-
1
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano, R. L., and Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta, 455: 152-62, 1976.
-
(1976)
Biochim. Biophys. Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
2
-
-
0023447098
-
Cellular localization of the multidrug resistance gene product in normal human tissues
-
Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C. Cellular localization of the multidrug resistance gene product in normal human tissues. Proc Natl Acad Sci U S A, 84: 7735-8, 1987.
-
(1987)
Proc. Natl. Acad. Sci. U. S. A.
, vol.84
, pp. 7735-7738
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
3
-
-
0037457796
-
Considerations in the design and development of transport inhibitors as adjuncts to drug therapy
-
Dantzig, A. H., de Alwis, D. P., and Burgess, M. Considerations in the design and development of transport inhibitors as adjuncts to drug therapy. Adv Drug Deliv Rev, 55: 133-50, 2003.
-
(2003)
Adv. Drug Deliv. Rev.
, vol.55
, pp. 133-150
-
-
Dantzig, A.H.1
de Alwis, D.P.2
Burgess, M.3
-
4
-
-
0034185251
-
Regulation of the multidrug resistance genes by stress signals
-
Sukhai, M., and Piquette-Miller, M. Regulation of the multidrug resistance genes by stress signals. J Pharm Pharm Sci, 3: 268-80, 2000.
-
(2000)
J. Pharm. Pharm. Sci.
, vol.3
, pp. 268-280
-
-
Sukhai, M.1
Piquette-Miller, M.2
-
5
-
-
0032754284
-
The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin
-
Greiner, B., Eichelbaum, M., Fritz, P., Kreichgauer, H. P., von Richter, O., Zundler, J., and Kroemer, H. K. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin. J Clin Invest, 104: 147-53, 1999.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 147-153
-
-
Greiner, B.1
Eichelbaum, M.2
Fritz, P.3
Kreichgauer, H.P.4
von Richter, O.5
Zundler, J.6
Kroemer, H.K.7
-
6
-
-
0025293764
-
Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: A review
-
Wadler, S., and Schwartz, E. L. Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review. Cancer Res., 50: 3473-86, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 3473-3486
-
-
Wadler, S.1
Schwartz, E.L.2
-
7
-
-
0037281616
-
Cytokine regulation of P-glycoprotein
-
McRae, M. P., Brouwer, K. L. R., and Kashuba, A. D. M. Cytokine regulation of P-glycoprotein. Drug Metab Rev, 35: 19-33, 2003.
-
(2003)
Drug Metab. Rev.
, vol.35
, pp. 19-33
-
-
McRae, M.P.1
Brouwer, K.L.R.2
Kashuba, A.D.M.3
-
8
-
-
0027363563
-
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
-
Smit, J. J., Schinkel, A. H., Oude-Elferink, R. P., Groen, A. K., Wagenaar, E., van Deemter, L., Mol, C. A., Ottenhoff, R., van der Lugt, N. M., van Roon, M. A., Offerhaus, G. J. A., Berns, A. J. M., and Borst, P. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell, 75: 451-62, 1993.
-
(1993)
Cell
, vol.75
, pp. 451-462
-
-
Smit, J.J.1
Schinkel, A.H.2
Oude-Elferink, R.P.3
Groen, A.K.4
Wagenaar, E.5
van Deemter, L.6
Mol, C.A.7
Ottenhoff, R.8
van der Lugt, N.M.9
van Roon, M.A.10
Offerhaus, G.J.A.11
Berns, A.J.M.12
Borst, P.13
-
9
-
-
0028825399
-
Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
-
Schinkel, A. H., Wagenaar, E., van Deemter, L., Mol, C. A., and Borst, P. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest, 96: 1698-705, 1995.
-
(1995)
J. Clin. Invest.
, vol.96
, pp. 1698-1705
-
-
Schinkel, A.H.1
Wagenaar, E.2
van Deemter, L.3
Mol, C.A.4
Borst, P.5
-
10
-
-
0028892249
-
Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta
-
Barrand, M. A., Robertson, K. J., and von Weikersthal, S. F. Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta. FEBS Lett, 374: 179-83, 1995.
