Stimuli-responsive gene delivery vectors

Current Opinion in Molecular Therapeutics

Volumn 5, Issue 4, 2003, Pages 345-350

  Oupický, David ^a   Diwadkar, Veena ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Gene delivery; Magnetic; pH; Photochemical; Polycations; Redox; Stimulus; Ultrasound

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ACRYLIC ACID DERIVATIVE; AZOBENZENE; CONTRAST MEDIUM; COPOLYMER; DENDRIMER; DISULFIDE; DNA; GLUTATHIONE; GREEN FLUORESCENT PROTEIN; LIPID; LISTERIOLYSIN; MACROGOL; MALEIC ACID DERIVATIVE; MELITTIN; MESSENGER RNA; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; NITROREDUCTASE; NUCLEIC ACID; PEPTIDE DERIVATIVE; PHOSPHOLIPID; PHOTOSENSITIZING AGENT; PLASMID DNA; POLY(ETHYL METHACRYLATE); POLY(N ISOPROPYLACRYLAMIDE); POLYCATION; POLYLYSINE; POLYMER; PROTAMINE; UNINDEXED DRUG;

CELL NUCLEUS; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CROSS LINKING; CYTOSOL; DISULFIDE BOND; DRUG HALF LIFE; ENCAPSULATION; ENDOCYTOSIS; EXPRESSION VECTOR; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; IC 50; MAGNETIC FIELD; MICROENVIRONMENT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; OXIDATION REDUCTION POTENTIAL; PH MEASUREMENT; PHOTOCHEMISTRY; REVIEW; STIMULUS RESPONSE; TEMPERATURE SENSITIVITY; ULTRASOUND;

ACOUSTIC STIMULATION; ANIMALS; DRUG DELIVERY SYSTEMS; GENE THERAPY; GENETIC VECTORS; HUMANS; HYDROGEN-ION CONCENTRATION; STIMULATION, CHEMICAL;

VECTORS;

EID: 0042827496     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (53)

