Direct Interaction between Substrates and Endogenous Steroids in the Active Site May Change the Activity of Cytochrome P450 3A4

Biochemistry

Volumn 42, Issue 51, 2003, Pages 15068-15077

  Torimoto, Nao ^a   Ishii, Itsuko ^a   Hata, Masayuki ^a   Nakamura, Hiroyoshi ^a,b   Imada, Hiroshi ^a   Ariyoshi, Noritaka ^a,b   Ohmori, Shigeru ^a,c   Igarashi, Takashi ^a,d   Kitada, Mitsukazu ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY HOSPITAL   (Japan)

^c SHINSHU UNIVERSITY HOSPITAL   (Japan)

^d NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; HYDROXYLATION; MATHEMATICAL MODELS; METABOLISM; SUBSTRATES;

LIGANDS;

DRUG PRODUCTS;

ALDOSTERONE; ANDROSTENEDIONE; CARBAMAZEPINE; CYTOCHROME P450 3A4; ESTRADIOL; HEME; NEVIRAPINE; STEROID;

ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; COMPUTER MODEL; CONCENTRATION RESPONSE; DENSITY FUNCTIONAL THEORY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; EPOXIDATION; MICHAELIS CONSTANT; PRIORITY JOURNAL;

ADULT; ALDOSTERONE; ANDROSTENEDIONE; BINDING SITES; CARBAMAZEPINE; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME STABILITY; ESTRADIOL; HUMANS; HYDROXYLATION; KINETICS; MUTATION; NEVIRAPINE; SERINE; SUBSTRATE SPECIFICITY;

UNIDENTIFIED BACULOVIRUS;

EID: 0346963231     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034409n     Document Type: Article

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