Induction of Mdr1b expression by tumor necrosis factor-α in rat liver cells is independent of p53 but requires NF-κB signaling

Hepatology

Volumn 33, Issue 6, 2001, Pages 1425-1431

  Ros, Jenny E ^a   Schuetz, John D ^d   Geuken, Mariska ^a   Streetz, Konrad ^c   Moshage, Han ^a   Kuipers, Folkert ^b   Manns, Michael P ^c   Jansen, Peter L M ^a   Trautwein, Christian ^c   Müller, Michael ^a  

^a Department of Internal Medicine   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; FAS ANTIGEN; MULTIDRUG RESISTANCE PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; LIVER CELL; LIVER CELL CARCINOMA; LIVER REGENERATION; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION;

EID: 0034994147     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.24667     Document Type: Article

References (50)

1. An inventory of the human ABC proteins
2. Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture
3. Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes
4. Wild-type p53-mediated induction of rat mdr1b expression by the anticancer drug daunorubicin
5. Up-regulation of P-glycoprotein expression in rat liver cells by acute doxorubicin treatment
6. Multidrug resistance gene expression in rodents and rodent hepatocytes treated with mitoxantrone
7. Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter
8. Regulation of mdr1b gene expression in Fischer, Wistar and Sprague-Dawley rats in vivo and in vitro
9. 2-Acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B Pathway
10. NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells
11. Reactive oxygen species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures
12. Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis
13. Regulation of hepatic transport systems involved in bile secretion during liver regeneration in rats
14. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
15. Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy
16. Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: Requirement for type 1 but not type 2 receptor
17. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides
18. Induction of mdr1b mRNA and P-glycoprotein expression by tumor necrosis factor alpha in primary rat hepatocyte cultures
19. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity
20. Tumor necrosis factor-alpha generates reactive oxygen species via a cytosolic phospholipase A2-linked cascade
21. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation
22. Tumor necrosis factor receptor and Fas signaling mechanisms
23. Death receptors: Signaling and modulation
24. Inhibition of NFkappaB in activated rat hepatic stellate cells by protea some inhibitors and an IkappaB super-repressor
25. Involvement of p85 in p53-dependent apoptotic response to oxidative stress
26. NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress
27. CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling
28. Transcriptional cross talk between NF-kappaB and p53
29. p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents
30. Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes
31. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells
32. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release
33. TNF receptor-associated factor-2 is involved in both IL-1β and TNF-α signaling cascades leading to NF-kappaB activation and IL-8 expression in human intestinal epithelial cells
34. A rapid and versatile method to synthesize internal standards for competitive PCR
35. Differential binding activity of the transcription factor LlL-Stat in immature and differentiated normal and leukemic myeloid cells
36. Sp1 and Egr-1 have oppsing effects on the regulation of the rat pgp2/mdr1b gene
37. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
38. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
39. Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833
40. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
41. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis
42. SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drugresistant cancer cells
43. Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport
44. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
45. Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis
46. Effect of liver regeneration on hepatic cytochrome P450 isozymes and serum sex steroids in the male rat
47. Effects of bile duct ligation on hepatic expression of female-specific CYP2C12 in male and female rats
48. Down-regulation of the expression of three major rat liver cytochrome P450S by endotoxin in vivo occurs independently of nitric oxide production
49. Suppression of the constitutive expression of cytochrome P-450 2C11 by cytokines and interferons in primary cultures of rat hepatocytes: Comparison with induction of acute-phase genes and demonstration that CYP2C11 promoter sequences are involved in the suppressive response to interleukins 1 and 6
50. Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdrl genes