Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C

Journal of Neurochemistry

Volumn 68, Issue 6, 1997, Pages 2523-2529

  Caputi, A ^a,d   Barindelli, S ^a   Pastorino, L ^a   Cimino, M ^b   Buxbaum, J D ^c   Cattabeni, F ^a   Di Luca, M ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c ROCKEFELLER UNIVERSITY   (United States)

^d University of Pharmacological Sciences   (Italy)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Methylazoxymethanol; Protein kinase C; Rat

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PROTEIN KINASE C;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SECRETION; RAT;

EID: 0030921730     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68062523.x     Document Type: Article

References (42)

1. Balduini W., Lombardelli G., Peruzzi G., and Cattabeni F. (1991) Treatment with methylazoxymethanol at different gestational days: physical, reflex development and spontaneous activity in the offspring. Neurotoxicology 12, 201-210.
2. Balduini W., Lombardelli G., Peruzzi G., and Cattabeni F. (1992) Cholinergic hyperinnervation in the cerebral cortex of microencephalic rats does not result in muscarinic receptor down-regulation or in alteration of receptor-stimulated phosphoinositide metabolism. Neurochem. Res. 17, 761-766.
3. Bayer S. A., Altman J., Russo R. J., and Zhang X. (1993) Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology 14, 83-144.
4. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Buxbaum J. D., Gandy S. E., Cicchetti P., Ehrlich M. E., Czernik A. J., Fracasso R. P., Ramabhadran T. V., Unterbeck A. J., and Greengard P. (1990) Processing of Alzheimer β/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proc. Natl. Acad. Sci. USA 87, 6003-6006.
6. Buxbaum J. D., Oishi M., Chen H. I., Pinkas-Kramarski R., Jaffe E. A., Gandy S. E., and Greengard P. (1992) Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA 89, 10075-10078.
7. Buxbaum J. D., Ruefli A. A., Parker C. A., Cypess A. M., and Greengard P. (1994) Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc. Natl. Acad. Sci. USA 91, 4489-4493.
8. Caporaso G. L., Gandy S. E., Buxbaum J. D., Ramabhadran T. V., and Greengard P. (1992) Protein phosphorylation regulates secretion of Alzheimer β/A4 amyloid precursor protein. Proc. Natl. Acad. Sci. USA 89, 3055-3059.
9. Caputi A., Rurale S., Pastorino L., Cimino M., Cattabeni F., and Di Luca M. (1996) Differential translocation of protein kinase C in rats characterized by a chronic lack of LTP induction and cognitive impairment. FEBS Lett. 393, 121-123.
10. Cattaneo E., Reinach B., Caputi A., Cattabeni F., and Di Luca M. (1995) Selective in vitro blockade of neuroepithelial cell proliferation by methylazoxymethanol, a molecule capable of inducing long lasting functional impairments. J. Neurosci. Res. 41, 640-647.
11. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
12. Di Luca M. and Cattabeni F. (1991) Transplacentally induced brain lesions: an animal model to study molecular correlates of cognitive deficits. Neurosci. Res. Commun. 9, 127-136.
13. Di Luca M., Cimino M., Caputi A., and Cattabeni F. (1993) Microencephaly induces a long-lasting change in B-50 phosphorylation in rats. Neurosci. Res. Commun. 13, 91-97.
14. Di Luca M., Caputi A., Cinquanta M., Cimino M., Marini P., Princivalle A., De Graan P. N. E., Gispen W. H., and Cattabeni F. (1995) Changes in protein kinase C and its presynaptic substrate B-50/GAP-43 after intrauterine exposure to methylazoxymethanol, a treatment inducing cortical and hippocampal damage and cognitive deficit in rats. Eur. J. Neurosci. 7, 899-906.
15. Di Luca M., Caputi A., Cattabeni F., de Graan P. N. E., Gispen W. H., Raiteri M., Fassio A., Schmid G., and Bonanno G. B. (1997) Increased presynaptic protein kinase C activity and glutamate release in rats with a prenatally induced hippocampal lesion. Eur. J. Neurosci. 9, 472-479.
16. Dunkley P. R., Health J. W., Harrison S. M., Jarvie P. E., Glenfield P. J., and Rostas J. A. P. (1988) A rapid Percoll gradient procedure for isolation of synaptosomes directly from S1 fraction: homogeneity and morphology of subcellular fractions. Brain Res. 441, 59-71.
17. Efthimiopoulos S., Felsenstein K. M., Sambamurti K., Robakis N. K., and Refolo L. M. (1994) Study of the phorbol ester effect on Alzheimer amyloid precursor protein processing: sequence requirements and involvement of a cholera toxin sensitive protein. J. Neurosci. Res. 38, 81-90.
18. Farber S. A., Nitsch R. M., Schulz J. G., and Wurtman R. J. (1995) Regulated secretion of β amyloid precursor protein in rat brain. J. Neurosci. 15, 7442-7451.
