Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4

Drug Metabolism and Disposition

Volumn 29, Issue 11, 2001, Pages 1473-1479

  Lu, Ping ^a   Lin, Yuh ^a   Rodrigues, A David ^a   Rushmore, Thomas H ^a   Baillie, Thomas A ^a   Shou, Magang ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 BENZYLOXY 4 TRIFLUOROMETHYLCOUMARIN; 7 BENZYLOXYQUINOLINE; COUMARIN DERIVATIVE; CYTOCHROME P450 3A4; QUINOLINE DERIVATIVE; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG INHIBITION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE; MICHAELIS CONSTANT; PRIORITY JOURNAL; STEREOSPECIFICITY;

BACULOVIRIDAE; BINDING SITES; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; FLUORESCENT DYES; GONADAL STEROID HORMONES; KINETICS; MIXED FUNCTION OXYGENASES; PROTEIN STRUCTURE, TERTIARY; QUINOLINES; SUBSTRATE SPECIFICITY; TESTOSTERONE;

EID: 0034777692     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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