Biancani. Distinct muscarinic receptors, G proteins, and phospholipases in esophageal and lower esophageal sphincter (LES) circular muscle. J. Pharmacol. Exp. Ther. 267:1205-1214 (1993).
9. Zoukhri, D., R. R. Hodges, C. Sergheraert, and D. Dartt. Lacrimal gland PKC isoforms are differentially involved in agonist-induced protein secretion. Am. J. Physiol.
10. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227:680-685 (1970).
11. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Annal. Biochem. 72:248-254 (1976).
12. 50 and the number of binding sites per receptor molecule using logit transformation. Arzneim.-Forsch. 27:1871-1873, 1977.
13. 2+, phospholipid-dependent protein kinase associated with the plasma membrane. Nature (Lond.) 301:621-623 (1983).
14. Khalil, R. A., and K. G. Morgan. Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells. Circ. Res. 69: 1626-1631 (1991).
15. Haller, H., J. I. Smallwood, and H. Rasmussen. Protein kinase C translocation in intact vascular smooth muscle strips. Biochem. J. 270:375-381 (1990).
16. Jiang, M. J., and K. G. Morgan. Intracellular calcium levels in phorbol ester-induced contractions of vascular muscle. Am. J. Physiol. 253:H1365-H1371 (1987).
17. Jiang, M. J., and K. G. Morgan. Agonist-specific myosin phosphorylation and intracellular calcium during isometric contractions of arterial smooth muscle. Pflueg. Arch. Eur. J. Physiol. 413:637-643 (1989).
18. Singer, H. A., and K. M. Baker. Calcium dependence of phorbol ester-induced force and myosin light chain phosphorylation in arterial smooth muscle. J. Pharmacol. Exp. Ther. 243:814-821 (1987).
19. Hillemeier, C., K. N. Bitar, U. D. Sohn, and P. Biancani. Protein kinase C mediates spontaneous tone in the cat lower esophageal sphincter. J. Pharmacol. Exp. Ther. 277:144-149 (1996).
20. Sohn, U. D., B. Han, A. H. Tashjian Jr., J. Behar, and P. Biancani. Agonist independent, muscle type specific signal transduction pathways in cat esophageal and lower esophageal sphincter (LES) circular smooth muscle. J. Pharmacol. Exp. Ther. 273:482-491 (1995).
21. Sohn, U. D., D. K. Kim, J. V. Bonventre, J. Behar, and P. Biancani. Role of 100 kDa cytosolic PLA2 in ACh-induced contraction of esophageal circular muscle. Am. J. Physiol. 267:G433-G441 (1994).
22. Nishizuka, Y. The family of protein kinase C for signal transduction. JAMA 262:1826-1833 (1991).
23. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science (Washington D. C.) 258:607-614 (1992).
24. Ono, Y., K. Fuji, U. Ogita, K. Kikkawa, K. Igarashi, and Y. Nishizuka. Protein kinase C subspecies from rat brain: its structure, expression, and properties. Proc. Natl. Acad. Sci. USA 86:3099-3103 (1989).
25. Ali, S., M. W. Becker, M. G. Davis, and G. W. Dorn. Dissociation of vasoconstrictor-stimulated basic fibroblast growth factor expression from hypertrophic growth in cultured vascular smooth muscle cells: relevant roles of protein kinase C. Circ. Res. 75:836-843 (1994).
26. Ignoguchi, T., R. Battan, E. Handler, J. R. Sportsman, W. Health, and G. I. King. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in aorta and heart of diabetic rats: differential reversibility to glycemic control by island cell transplantation. Proc. Natl. Acad. Sci. USA 89:11059-11063 (1992).
27. 2+-independent isoforms of protein kinase C differentially translocate in smooth muscle. Am. J. Physiol. 263:C714-C719 (1992).
28. Assender, J. W., E. Knotny, and B. B. Fredholm. Expression of protein kinase C isoforms in smooth muscle cells in various states of differentiation. FEBS Lett. 342:76-80 (1994).
29. Dixon, B. S., R. V. Sharma, T. Dickerson, and J. Fortune. Bradykinin and angiotensin II: activation of protein kinase C in arterial smooth muscle. Am. J. Physiol. 266:C1406-C1420 (1994).
30. Mochly-Rosen, D., H. Khaner, and J. Lopez. Identification of intracellular receptor proteins for activated protein kinase C. Proc. Natl. Acad. Sci. USA 88:3997-4000 (1991).
31. Mochly-Rosen, D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science (Washington D. C.) 268:247-250 (1995).
32. Baier, G., D. Telford, L. Giampa, K. M. Coggsshall, G. Baier-Bitterlich, N. Isakov, and A. Altman. Molecular cloning and characterization of PKCθ, a novel member of the protein kinase C (PKC) family expressed predominantly in hematopoietic cells. J. Biol. Chem. 268:4997-5004 (1993).
33. Johannes, F.-J., J. Prestle, S. Eis, P. Oberhagamann, and K. Pfizenmaier. PKCμ is a novel, atypical member of the protein kinase C family. J. Biol. Chem. 269:6140-6148 (1994).
34. Osadas, S., K. Mizuno, T. C. Saido, K. Suzuki, T. Kuroki, and S. Ohno. A new member of the protein kinase family, nPKCθ, predominantly expressed in skeletal muscle. Mol. Cell. Biol. 12:3030-3938 (1992).
35. Flint, A. J., R. D. Paladini, and D. E. J. Koshland. Autophosphorylation of protein kinase C at separated regions of its primary sequence. Science (Washington D. C.) 249:408-111 (1990).
36. Mitchell, F. E., R. M. Marias, and P. J. Parker. The phosphorylation of protein kinase C as a potential measure of activation. Biochem. J. 261: 131-136 (1989).
37. Zhang, J., L. Wang, J. Schwartz, R. W. Bond, and W. R. Bishop. Phosphorylation of Thr 642 is an early event in the processing of newly synthesized protein kinase C beta I and is essential for its activation. J. Biol. Chem. 269:19578-19584 (1994).
38. House, C., and B. E. Kemp. Protein kinase C contains a pseudosubstrate prototype in its regulatory domain. Science (Washington D. C.) 238:1726-1728 (1987).
39. Eichholtz, T., D. B. deBont, J. deWidt, R. M. J. Liskmp, H. L. Ploegh. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. J. Biol. Chem. 268:1982-1986 (1993).