-
(1995)
FEBS Lett.
, vol.374
, pp. 179-183
-
-
Barrand, M.A.1
Robertson, K.J.2
von Weikersthal, S.F.3
-
11
-
-
0028951303
-
MDR expression in normal tissues. Pharmacologic implications for the clinical use of P-glycoprotein inhibitors
-
Lum, B. L., and Gosland, M. P. MDR expression in normal tissues. Pharmacologic implications for the clinical use of P-glycoprotein inhibitors. Hematol Oncol Clin North Am, 9: 319-36, 1995.
-
(1995)
Hematol. Oncol. Clin. North Am.
, vol.9
, pp. 319-336
-
-
Lum, B.L.1
Gosland, M.P.2
-
12
-
-
0033961896
-
Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain
-
Golden, P. L., and Pardridge, W. M. Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain. Cell Mol Neurobiol, 20: 165-81, 2000.
-
(2000)
Cell Mol. Neurobiol.
, vol.20
, pp. 165-181
-
-
Golden, P.L.1
Pardridge, W.M.2
-
13
-
-
0034802307
-
Functional expression of P-glycoprotein in rat brain microglia
-
Lee, G., Schlichter, L., Bendayan, M., and Bendayan, R. Functional expression of P-glycoprotein in rat brain microglia. J Pharmacol Exp Ther, 299: 204-12, 2001.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 204-212
-
-
Lee, G.1
Schlichter, L.2
Bendayan, M.3
Bendayan, R.4
-
14
-
-
0033616684
-
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier
-
Rao, V. V., Dahlheimer, J. L., Bardgett, M. E., Snyder, A. Z., Finch, R. A., Sartorelli, A. C., and Piwnica-Worms, D. Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci U S A, 96: 3900-5, 1999.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 3900-3905
-
-
Rao, V.V.1
Dahlheimer, J.L.2
Bardgett, M.E.3
Snyder, A.Z.4
Finch, R.A.5
Sartorelli, A.C.6
Piwnica-Worms, D.7
-
15
-
-
0037229942
-
Role of P-glycoprotein in pharmacokinetics: Clinical implications
-
Lin, J. H., and Yamazaki, M. Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet, 42: 59-98, 2003.
-
(2003)
Clin. Pharmacokinet.
, vol.42
, pp. 59-98
-
-
Lin, J.H.1
Yamazaki, M.2
-
16
-
-
0034105897
-
The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice
-
van Asperen, J., van Tellingen, O., and Beijnen, J. H. The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice. Drug Metab Dispos., 28: 264-7, 2000.
-
(2000)
Drug. Metab. Dispos.
, vol.28
, pp. 264-267
-
-
van Asperen, J.1
van Tellingen, O.2
Beijnen, J.H.3
-
17
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
Schinkel, A. H., Wagenaar, E., Mol, C. A., and van Deemter, L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest, 97: 2517-24, 1996.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.3
van Deemter, L.4
-
18
-
-
0029860174
-
Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein
-
Mayer, U., Wagenaar, E., Beijnen, J. H., Smit, J. W., Meijer, D. K., van Asperen, J., Borst, P., and Schinkel, A. H. Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein. Br J Pharmacol, 119: 1038-44, 1996.
-
(1996)
Br. J. Pharmacol.
, vol.119
, pp. 1038-1044
-
-
Mayer, U.1
Wagenaar, E.2
Beijnen, J.H.3
Smit, J.W.4
Meijer, D.K.5
van Asperen, J.6
Borst, P.7
Schinkel, A.H.8
-
19
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel, A. H., Smit, J. J., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A., van der Valk, M. A., Robanus-Maandag, E. C., and te Riele, H. P. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell, 77: 491-502, 1994.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
van Deemter, L.6
Mol, C.A.7
van der Valk, M.A.8
Robanus-Maandag, E.C.9
te Riele, H.P.10
-
20
-
-
0027218689
-
Biochemistry of multidrug resistance mediated by the multidrug transporter
-
Gottesman, M. M., and Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem, 62: 385-427, 1993.
