Biodegradable, endosome disruptive, and cationic network-type polymer as a highly efficient and nontoxic gene delivery carrier

Bioconjugate Chemistry

Volumn 13, Issue 5, 2002, Pages 952-957

  Lim, Yong Beom ^a   Kim, Seon Mi ^a   Suh, Hearan ^a   Park, Jong Sang ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADABLE POLYMERS; BIODEGRADATION; EFFICIENCY; GENE THERAPY; MOLECULAR BIOLOGY; VECTORS;

CATIONICS; DELIVERY CARRIERS; DELIVERY VECTOR; ENDOSOMES; GENE DELIVERY; GENE DELIVERY VECTORS; NETWORK TYPES; POLY (AMINO ESTER); POLY(ETHYLENIMINE); TRANSFECTION EFFICIENCY;

GENE TRANSFER;

LUCIFERASE; POLYAMINE; POLYCATIONS; POLYESTER;

ARTICLE; BIOREMEDIATION; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; ENDOSOME; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; METHODOLOGY; PLASMID; REPORTER GENE; STANDARD; SYNTHESIS;

BIODEGRADATION, ENVIRONMENTAL; CELL SURVIVAL; ENDOSOMES; GENES, REPORTER; HUMANS; LUCIFERASES; PLASMIDS; POLYAMINES; POLYESTERS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036740007     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc025541n     Document Type: Article

References (19)

1. Kay, M. A., Liu, D., and Hoogerbrugge, P. M. (1997) Gene therapy. Proc. Natl Acad. Sci. U.S.A. 94, 12744-12746.
2. Lee, H. C., Kim, S., Kim, K., Shin, H., and Yoon, J. (2000) Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature 408, 483-488.
3. Nishikawa, M., and Huang, L. (2001) Nonviral vectors in the new millennium: Delivery barriers in gene transfer. Hum. Gene Ther. 12, 861-870.
4. Wagner, E., Plank, C., Zatloukal, K., Cotton, M., and Birnstiel, M. L. (1992) Transferrin-polycation-DNA complexes: The effect of polycations on the structure of the complex and DNA delivery to cells. Proc. Natl. Acad. Sci. U.S.A. 89, 7934-7938.
5. Vigneron, J., Oudrhiri, N., Fauquet, M., Vergely, L., Bradley, J., Basseville, M., Lehn, P., and Lehn, J. (1996) Guanidinium-cholesterol cationic lipids: Efficient vectors for the transfection of eukaryotic cells. Proc. Natl. Acad. Sci. U.S.A. 93, 9682-9686.
6. Godbey, W. T., Wu, K. K., and Mikos, A. G. (1999) Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc. Natl Acad. Sci. U.S.A. 96, 5177-5181.
7. Lim, Y., Choi, Y. H., and Park, J. (1999) A self-destroying polycationic polymer: Biodegradable poly(4-hydroxy-L-proline ester). J. Am. Chem. Soc. 121, 5633-5639.
8. Putnam, D., and Langer, R. (1999) Poly(4-hydroxy-L-proline ester): Low-temperature polycondensation and plasmid DNA complexation. Macromolecules 32, 3658-3662.
9. Lim, Y., Kim, C., Kim, K., Kim, S. W., and Park, J. (2000) Development of a safe gene delivery system using biodegradable polymer, poly[α-(4-aminobutyl)-L-glycolic acid]. J. Am. Chem. Soc. 122, 6524-6525.
10. Lim, Y., Han, S., Kong, H., Lee, Y., Park, J., Jeong, B., and Kim, S. W. Pharm. Res. (2000) Biodegradable polyester, poly[α-(4-aminobutyl)-L-glycolic acid], as a nontoxic gene carrier. 17, 811-816.
11. Lynn, D. M., and Langer, R. (2000) Degradable poly(β-amino esters): Synthesis, characterization, and self-assembly with plasmid DNA. J. Am. Chem. Soc. 122, 10761-10786.
12. Wang, J., Mao, H., and Leong, K. W. (2001) A novel biodegradable gene carrier based on polyphosphoester. J. Am. Chem. Soc. 123, 9480-9481.
13. Lim, Y., Kim, S., Lee, Y., Lee, W., Yang, T., Lee, M., Suh, H., and Park, J. (2001) Cationic hyperbranched poly(amino ester): A novel class of DNA condensing molecule with cationic surface, biodegradable three-dimensional structure, and tertiary amine groups in the interior. J. Am. Chem. Soc. 123, 2460-2461.
14. Lee, Y., Park, E. J., Yu, S. S., Kim, D., and Kim, S. (2000) Improved expression of vascular endothelial growth factor by naked DNA in mouse skeletal muscle: Implication for gene therapy of ischemic disease. Biochem. Biophys. Res. Commun. 272, 230-235.
15. Udenfriend, S., Stein, S., Bohlen, P., Dairman, W., Leimgruber, W., and Weigele, M. (1972) Fluorescamine: A reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range. Science 178, 871-872.
16. Feast, W. J., and Stainton, N. M. (1995) Synthesis, structure and properties of some hyperbranched polyesters. J. Mater. Chem. 5, 405-411.
17. Plank, C., Zatloukal, K., Cotton, M., Mechtler, K., and Wagner, E. (1992) Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand. Bioconjugate Chem. 3, 533-539.
18. Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., and Behr, J. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc. Natl Acad. Sci. U.S.A. 92, 7297-7301.
19. Uherek, C., Fominaya, J., and Wels, W. (1998) A modular DNA carrier protein based on the structure of diphtheria toxin mediates target cell-specific gene delivery. J. Biol. Chem. 273, 8835-8841.