1. Wiethoff CM, Middaugh CR: Barriers to nonviral gene delivery. J Pharm Sci (2003) 92(2):203-217.
2. Merdan T, Kopecek J, Kissel T: Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev (2002) 54(5):715-758.
3. Zuber G, Dauty E, Nothisen M, Belguise P, Behr JP: Towards synthetic viruses. Adv Drug Deliv Rev (2001) 52(3):245-253.
4. Plank C, Mechtler K, Szoka FC Jr, Wagner E: Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery. Hum Gene Ther (1996) 7(12):1437-1446.
5. Zou SM, Erbacher P, Remy JS, Behr JP: Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse. J Gene Med (2000) 2(2):128-134.
6. Chollet P, Favrot MC, Hurbin A, Coll JL: Side-effects of a systemic injection of linear polyethylenimine-DNA complexes. J Gene Med (2002) 4(1):84-91.
7. Oupický D, Howard KA, Konak C, Dash PR, Ulbrich K, Seymour LW: Steric stabilization of poly-L-Lysine/DNA complexes by the covalent attachment of semitelechelic poly[N(2-hydroxypropyl)-methacrylamide]. Bioconjug Chem (2000) 11(4):492-501.
8. Oupický D, Ogris M, Howard KA, Dash PR, Ulbrich K, Seymour LW: Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol Ther (2002) 5(4):463-472.
9. Schaffer DV, Fidelman NA, Dan N, Lauffenburger DA: Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery. Biotechnol Bioeng (2000) 67(5):598-606.
10. Saito G, Swanson JA, Lee KD: Drug delivery strategy utilizing conjugation via reversible disulfide linkages: Role and site of cellular reducing activities. Adv Drug Deliv Rev (2003) 55(2):199-215.
11. Meister A: Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy. Pharmacol Ther (1991) 51(2):155-194.
12. Rogers JM, Hunter ES 3rd: Redox redux: A closer look at conceptal low molecular weight thiols. Toxicol Sci (2001) 62(1):1-3.
13. Clark AG, Civetta A: Evolutionary biology. Protamine wars. Nature (2000) 403(6767):261-263.
14. Zuelke KA, Jeffay SC, Zucker RM, Perreault SD: Glutathione (GSH) concentrations vary with the cell cycle in maturing hamster oocytes, zygotes, and pre-implantation stage embryos. Mol Reprod Dev (2003) 64(1):106-112.
15. Shimada A, Kikuchi K, Noguchi J, Akama K, Nakano M, Kaneko H: Protamine dissociation before decondensation of sperm nuclei during in vitro fertilization of pig oocytes. J Reprod Fertil (2000) 120(2):247-256.
16. Kwok KY, Yang Y, Rice KG: Evolution of cross-linked non-viral gene delivery systems. Curr Opin Mol Ther (2001) 3(2):142-146.
17. McKenzie DL, Kwok KY, Rice KG: A potent new class of reductively activated peptide gene delivery agents. J Biol Chem (2000) 275(14):9970-9977.
18. McKenzie DL, Smiley E, Kwok KY, Rice KG: Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers. Bioconjug Chem (2000) 11(6):901-909.
19. Park Y, Kwok KY, Boukarim C, Rice KG: Synthesis of sulfhydryl cross-linking poly(ethylene glycol)-peptides and glycopeptides as carriers for gene delivery. Bioconjug Chem (2002) 13(2):232-239.
20. Oupický D, Carlisle RC, Seymour LW: Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo. Gene Ther (2001) 8(9):713-724.
21. Oupický D, Parker AL, Seymour LW: Laterally stabilized complexes of DNA with linear reducible polycations: Strategy for triggered intracellular activation of DNA delivery vectors. J Am Chem Soc (2002) 124(1):8-9.
22. Read ML, Bremner KH, Oupický D, Green NK, Searle PF, Seymour LW: Vectors based on reducible polycations facilitate intracellular release of nucleic acids. J Gene Med (2003) 5(3):232-245.
23. Weedon S, Mautner V, Green N, McNeish I, Gilligan M, Searle P, Young L, Kerr D: Nitroreductase-expressing adenoviral vectors for enzyme/prodrug cancer therapy. Ann Oncol (1998) 9:120.
24. Bettinger T, Carlisle RC, Read ML, Ogris M, Seymour LW: Peptide-mediated RNA delivery: A novel approach for enhanced transfection of primary and post-mitotic cells. Nucleic Acids Res (2001) 29(18):3882-3891.
25. Pichon C, LeCam E, Guerin B, Coulaud D, Delain E, Midoux P: Poly[Lys-(AEDTP)]: A cationic polymer that allows dissociation of pDNA/cationic polymer complexes in a reductive medium and enhances polyfection. Bioconjug Chem (2002) 13(1):76-82.
26. Saito G, Amidon GL, Lee KD: Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential. Gene Ther (2003) 10(1):72-83.
27. Asokan A, Cho MJ: Exploitation of intracellular pH gradients in the cellular delivery of macromolecules. J Pharm Sci (2002) 91(4):903-913.
28. Gerweck LE, Seetharaman K: Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer. Cancer Res (1996) 56(6):1194-1198.