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 385-427
-
-
Gottesman, M.M.1
Pastan, I.2
-
21
-
-
0344157469
-
The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system
-
Munoz-Fernandez, M. A., and Fresno, M. The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system. Progress Neurobiol, 56: 307-40, 1998.
-
(1998)
Progress Neurobiol.
, vol.56
, pp. 307-340
-
-
Munoz-Fernandez, M.A.1
Fresno, M.2
-
22
-
-
0027443904
-
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
-
Abdel-Razzak, Z., Loyer, P., Fautrel, A., Gautier, J. C., Corcos, L., Turlin, B., Beaune, P., and Guillouzo, A. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol, 44: 707-15, 1993.
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 707-715
-
-
Abdel-Razzak, Z.1
Loyer, P.2
Fautrel, A.3
Gautier, J.C.4
Corcos, L.5
Turlin, B.6
Beaune, P.7
Guillouzo, A.8
-
23
-
-
0030827807
-
Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6 and dexamethasone in cultured fetal rat hepatocytes
-
Parmentier, J. H., Schohn, H., Bronner, M., Ferrari, L., Batt, A. M., Daucat, M., and Kremers, P. Regulation of CYP4A1 and peroxisome proliferator-activated receptor alpha expression by interleukin-1beta, interleukin-6 and dexamethasone in cultured fetal rat hepatocytes. Biochem Pharmacol, 54: 889-98, 1997.
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 889-898
-
-
Parmentier, J.H.1
Schohn, H.2
Bronner, M.3
Ferrari, L.4
Batt, A.M.5
Daucat, M.6
Kremers, P.7
-
24
-
-
0035279012
-
Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide
-
Turrin, N. P., Gayle, D., Ilyin, S. E., Flynn, M. C., Langhans, W., Schwartz, G. J., and Plata-Salaman, C. R. Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide. Brain Res Bull, 54: 443-53, 2001.
-
(2001)
Brain Res. Bull.
, vol.54
, pp. 443-453
-
-
Turrin, N.P.1
Gayle, D.2
Ilyin, S.E.3
Flynn, M.C.4
Langhans, W.5
Schwartz, G.J.6
Plata-Salaman, C.R.7
-
25
-
-
0030612938
-
Interferon-gamma potentiates interleukin (IL)-6 and tumor necrosis factor-alpha but not IL-1beta induced by endotoxin in the brain
-
De Simoni, M. G., Terreni, L., Chiesa, R., Mangiarotti, F., and Forloni, G. L. Interferon-gamma potentiates interleukin (IL)-6 and tumor necrosis factor-alpha but not IL-1beta induced by endotoxin in the brain. Endocrinology, 138: 5220-6, 1997.
-
(1997)
Endocrinology
, vol.138
, pp. 5220-5226
-
-
De Simoni, M.G.1
Terreni, L.2
Chiesa, R.3
Mangiarotti, F.4
Forloni, G.L.5
-
26
-
-
0027377964
-
Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis
-
Teeter, L. D., Estes, M., Chan, J. Y., Atassi, H., Sell, S., Becker, F. F., and Kuo, M. T. Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol Carcinog, 8: 67-73, 1993.
-
(1993)
Mol. Carcinog.
, vol.8
, pp. 67-73
-
-
Teeter, L.D.1
Estes, M.2
Chan, J.Y.3
Atassi, H.4
Sell, S.5
Becker, F.F.6
Kuo, M.T.7
-
27
-
-
0028817783
-
Modulation of P-glycoprotein and mdr1b mRNA expression by growth factors in primary rat hepatocyte culture
-
Hirsch-Ernst, K. I., Ziemann, C., Foth, H., Kozian, D., Schmitz-Salue, C., and Kahl, G. F. Modulation of P-glycoprotein and mdr1b mRNA expression by growth factors in primary rat hepatocyte culture. Biochem Biophys Res Commun, 215: 179-85, 1995.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.215
, pp. 179-185
-
-
Hirsch-Ernst, K.I.1
Ziemann, C.2
Foth, H.3
Kozian, D.4
Schmitz-Salue, C.5
Kahl, G.F.6
-
28
-
-
0037716531
-
Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin
-
Goralski, K. B., Hartmann, G., Piquette-Miller, M., and Renton, K. W. Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Br J Pharmacol, 139: 35-48, 2003.
