Cooperative binding of midazolam with testosterone and α- naphthoflavone within the CYP3A4 active site: A NMR T1 paramagnetic relaxation study

Biochemistry

Volumn 44, Issue 43, 2005, Pages 14143-14151

  Cameron, Michael D ^a   Wen, Bo ^a   Allen, Kyle E ^a   Roberts, Arthur G ^a   Schuman, Jason T ^a   Campbell, A Patricia ^a   Kunze, Kent L ^a   Nelson, Sidney D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; IRON; METABOLITES; NUCLEAR MAGNETIC RESONANCE; REACTION KINETICS; RELAXATION PROCESSES;

COOPERATIVE BINDING; HEME IRON; MIDAZOLAM; PARAMAGNETIC RELAXATION;

HORMONES;

4 HYDROXYMIDAZOLAM; ALPHA HYDROXYMIDAZOLAM; ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 3A4; DAPSONE; FLURBIPROFEN; HEME; MIDAZOLAM; PROTON; TESTOSTERONE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; MICHAELIS MENTEN KINETICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

BENZOFLAVONES; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; HEME; KINETICS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MIDAZOLAM; PROTONS; TESTOSTERONE;

EID: 27444443492     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051689t     Document Type: Article

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