19. Gabuzda D., Busciglio J., and Yankner B. A. (1993) Inhibition of β-amyloid production by activation of protein kinase C. J. Neurochem. 61, 2326-2329.
20. Gillespie S. L., Golde T. E., and Younkin S. G. (1992) Secretory processing of the Alzheimer amyloid β A4 protein precursor is increased by protein phosphorylation. Biochem. Biophys. Res. Commun. 187, 1285-1290.
21. Glenner G. G. and Wong C. W. (1984) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
22. Haass C., Koo E. H., Teplow D. B., and Selkoe D. J. (1994) Polarized secretion of β-amyloid precursor protein and amyloid β-peptide in MDCK cells. Proc. Natl. Acad. Sci. USA 91, 1564-1568.
23. Hung A. Y. and Selkoe D. J. (1994) Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. EMBO J. 13, 534-542.
24. Jacobsen J. S., Spruyt M. A., Brown A. M., Sahasrabudhe S. R., Blume A. J., Vitek M. P., Muenkel H. A., and Sonnenberg-Reines J. (1994) The release of Alzheimer's disease beta-amyloid peptide is reduced by phorbol treatment. J. Biol. Chem. 269, 8376-8382.
25. Johnston M. V. and Coyle J. T. (1982) Cytotoxic lesions and the development of transmitter systems. Trends Neurosci. 5, 153-156.
26. Kinouchi T., Sorimachi H., Moryama K., Mizuno K., Ohno S., Ischiura S., and Suzuki K. (1993) Conventional protein kinase C (PKC)-α and novel PKC∈, but not δ, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblast. FEBS Lett. 364, 203-206.
27. Koo E. H. and Squazzo S. L. (1994) Evidence that production and release of amyloid β-protein involves the endocytic pathway. J. Biol. Chem. 269, 17386-17389.
28. Lee R. K. K., Wurtman R. J., Cox A. J., and Nitsch R. M. (1995) Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Proc. Natl. Acad. Sci. USA 92, 8083-8087.
29. Masters C. L., Simons G., Weinman N. A., Multhaup G., McDonald B. L., and Beyreuther K. (1985) Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc. Natl. Acad. Sci. USA 82, 4245-4249.
30. Mullan M. and Crawford F. (1993) Genetic and molecular advances in Alzheimer's disease. Trends Neurosci. 16, 398-403.
31. Nitsch R. M. and Growdon J. H. (1994) Role of the neurotransmission in the regulation of amyloid b-protein precursor processing. Biochem. Pharmacol. 48, 1275-1284.
32. Nitsch R. M., Slack B. E., Wurtman R. J., and Growdon J. H. (1992) Release of Alzheimer amyloid precursor protein derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258, 304-307.
33. Oltersdorf T., Ward P. J., Henriksson T., Beattie E. C., Neve R., Lieberburg I., and Fritz L. C. (1990) The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway. J. Biol. Chem. 265, 4492-4497.
34. Palmert M. R., Berman Podlisny M., Witker D. S., Oltersdorf T., Younkin L. H., Selkoe D. J., and Younkin S. G. (1989) The β-amyloid protein precursor of Alzheimer's disease has soluble derivative found in human brain and cerebrospinal fluid. Proc. Natl. Acad. Sci. USA 86, 6338-6342.
35. Ramakers G. M. J., Urban I. J. A., De Graan P. N. E., Di Luca M., Cattabeni F., and Gispen W. H. (1993) The impaired long-term potentiation in the CA1 field of the hippocampus of cognitive deficient microencephalic rats is restored by D-serine. Neuroscience 54, 49-60.
36. Seubert P., Oltersdorf T., Lee M. G., Barbour R., Blomquist C., Davis D. L., Bryant K., Fritz L. C., Galasko D., Thal L. J., Lieberburg I., and Schenk D. B. (1993) Secretion of β-amyloid precursor protein cleaved at the amino-terminus of the β-amyloid peptide. Nature 361, 260-263.
37. Slack B. E., Nitsch R. M., Livneh E., Kunz G. M., Breu J., Eldar H., and Wurtman R. J. (1993) Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase Ca. J. Biol. Chem. 268, 21097-21101.
38. Suzuki T., Oishi M., Marshak D. R., Czernik A. J., Nairn A. C., and Greengard P. (1994) Cell cycle formation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. EMBO J. 13, 1114-1122.
39. Wasco W., Bupp K., Magendantz M., Gusella J. F., Tanzi R. E., and Solomon F. (1992) Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated β-protein precursor. Proc. Natl. Acad. Sci. USA 89, 10758-10762.
40. Wasco W., Gurubhagavatula S., Paradis M., Romano D. M., Sisodia S. S., Hyman B. T., Neve R. L., and Tanzi R. E. (1993) Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor. Nat. Genet. 5, 95-99.
41. Weidemann A., Konig G., Bunke D., Fischer P., Salbaum J. M., Masters C. L., and Beyreuther K. (1989) Identification, biogenesis and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126.
42. Xu H., Greengard P., and Gandy S. (1995) Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein. J. Biol. Chem. 270, 23243-23245.