-
(2003)
Br. J. Pharmacol.
, vol.139
, pp. 35-48
-
-
Goralski, K.B.1
Hartmann, G.2
Piquette-Miller, M.3
Renton, K.W.4
-
29
-
-
0035190547
-
Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats
-
Ando, H., Nishio, Y., Ito, K., Nakao, A., Wang, L., Zhao, Y. L., Kitaichi, K., Takagi, K., and Hasegawa, T. Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats. Antimicrob Agents Chemother, 45: 3462-7, 2001.
-
(2001)
Antimicrob. Agents Chemother.
, vol.45
, pp. 3462-3467
-
-
Ando, H.1
Nishio, Y.2
Ito, K.3
Nakao, A.4
Wang, L.5
Zhao, Y.L.6
Kitaichi, K.7
Takagi, K.8
Hasegawa, T.9
-
30
-
-
0031738416
-
Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
-
Vos, T. A., Hooiveld, G. J., Koning, H., Childs, S., Meijer, D. K., Moshage, H., Jansen, P. L., and Muller, M. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology, 28: 1637-44, 1998.
-
(1998)
Hepatology
, vol.28
, pp. 1637-1644
-
-
Vos, T.A.1
Hooiveld, G.J.2
Koning, H.3
Childs, S.4
Meijer, D.K.5
Moshage, H.6
Jansen, P.L.7
Muller, M.8
-
31
-
-
0034436741
-
Inflammation and interleukin-6 mediate reductions in the hepatic expression and transcription of the mdr1a and mdr1b Genes
-
Sukhai, M., Yong, A., Kalitsky, J., and Piquette-Miller, M. Inflammation and interleukin-6 mediate reductions in the hepatic expression and transcription of the mdr1a and mdr1b Genes. Mol Cell Biol Res Commun, 4: 248-56, 2000.
-
(2000)
Mol. Cell Biol. Res. Commun.
, vol.4
, pp. 248-256
-
-
Sukhai, M.1
Yong, A.2
Kalitsky, J.3
Piquette-Miller, M.4
-
32
-
-
0031750862
-
Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation
-
Piquette-Miller, M., Pak, A., Kim, H., Anari, R., and Shahzamani, A. Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation. Pharm Res, 15: 706-11, 1998.
-
(1998)
Pharm. Res.
, vol.15
, pp. 706-711
-
-
Piquette-Miller, M.1
Pak, A.2
Kim, H.3
Anari, R.4
Shahzamani, A.5
-
33
-
-
0035115303
-
Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice
-
Hartmann, G., Kim, H., and Piquette-Miller, M. Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice. Int Immunopharmacol, 1: 189-99, 2001.
-
(2001)
Int. Immunopharmacol.
, vol.1
, pp. 189-199
-
-
Hartmann, G.1
Kim, H.2
Piquette-Miller, M.3
-
34
-
-
0030963906
-
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
-
Trauner, M., Arrese, M., Soroka, C. J., Ananthanarayanan, M., Koeppel, T. A., Schlosser, S. F., Suchy, F. J., Keppler, D., and Boyer, J. L. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology, 113: 255-64, 1997.
-
(1997)
Gastroenterology
, vol.113
, pp. 255-264
-
-
Trauner, M.1
Arrese, M.2
Soroka, C.J.3
Ananthanarayanan, M.4
Koeppel, T.A.5
Schlosser, S.F.6
Suchy, F.J.7
Keppler, D.8
Boyer, J.L.9
-
35
-
-
0031856545
-
Induction of mdr1b mRNA and P-glycoprotein expression by tumor necrosis factor alpha in primary rat hepatocyte cultures
-
Hirsch-Ernst, K. I., Ziemann, C., Foth, H., Kozian, D., Schmitz-Salue, C., and Kahl, G. F. Induction of mdr1b mRNA and P-glycoprotein expression by tumor necrosis factor alpha in primary rat hepatocyte cultures. J Cell Physiol, 176: 506-15, 1998.
