Adenosine A(2B) receptors as therapeutic targets

Drug Development Research

Volumn 45, Issue 3-4, 1998, Pages 198-206

  Feoktistov, Igor ^a   Wells, Jack N ^a   Biaggioni, Italo ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Asthma; G coupled receptors; Intracellular pathways; Mast cells; Receptors, purinergic

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2B RECEPTOR; ENPROFYLLINE;

CONFERENCE PAPER; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; PROTEIN ANALYSIS; RECEPTOR INTRINSIC ACTIVITY;

EID: 0032452871     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1098-2299(199811/12)45:3/4<198::aid-ddr17>3.0.co;2-%23     Document Type: Conference Paper

References (5)

1. 2B4) cells. Br J Pharmacol 119:1286-1290.
2. Ali S, Mustafa SJ, Metzger MJ. 1994a. Adenosine receptor-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbit model. Am J Physiol 94:L271-L277.
3. Bellardinelli L, Linden J, Berne RM. 1989. The cardiac effects of adenosine. Prog Cardiovasc Dis 32:73-97.
4. Björck T, Gustafsson LE, Dahlën SE. 1992. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am Rev Respir Dis 145:1087-1091.
5. Brackett LE, Daly JW. 1994. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol 47:801-814.