29. Plank C, Oberhauser B, Mechtler K, Koch C, Wagner E: The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems. J Biol Chem (1994) 269(17):12918-12924.
30. Cheung CY, Murthy N, Stayton PS, Hoffman AS: A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer. Bioconjug Chem (2001) 12(6):906-910.
31. Guo X, Szoka FC Jr: Static stabilization of fusogenic liposomes by a low-pH sensitive PEG-diortho ester-lipid conjugate. Bioconjug Chem (2001) 12(2):291-300.
32. Boomer JA, Thompson DH, Sullivan SM: Formation of plasmid-based transfection complexes with an acid-labile cationic lipid: Characterization of in vitro and in vivo gene transfer. Pharm Res (2002) 19(9):1292-1301.
33. Rozema DB, Ekena K, Lewis DL, Loomis AG, Wolff JA: Enclosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules. Bioconjug Chem (2003) 14(1):51-57.
34. Unger EC, Matsunaga TO, McCreery T, Schumann P, Sweitzer R, Quigley R: Therapeutic applications of microbubbles. Eur J Radiol (2002) 42(2):160-168.
35. Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Morishita R: Development of safe and efficient novel nonviral gene transfer using ultrasound: Enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther (2002) 9(6):372-380.
36. Danialou G, Comtois AS, Dudley RW, Nalbantoglu J, Gilbert R, Karpati G, Jones DH, Petrof BJ: Ultrasound increases plasmid-mediated gene transfer to dystrophic muscles without collateral damage. Mol Ther (2002) 6(5):687-693.
37. Price RJ, Skyba DM, Kaul S, Skalak TC: Delivery of colloidal, particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound. Circulation (1998) 98(13):1264-1267.
38. Skyba DM, Price RJ, Linka AZ, Skalak TC, Kaul S: Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation (1998) 98(4):290-293.
39. Seemann S, Hauff P, Schultze-Mosgau M, Lehmann C, Reszka R: Pharmaceutical evaluation of gas-filled microparticles; as gene delivery system. Pharm Res (2002) 19(3):250-257.
40. Frenkel PA, Chen S, Thai T, Shohet RV, Grayburn PA: DNA-loaded albumin microbubbles; enhance ultrasound-mediated transfection in vitro. Ultrasound Med Biol (2002) 28(6):817-822.
41. Unger EC, Hersh E, Vannan M, McCreery T: Gene delivery using ultrasound contrast agents. Echocardiography (2001) 18(4):355-361.
42. Vannan M, McCreery T, Li P, Han Z, Unger E, Kuersten B, Nabel E, Rajagopalan S: Ultrasound-mediated transfection of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA. J Am Soc Echocardiogr (2002) 15(3):214-218.
43. Yokoyama M: Gene delivery using temperature-responsive polymeric carriers. Drug Disc Today (2002) 7(7):426-432.
44. Kurisawa M, Yokoyama M, Okano T: Gene expression control by temperature with thermo-responsive polymeric gone carriers. J Control Release (2000) 69(1):127-137.
45. Kurisawa M, Yokoyama M, Okano T: Transfection efficiency increases by incorporating hydrophobic monomer units into polymeric gene carriers. J Control Release (2000) 68(1):1-8.
46. Oupický D, Reschel T, Konak C, Oupicka L: Temperature controlled behavior of self-assembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly(N-isopropylacrylamide). Macromolecules (2003): in press.
47. Scherer F, Anton M, Schillinger U, Henke J, Bergemann C, Kruger A, Gansbacher B, Plank C: Magnetofection: Enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther (2002) 9(2):102-109.
48. Krotz F, Wit C, Sohn H-Y, Zahler S, Gloe T, Pohl U, Plank C: Magnetofection - A highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo. Mol Ther (2003) 7(5):700-710.
49. Prasmickaite L, Hogset A, Berg K: The role of the cell cycle on the efficiency of photochemical gene transfection. Biochim Biophys Acta (2002) 1570(3):210-218.
50. Nagasaki T, Atarashi K, Makino K, Noguchi A, Tamagaki S: Synthesis of a novel water-soluble polyazobenzene dendrimer and photoregulation of affinity toward DNA. Mol Cryst Liq Cryst (2000) 345:227-232.
51. Nagasaki T, Wada K, Tamagaki S: Photo-enhancement of transfection efficiency with a novel azobenzene-based cationic lipid. Chem Lett (2003) 32(1):88-89.
52. Nagasaki T, Taniguchi A, Tamagaki S: Photoenhancement of transfection efficiency using novel cationic lipids having a photocleavable spacer. Bioconjug Chem (2003) 14(3):513-516.
53. Varga CM, Hong K, Lauffenburger DA: Quantitative analysis of synthetic gene delivery vector design properties. Mol Ther (2001) 4(5):438-446.