-
(1998)
J. Cell Physiol.
, vol.176
, pp. 506-515
-
-
Hirsch-Ernst, K.I.1
Ziemann, C.2
Foth, H.3
Kozian, D.4
Schmitz-Salue, C.5
Kahl, G.F.6
-
36
-
-
0034762163
-
Influence of IL-6 on MDR and MRP-mediated multidrug resistance in human hepatoma cells
-
Lee, G., and Piquette-Miller, M. Influence of IL-6 on MDR and MRP-mediated multidrug resistance in human hepatoma cells. Can J Physiol Pharmacol, 79: 876-84, 2001.
-
(2001)
Can. J. Physiol. Pharmacol.
, vol.79
, pp. 876-884
-
-
Lee, G.1
Piquette-Miller, M.2
-
37
-
-
0034924657
-
Decreased expression of P-glycoprotein in interleukin-1beta and interleukin-6 treated rat hepatocytes
-
Sukhai, M., Yong, A., Pak, A., and Piquette-Miller, M. Decreased expression of P-glycoprotein in interleukin-1beta and interleukin-6 treated rat hepatocytes. Inflamm Res, 50: 362-70, 2001.
-
(2001)
Inflamm. Res.
, vol.50
, pp. 362-370
-
-
Sukhai, M.1
Yong, A.2
Pak, A.3
Piquette-Miller, M.4
-
38
-
-
0036785558
-
Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes
-
Akazawa, Y., Kawaguchi, H., Funahashi, M., Watanabe, Y., Yamaoka, K., Hashida, M., and Takakura, Y. Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes. J Pharm Sci, 91: 2110-5, 2002.
-
(2002)
J. Pharm. Sci.
, vol.91
, pp. 2110-2115
-
-
Akazawa, Y.1
Kawaguchi, H.2
Funahashi, M.3
Watanabe, Y.4
Yamaoka, K.5
Hashida, M.6
Takakura, Y.7
-
39
-
-
0031867354
-
Nitric oxide production and MDR expression by human brain endothelial cells
-
Mandi, Y., Ocsovszki, I., Szabo, D., Nagy, Z., Nelson, J., and Molnar, J. Nitric oxide production and MDR expression by human brain endothelial cells. Anticancer Res, 18: 3049-52, 1998.
-
(1998)
Anticancer Res.
, vol.18
, pp. 3049-3052
-
-
Mandi, Y.1
Ocsovszki, I.2
Szabo, D.3
Nagy, Z.4
Nelson, J.5
Molnar, J.6
-
40
-
-
0142071056
-
Influence of tumor necrosis factor-alpha on the expression and function of P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT
-
Theron, D., Barraud de Lagerie, S., Tardivel, S., Pelerin, H., Demeuse, P., Mercier, C., Mabondzo, A., Farinotti, R., Lacour, B., Roux, F., and Gimenez, F. Influence of tumor necrosis factor-alpha on the expression and function of P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT. Biochem Pharmacol, 66: 579-87, 2003.
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 579-587
-
-
Theron, D.1
Barraud de Lagerie, S.2
Tardivel, S.3
Pelerin, H.4
Demeuse, P.5
Mercier, C.6
Mabondzo, A.7
Farinotti, R.8
Lacour, B.9
Roux, F.10
Gimenez, F.11
-
41
-
-
0037195601
-
Shiga-like toxin II modifies brain distribution of a P-glycoprotein substrate, doxorubicin, and P-glycoprotein expression in mice
-
Zhao, Y. L., Du, J., Kanazawa, H., Cen, X. B., Takagi, K., Kitaichi, K., Tatsumi, Y., Takagi, K., Ohta, M., and Hasegawa, T. Shiga-like toxin II modifies brain distribution of a P-glycoprotein substrate, doxorubicin, and P-glycoprotein expression in mice. Brain Res, 956: 246-53, 2002.
-
(2002)
Brain Res.
, vol.956
, pp. 246-253
-
-
Zhao, Y.L.1
Du, J.2
Kanazawa, H.3
Cen, X.B.4
Takagi, K.5
Kitaichi, K.6
Tatsumi, Y.7
Takagi, K.8
Ohta, M.9
Hasegawa, T.10
-
42
-
-
0033382907
-
Interaction of Shiga toxins with human brain microvascular endothelial cells: Cytokines as sensitizing agents
-
Ramegowda, B., Samuel, J. E., and Tesh, V. L. Interaction of Shiga toxins with human brain microvascular endothelial cells: cytokines as sensitizing agents. J Infect Dis, 180: 1205-13, 1999.
-
(1999)
J. Infect. Dis.
, vol.180
, pp. 1205-12013
-
-
Ramegowda, B.1
Samuel, J.E.2
Tesh, V.L.3
-
43
-
-
2342491501
-
Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF
-
Monville, C., Fages, C., Feyens, A. M., D'Hondt, V., Guillet, C., Vernallis, A., Gascan, H., and Peschanski, M. Astroglial expression of the P-glycoprotein is controlled by intracellular CNTF. BMC Cell Biol, 3: 20, 2002.
-
(2002)
BMC Cell Biol.
, vol.3
, pp. 20
-
-
Monville, C.1
Fages, C.2
Feyens, A.M.3
D'Hondt, V.4
Guillet, C.5
Vernallis, A.6
Gascan, H.7
Peschanski, M.8
-
44
-
-
0029060249
-
Gene transfer of human TNF alpha into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity
-
Walther, W., Stein, U., and Pfeil, D. Gene transfer of human TNF alpha into glioblastoma cells permits modulation of mdr1 expression and potentiation of chemosensitivity. Int J Cancer, 61: 832-9, 1995.
-
(1995)
Int. J. Cancer.
, vol.61
, pp. 832-839
-
-
Walther, W.1
Stein, U.2
Pfeil, D.3
-
45
-
-
0035038677
-
Cytokines influence mRNA expression of cytochrome P450 3A4 and MDRI in intestinal cells
-
Bertilsson, P. M., Olsson, P., and Magnusson, K. E. Cytokines influence mRNA expression of cytochrome P450 3A4 and MDRI in intestinal cells. J Pharm Sci, 90: 638-46, 2001.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 638-646
-
-
Bertilsson, P.M.1
Olsson, P.2
Magnusson, K.E.3
-
46
-
-
0029828921
-
Modulation of mdr1 expression by cytokines in human colon carcinoma cells: An approach for reversal of multidrug resistance
-
Stein, U., Walther, W., and Shoemaker, R. H. Modulation of mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance. Br J Cancer, 74: 1384-91, 1996.
-
(1996)
Br. J. Cancer
, vol.74
, pp. 1384-1391
-
-
Stein, U.1
Walther, W.2
Shoemaker, R.H.3
-
47
-
-
0029758014
-
Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells
-
Stein, U., Walther, W., and Shoemaker, R. H. Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells. J Natl Cancer Inst, 88: 1383-92, 1996.
-
(1996)
J. Natl. Cancer Inst.
, vol.88
, pp. 1383-1392
-
-
Stein, U.1
Walther, W.2
Shoemaker, R.H.3
-
48
-
-
0035994885
-
Effect of hr-IL2 treatment on intestinal P-glycoprotein expression and activity in Caco-2 cells
-
Belliard, A. M., Tardivel, S., Farinotti, R., Lacour, B., and Leroy, C. Effect of hr-IL2 treatment on intestinal P-glycoprotein expression and activity in Caco-2 cells. J Pharm Pharmacol, 54: 1103-9, 2002.
-
(2002)
J. Pharm. Pharmacol.
, vol.54
, pp. 1103-1129
-
-
Belliard, A.M.1
Tardivel, S.2
Farinotti, R.3
Lacour, B.4
Leroy, C.5
-
49
-
-
0036176968
-
Recombinant interleukin-2 treatment decreases P-glycoprotein activity and paclitaxel metabolism in mice
-
Bonhomme-Faivre, L., Pelloquin, A., Tardivel, S., Urien, S., Mathieu, M. C., Castagne, V., Lacour, B., and Farinotti, R. Recombinant interleukin-2 treatment decreases P-glycoprotein activity and paclitaxel metabolism in mice. Anticancer Drugs, 13: 51-7, 2002.
-
(2002)
Anticancer Drugs
, vol.13
, pp. 51-57
-
-
Bonhomme-Faivre, L.1
Pelloquin, A.2
Tardivel, S.3
Urien, S.4
Mathieu, M.C.5
Castagne, V.6
Lacour, B.7
Farinotti, R.8
-
50
-
-
0036073339
-
Effect of interleukin-2 on intestinal P-glycoprotein expression and functionality in mice
-
Veau, C., Faivre, L., Tardivel, S., Soursac, M., Banide, H., Lacour, B., and Farinotti, R. Effect of interleukin-2 on intestinal P-glycoprotein expression and functionality in mice. J Pharmacol Exp Ther, 302: 742-50, 2002.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.302
, pp. 742-750
-
-
Veau, C.1
Faivre, L.2
Tardivel, S.3
Soursac, M.4
Banide, H.5
Lacour, B.6
Farinotti, R.7
-
51
-
-
0842304217
-
Effect of recombinant interleukin-2 pre-treatment on oral and intravenous digoxin pharmacokinetics and P-glycoprotein activity in mice
-
Castagne, V., Bonhomme-Faivre, L., Urien, S., Reguiga, M. B., Soursac, M., Gimenez, F., and Farinotti, R. Effect of recombinant interleukin-2 pre-treatment on oral and intravenous digoxin pharmacokinetics and P-glycoprotein activity in mice. Drug Metab Dispos., 32:168-71, 2004.
-
(2004)
Drug Metab Dispos.
, vol.32
, pp. 168-171
-
-
Castagne, V.1
Bonhomme-Faivre, L.2
Urien, S.3
Reguiga, M.B.4
Soursac, M.5
Gimenez, F.6
Farinotti, R.7
-
52
-
-
0031432550
-
IL-6-regulated transcription factors
-
Akira, S. IL-6-regulated transcription factors. Int J Biochem Cell Biol, 29: 1401-18, 1997.
-
(1997)
Int. J. Biochem. Cell Biol.
, vol.29
, pp. 1401-1418
-
-
Akira, S.1
-
53
-
-
0035893768
-
Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells
-
Conze, D., Weiss, L., Regen, P. S., Bhushan, A., Weaver, D., Johnson, P., and Rincon, M. Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells. Cancer Res, 61: 8851-8, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 8851-8858
-
-
Conze, D.1
Weiss, L.2
Regen, P.S.3
Bhushan, A.4
Weaver, D.5
Johnson, P.6
Rincon, M.7
-
54
-
-
1842533016
-
CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells
-
Chen, G. K., Sale, S., Tan, T., Ermoian, R. P., and Sikic, B. I. CCAAT/enhancer-binding protein beta (nuclear factor for interleukin 6) transactivates the human MDR1 gene by interaction with an inverted CCAAT box in human cancer cells. Mol Pharmacol, 65: 906-16, 2004.
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 906-916
-
-
Chen, G.K.1
Sale, S.2
Tan, T.3
Ermoian, R.P.4
Sikic, B.I.5
-
55
-
-
0028149768
-
NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter
-
Combates, N. J., Rzepka, R. W., Chen, Y. N., and Cohen, D. NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene promoter. J Biol Chem, 269: 29715-9, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 29715-29719
-
-
Combates, N.J.1
Rzepka, R.W.2
Chen, Y.N.3
Cohen, D.4
-
56
-
-
0034994147
-
Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling
-
Ros, J. E., Schuetz, J. D., Geuken, M., Streetz, K., Moshage, H., Kuipers, F., Manns, M. P., Jansen, P. L., Trautwein, C., and Muller, M. Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling. Hepatology, 33: 1425-31, 2001.
-
(2001)
Hepatology
, vol.33
, pp. 1425-1431
-
-
Ros, J.E.1
Schuetz, J.D.2
Geuken, M.3
Streetz, K.4
Moshage, H.5
Kuipers, F.6
Manns, M.P.7
Jansen, P.L.8
Trautwein, C.9
Muller, M.10
-
57
-
-
0037427122
-
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells
-
Bentires-Alj, M., Barbu, V., Fillet, M., Chariot, A., Relic, B., Jacobs, N., Gielen, J., Merville, M. P., and Bours, V. NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene, 22: 90-7, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 90-97
-
-
Bentires-Alj, M.1
Barbu, V.2
Fillet, M.3
Chariot, A.4
Relic, B.5
Jacobs, N.6
Gielen, J.7
Merville, M.P.8
Bours, V.9
-
58
-
-
4043150782
-
Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells
-
Manara, M. C., Serra, M., Benini, S., Picci, P., and Scotlandi, K. Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma. cells. Int J Oncol, 24: 365-72, 2004.
-
(2004)
Int. J. Oncol.
, vol.24
, pp. 365-372
-
-
Manara, M.C.1
Serra, M.2
Benini, S.3
Picci, P.4
Scotlandi, K.5
-
59
-
-
0035042684
-
Cyp3A regulation: From pharmacology to nuclear receptors
-
Quattrochi, L. C., and Guzelian, P. S. Cyp3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos., 29: 615-22, 2001.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 615-622
-
-
Quattrochi, L.C.1
Guzelian, P.S.2
-
60
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterstrom, R. H., Perlmann, T., and Lehmann, J. M. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell, 92: 73-82, 1998.
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
61
-
-
0034088790
-
Rabbit pregnane X receptor is activated by rifampicin
-
Savas, U., Wester, M. R., Griffin, K. J., and Johnson, E. F. Rabbit pregnane X receptor is activated by rifampicin. Drug Metab Dispos., 28: 529-37, 2000.
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 529-537
-
-
Savas, U.1
Wester, M.R.2
Griffin, K.J.3
Johnson, E.F.4
-
62
-
-
0033178677
-
Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation
-
Zhang, H., LeCulyse, E., Liu, L., Hu, M., Matoney, L., Zhu, W., and Yan, B. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch Biochem Biophys, 368: 14-22, 1999.
-
(1999)
Arch. Biochem. Biophys.
, vol.368
, pp. 14-22
-
-
Zhang, H.1
LeCulyse, E.2
Liu, L.3
Hu, M.4
Matoney, L.5
Zhu, W.6
Yan, B.7
-
63
-
-
13144260727
-
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
-
Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L., Sydow-Backman, M., Ohlsson, R., Postlind, H., Blomquist, P., and Berkenstam, A. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A, 95: 12208-13, 1998.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 12208-12213
-
-
Bertilsson, G.1
Heidrich, J.2
Svensson, K.3
Asman, M.4
Jendeberg, L.5
Sydow-Backman, M.6
Ohlsson, R.7
Postlind, H.8
Blomquist, P.9
Berkenstam, A.10
-
64
-
-
0036136534
-
A pharmacophore for human pregnane X receptor ligands
-
Ekins, S., and Erickson, J. A. A pharmacophore for human pregnane X receptor ligands. Drug Metab Dispos., 30: 96-9, 2002.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 96-99
-
-
Ekins, S.1
Erickson, J.A.2
-
65
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
Synold, T. W., Dussault, I., and Forman, B. M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med, 7: 584-90, 2001.
-
(2001)
Nat. Med.
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
66
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick, A., Eichelbaum, M., and Burk, O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem, 276: 14581-7, 2001.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
67
-
-
4944230477
-
Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier
-
Bauer, B., Hartz, A. M., Fricker, G., and Miller, D. S. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol, 66: 413-9, 2004.
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 413-419
-
-
Bauer, B.1
Hartz, A.M.2
Fricker, G.3
Miller, D.S.4
-
68
-
-
0034637122
-
Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes
-
Pascussi, J. M., Gerbal-Chaloin, S., Pichard-Garcia, L., Daujat, M., Fabre, J. M., Maurel, P., and Vilarem, M. J. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun, 274: 707-13, 2000.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.274
, pp. 707-713
-
-
Pascussi, J.M.1
Gerbal-Chaloin, S.2
Pichard-Garcia, L.3
Daujat, M.4
Fabre, J.M.5
Maurel, P.6
Vilarem, M.J.7
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